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  • regulation
  • QIAGEN provides a broad range of assay technologies for protein phosphatase research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • residues
  • Corresponding residues in the active site of glucose-6-phosphatase-α include Arg170 and Arg83, which donate hydrogen ions to the phosphate, stabilizing the transition state, His119, which provides a proton to the dephosphorylated oxygen attached to glucose, and His176, which completes a nucleophilic attack on the phosphate to form a covalently bound phosphoryl enzyme intermediate. (wikipedia.org)
  • Gene
  • Alterations in phosphatase activity, including changes in gene expression, have been implicated in central nervous system and metabolic disorders, infectious diseases, and cancer. (qiagen.com)
  • serum
  • Different forms of acid phosphatase are found in different organs, and their serum levels are used to evaluate the success of the surgical treatment of prostate cancer. (wikipedia.org)
  • PP2B
  • Calcineurin (PP2B), the calmodulin-dependent protein phosphatase, acts as a calcium ion-dependent regulator of phosphorylation and plays a role in a wide range of biological activities. (qiagen.com)
  • hydrolysis
  • Glucose-6-phosphatase-α and glucose-6-phosphatase-β are both functional phosphohydrolases, and have similar active site structure, topology, mechanism of action, and kinetic properties with respect to G6P hydrolysis. (wikipedia.org)