Phosphopeptide 14 3 3 proteins. Medical search. Frequent questions

We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)
In the discovery set of fresh-frozen tissue specimens (14), the A-kinase anchor protein 12 (AKAP12) protein was found downregulated across the grades. (nature.com)
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation. (nih.gov)
Although intracellular signal transduction is often portrayed as a protein kinase 'domino effect', the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. (ac.be)
The Src Homology 2 (SH2) domain is a major protein interaction module that is central to tyrosine kinase signaling. (eu.org)
B-Raf (RAFB1) is a protein-serine/threonine kinase of the TKL group and RAF family. (kinexusproducts.ca)
B-RAF is a known oncoprotein (OP). Cancer-related mutations in human tumours point to a gain of function of the protein kinase. (kinexusproducts.ca)
[ 11 ] They revealed that whereas Noonan syndrome is caused by gain-of-function PTPN11 mutations, LEOPARD syndrome mutants are catalytically defective and act as dominant negative mutations that interfere with growth factor/Erk-mitogen-activated protein kinase-mediated signaling. (medscape.com)
AURK significantly promotes activation of IκBα at serine 32, but not serine 36 residues, unlike IκB kinase (IKK) family proteins activate both IκBα serine residues. (researchsquare.com)
Stable isotope labeling of phosphopeptides for multiparallel kinase target analysis and identification of phosphorylation sites. (mpg.de)
2004) S6K1(−/−)/S6K2(−/−) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. (concordia.ca)
TLK16998 alone had no effect on IR signaling in mouse 3T3-L1 adipocytes but, at concentrations as low as 3.2 μmol/l, enhanced the effects of insulin on the phosphorylation of the IR β-subunit and IR substrate 1, and on the amount of phosphatidylinositol 3-kinase that coimmunoprecipitated with IRS-1. (diabetesjournals.org)
Phosphopeptide mapping revealed that the effect of TLK16998 on the IR was associated with increased tyrosine phosphorylation of the activation loop of the β-subunit tyrosine kinase domain. (diabetesjournals.org)
Many molecular pathways in eukaryotic cells are modulated by specific signaling proteins that are controlled, by phosphorylation and dephosphorylation, through the activity of kinase and phosphatase enzymes. (biomedcentral.com)

Cancer Res (2021) 81 (14): 3930-3941. (aacrjournals.org)
2021. "Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. (pnnl.gov)
2021. "Resin Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation. (pnnl.gov)
2021. "A Sweet H2S/H2O2 Dual Release System and Specific Protein S-Persulfidation Mediated by Thioglucose/Glucose Oxidase. (pnnl.gov)

14-3-3 binds to peptides. (wikipedia.org)
The formation of 3-(1-piperidinyl)alanyl-containing peptides via phosphoryl β -elimination was identified from the application of Fmoc-Ser(PO 3 Bzl,H)-OH in peptide synthesis as shown by RP-HPLC, ES-MS and 31 P-NMR analysis. (springer.com)
The generation of 3-(1-piperidinyl)alanyl-peptides was also shown to be enhanced by the use of microwave radiation during Fmoc deprotection. (springer.com)
The application of the alternative N α -deprotection protocol using 50% cyclohexylamine/DCM (v/v) is therefore recommended for deprotection of the Fmoc group from the Fmoc-Ser(PO 3 Bzl,H) residue, with particular benefit anticipated for the synthesis of multiphosphoseryl peptides. (springer.com)
Lukszo J, Patterson D, Albericio F, Kates SA (1996) 3-(1-Piperidinyl)alanine formation during the preparation of C-terminal cysteine peptides with the Fmoc/t-Bu strategy. (springer.com)
Ottinger EA, Shekels LL, Bernlohr DA, Barany G (1993) Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases. (springer.com)
Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides. (liverpool.ac.uk)
The researchers then used these variants and expressed transcripts from each patient to build a sample-specific database and identified 156,135 peptides, 28,944 phosphopeptides, and 4,376 N-glycopeptides from the global proteomes, phosphoproteomes, and N-glycoproteomes, respectively. (genomeweb.com)
These peptides were mapped to 10,295 protein-coding genes, on average. (genomeweb.com)

Elevated amounts of 14-3-3 proteins in cerebrospinal fluid may be a sign of Creutzfeldt-Jakob disease. (wikipedia.org)

2023 Oct 9;14(1):6316. (nih.gov)
2023 May 15;14(1):2789. (nih.gov)

14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. (wikipedia.org)
4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)

