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  • Cgamma1
  • Together, these observations suggest that multivalent interactions recruit Itk to LAT-nucleated signaling complexes and facilitate the activation of LAT-associated phospholipase Cgamma1 by Itk. (umassmed.edu)
  • motifs
  • The two cytosolic components, p47 phox and p67 phox , contain Src homology 3 motifs that direct their translocation to the membranes by binding to specific targets in p22 phox and to each other ( Leto, 1999 ). (rupress.org)
  • activates
  • PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. (jove.com)
  • stat
  • HGF functions as a scattering (dissociation/motility) factor for epithelial cells, and this ability seems to be mediated through the activation of STAT-3. (rrnursingschool.biz)
  • neuron-specific
  • However, the short inserts found in neuron-specific isoforms of Src prevented the binding of tau. (edu.au)
  • receptors
  • In addition, expression of several receptors of these growth factors and ligands has been described, including stem cell factor receptor (c-KIT), epidermal growth factor receptors (EGFR), VEGF receptors (VEGFR)-2 and 3, IGF receptors (IGF-R), and PDGF receptors (PDGFR). (aacrjournals.org)
  • mutations
  • Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. (nih.gov)
  • PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment. (nih.gov)
  • motif
  • Dip1 contained a PPXY motif, and its domain organization was similar to that of the splicing factor FBP21 in that it possessed one zinc finger and two WW domains. (embl-heidelberg.de)
  • Sequences of ARF-GAP domains show no recognizable similarity to those of other GAPs, and contain a characteristic Cys-X(2)-Cys-X(16-17)-Cys-X(2)-Cys motif. (embl-heidelberg.de)
  • The ARF-GAP domain comprises a central three-stranded beta-sheet flanked by five alpha-helices, with a Zn(2+) ion coordinated by the four cysteines of the cysteine-rich motif. (embl-heidelberg.de)
  • pathways
  • Emerging studies are providing insights into specific deregulation in proliferative and growth signaling pathways of various PNET subsets ( 3 ). (aacrjournals.org)