• Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a condition in which red blood cells break down when the body is exposed to certain drugs or the stress of infection. (medlineplus.gov)
  • G6PD deficiency occurs when a person is missing or does not have enough of an enzyme called glucose-6-phosphate dehydrogenase. (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase in western Islamic Republic of Iran) to [G6PD] deficiency is a common X-linked find the prevalence of G6PD deficiency. (who.int)
  • 6-phosphate dehydrogenase (G6PD) of Physicians and Surgeons Pakistan , deficiency. (who.int)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficient individuals are at risk of developing drug-induced acute hemolysis, after exposure to the antimalarial drug, primaquine (PQ). (confex.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic defect common in people with African ancestry that can result in hemolysis after acute illnesses or intake of oxidant drugs (including salicylates and sulfonamides). (merckmanuals.com)
  • BackgroundX-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. (tropmedres.ac)
  • Background The World Health Organization recommends that primaquine should be given once weekly for 8-weeks to patients with Plasmodium vivax malaria and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but data on its antirelapse efficacy and safety are limited. (tropmedres.ac)
  • What are the signs and symptoms of glucose-6-phosphate dehydrogenase (G6PD) deficiency? (rareguru.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by mutations in the G6PD __ gene. (rareguru.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder that can result in destruction of red blood cells (hemolysis) after an acute illness or use of certain drugs. (msdmanuals.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and one of the most common genetic disorders worldwide, with an estimated 400 million people worldwide carrying a mutation in the G6PD gene that causes deficiency of the enzyme. (tau.ac.il)
  • Here, we conducted a study on G6PD-deficient subjects in Mauritania to evaluate the molecular characteristics associated with a deficiency in this enzyme and the frequency of nucleotide polymorphisms in the glucose-6-phosphate dehydrogenase gene . (bvsalud.org)
  • Predicted to be part of glycerol-3-phosphate dehydrogenase complex. (nih.gov)
  • Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). (nih.gov)
  • Mouse GPDH(glycerol-3-phosphate dehydrogenase) ELISA. (istechk.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Glycerol-3-Phosphate Dehydrogenase 1 (GPD1) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Glycerol-3-Phosphate Dehydrogenase 1 (GPD1) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • This assay has high sensitivity and excellent specificity for detection of Glycerol-3-Phosphate Dehydrogenase 1 (GPD1). (biomatik.com)
  • No significant cross-reactivity or interference between Glycerol-3-Phosphate Dehydrogenase 1 (GPD1) and analogues was observed. (biomatik.com)
  • Light activation: Chloroplastic glyceraldehyde-3-phosphate dehydrogenase and malate dehydrogenase. (uic.edu)
  • Scholars@Duke publication: Glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntington disease fibroblasts. (duke.edu)
  • The specific activity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in normally cultured HD fibroblasts was not different from that in control and escapee fibroblasts. (duke.edu)
  • Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a cellular metabolic protein, was found to colocalize with viral RNA-dependent RNA polymerase (NS5) in JEV-infected cells. (biomedcentral.com)
  • Crystalline lobster-muscle glyceraldehyde-3-posphate dehydrogenase (d-glyceraldehyde-3-phosphate: NAD + oxidoreductase (phosphorylating), EC 1.2.1.12) possesses 7.3 ± 0.3 cysteine residues per mole of enzyme (140 000 g), i.e. approx. (mssm.edu)
  • The reaction of 5,5' dithiobis(2 nitrobenzoic acid) (DTNB) with rabbit muscle glyceraldehyde 3 phosphate dehydrogenase [d glyceraldehyde 3 phosphate: NAD + oxidoreductase (phosphorylating), EC 1.2.1.12] consists of an initial burst of reaction over several minutes, corresponding to 2 thiols/subunit, followed by a further slow reaction of the 2 remaining groups. (edu.au)
