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  • erectile dysfunction
  • Phentolamine should not be used as a sexual aid by men who do not have erectile dysfunction. (drugs.com)
  • Although there is no specific information comparing the use of phentolamine for erectile dysfunction in the elderly, it is not expected to cause different side effects or problems in older people than it does in younger adults. (drugs.com)
  • phentolamine Introduction Recent epidemiological data determined that the annual incidence rate of erectile dysfunction (ED) is 26=1000 men=year and about one million new cases are expected annually in the USA alone.1 Such high incidence rate, together with the advances in the treatment of ED - mainly due to the availability of oral agents in the market - brought into consideration the urgent need for the development of prevention strategies. (spotidoc.com)
  • The objective of the study is to determine the effects of oral phentolamine, administered before sleep in men with mild to moderate erectile dysfunction, on nocturnal penile erectile activity. (spotidoc.com)
  • Effects of phentolamine on nocturnal erection DG Hatzichristou et al 304 Materials and methods This is a double-blind, placebo-controlled, crossover, phase II study designed to evaluate the effects of 40 mg oral phentolamine (VasomaxTM, Zonagen Inc.) on the nocturnal erectile activity in patients with a history of mild to moderate erectile dysfunction. (spotidoc.com)
  • erections
  • Nocturnal erections have been proposed to play a protective role on the trabecular tissue, increasing tissue oxygenation, specifically during long periods of sexual abstinence.5 As orally taken vasoactive drugs, such as sildenafil and phentolamine have shown to be effective in enhancing erectile capabilities,6,7 it was postulated that it may be possible to pharmacologically manipulate nocturnal erections with regular administration of such agents before sleep. (spotidoc.com)
  • blockade
  • In pithed SHR the pressor responses to norepinephrine or electrical stimulation of the spinal cord were less inhibited after phentolamine than after prazosin (0.3 mg/kg, i.v.). Furthermore, only phentolamine induced a significantly smaller blockade of responses to electrical spinal cord stimulation than to exogenous norepinephrine. (ovid.com)
  • Synergistic hypotensive effect of vasoactive intestinal polypeptide and alpha-blockade with phentolamine. (ahajournals.org)
  • Phentolamine causes a reduction in peripheral resistance through blockade of alpha 1 receptors and possibly alpha 2 receptors on vascular smooth muscle. (resus.me)
  • Prazosin
  • The 5-hydroxytryptamine pressor responses were significantly reduced by both i.v. methysergide (5 μg/kg) and phentolamine (1.0 mg/kg), but were unchanged or slightly enhanced by prazosin (0.3 and 1.0 mg/kg). (ovid.com)
  • Prazosin differed from phentolamine in that it inhibited the pressor responses to endogenous and exogenous norepinephrine similarly and interfered neither with cardiac presynaptic α-adrenoceptors nor with vascular postsynaptic 5-hydroxytryptamine receptors. (ovid.com)
  • dose
  • CONCLUSIONS: A subpressor dose of phentolamine has complex effects on ocular hydrodynamics. (biomedsearch.com)
  • All patients received oral phentolamine (VasomaxTM) at a dose of 40 mg and placebo for three consecutive nights respectively and were submitted to nocturnal penile tumescence and rigidity monitoring (NPTR) with the Rigiscan1 device. (spotidoc.com)
  • drugs
  • Using phentolamine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (drugs.com)
  • effects
  • Vasoconstrictive and hypertensive effects of epinephrine and ephedrine are antagonized by phentolamine. (drugs.com)
  • Phentolamine may also be used to reverse the effects of an anesthetic medicine in soft tissues, such as the lips and tongue. (drugs.com)
  • Appropriate studies have not been performed on the relationship of age to the effects of phentolamine for the reversal of soft-tissue anesthesia in children younger than 6 years of age. (drugs.com)
  • Phentolamine and diphenhydrAMINE may have additive effects in lowering your blood pressure. (drugs.com)
  • The a-adrenergic blocking characteristics of phentolamine administered by a variety of methods have proved effective in reversing the effects of epinephrine in these cases. (jaoa.org)
  • In series 3, the hemodynamic effects of phentolamine in the presence of VIP receptor binding inhibitor were studied. (ahajournals.org)
  • Effects of clonidine and phentolamine on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in mice. (jax.org)
  • diagnostic
  • Determination of blood catecholamine concentrations, urinary assay of catecholamines, or other biochemical assays are the safest and most reliable diagnostic methods and they have largely replaced phentolamine and other pharmaceutical tests. (drugs.com)
  • medicines
  • Tell your doctor if you have ever had any unusual or allergic reaction to phentolamine or any other medicines. (drugs.com)
  • When you are taking phentolamine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (drugs.com)
  • Using phentolamine with any of the following medicines is usually not recommended, but may be required in some cases. (drugs.com)
  • less
  • Phentolamine Mesylate contains not less than 98.0 percent and not more than 102.0 percent of C 17 H 19 N 3 O·CH 4 O 3 S, calculated on the dried basis. (drugfuture.com)
  • In early newborn puppies, phentolamine alone resulted in a 24% decrease (p less than 0.005) in blood pressure, compared with a 54% decrease (p less than 0.005) in early newborn puppies preexposed to VIP infusion. (ahajournals.org)
  • patients
  • Sickle cell disease-Patients with these conditions have an increased risk of priapism (erection lasting longer than 4 hours) while using phentolamine. (mayoclinic.org)