• Subsequently, a lot more than 4 million toddlers are already https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase brought to existence using the help of In vitro fertilization worldwide. (dailystrength.org)
  • Glucose 6-phosphatase ( EC 3.1.3.9 , G6Pase) is an enzyme that hydrolyzes glucose 6-phosphate , resulting in the creation of a phosphate group and free glucose. (wikipedia.org)
  • and glucose 6-phosphatase-β, encoded by G6PC3 . (wikipedia.org)
  • Glucose 6-phosphatase-α and glucose 6-phosphatase-β are both functional phosphohydrolases, and have similar active site structure, topology, mechanism of action, and kinetic properties with respect to G6P hydrolysis. (wikipedia.org)
  • Vanadium containing chloroperoxidase has a similar structure and active site as glucose 6-phosphatase. (wikipedia.org)
  • Although a clear consensus has not been reached, a large number of scientists adhere to a substrate-transport model to account for the catalytic properties of glucose 6-phosphatase. (wikipedia.org)
  • In this model, glucose 6-phosphatase has a low degree of selectivity. (wikipedia.org)
  • Glucose 6-phosphatase consists of 357 amino acids, and is anchored to the endoplasmic reticulum (ER) by nine transmembrane helices. (wikipedia.org)
  • Due to its tight association to the ER, the exact structure of glucose 6-phosphatase remains unknown. (wikipedia.org)
  • However, sequence alignment has shown that glucose 6-phosphatase is structurally similar to the active site of the vanadium-containing chloroperoxidase found in Curvularia inaequalis. (wikipedia.org)
  • Based on pH kinetic studies of glucose 6-phosphatase-α catalysis, it was proposed that the hydrolysis of glucose 6-phosphate was completed via a covalent phosphohistidine glucose 6-phosphate intermediate. (wikipedia.org)
  • Corresponding residues in the active site of glucose 6-phosphatase-α include Arg170 and Arg83, which donate hydrogen ions to the phosphate, stabilizing the transition state, His119, which provides a proton to the dephosphorylated oxygen attached to glucose, and His176, which completes a nucleophilic attack on the phosphate to form a covalently bound phosphoryl enzyme intermediate. (wikipedia.org)
  • However, the corresponding residue in glucose 6-phosphatase-α (Lys76) resides within the ER membrane and its function, if any, is currently undetermined. (wikipedia.org)
  • Glucose 6-phosphatase-β is a ubiquitously expressed, 346-amino acid membrane protein that shares 36% sequence identity with glucose 6-phosphatase-α. (wikipedia.org)
  • Within the glucose 6-phosphatase-β enzyme, sequence alignments predict that its active site contains His167, His114, and Arg79. (wikipedia.org)
  • Similar to that of the glucose 6-phosphatase-α active site, His167 is the residue that provides the nucleophilic attack, and His114, and Arg79 are the hydrogen donors. (wikipedia.org)
  • Glucose 6-phosphatase-β is also localized in the ER membrane, although its orientation is unknown. (wikipedia.org)
  • This group represents a glucose-6-phosphatase. (ebi.ac.uk)
  • It consists of three subunits, each of which are vital components of the multi-enzyme Glucose-6-Phosphatase Complex (G6Pase). (wikipedia.org)
  • Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. (wikipedia.org)
  • Human placental alkaline phosphatase (PLAP) is one of three tissue-specific human APs extensively studied because of its ectopic expression in tumors. (rcsb.org)