  • Description: Quantitative sandwich ELISA for measuring Human Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Description: A competitive ELISA for quantitative measurement of Mouse Glyceraldehyde 3 Phosphate Dehydrogenase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
  • The enzyme activity of glyceraldehyde-3-phosphate dehydrogenase (GADPH), neuron specific enolase (NSE), succinate dehydrogenase (SDH), and lactate dehydrogenase (LDH), has been examined in saline-perfused, desheathed and denervated peroneal (P) and tibial (T) nerves from cats treated with acrylamide (15 mg/kg/day, s.c.) or vehicle for 15 days. (cdc.gov)
  • The lactate dehydrogenase activity was more distinctly decreased than the glucose-6-phosphate dehydrogenase activity. (msk.ru)
  • Drel' K.A., Shelest Iu.P. (1976) Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in the erythrocytes in diabetes mellitus. (msk.ru)
  • Tests to rule out hemolysis include CBC with differential, reticulocyte count, peripheral blood smear, lactate dehydrogenase (LDH), bilirubin, serum haptoglobin, free serum hemoglobin and Heinz body preparation. (cdc.gov)
  • Incidence and molecular polymerase-chain-reaction amplification analysis of glucose-6-phosphate dehyd- of the entire coding region from genomic rogenase deficiency in the province of DNA. (who.int)
  • Genetic of glucose-6-phosphate dehydrogenase blood disorders survey in the Sultanate deficiency in the Fars province of Iran. (who.int)
  • dehydrogenase deficiency in some ethnic recommended screening test for glucose- groups of Pakistan. (who.int)
  • Glucose-6-phosphate 1-dehydrogenase (Buchnera aphidicola str. (nih.gov)
  • Glucose-6-phosphate dehydrogenase has been purified from pigeon pea (Cajanus cajan) seeds and subjected to characterization. (scirp.org)
  • The enzyme shows more affinity towards NADP + than glucose-6-phosphate. (scirp.org)
  • It catalyzes the transformation of glucose-6-phosphate to 6-phosphogluconolactone concomitant with conversion of NADP to NADPH. (scirp.org)
  • Affinity chromatography (2', 5'-ADP Sepharose 4B) first used by De Flora [20] is a common tech- nique for purification of glucose-6-phosphate dehydrogenase. (scirp.org)
  • The reports on purification of glucose-6-phos- phate dehydrogenase from plant sources are very less. (scirp.org)
  • Glucose-6-phosphate dehydrogenase deficiency causes haemolytic anaemia in the presence of simple infection, ingestion of fava beans or reaction with certain medicines, antibiotics, antipyrectics and anti- malarial. (scirp.org)
  • Keeping in view the clinical significance of the enzyme and less studied from plant sources the present study has been aimed with purification and characterization of glucose-6-phosphate dehydrogenase from pigeon pea seeds. (scirp.org)
  • Glucose-6-phosphate dehydrogenase is the first enzyme in the pentose phosphate pathway and the main intracellular source of reduced nicotidamineadenine nucleotidephosphate (NADPH), involved in diverse physiological processes such as antioxidant defense, (for instance in the erythrocyte) endothelial growth modulation, erithropoyesis, vascularization and phagocitosis. (univalle.edu.co)
  • Scholars@Duke publication: Cytologic studies of glucose-6-phosphate dehydrogenase in malignancy. (duke.edu)
  • Title : Glucose-6-Phosphate Dehydrogenase Deficiency In Project Head Start Children Personal Author(s) : Kelly, S.;Almy, R. (cdc.gov)
  • D-glucose 6-phosphate + NADPH(+) = d-glucono-1,5-lactone 6-phosphate + NADPH. (lu.se)
  • Connect with other caregivers and patients with Glucose-6-phosphate dehydrogenase deficiency and get the support you need. (rareguru.com)
  • It occurs when a person is missing or has low levels of the enzyme glucose-6-phosphate dehydrogenase. (rareguru.com)
  • An anomaly in the level of glucose-6-phosphate dehydrogenase in tissue. (nih.gov)
  • Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. (nih.gov)
  • In human erythrocytes activities of glucose-6-phosphate and lactate dehydrogenases were decreased approximately 2-fold in moderately severe and critical forms of diabetes mellitus, as compared with normal state. (msk.ru)
  • Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH) activity in the pathogenesis of insulin resistance in skeletal muscle. (edu.au)
  • We identified increased glucose-6-phosphate dehydrogenase (G6PDH) activity as a common intracellular adaptation that occurs in parallel with the induction of insulin resistance in skeletal muscle and is present across animal and human disease states with an underlying pathology of insulin resistance and glucose intolerance. (edu.au)
  • Dosage compensation in the regulation of erythrocyte glucose-6-phosphate dehydrogenase activity. (mcmaster.ca)
  • The importance of glucose-6-phosphate dehydrogenase deficiency in the causation of severe neonatal jaundice in Israel was investigated. (openu.ac.il)
  • The overall results suggest that although a few such cases may occur in this country, glucose-6- phosphate dehydrogenase deficiency cannot be considered an important aetiological factor in the causation of severe haemolytic neonatal jaundice in Israel, in spite of the existence of population groups with a very high frequency of the enzyme deficiency. (openu.ac.il)
  • Molecular Characterization of Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency in Different Ethnic Groups of Blood Donors in Mauritania. (bvsalud.org)
  • Pentose phosphate pathway. (lu.se)
  • The systematic name of this enzyme class is propane-1,2-diol-1-phosphate:NAD+ oxidoreductase. (wikipedia.org)
  • Other names in common use include PDP dehydrogenase, 1,2-propanediol-1-phosphate:NAD+ oxidoreductase, and propanediol phosphate dehydrogenase. (wikipedia.org)
  • Predicted to enable calcium ion binding activity and sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity. (nih.gov)
  • Predicted to be involved in glycerol catabolic process and glycerol-3-phosphate metabolic process. (nih.gov)
  • In enzymology, a propanediol-phosphate dehydrogenase (EC 1.1.1.7) is an enzyme that catalyzes the chemical reaction propane-1,2-diol 1-phosphate + NAD+ ⇌ {\displaystyle \rightleftharpoons } hydroxyacetone phosphate + NADH + H+ Thus, the two substrates of this enzyme are propane-1,2-diol 1-phosphate and NAD+, whereas its 3 products are hydroxyacetone phosphate, NADH, and H+. (wikipedia.org)
  • In contrast, only small changes occurred in the specific activity of lipoamide dehydrogenase (LADH) over the same time period, and the values were not significantly different among the three groups at any time point. (duke.edu)
  • For detailed information about galactitol-1-phosphate 5-dehydrogenase, go to the full flat file . (brenda-enzymes.info)
  • It occurs when a person is missing or has low levels of the enzyme glucose-6-phosphate dehydrogenase. (nih.gov)
  • In enzymology, a propanediol-phosphate dehydrogenase (EC 1.1.1.7) is an enzyme that catalyzes the chemical reaction propane-1,2-diol 1-phosphate + NAD+ ⇌ {\displaystyle \rightleftharpoons } hydroxyacetone phosphate + NADH + H+ Thus, the two substrates of this enzyme are propane-1,2-diol 1-phosphate and NAD+, whereas its 3 products are hydroxyacetone phosphate, NADH, and H+. (wikipedia.org)
  • The systematic name of this enzyme class is propane-1,2-diol-1-phosphate:NAD+ oxidoreductase. (wikipedia.org)
  • In affected individuals, a defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely. (medlineplus.gov)
  • This gene provides instructions for making an enzyme called glucose-6-phosphate dehydrogenase. (medlineplus.gov)
  • Comparison of detection of glucose-6-phosphate dehydrogenase deficiency using fluorescent spot test, enzyme assay and molecular method for prediction of severe neonatal hyperbilirubinaemia. (medscape.com)
  • The 21-amino acid sequence from the bovine protein exhibited 90.5% identity with the human sequence of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). (nih.gov)
  • Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. (diabetesjournals.org)
  • It is concluded that the epsilon-amino group of the lysine residue that is acetylated during the inactivation reaction with acetylsalicylic acid is not necessary for binary complex formation between the enzyme and NADP+, but that it is situated in a part of the molecule affected by formation of the enzyme--glucose-6-phosphate complex. (nih.gov)
