Feeding of this vitamin has beneficial effect on testes weight, semen quality indexes, testosterone and antioxidant enzymes such as glutathione peroxidase and superoxide dismutase in birds and mammals. (ac.ir)
The results indicate that dexamethasone-induced oxidant stress caused an increase in MDA levels (5.4) and a decrease in the activity of antioxidant enzymes such as glutathione peroxidase (52.51) and superoxide dismutase (108.62), as well as sperm motility parameters and sperm cell membrane integrity in comparison to the control group. (ac.ir)
2011 ). On the other side, plants have developed some enzymatic systems including superoxide dismutases (SOD), catalases (CAT), ascorbate peroxidases (APX), peroxiredoxins and non-enzymatic mechanisms to protect against oxidative damage caused by these ROS (Agrawal et al. (springeropen.com)
To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD). (carmk.net)
While SOD catalyzes the dismutation of superoxide anion (O2') to H2O2, catalase and glutathione (peroxidase, reductase) system reduce cellular toxicity degrading peroxides into oxygen and water 9 . (bvsalud.org)
4) Phospholipid GPx (PHGPx or GPx4) is found in the nucleus, cytosol, and mitochondria of various tissues. (biomedcentral.com)
In addition, Se and Se + VE significantly enhanced the glutathione peroxidase (GPx) activity and the expression of GPx1 and GPx4 in breast muscle tissues. (springeropen.com)
Ferroptosis, a form of regulated cell death (RCD), has been recently reported to be primed by missing activity of the ubiquitous selenoperoxidase glutathione peroxidase 4 (GPx4). (unipd.it)
GPx4 catalyzes a glutathione (GSH)-dependent reduction of membrane hydroperoxides to corresponding alcohols. (unipd.it)
Furthermore, since phospholipid hydroperoxides (PL-OOH) have a key role in membrane lipid peroxidation -i.e. their decomposition generates radicals in the membranes- GPx4-mediated regulation of ferroptosis is consistent with both, the mechanisms of lipid peroxidation and protection which have been finely elucidated in vitro in the last forty years of the XX century. (unipd.it)
Hydrogen peroxide4
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. (joplink.net)
Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage. (microbiologyresearch.org)
In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)
Reductase2
The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm. (carmk.net)
The oxidized glutathione is then reduced by glutathione reductase (GR) and b-nicotinamide adenine dinucleotide phosphate (NADPH) forming NADP+ (resulting in decreased absorbance at 340 nm) and recycling the GSH. (nwlifescience.com)
Enzyme5
In enzymology, a phospholipid-hydroperoxide glutathione peroxidase (EC 1.11.1.12) is an enzyme that catalyzes the chemical reaction 2 glutathione + a lipid hydroperoxide ⇌ {\displaystyle \rightleftharpoons } glutathione disulfide + lipid + 2 H2O Thus, the two substrates of this enzyme are glutathione and lipid hydroperoxide, whereas its 3 products are glutathione disulfide, lipid, and H2O. (wikipedia.org)
This enzyme belongs to the family of oxidoreductases, to be specific those acting on a peroxide as acceptor (peroxidases). (wikipedia.org)
The systematic name of this enzyme class is glutathione:lipid-hydroperoxide oxidoreductase. (wikipedia.org)
Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB: 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (drugbank.com)
PHGPX1
ly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. (trigoats.com)
GPX11
To help identify the macromolecular target(s) of Cr-dependent oxidative damage, cells deficient for the reduction of phospholipid hydroperoxides ( gpx3 Δ and gpx1 Δ/ gpx2 Δ/ gpx3 Δ) and for the repair of DNA oxidation ( ogg1 Δ and rad30 Δ/ ogg1 Δ) were tested, but were found not to be Cr-sensitive. (microbiologyresearch.org)
GPxs are members of a multiple-isozyme family that catalyze the reduction of H 2 O 2 or organic hydroperoxides to generate water or corresponding alcohols using reduced glutathione (GSH) as an electron donor [ 11 ]. (biomedcentral.com)
A novel cDNA encoding glutathione peroxidase of tea plant (Camellia sinensis) was isolated by rapid amplification of cDNA ends (RACE) method and designated as CsGPX2 (GenBank Accession No. JQ247186). (springeropen.com)
Organic1
Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. (drugbank.com)
Modern mass spectrometry based analytical techniques play a crucial role in the discovery of metabolic alteration regulating ferroptosis by extensive analysis of metabolites such as the sulfhydryl residue containing cysteine metabolites, RTAs, and membrane phospholipids. (bmbreports.org)
Intracellular2
Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. (carmk.net)
GPx-1 is the classic intracellular form while GPx-2 to 4 are gastrointestinal, plasma and phospholipid hydroperoxide metabolizing forms respectively. (nwlifescience.com)
Membrane2
May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (joplink.net)
A huge diversification of phospholipids, forming the aqueous interfaces of all biomembranes, cannot be accommodated within a simple concept of their role as membrane building blocks. (cdc.gov)
Nucleus1
cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. (broadinstitute.org)
Sperm production1
You may have never heard of it but glutathione is the single most important antioxidant for male fertility, protecting sperm from damage during sperm production. (nuafertility.com)
Activity3
Genetic dissection of the phospholipid hydroperoxidase activity of yeast Gpx3 reveals its functional importance. (microbiologyresearch.org)
Glutathione peroxidase (GPx) activity is detectable in the supernatant from homogenates of cultured cells but is likely not present in sufficient quantities in the cell culture medium to be detectable. (nwlifescience.com)
Concentration1
Because glutathione peroxidase (GPx) is limiting, the decrease in absorbance at 340 nm is directly proportional to the glutthione (GPx) concentration. (nwlifescience.com)
Accumulation1
Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
To understand the mechanism of tolerance to deferent stresses in tea plant, a new glutathione peroxidase gene of tea plant was cloned and its expression pattern was analyzed under abiotic and biotic stresses. (springeropen.com)
Molecular cloning and expression profiling of phospholipid hydroperoxide glutathione peroxidase genes in Bemisia tabaci MEAM1 (Hemiptera: Aleyrodidae) [J]. Acta Entomologica Sinica, 2019, 62(2): 141-149. (insect.org.cn)