AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
Phospholipase DPhospholipases A2Phospholipases AType C PhospholipasesPhospholipasesPhospholipase C gammaPhosphoinositide Phospholipase CPhospholipase C betaPhospholipase A2 InhibitorsPhospholipases A1Phospholipase C deltaReceptors, Phospholipase A2Group IV Phospholipases A2Group II Phospholipases A2Phosphatidylinositol Diacylglycerol-LyasePhosphatidic AcidsArachidonic AcidPhospholipases A2, SecretoryEnzyme ActivationLysophospholipasePhosphatidylinositolsEstrenesIsoenzymesCalciumGroup VI Phospholipases A2GlycerophospholipidsDiglyceridesPyrrolidinonesQuinacrine1-ButanolPhosphatidylcholinesInositol PhosphatesPhospholipidsLysophosphatidylcholinesHydrolysisPhosphatidylinositol 4,5-DiphosphatePhospholipases A2, CytosolicSignal TransductionCytosolArachidonic AcidsProtein Kinase CPhosphoric Diester HydrolasesKineticsGTP-Binding ProteinsPyrones1-Alkyl-2-acetylglycerophosphocholine EsteraseGroup X Phospholipases A2Enzyme InhibitorsInositol 1,4,5-TrisphosphateGroup V Phospholipases A2Cell MembraneCrotalid VenomsSnake VenomsCell LineBee VenomsCells, CulturedGuanosine 5'-O-(3-Thiotriphosphate)Molecular Sequence DataAmino Acid SequenceGroup IB Phospholipases A2Phospholipases A2, Calcium-IndependentButanolsThionesCobra VenomsLysophospholipidsTetradecanoylphorbol AcetatePhosphorylationSubstrate SpecificityCalcimycinSnakesPhosphatidylethanolaminesReptilian ProteinsPertussis ToxinVirulence Factors, BordetellaPhosphodiesterase InhibitorsGlycosylphosphatidylinositolsBridged CompoundsGTP-Binding Protein alpha Subunits, Gq-G11DinoprostoneNaphthalenesNeomycinAcetophenonesBlood PlateletsPhosphatidylinositol PhosphatesEicosanoidsElapidaeCalcium SignalingRecombinant ProteinsDose-Response Relationship, DrugADP-Ribosylation FactorsMembrane LipidsCrotoxinAgkistrodonPancreasPlatelet Activating FactorBacillus cereusN-Formylmethionine Leucyl-PhenylalanineProtein-Tyrosine KinasesTransfectionProtein Binding
SPLA2PLA2SPLAEnzymesProteinCytosolicExtracellularAnti-inflammatorySecretionVirulenceProteinsGroupActivityProteasesCellsTypeInhibitorRECEPTORSInhibitionSPLA2sPhosphatidylinositolMacrophagesPLA2G2APathogenesisCardiovascular DiseaseMembraneReceptorSubclassRegulationHydrolysisExpressionCellsStrokeRoleOral
SPLA25
  • Recently, bile acid was found to cause surfactant inactivation by enhancing the activity of secretory phospholipase A2 (sPLA2) and induce inflammatory response of fetal lung [ 5 , 8 ]. (hindawi.com)
  • Secreted phospholipase A2 (sPLA2) is a protein secreted by Clonorchis sinensis and is a component of excretory and secretory products ( Cs ESPs). (biomedcentral.com)
  • On days 0, 7, 14 and 28 following surgery, the changes in the post-limb mechanical claw threshold, the phospholipase A2 (PLA2), interleukin (IL)-6 and tumor necrosis factor (TNF)-α mRNA expression levels, the secretory PLA2 (sPLA2) expression, the IL-6 and TNF-α content, the nuclear factor (NF)-κBp65 protein expression level in the nucleus pulposus, and the apoptotic rate of the nucleus pulposus cells were detected. (iasp-pain.org)
  • Plant secretory phospholipase A2 (sPLA2) is a family of lipolytic enzymes involved in the sn-2 hydrolysis of phospholipid carboxyester bonds, characterized by the presence of a conserved PA2c domain. (cas.cz)
  • The aim of this study was to evaluate the presence of type-II secretory phospholipase A2 (sPLA2-IIA) in alveolar space and its possible role in the destruction of surfactant in three rat models of acute lung injury. (hal.science)
PLA23
  • A series of trimethoxyphenyl isoxazolidine derivatives, 5a(i-v) and 5b(i-v), bearing different constituents at the 5th position of the isoxazolidine ring were synthesized and evaluated in vitro and in vivo for their inhibitory activity against purified group I and II phospholipase A2 (PLA2) enzymes from snake venom and human inflammatory synovial fluid. (uni-mysore.ac.in)
  • PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. (nih.gov)
  • We described a novel PA2c-containing gene family present in all plant lineages and lacking secretory peptide, which we termed PLA2-like. (cas.cz)
SPLA5
  • Secreted phospholipase A2 group X (sPLA(2)-X) is one of the most potent enzymes of the phospholipase A(2) lipolytic enzyme superfamily. (ox.ac.uk)
  • The intrinsic overexpression of secretory phospholipase A2 (sPLA 2 ) in various pro-inflammatory diseases and cancers has the potential to be exploited as a therapeutic strategy for diagnostics and treatment. (rsc.org)
  • Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
  • Secreted phospholipases A 2 (sPLA 2 s) (EC 3.1.1.4) are a structurally related group of low-molecular-mass enzymes (14-18 kDa) that catalyse the hydrolysis of glycerophospholipids (phospholipids hereafter) at their sn -2 position, to produce lysophospholipids and free fatty acids. (ijbs.com)
  • Secreted phospholipase A 2 -IIA (sPLA 2 -IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. (elsevierpure.com)
Enzymes1
Protein1
  • We compared phenotypic markers of pathogenesis, including adherence, biofilm formation, and protein secretion (secretory aspartic protease [SAP] and phospholipase). (cdc.gov)
Cytosolic2
  • 3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1 H -indazol-5-yl)-phenyl]-propionic acid (AK106-001616) is a novel, potent, and selective inhibitor of the cytosolic phospholipase A 2 (cPLA 2 ) enzyme. (aspetjournals.org)
  • Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. (nih.gov)
Extracellular2
  • Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. (icr.ac.uk)
  • Investigation of extracellular elastase, acid proteinase and phospholipase activities as putative virulence factors in clinical isolates of Aspergillus species . (irost.ir)
Anti-inflammatory1
  • Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. (ox.ac.uk)
Secretion1
  • Moreover, inhibition of Ca(2+)-activated secretion by PtdIns(4,5)P2-specific antibodies and phospholipase C implies that 5-phosphorylated inositides play a novel, necessary role in the regulated secretory pathway. (nih.gov)
Virulence1
  • Although phospholipase B expression has been well studied in C. albicans ( 18 ), the relationship between C. parapsilosis virulence and phospholipase phenotype is unclear. (cdc.gov)
Proteins1
  • This gene encodes a member of the phospholipase A2 family of proteins. (nih.gov)
Group1
  • Orthologous to human PLA2G12A (phospholipase A2 group XIIA). (zfin.org)
Activity2
  • Predicted to enable phospholipase A2 activity. (zfin.org)
  • In orde r to increase phospholipase activity, the selected strain was exposed to random mutation by gamma rays irradiation at various doses of 200, 400, 600 and 800 Gy. (irost.ir)
Proteases1
  • Phospholipases (e.g., phospholipase B) and proteases (e.g., secreted aspartyl proteases [SAPs]) are two of the best-characterized. (cdc.gov)
Cells1
  • Phospholipase A2 is well known for its role in liver fibrosis and inhibition of tumour cells. (biomedcentral.com)
Type1
  • Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. (embl.de)
Inhibitor3
  • Neomycin sulfate is a known phospholipase C (PLC) inhibitor. (medchemexpress.com)
  • U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC 50 of 1-2.1 µM for PLC. (medchemexpress.com)
  • Less abundant, but still representative, were cysteine-rich secretory proteins, L-amino-acid oxidases, phospholipases A2, venom 5'-nucleotidase and a serine peptidase inhibitor. (fapesp.br)
RECEPTORS2