  • The enzyme catalyses the the first step in the pentose pathway: the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. (ebi.ac.uk)
  • Glucose 6 Phosphate Dehydrogenase is an enzyme that helps red blood cells function normally and protects them against oxidative stress. (dawaai.pk)
  • We recently established that cortisone reductase deficiency is a digenic disease requiring mutations in both the gene encoding 11 beta-HSD1 and in the gene for a novel enzyme located within the lumen of the endoplasmic reticulum (ER), hexose-6-phosphate dehydrogenase (H6PDH). (ox.ac.uk)
  • The encodes the glycerol phosphate dehydrogenase 1-like protein with homology to glycerol phosphate dehydrogenase (GPD1) however the CCT129202 function because of this enzyme is unknown. (ecolowood.com)
  • Examples of RBC disorders that involve enzyme deficiencies include glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency . (medicalnewstoday.com)
  • Recently it was reported that metformin lowers blood glucose by a redox mechanism ( 2 ) caused by a 30-50% inhibition of mitochondrial glycerol phosphate dehydrogenase (mGPD) ( 3 ) that suppresses gluconeogenesis in the liver. (diabetesjournals.org)
  • Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. (uthscsa.edu)
  • Kaplan M, Hammerman C, Vreman HJ, Stevenson DK, Beutler E. Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes. (medscape.com)
  • Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH), one of the key enzymes of glycolysis, was reported as a surface multifunctional molecule in several bacteria. (biomedcentral.com)
  • The 8.5 kDa chloroplast protein CP12 is essential for assembly of the phosphoribulokinase ⁄ glyceraldehyde-3-phosphate dehydrogenase (GAPDH) complex from Chlamydomonas reinhardtii. (maynoothuniversity.ie)
  • Partial amino acid sequencing establishes its identity as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). (johnshopkins.edu)
  • The most common medical problem associated with glucose-6-phosphate dehydrogenase deficiency is hemolytic anemia, which occurs when red blood cells are destroyed faster than the body can replace them. (medlineplus.gov)
  • In people with glucose-6-phosphate dehydrogenase deficiency, hemolytic anemia is most often triggered by bacterial or viral infections or by certain drugs (such as some antibiotics and medications used to treat malaria). (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase deficiency occurs most frequently in areas of the world where malaria is common. (medlineplus.gov)
  • When Do Symptoms of Class I glucose-6-phosphate dehydrogenase deficiency Begin? (nih.gov)
  • Glucose-6-phosphate dehydrogenase deficiency is a genetic disorder that affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase deficiency is also a significant cause of mild to severe jaundice in newborns. (medlineplus.gov)
  • An estimated 400 million people worldwide have glucose-6-phosphate dehydrogenase deficiency. (medlineplus.gov)
  • Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. (medscape.com)
  • Beutler E. Glucose-6-phosphate dehydrogenase deficiency: a historical perspective. (medscape.com)
  • Manganelli G, Masullo U, Passarelli S, Filosa S. Glucose-6-phosphate dehydrogenase deficiency: disadvantages and possible benefits. (medscape.com)
  • Anaesthetic management in patients with glucose-6-phosphate dehydrogenase deficiency undergoing neurosurgical procedures. (medscape.com)
  • Kaplan M, Hammerman C. Glucose-6-phosphate dehydrogenase deficiency: a hidden risk for kernicterus. (medscape.com)
  • Glucose-6-phosphate dehydrogenase deficiency and risk of diabetes: a systematic review and meta-analysis. (medscape.com)
  • Mortality in a cohort of men expressing the glucose-6-phosphate dehydrogenase deficiency. (medscape.com)
  • Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: A retrospective observational study. (medscape.com)
  • Incidence and molecular polymerase-chain-reaction amplification analysis of glucose-6-phosphate dehyd- of the entire coding region from genomic rogenase deficiency in the province of DNA. (who.int)
