Phosphatidylethanolamine N-methyltransferase (abbreviated PEMT) is a transferase enzyme (EC 2.1.1.17) which converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. (wikipedia.org)
The PEMT enzyme converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) via three sequential methylations by S-adenosyl methionine (SAM). (wikipedia.org)
PEMT (phosphatidylethanolamine methyltransferase) is a gene that is important for the formation of the nutrient phosphatidylcholine (PC). (metabolichealing.com)
Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT). (disgenet.org)
Phosphatidylcholine6
Exposure of cortical neurons to neurotoxic concentrations of NMDA increased extracellular choline and activated hydrolysis of phosphatidylcholine and phosphatidylinositol by phospholipase A 2 but did not induce significant degradation of phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, or phosphatidylserine. (jneurosci.org)
These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
Choline can be obtained from the diet and via de novo biosynthesis through the methylation of phosphatidylethanolamine to phosphatidylcholine. (cytoplan.co.uk)
The methylation pathway involves the 3 successive methylations of phosphatidylethanolamine to form phosphatidylcholine. (smpdb.ca)
Betaine may attenuate ALD by increasing the synthesis of SAM and, eventually, glutathione, decreasing the hepatic concentrations of homocysteine and SAH, and increasing the SAM-SAH ratio, which can trigger a cascade of events that lead to the activation of phosphatidylethanolamine methyltransferase, increased phosphatidylcholine synthesis, and formation of VLDL for the export of triacylglycerol from the liver to the circulation. (nebraska.edu)
Among them, lysophospholipids produced a designated effect on the phospholipid composition of trypanosomatids, in which the biosynthesis of phosphatidylcholine (Personal computer) is definitely inhibited at the level of phosphatidylethanolamine N-methyltransferase (15). (icsv20.org)
Catechol-O-methyltransfera4
Catechol-O-methyltransferase is shown in green boxes. (en-academic.com)
In humans, catechol- O -methyltransferase protein is encoded by the COMT gene . (en-academic.com)
Catechol- O -methyltransferase is involved in the inactivation of the catecholamine neurotransmitters ( dopamine , epinephrine , and norepinephrine ). (en-academic.com)
Nicotinamide N-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
This graph shows the total number of publications written about "Nicotinamide N-Methyltransferase" by people in this website by year, and whether "Nicotinamide N-Methyltransferase" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Nicotinamide N-Methyltransferase" by people in Profiles. (ouhsc.edu)
Phosphatidylserine1
Phosphatidylethanolamine is also synthesized from phosphatidylserine in the mitochondrial membrane by phosphatidylserine decarboxylase. (smpdb.ca)
Enzyme2
A parallel Kennedy pathway forms phosphatidylethanolamine from ethanolamine - the only difference being a different enzyme, ethanolamine-phosphate cytidylyltransferase, catalyzing the second step. (smpdb.ca)
Just to make things more intriguing, rat studies found a choline-related enzyme (with the jaw-breaking name of phosphatidylethanolamine-N-methyltransferase) in the the newborn rat brain that doesn't even exist in the adult's! (mypregnanthealth.com)
Protein2
A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT), a key protein in the regulation of folate, methyl group, and homocysteine metabolism. (illinois.edu)
phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine binding- protein, ribosomal protein L18 and testis-specific farnesyl pyrophosphate were up- regulated while protectin/CD59 was repressed. (inrs.ca)