  • Members of this group bind specifically to PHOSPHOLIPASE A2 RECEPTORS . (online-medical-dictionary.org)
  • Members of this group have specificity for PHOSPHOLIPASE A2 RECEPTORS . (nih.gov)
Inhibition1
  • Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. (prospecbio.com)
SPLA2s1
  • We sought to investigate if mast cell activation and increases in secretory sPLA2s are associated with an increase in PAF and occurrence of dengue haemorrhagic fever (DHF). (ox.ac.uk)
Phosphatidylinositol1
Macrophages1
  • Lipoprotein-associated phospholipase A 2 (Lp-PLA2), a member of the phospholipase superfamily, is an enzyme produced by monocytes and macrophages, T cells, and mast cells. (nih.gov)
PLA2G2A1
  • The association of PLA2G2A single nucleotide polymorphisms with type IIa secretory phospholipase A2 level but not its activity in patients with stable coronary heart disease. (cdc.gov)
Pathogenesis1
  • Secretory phospholipase A2 in the pathogenesis of acute dengue infection. (ox.ac.uk)
Cardiovascular Disease1
  • Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. (cdc.gov)
Membrane1
  • Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. (medchemexpress.com)
Receptor1
  • Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora K, et. (leica-microsystems.com)
Subclass1
  • Phospholipases and acetylcholinesterases are members of the subclass of esterases. (axonmedchem.com)
Regulation1
  • 1] Properties and Regulation of Cytosolic Phospholipase A2. (axonmedchem.com)
Hydrolysis1
Expression3
  • Although phospholipase B expression has been well studied in C. albicans ( 18 ), the relationship between C. parapsilosis virulence and phospholipase phenotype is unclear. (cdc.gov)
  • Galecki first documented altered expression of mRNA coding for cyclooxygenase-2, myeloperoxidase, inducible nitric oxide synthase and secretory phospholipase A2 type IIA in people with recurrent depressive disorder [12]. (weeksmd.com)
  • In this study, functional knockdown of EGFR was achieved through expression of an affibody construct, (ZEGFR:1907)(2-)KDEL, with high affinity for EGFR and extended with the amino acids KDEL to make it resident in the secretory compartments. (uni-bielefeld.de)
Cells3
  • The mucus layer is produced by specialized secretory cells that are found throughout the entire intestinal tract ( Fig. 1 ). (nature.com)
  • SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. (prospecbio.com)
  • A subcategory of phospholipases A2 that are secreted from cells. (nih.gov)
Stroke2
  • Association between serum secretory phospholipase A2 and risk of ischemic stroke. (medscape.com)
  • CDP-choline Significantly Restores Phoshatidylcholine Levels by Differentially Affecting Phospholipase A2 and CTP:Phosphocholine Cytidylyltransferase after Stroke. (nih.gov)
Role1
  • Background: Increasing evidence suggests a proatherogenic role for lipoprotein-associated phospholipase A 2 (Lp-PLA2). (nih.gov)
Oral5
  • Tomar de 600-1800 mg de ácido alfa lipoico por vía oral o por vía intravenosa parece mejorar los síntomas como ardor, dolor y entumecimiento en las piernas y los brazos de las personas con diabetes. (medlineplus.gov)
  • Tomar ácido alfa lipoico por vía oral puede reducir ligeramente el peso corporal en adultos con sobrepeso. (medlineplus.gov)
  • Tomar ácido alfa lipoico por vía oral todos los días durante un máximo de 6 meses no mejora la función hepática ni reduce el daño hepático en personas con enfermedad hepática relacionada con el alcohol. (medlineplus.gov)
  • Tomar ácido alfa lipoico por vía oral o por vía intravenosa no mejora los niveles de azúcar en sangre en personas con diabetes tipo 2. (medlineplus.gov)
  • Tomar ácido alfa lipoico por vía oral no tiene ningún efecto sobre los problemas de pensamiento en personas con VIH. (medlineplus.gov)