  • Genetic of glucose-6-phosphate dehydrogenase blood disorders survey in the Sultanate deficiency in the Fars province of Iran. (who.int)
  • dehydrogenase deficiency in some ethnic recommended screening test for glucose- groups of Pakistan. (who.int)
  • Instability of reduced glutathione and deficiency of glucose-6-phosphate dehydrogenase activity of red cells in normal Indians. (nih.gov)
  • Glucose-6-Phosphate Dehydrogenase Deficiency" Encyclopedia , https://encyclopedia.pub/entry/4020 (accessed December 11, 2023). (encyclopedia.pub)
  • Glucose-6-phosphate dehydrogenase deficiency is a genetic disorder that occurs almost exclusively in males. (encyclopedia.pub)
  • Dichloroacetate (DCA) is a structural analog of pyruvate that has been recommended for the treatment of primary lactic acidemia, particularly in patients with pyruvate dehydrogenase (PDHC) deficiency. (nature.com)
  • Hemolysis can be caused by oxidant agents during peroperative medications in patients with Glucose-6-phosphate dehydrogenase deficiency. (ispub.com)
  • This report presents a case of general anaesthesia management in a patient with glucose-6-phosphate dehydrogenase deficiency. (ispub.com)
  • The conversion of nicotinamide adenine dinucleotide phosphate to its reduced form in erythrocytes is the basis of diagnostic testing for the deficiency. (ispub.com)
  • Glucose-6-phosphate dehydrogenase deficiency associated hemolysis in COVID-19 patients treated with hydroxychloroquine/chloroquine: New case reports coming out. (univr.it)
  • Glucose-6-phosphate dehydrogenase (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types. (ebi.ac.uk)
  • Although brilliant cresyl blue positive (BCB+) oocytes with low glucose-6-phosphate dehydrogenase (G6PDH) activity have shown superior quality than BCB negative (−) oocytes with high G6PDH activity, the use of a BCB staining test before IVM is still controversial. (animbiosci.org)
  • The activity of glucose-6-phosphate dehydrogenase is measured in the presence of excess glucose 6-phosphate and NADP by the increase in absorbance at 340 nm, which corresponds to the formation of NADPH. (dundee.ac.uk)
  • Academy of Sciences of the United States phosphate dehydrogenase phenotypes of America , 1988, 85:5171-5. (who.int)
  • Beutler E, Westwood B, Prchal JT, Vaca G, Bartsocas CS, Baronciani L. New glucose-6-phosphate dehydrogenase mutations from various ethnic groups. (medscape.com)
  • This chapter describes the assay method, purification procedure, and properties of glucose-6-phosphate dehydrogenase from human erythrocytes. (dundee.ac.uk)
  • the characters Tmem1 are a symbol of glycerol 3-phosphate dehydrogenase 1-like since it stocks 84% homology with glycerol 3-phosphate dehydrogenase 1 (GPD1) (13). (ecolowood.com)
  • GPD1 catalyzes the reversible transformation of glycerol-3-phosphate (G3P) to dihydroxyacetone phosphate (DHAP). (ecolowood.com)
  • 3-Phosphoglyceric phosphokinase catalyzes the reversible transfer of a phosphate group from 1,3-diphosphoglycerate to ADP to generate ATP and 3-phosphoglycerate. (sigmaaldrich.com)
  • Insulin secretion in mGPD knockout mouse β-cells is normal because, like liver, β-cells possess the malate aspartate redox shuttle whose redox action is redundant to the glycerol phosphate shuttle. (diabetesjournals.org)
  • Chemical reactions involving glucose-6-phosphate dehydrogenase produce compounds that prevent reactive oxygen species from building up to toxic levels within red blood cells. (medlineplus.gov)
  • A reduction in the amount of functional glucose-6-phosphate dehydrogenase appears to make it more difficult for this parasite to invade red blood cells. (medlineplus.gov)
  • Transient transfection of chinese hamster ovary (CHO) cells with 11 beta-HSD1 resulted in the appearance of both oxo-reductase and dehydrogenase activities in intact cells. (ox.ac.uk)
  • Conversely in HEK 293 cells stably transfected with 11 beta-HSD1 cDNA, transfection of an H6PDH siRNA reduced 11 beta-HSD1 oxo-reductase activity whilst simultaneously increasing 11 beta-HSD1 dehydrogenase activity. (ox.ac.uk)