Phosphate transaminase. Medical search. Frequent questions

The systematic name of this enzyme class is pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming). (wikipedia.org)
Other names in common use include pyridoxamine phosphate aminotransferase, pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase, and pyridoxamine 5'-phosphate transaminase. (wikipedia.org)

Seven biochemical blood parameters were measured pre and post exposure and 20 hours after the second exposure: serum glutathione, red blood cell glutathione reductase, red blood cell glucose-6-phosphate dehydrogenase, lysozyme, serum glutamic oxaloacetic acid transaminase, serum vitamin E and 2,3-diphosphoglycerate. (epa.gov)
When baker's yeast spheroplasts were lysed by mild osmotic shock, practically all of the isopropylmalate isomerase and the β-isopropylmalate dehydrogenase was released into the 30,000 × g supernatant fraction, as was the cytosol marker enzyme, glucose-6-phosphate dehydrogenase. (ku.edu)

The most common liver enzymes are alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphate (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT). (epainassist.com)

Serum level of transaminases, alkaline phosphate, and total bilirubin were used as biochemical markers of hepatotoxicity. (ijpsonline.com)

Direct biomarkers measure B6 vitamers in plasma/serum, urine and erythrocytes, and among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used. (nih.gov)
Vitamin B6 status is best assessed by using a combination of biomarkers because of the influence of potential confounders, such as inflammation, alkaline phosphatase activity, low serum albumin, renal function, and inorganic phosphate. (nih.gov)
INH hepatotoxicity is a common complication of antituberculosis therapy, ranging in severity from asymptomatic elevation of serum transaminases to hepatic failure necessitating liver transplantation. (medscape.com)

Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
One patient in MSaminotransferase increased, hepatic enzyme increased, abnormal liver function test, and increased transaminases.Study 1 discontinued ZEPOSIA because of dyspnea. (usmedicine.com)
Hepatic transaminase values may be increased in patients with hepatic involvement, with this being particularly evident during intercurrent metabolic crises. (medscape.com)

In enzymology, a pyridoxamine-phosphate transaminase (EC 2.6.1.54) is an enzyme that catalyzes the chemical reaction pyridoxamine 5'-phosphate + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } pyridoxal 5'-phosphate + D-glutamate Thus, the two substrates of this enzyme are pyridoxamine 5'-phosphate and 2-oxoglutarate, whereas its two products are pyridoxal 5'-phosphate and D-glutamate. (wikipedia.org)
A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-chain AMINO ACIDS to 2-oxoglutarate. (lookformedical.com)

Vitamin-B6 status was evaluated using the erythrocyte glutamic-pyruvic-transaminase (EGPT) assay and quantification of plasma pyridoxal-5'-phosphate. (cdc.gov)

2017) Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. (unmc.edu)
We elucidate how mTORC2 modulates a glutamine-requiring biosynthetic pathway, the hexosamine biosynthesis pathway (HBP) via regulation of expression of glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of the HBP. (princeton.edu)

1) Rats received single intraperitoneal injections of various neuroactive chemicals in order to compare the changes of gross behaviour and the level of pyridoxal phosphate as well as the activity of decarboxylase of aromatic amino acids, of glutamate decarboxylase and of tyrosine transaminase in the brain. (erowid.org)
Of the total glutamate-α-ketoisocaproate transaminase activity, approximately 20% was in the initial soluble fraction, whereas solubilization of the remainder again required homogenization of the spheroplast lysate. (ku.edu)
It thus appears that, in yeast, the first specific enzyme in the leucine biosynthetic pathway (α-isopropylmalate synthase) is particulate, whereas the next two enzymes in the pathway (isopropylmalate isomerase and β-isopropylmalate dehydrogenase) are "soluble," with glutamate-α-ketoisocaproate transaminase activity being located in both the cytosol and particulate cell fractions. (ku.edu)

Thereby, the latter is neither regularly related to corresponding variations of the total cerebral pyridoxal phosphate nor to hitherto described alterations of the monoamine turnover nor to effects on other vitamin B6-dependent enzymes. (erowid.org)

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. (wikipedia.org)

Functional biomarkers include erythrocyte transaminase activities and, more recently, plasma levels of metabolites involved in PLP-dependent reactions, such as the kynurenine pathway, one-carbon metabolism, transsulfuration (cystathionine), and glycine decarboxylation (serine and glycine). (nih.gov)

5) Tyrosine transaminase activity was significantly diminished by amino-oxyacetate only and showed a late increase after tranylcypromine. (erowid.org)

The level of pyridoxal phosphate was only partially parallel. (erowid.org)

Upper respiratory infection 26 23bcCertain foods that may contain very high amounts (i.e., more than 150 mg) of tyramine could cause severe hypertensionHepatic transaminase elevation10 5because of potential tyramine interaction in patients taking ZEPOSIA, even at the recommended doses. (usmedicine.com)
The mild elevation of transaminases seen in as many as 20% of patients who are treated during the first 2 months of therapy may reflect direct toxicity from hydrazine metabolites, which can covalently bind to cellular macromolecules, including DNA. (medscape.com)