2017;101(3):320-3. (smw.ch)
Prev Chronic Dis 2017;14:160372. (cdc.gov)

14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. (wikipedia.org)
Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. (ac.be)
But advances in the understanding of protein phosphatases make now clear that these enzymes are precisely regulated and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. (ac.be)

BRaf-3 pan-specific antibody (Cat. (kinexusproducts.ca)
After the primary antibody is bound to the target protein, a complex with HRP-linked secondary antibody is formed. (cellsignal.com)
But the TCGA approach, which was performed using reverse-phase protein arrays, is limited by antibody availability. (genomeweb.com)
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. (abcam.com)
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. (abcam.com)

We used cysteine mutagenesis and 14 C-NEM- labeling to show that the p110-binding site in the iSH2 domain includes two regions: residues 482-484 and 532-541. (elsevierpure.com)
We then used spin labeling and EPR spectroscopy to demonstrate that the conformation of the iSH2 domain is unaffected by binding to the N-terminal fragment of p110 (residues 1-108), and/or by phosphopeptide binding to p85ni/p110(1-108) heterodimers. (elsevierpure.com)
Piperidine-induced β -elimination was found only to occur in Ser(PO 3 Bzl,H) residues that were in the N-terminal position, since the addition of the next residue in the sequence rendered the phosphoseryl residue stable to multiple piperidine treatments. (springer.com)
Inspection of known binders reveals that weak residues are tolerated at pY+3 when pY+1 is strong and vice-versa, but are not tolerated at both positions. (eu.org)
Positively charged residues are disfavoured at pY-1 and pY-2 due to the positively charged SH2 domain surface, but are tolerated when pY+1 and pY+3 are strong residues. (eu.org)

Our results confirm the important role played by the +2 proline residue in the thermodynamics and structure of the phosphoepitope/14-3-3 interaction. (rcsb.org)
These proteins contain a number of known common modification domains, including regions for divalent cation interaction, phosphorylation & acetylation, and proteolytic cleavage, among others established and predicted. (wikipedia.org)
Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
Protein-protein interaction (PPI) networks are fundamental for cellular processes. (diamond.ac.uk)
Phosphorylation of S729 increases phosphotransferase activity and induces interaction with 14-3-3 beta. (kinexusproducts.ca)
[ 9 ] Because the vast majority of mutations reside in and around the broad intramolecular interaction surface between the N-SH2 and PTP domains of the PTPN11 protein, they have been suggested to affect the intramolecular N-SH2/PTP binding in the absence of a phosphopeptide, leading to excessive phosphatase activities. (medscape.com)
This occurs through specific modulation of regulatory proteins during the host-pathogen interaction, especially proteins with roles in pathogenesis [ 27 ]. (biomedcentral.com)

There are common recognition motifs for 14-3-3 proteins that contain a phosphorylated serine or threonine residue, although binding to non-phosphorylated ligands has also been reported. (wikipedia.org)

Here we describe the synthesis of a series of α,β-phosphopeptides, based on the phosphoepitope site on YAP1 (yes-associated protein 1), and the biochemical, biophysical and structural characterization of their binding to 14-3-3 proteins. (rcsb.org)
Attard TJ, O'Brien-Simpson N, Reynolds EC (2007) Synthesis of phosphopeptides in the Fmoc mode. (springer.com)
Brandt M, Gammeltoft S, Jensen KJ (2006) Microwave heating for solid-phase peptide synthesis: general evaluation and application to 15-mer phosphopeptides. (springer.com)
Otvos L Jr, Elekes I, Lee VM (1989) Solid-phase synthesis of phosphopeptides. (springer.com)
Perich JW, Ede NJ, Eagle S, Bray AM (1999) Synthesis of phosphopeptides by the Multipin method: evaluation of coupling methods for the incorporation of Fmoc-Tyr(PO3Bzl, H)-OH, Fmoc-Ser(PO3Bzl, H)-OH and Fmoc-Thr(PO3Bzl, H)-OH. (springer.com)

Scoring and identifying organism-specific functional patterns and putative phosphorylation sites in protein sequences using mutual information. (mpg.de)

Class IA PI 3-kinases are heterodimeric proteins with distinct catalytic (p110) and regulatory (p85) subunits. (elsevierpure.com)
The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)

More than 200 signaling proteins have been reported as 14-3-3 ligands. (wikipedia.org)
In this article, we describe a simple computational approach, based on the effect allosteric ligands exert on protein flexibility upon binding, to predict the existence and position of allosteric sites on a given protein structure. (biomedcentral.com)

Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signalling pathways. (eu.org)
We identified a great number of proteins and phosphoproteins that remain continuously dysregulated from 3 to 24 weeks. (biomedcentral.com)

Seven genes encode seven distinct 14-3-3 proteins in most mammals (See Human genes below) and 13-15 genes in many higher plants, though typically in fungi they are present only in pairs. (wikipedia.org)
Eukaryotes can tolerate the loss of a single 14-3-3 gene if multiple genes are expressed, but deletion of all 14-3-3s (as experimentally determined in yeast) results in death. (wikipedia.org)
The bcl-3 protein does not inhibit either the DNA-binding activity of the Rel protein or its ability to trans-activate genes linked to the kappa B site. (duke.edu)
Cadherin genes encode a superfamily of calcium-dependent adhesion-related type-1 transmembrane proteins. (biomedcentral.com)
Further, we review the corresponding genes and the proteins encoded by these genes, their possible role in the developing brain and reported mutations of these genes. (biomedcentral.com)
The term RASopathies includes disorders with mutations in the genes that code for the proteins of the RAS/MAPK pathway, such as neurofibromatosis type 1, Noonan syndrome, Legius syndrome, LEOPARD syndrome, Costello syndrome, and cardiofaciocutaneous syndrome. (medscape.com)

A human 37-kD protein (I kappa B alpha), identified previously as a member of the I kappa B family, is also unable to inhibit DNA-binding activity of the Rel protein. (duke.edu)
However, unlike bcl-3, the 37-kD (I kappa B alpha) protein has no effect on the DNA-binding activity of p50 or p49 homodimers. (duke.edu)
Two dimensional phosphotryptic peptide maps of the human bcl-3 and the human 37-kD (I kappa B alpha) proteins reveal that the phosphopeptides from the 37-kD (I kappa B alpha) protein are nested within the bcl-3 protein. (duke.edu)
Furthermore, bcl-3 antisera immunoprecipitates an in vitro-radiolabeled 37-kD (I kappa B alpha) protein. (duke.edu)
Removal of the amino-terminal sequences of the bcl-3 protein generates a protein that inhibits the DNA binding of the p50-p65 heterodimer but, like the 37-kD (I kappa B alpha) protein, is no longer able to inhibit the binding of the p50 and p49 homodimers with kappa B DNA. (duke.edu)
We propose that the bcl-3 and 37-kD (I kappa B alpha) proteins are related and are members of the I kappa B family. (duke.edu)

Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches to better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. (pnnl.gov)

No immunoreactivity on protein dot blots with recombinant human Raf1. (kinexusproducts.ca)

citation needed] 14-3-3 proteins are structurally similar to the Tetratrico Peptide Repeat (TPR) superfamily, which generally have 9 or 10 alpha helices, and usually form homo- and/or hetero-dimer interactions along their amino-termini helices. (wikipedia.org)
Binding of 14-3-3 has little effect on Cdc25C activity, and it is believed that 14-3-3 regulates Cdc25C by sequestering it to the cytoplasm, thereby preventing the interactions with CycB-Cdk1 that are localized to the nucleus at the G2/M transition. (wikipedia.org)
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). (hmdb.ca)
They are able to bind specific motifs containing a phosphorylated tyrosine residue, propagating the signal downstream by promoting protein-protein interactions and/or modifying enzymatic activities. (eu.org)
In NCK SH2 domains, the EF loop is positioned away from the BG loop, exposing the pY+3 binding pocket where the side chain of Val forms tight interactions. (eu.org)
SH2 domains are phosphotyrosine recognition domains, often mediating transient interactions with target proteins. (eu.org)
Most of the important molecular processes in the cell, such as DNA replication, are performed by large molecular network of protein-protein interactions. (researchsquare.com)
We need to acquire more knowledge of various protein-protein interactions in order to understand biological phenomena, including diseases, and to provide the basis for new therapeutic approaches. (researchsquare.com)
These proteins display interactions and are involved in the regulation of the cellular cytoskeleton. (biomedcentral.com)

Recent developments in mass spectrometry-based phosphoproteomics have led to the identification of thousands of differentially phosphorylated proteins and their phosphorylation sites. (molcells.org)

In this research project, we successfully developed several original methods (or synthetic small molecules) based on chemistry that allow for selective labeling and imaging target proteins under nearly natural conditions. (nii.ac.jp)

