• Any substance that inhibits phosphodiesterase, an enzyme that catalyzes the breaking of a phosphodiester bond. (fpnotebook.com)
  • citation needed] Zaprinast inhibits the growth of asexual blood-stage malaria parasites (P. falciparum) in vitro with an ED50 value of 35 μM, and inhibits PfPDE1, a P. falciparum cGMP-specific phosphodiesterase, with an IC50 value of 3.8 μM. (wikipedia.org)
  • Patients on treatment with prostanoids, endothelial receptor antagonists (ERA), PDE-5 inhibitors or any other vasodilators with in 1month prior to screening were excluded. (clinicaltrials.gov)
  • particularly the underuse of ACE inhibitors and β-blockers and aldosterone antagonists which have been shown to provide mortality benefit. (wikipedia.org)
  • However, the phosphodiesterase inhibitor may carries its own side effects such as cardiac arrhythmias, nausea, vomiting and thrombocytopenia. (medicalzone.net)
  • Aminophylline causes bronchodilation, diuresis†, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells. (wikipedia.org)
  • The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof within the context of an effective dosing regimen. (google.com.au)