Vitamin-B6 status was evaluated using the erythrocyte glutamic-pyruvic-transaminase (EGPT) assay and quantification of plasma pyridoxal-5'-phosphate. (cdc.gov)
There was a 5- to 6-fold increase in the activity of serum glutamic pyruvic transaminase (SGPT) in male and female mice in the 10.0 mg/kg groups. (nih.gov)
It was originally referred to as serum glutamic pyruvic transaminase (SGPT). (yemialadeworld.com)

This general designation covers both 2.6.1.76 (diaminobutyrate-2-oxoglutarate transaminase, which uses glutamate as the amino donor in DABA biosynthesis), and 2.6.1.46 (diaminobutyrate--pyruvate transaminase, which uses alanine as the amino donor). (nih.gov)
Forms part of the pyridoxal-5′-phosphate cofactor biosynthesis pathway in Escherichia coli , along with EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5′-phosphate synthase) and EC 1.4.3.5 (pyridoxamine-phosphate oxidase). (enzyme-database.org)
Zhao, G., Pease, A.J., Bharani, N. and Winkler, M.E. Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5′-phosphate biosynthesis. (enzyme-database.org)
Yang, Y., Zhao, G., Man, T.K. and Winkler, M.E. Involvement of the gapA - and epd ( gapB )-encoded dehydrogenases in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12. (enzyme-database.org)
Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. (cornell.edu)

ALT (and all aminotransferases) require the coenzyme pyridoxal phosphate , which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. (wikidoc.org)
aspC - Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes,such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. (string-db.org)
these sequences are defined by the aminotransferases class-I pyridoxal-phosphate attachment site signature, which contains the lysine residue involved in pyridoxal-phosphate binding. (string-db.org)

16. NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer . (nih.gov)
An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus glucosamine-6-phosphate. (nih.gov)
Objective: To determine whether overexpression of glutamine: fructose-6-phosphate amidotransferase (GFAT) in synoviocytes will antagonize the response to interleukin-1β (IL-1β) of chondrocytes and synovial fibroblasts in co-culture. (elsevierpure.com)

In enzymology, a pyridoxamine-phosphate transaminase (EC 2.6.1.54) is an enzyme that catalyzes the chemical reaction pyridoxamine 5'-phosphate + 2-oxoglutarate ⇌ {\displaystyle \rightleftharpoons } pyridoxal 5'-phosphate + D-glutamate Thus, the two substrates of this enzyme are pyridoxamine 5'-phosphate and 2-oxoglutarate, whereas its two products are pyridoxal 5'-phosphate and D-glutamate. (wikipedia.org)
In the process, the cofactor shuttles between PLP and the pyridoxamine phosphate (PMP) form. (yemialadeworld.com)
The transaminase activity of two new semisynthetic RNase-S proteins incorporating a pyridoxamine moiety at the active site has been evaluated. (ward-lab.ch)
The chimeric Pam residue integrates the heterocyclic functionality of pyridoxamine phosphate into the side chain of an alpha-amino acid and was introduced instead of Phe8 into the C-peptide sequence via standard solid phase methodology. (ward-lab.ch)

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. (nih.gov)

Pyridoxal-5′-phosphate (P5′P) functions as coenzyme in the amino transfer reactions. (yemialadeworld.com)

Most of these enzymes are pyridoxyl phosphate proteins. (bvsalud.org)

Serum enzyme activity of alkaline phosphate (AP) was also increased in mice given the highest dose of PBB. (nih.gov)

The glucose-6-phosphate dehydrogenase level was within the normal range. (karger.com)
CDC recommended further treatment for malaria with primaquine after arrival, after glucose-6-phosphate dehydrogenase testing, to target liver-stage parasites. (cdc.gov)

It appears to catalyze the formation of glucosamine 6-phosphate. (nih.gov)

Ponvory (ponesimod) is a sphingosine 1-phosphate receptor modulator. (centerwatch.com)
Ponvory (ponesimod) is a sphingosine 1-phosphate (S1P) receptor 1 modulator that binds with high affinity to S1P receptor 1. (centerwatch.com)

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. (wikipedia.org)
This family consists of L-diaminobutyric acid transaminases. (nih.gov)

The term transaminase is outdated and no longer used in liver disease. (wikidoc.org)

Salt, phosphate and nitrite are essential ingredients in the processing of various meat products and they play an important role in maintaining the quality of meat products. (foodchem.com)
Therefore, it can be confirmed that TG can fully play the role of phosphate additives in increasing the cohesion of intestinal filling and increasing water retention in meat products. (foodchem.com)

Aminotransferase2

Glucose-6-phosphate d2

Aspartate transaminase1

Alkaline phosphate1

Serum3

Hepatic3

Enzyme that catalyzes2

Glutamic1

Biosynthesis2

Glutamate3

Vitamin1

Nitrogenous groups1

Erythrocyte1

Activity1

Level1

Patients2

Glutamic pyruvic3

Biosynthesis5

Aminotransferases3

Glutamine3

Pyridoxamine4

Pyridoxal-phosphate dependent1

Coenzyme1

Enzymes1

Alkaline1

Glucose2

Glucosamine1

Modulator2

Family2

Term1

Role2