2 Protein phosphatase 2A (PP2A) is a very abundant - it accounts for as much as 1% of total cellular proteins - ubiquitous and remarkably conserved enzyme. (ac.be)

The bcl-3 protein is able to inhibit the DNA binding and trans-activation of authentic NF-kappa B heterodimers p50-p65 and p49-p65, as well as p50 and p49 homodimers. (duke.edu)
These findings suggest that parasite proteins are able to inhibit erythroid cell growth by down-regulation of ezrin phosphorylation, leading to ineffective erythropoiesis ultimately resulting in severe malarial anaemia. (biomedcentral.com)

Scholars@Duke publication: The proto-oncogene bcl-3 encodes an I kappa B protein. (duke.edu)

A variety of extracellular stimuli including mitogens, cytokines, antigens, stress inducing agents, UV light and viral proteins initiate a signal transduction pathway that ultimately leads to NF-κB release and activation. (justia.com)
The regulation of complex and dynamic signal transduction proteins contributes to the destination of targeting proteins and the signal transduction of cell growth, and exposure to parasites can also influence signaling pathways. (biomedcentral.com)

By contrast, the 14-3-3 overexpressing line displays an attenuated shade phenotype. (elifesciences.org)

citation needed] 14-3-3 proteins were initially found in brain tissue in 1967 and purified using chromatography and gel electrophoresis. (wikipedia.org)

14-3-3 proteins bind to and sequester the transcriptional coregulators YAP/TAZ to the cytoplasm, inhibiting their function. (wikipedia.org)

Raf-1 Bad - see Bcl-2 Bax Cdc25 Akt SOS1 - see RSK YWHAB - "14-3-3 beta" YWHAE - "14-3-3 epsilon" YWHAG - "14-3-3 gamma" YWHAH - "14-3-3 eta" YWHAQ - "14-3-3 tau" YWHAZ - "14-3-3 zeta" SFN or YWHAS - "14-3-3 sigma" (Stratifin) The 14-3-3 proteins alpha and delta (YWHAA and YWHAD) are phosphorylated forms of YWHAB and YWHAZ, respectively. (wikipedia.org)

A phylogenetic analysis of 27 plant species clustered the 14-3-3 proteins into four groups. (wikipedia.org)
We observed 39 common proteins that were upregulated in both species and 24 common pathways associated with these proteins. (biomedcentral.com)

By querying the literature and a recently available database of allosteric sites, we gathered 213 allosteric proteins with structural information that we further filtered into a non-redundant set of 91 proteins. (biomedcentral.com)
Furthermore, we implemented an approach that achieves 65% positive predictive value in identifying allosteric sites within the set of predicted cavities of a protein (stricter parameters set, 0.22 sensitivity), by combining the current analysis on dynamics with previous results on structural conservation of allosteric sites. (biomedcentral.com)

Degradation of a protein via the ubiquitin pathway proceeds by two discrete and successive steps: (a) covalent attachment of multiple ubiquitin molecules to the protein substrate, and (b) degradation of the targeted protein by the 26S proteasome complex. (justia.com)

However, at 3 weeks post-TBI, only pathways associated with total proteins are upregulated, while pathways driven by phosphoproteins are downregulated. (biomedcentral.com)

We also compared canonical pathway activation associated with either total proteins or phosphoproteins and revealed that they both are upregulated at 24 weeks. (biomedcentral.com)

The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)

Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare autosomal dominant disorder most often caused by missense mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP2. (medscape.com)
[ 4 ] Molecular studies have proven that LEOPARD syndrome and Noonan syndrome are allelic disorders caused by different missense mutations in PTPN11, a gene encoding the protein tyrosine phosphatase SHP-2 located at band 12q24.1. (medscape.com)

In cardiac hypertrophy, phosphorylation-dependent functional modulation of proteins, especially sarcoplasmic reticulum (SR) and sarcomere proteins, has been demonstrated. (molcells.org)
NCK is a major adaptor protein involved in membrane receptor signalling and modulation of actin cytoskeleton dynamics. (eu.org)
However, for most allosteric proteins identified to date the mechanistic details of allosteric modulation are not yet well understood. (biomedcentral.com)

1 Reversible protein phosphorylation is an important regulatory mechanism that controls the activities of a myriad of proteins and is thus involved in virtually every major physiological process. (ac.be)

