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  • phenylketonuria
  • On the other hand, a rare metabolic disorder called phenylketonuria (PKU) occurs in people who are missing an enzyme that the body needs to use phenylalanine. (umm.edu)
  • People with phenylketonuria (PKU), and women who are breastfeeding or are pregnant, should not take phenylalanine supplements. (umm.edu)
  • substrate
  • During the reaction, molecular oxygen is heterolytically cleaved with sequential incorporation of one oxygen atom into BH4 and phenylalanine substrate. (wikipedia.org)
  • heterolytic cleavage of the O-O bond to yield the ferryl oxo hydroxylating intermediate Fe(IV)=O attack on Fe(IV)=O to hydroxylate phenylalanine substrate to tyrosine. (wikipedia.org)
  • Like other lyases, phenylalanine requires only one substrate for the forward reaction, but two for the reverse. (wikipedia.org)
  • aromatic
  • When productive, though, the Fe(IV)=O intermediate is added to phenylalanine in an electrophilic aromatic substitution reaction that reduces iron from the ferryl to the ferrous state. (wikipedia.org)
  • symptoms
  • DL-phenylalanine should not be used in people taking antipsychotic drugs, as it may cause or worsen symptoms of tardive dyskinesia (TD). (umm.edu)
  • depression
  • One animal study suggests that D-phenylalanine may improve rigidity, walking disabilities, speech difficulties, and depression associated with Parkinson disease. (umm.edu)
  • Studies suggest that phenylalanine may be helpful as part of a comprehensive therapy for depression, most of the studies were done in the 1970s and 1980s and were not rigorously tested. (umm.edu)
  • More research is needed to tell whether phenylalanine has any real effect on depression. (umm.edu)