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  • citation
  • Because each style has its own formatting nuances that evolve over time and not all information is available for every reference entry or article, Encyclopedia.com cannot guarantee each citation it generates. (encyclopedia.com)
  • redox
  • The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. (sigmaaldrich.com)
  • metabolite
  • This metabolite leads to production of ATP, NADPH and precursors for the synthesis of macromolecules such as nucleic acids and phospholipids. (scielo.br)
  • Another glucose-derived metabolite, glycerol-3-phosphate ( Figure 1 ), is the backbone of the main lipid storage molecule, triacylglycerol, or phospholipids (which are important components of cell membranes). (scielo.br)
  • acetate
  • However, the original metabolic pathway devised to convert acetate to ethanol uses NADH-specific acetylating acetaldehyde dehydrogenase and alcohol dehydrogenase and quickly becomes constrained by limited NADH availability, even when glycerol formation is abolished. (asm.org)
  • S. cerevisiae can grow on acetate as the sole carbon source under oxic conditions by converting acetate to acetyl coenzyme A (acetyl-CoA) with acetyl-CoA synthetase (ACS) (EC 6.2.1.1) and by either respiring acetyl-CoA in the tricarboxylic acid (TCA) cycle or upgrading acetyl-CoA to four-carbon intermediates in the glyoxylate pathway. (asm.org)
  • lactate
  • We found that lactate could enter endothelial cells through the monocarboxylate transporter MCT-1, trigger the phosphorylation/degradation of IκBα, and then stimulate an autocrine NF-κB/IL-8 (CXCL8) pathway driving cell migration and tube formation. (aacrjournals.org)
  • In conclusion, our findings establish a signaling role for lactate in endothelial cells and they identify the lactate/NF-κB/IL-8 pathway as an important link between tumor metabolism and angiogenesis. (aacrjournals.org)
  • a parallel lactate-induced TGFβ-1-mediated pathway was also proposed to prevent maturation of neoformed tubes ( 21 ). (aacrjournals.org)
  • overexpression
  • OGD/reoxygenation-induced elevation of ROS, reduction of GSH, dysfunction of mitochondria, and activation of caspase-3 were rescued by overexpression of TIGAR or supplementation of NADPH, while knockdown of TIGAR aggravated these changes. (jneurosci.org)
  • cell
  • Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. (nih.gov)
  • However
  • NADPH + supply in absence of cytosolic ME in oleaginous yeasts like Yarrowia lipolytica and Lipomyces starkeyi is met by PPP, however, in M. alpina supply of reluctant is met by both [ 2 , 5 , 6 ]. (omicsonline.org)
  • brain
  • Supplementation of NADPH also reduced ischemia/reperfusion brain injury and alleviated TIGAR knockdown-induced aggravation of ischemic injury. (jneurosci.org)