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  • PDCs
  • The new patent protects both composition of matter and method of use for PDCs developed with Cellectar's proprietary phospholipid-ether delivery vehicle conjugated with any known or in-development anti-cancer agent, including the company's pipeline of internal and partnered PDC programs designed for targeted delivery to cancer cells and cancer stem cells. (cellectarbiosciences.com)
  • company's
  • The company intends to use the net proceeds from the offering for general corporate and working capital purposes, including continued development of CLR 131 for the potential treatment and management of multiple myeloma and other hematologic malignancies, as well as the continued development of targeted therapeutic cancer agents using the company's proprietary phospholipid drug conjugate (PDC) delivery platform. (biospace.com)
  • vinyl ether
  • After dehydrogenation at the 1- and 2-positions of the alkyl group by an electron transport system and plasmenylethanolamine desaturase the vinyl ether bond of plasmalogens is finally formed. (wikipedia.org)
  • HOCl causes oxidative chlorination of plasmalogens at the sn-1 chain by reacting with the vinyl ether bond. (wikipedia.org)
  • Methyl
  • Different forms of PEG are also available, depending on the initiator used for the polymerization process - the most common initiator is a monofunctional methyl ether PEG, or methoxypoly(ethylene glycol), abbreviated mPEG. (wikipedia.org)
  • carrier
  • The company designed its phospholipid ether (PLE) carrier platform to be coupled with a variety of payloads to facilitate the discovery and development of improved targeted novel therapeutic compounds. (globenewswire.com)
  • acid
  • Differences between the catabolism of ether glycerophospholipids by specific phospholipases enzymes might be involved in the generation of lipid second messenger systems such as prostaglandins and arachidonic acid that are important in signal transduction. (wikipedia.org)
  • bacteria
  • Phospholipids can occur in many biological classes (such as in plant roots, fungi, as well as in soil bacteria), so care has to be taken in over-assigning PLFA biomarkers to the wrong class. (wikipedia.org)
  • As the phospholipids of different groups of bacteria and fungi contain a variety of somewhat unusual fatty acids, they can serve as useful biomarkers for such groups. (wikipedia.org)
  • mammals
  • The formation of the ether bond in mammals requires two enzymes, dihydroxyacetonephosphate acyltransferase (DHAPAT) and alkyldihydroxyacetonephosphate synthase (ADAPS), that reside in the peroxisome. (wikipedia.org)
  • Platform
  • Our proprietary phospholipid ether (PLE) delivery platform was deliberately designed to be coupled with multiple warheads to facilitate both therapeutic and diagnostic applications. (cellectar.com)
  • drug
  • Egg-derived phospholipids as an ingredient in term and preterm infant formula, Food and Drug Administration, USA Unisci.com, Why Eggs Don't Contribute Much Cholesterol To Diet. (wikipedia.org)