3 This article will review the recent advances in the structure and regulation of this fascinating enzyme. (ac.be)
Allostery is one of the most powerful and common ways of regulation of protein activity. (biomedcentral.com)
Tight regulation of these processes is fundamental in all kingdoms of life and allostery represents one of the most commmon and powerful means of modulating protein activity[ 1 ]. (biomedcentral.com)
Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)

In a systematic review, 14-3-3η has been described as a welcome addition to the rheumatology field. (wikipedia.org)

Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. (ac.be)

Fig. 1: Serum mitogen-induced phosphorylation of PI3KC2-β induces complex formation with 14-3-3 proteins. (nature.com)

Immunoprecipitation of mTOR protein from MCF-7 cell extracts. (cellsignal.com)
Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900, and lane 3 is mTOR (7C10) Rabbit mAb. (cellsignal.com)

Comparison of tryptic peptide maps of the bcl-3 protein synthesized in vitro, and p56 and p38 from HeLa cells, shows that they are all structurally related. (duke.edu)

However, functional studies of these differentially phosphorylated proteins have not been conducted in a large-scale or high-throughput manner due to a lack of methods capable of revealing the functional relevance of each phosphorylation site. (molcells.org)
Proteins can be regarded as the functional building blocks of life, carrying out and coordinating almost all biological processes. (biomedcentral.com)

The 14-3-3 proteins are highly conserved in all eukaryotes. (elifesciences.org)

To map the mechanisms of aggressiveness we aimed to investigate changes in protein phosphorylation across WHO grades of human meningiomas. (nature.com)
We performed normal-mode analysis and observed significant changes in protein flexibility upon allosteric-ligand binding in 70% of the cases. (biomedcentral.com)
These results agree with the current view that allosteric mechanisms are in many cases governed by changes in protein dynamics caused by ligand binding. (biomedcentral.com)
We introduce a simple computational approach to predict the presence and position of allosteric sites in a protein based on the analysis of changes in protein normal modes upon the binding of a coarse-grained ligand at predicted cavities. (biomedcentral.com)

14-3-3 proteins activate the auto-inhibited plasma membrane P-type H+ ATPases. (wikipedia.org)

Subtype 3 uniquely represented metabolism-related processes (oxidative phosphorylation, fatty acid b-oxidation, and citrate cycle). (genomeweb.com)

Val and Pro confer high-affinity binding at pY+3 - Ala and Ile are tolerated but confer weaker binding. (eu.org)

Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)

The observed molecular mass of the processed target protein on SDS-PAGE gels is reported to be around 87-97 kDa. (kinexusproducts.ca)
3 Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York. (diabetesjournals.org)

Integrative profiling of metabolites and proteins: improving pattern recognition and biomarker selection for systems level approaches. (mpg.de)

Phosphorylation of Cdc25C by CDS1 and CHEK1 creates a binding site for the 14-3-3 family of phosphoserine binding proteins. (wikipedia.org)
These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
With the exception of ForI and ForC all other formins conform to the domain structure GBD/FH3-FH1-FH2-DAD, where DAD is the Diaphanous autoinhibition domain and GBD/FH3 is the Rho GTPase-binding domain/formin homology 3 domain that we propose to represent a single domain. (biomedcentral.com)
The other two positions important for binding are pY+3 and pY+1. (eu.org)

Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)

Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins. (justia.com)

Identification of noncoding RNA-encoded proteins on lipid droplets. (nih.gov)

Anatomy21

Organisms14

Diseases1

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes41

Disciplines and Occupations1

Information Science4

Health Care1

Kinase14

20214

Peptides9

Cerebrospinal fluid1

20232

Eukaryotic cells2

20172

Phosphatases4

Antibody5

Residues5

Interaction7

Serine1

Synthesis5

Putative1

Kinases2

Ligands2

Great number of proteins2

Genes6

Kappa B alpha6

Post- translationa1

Recombinant1

Interactions9

Phosphorylation sites1

Target proteins1

Cellular proteins1

Inhibit2

Oncogene1

Signal transduction2

Phenotype1

Chromatography1

Bind1

Sigma1

Species2

Structural2

Molecules1

Pathways1

Pathway1

Binds1

Mutations3

Modulation3

Regulatory1

Regulation4

Systematic1

Phosphatase1

Induces1

MTOR2

Peptide1

Functional2

Eukaryotes1

Changes in protein4

Plasma membrane1

Oxidation1

Affinity1

Actin2

Molecular2

Recognition1

Binding4

19931

Ubiquitin1

Lipid1