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  • HCNP
  • The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. (genecards.org)
  • putative
  • A nonredundant catalogue of 614 transcripts (573 of which are novel) is described, including 136 coding for proteins of a putative secretory nature. (biomedcentral.com)
  • Of these putative proteins, ten have been verified by Edman degradation of Coomassie blue-stained bands from sodium dodecyl sulfate/polyacrylamide gel electrophoresis (SDS-PAGE) of SG homogenates. (biomedcentral.com)
  • We describe 573 new transcripts, 136 of which code for proteins of a putative secretory nature, most of which have no known function. (biomedcentral.com)
  • mitogen-activa
  • It was demonstrated previously that a positive feedback loop, including protein kinase C (PKC) and mitogen-activated protein kinase (MAPK), is required for the gradual expression of cerebellar long-term depression (LTD). PKC and MAPK are mutually activated in this loop. (jneurosci.org)
  • We found previously that a positive feedback loop (see Fig. 1 A ) that includes protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) is responsible for prolonged kinase activation that underlies the long-lasting expression of LTD ( Tanaka and Augustine, 2008 ). (jneurosci.org)
  • ligands
  • In the present study, we investigated human PEBP1 by NMR to determine the binding site of four different ligands : GTP, FMN, and one Raf-1 peptide in tri-phosphorylated and non-phosphorylated forms. (cnrs-orleans.fr)
  • The study was carried out by NMR in near physiological conditions, allowing for the identification of the binding site and the determination of the affinity constants KD for different ligands. (cnrs-orleans.fr)
  • Our study demonstrates and/or confirms the binding of hPEBP1 to the four studied ligands. (cnrs-orleans.fr)
  • Although the affinities for GTP and FMN decrease as pH, salt concentration and temperature increase from pH 6.5/NaCl 0 mM/20°C to pH 7.5/NaCl 100 mM/30°C, both ligands clearly do bind under conditions similar to what is found in cells regarding pH, salt concentration and temperature. (cnrs-orleans.fr)
  • Sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • family
  • Anne Goriely ( anne.goriely@imm.ox.ac.uk) suggested adding the MRAS (RRAS3) -SHOC2.PPP1CA pathways that activate RAF kinase and ERF, an ETS-family protein that inhibits ERK1 (aka MAPK3) and 2 (MAPK1). (cancer.gov)
  • inhibition
  • Baritaki S, Katsman A, Chatterjee D, Yeung K, Spandidos D, Bonavida B. Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation. (labome.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • inhibitor
  • Serre L, Pereira de Jesus K, Zelwer C, Bureaud N, Schoentgen F, Benedetti H. Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein. (labome.org)
  • expression
  • Please note that protein expression levels are expected to vary in different sample types. (olink.com)
  • Additionally, a two-dimensional gel electrophoresis of salivary gland (SG) homogenates followed by tryptic digestion of selected protein bands and MS/MS analysis revealed the expression of 24 proteins. (biomedcentral.com)
  • Most of the 55 proteins coded by these SG transcripts have no known function and represent high-priority candidates for expression and functional analysis as antihemostatic or antimicrobial agents. (biomedcentral.com)
  • human
  • In the analysis of tumor samples from stage II colon cancer patients and the human colon carcinoma cell line HCT116, pRKIP and STAT3, 2 proteins potentially involved in the resistance to conventional treatments were detected. (biomedcentral.com)
  • membrane
  • Glycerophospholipids are a storage depot for precursors for second messengers, and may be involved in membrane fusion, apoptosis, and regulation of the activities of membrane-bound enzymes and ion-channels. (springer.com)
  • enzymes
  • This study used proteomics to identify inflammatory proteins and catabolic enzymes released in a serum-free explant model of articular cartilage stimulated with the pro-inflammatory cytokine interleukin 1β (IL-1β). (biomedcentral.com)
  • tumor
  • In contrast, activated signal transducer and activator of transcription 3 (STAT3) is a protein that promotes tumor cell survival by inhibiting apoptosis and has an important role in cancer progression in many of cancer types. (biomedcentral.com)
  • tissue
  • At first, we studied the impact of matrix deposition and laser ablation on protein extraction from the tissue section. (mdpi.com)
  • This workflow, performed as a proof-of-concept, suggests that a single tissue section can be used to perform MALDI-MSI and protein extraction, identification, and relative quantitation. (mdpi.com)
  • Literature
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • Function
  • Most salivary proteins found have no known function. (biomedcentral.com)
  • For my Master degree I studied GGA protein function in the group of prof. Margaret Robinson at the University of Cambridge (United Kindom) and MHC class II sorting into Multi-vesicular bodies in the Laboratory of prof. Willem Stoorvogel at the UMC Utrecht. (mendeley.com)
  • Structures
  • Choline and ethanolamine glycerophospholipids are synthesized at the endoplasmic reticulum and are transported to other membranous structures by phospholipid exchange and transfer proteins. (springer.com)
  • product
  • An unexpected finding is the occurrence of four protein families specific to SG that were probably a product of horizontal transfer from prokaryotic organisms to mosquitoes. (biomedcentral.com)