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  • acetate
  • Phospholipase C from Clostridium perfringens (PLC-Cp), which generates diacylglycerol from membrane phospholipids, and 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) induced increases in glucose transport activity (assessed using 3-O-methylglucose transport) that were approximately 80 and approximately 20% as great, respectively, as that induced by a maximal insulin stimulus. (osti.gov)
  • Jatropha
  • Phorbol esters of Jatropha meal were found to be promising as an alternative to replace the chemotherapeutic drugs for cancer therapy. (mdpi.com)
  • Following a request from the European Commission, the risks for human and animal health related to the presence of phorbol esters (PEs) in Jatropha kernel meal were assessed by the EFSA Panel of Contaminants in the Food Chain (CONTAM). (europa.eu)
  • Pereira CSS, Pessoa FLP, Mendonca S, Ribeiro JAA, Mendes MF (2015) Technical and Economic Evaluation of Phorbol Esters Extraction from Jatropha curcas Seed Cake using Supercritical Carbon Dioxide. (omicsonline.org)
  • Simulations of phorbol ester extraction from Jatropha curcas cake were carried out using SuperPro Designer 9.0 (Intelligen, Inc) to evaluate production costs of an industrial process to treat the necessary quantity of cake. (omicsonline.org)
  • proteins
  • Therefore, various chemical and physical treatments have been evaluated to extract or inactivate phorbol esters so that seed meals rich in proteins could be used as feed resources. (psu.edu)
  • Phorbol ester/PKC pathways have been proposed as potential therapeutic targets for chronic pain states, potentially by phosphorylating proteins involved in nociception, such as voltage-dependent Ca 2+ channels (VDCCs). (mdpi.com)
  • inositol
  • Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. (duke.edu)
  • The effect of phorbol esters on norepinephrine-stimulated inositol phospholipid turnover and alpha 1-receptor phosphorylation showed the same rapid time course with a t1/2 less than 2 min. (duke.edu)
  • derivatives
  • Besides, possessing antinutritional and toxic effects, few derivatives of the phorbol esters are also known for their antimicrobial and antitumor activities. (psu.edu)
  • Consistent with the activity of the lipophilic derivatives being masked by an inability to transfer from the aqueous to the lipid phase, phorbol 12,13-distearate added to the aqueous phase inhibited efficiently (apparent inhibitor equilibrium dissociation constant, 14 n M ) in the presence of 0.03% Triton X-100. (aacrjournals.org)
  • pathway
  • The phorbol ester/PKC pathway has been proposed to phosphorylate Ca V 2 subunits in expression systems [ 10 , 11 , 12 , 13 ]. (mdpi.com)
  • Effect
  • Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundus. (semanticscholar.org)
  • The effect of temperature (40-100°C) and pressure (100-500 bar) on the phorbol yield was investigated using a central composite design methodology to determine the significance and interactions of these parameters. (omicsonline.org)
  • The results showed that pressure had the most significant enhancing effect on the phorbol ester yield. (omicsonline.org)
  • Comparable results are obtained with OAG, while the non-tumour-promoting phorbol ester 4 alpha-phorbol 12,13-didecanoate is without effect. (biochemj.org)
  • animal
  • This toxicity limits the use of many nutritive plants and agricultural by-products containing phorbol esters to be used as animal feed. (psu.edu)
  • cell
  • J. Ballaron and J. M. Young, Edema and cell infiltration in the phorbol estertreated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents . (springer.com)
  • show
  • The phorbol esters, even at very low concentrations, show toxicological manifestations in animals fed diets containing them. (psu.edu)