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  • phospholipid
  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. (genecards.org)
  • All PLCs catalyze the hydrolysis of the membrane phospholipid phosphatidyl inositol 4,5-bisphosphate [PI(4,5)P 2 ] into inositol 1,4,5-trisphosphate (InsP 3 ) and diacylglycerol. (genetics.org)
  • domains
  • Comparison of intron positions demonstrates that extensive intron loss has occurred during invertebrate evolution and also reveals the presence of conserved introns in both the N- and C-terminal PLC-γ SH2 domains that are present in SH2 domains in many other genes. (genetics.org)
  • These and other conserved SH2 introns suggest that the SH2 domains in PLC-γ are derived from an ancestral domain that was shuffled not only into PLC-γ, but also into many other unrelated genes during animal evolution. (genetics.org)
  • Human T cells expressing CAR targeting mesothelin or fibroblast activation protein and containing CD3ζ and 4-1BB cytoplasmic domains were intravenously injected into immunodeficient mice bearing large, established human mesothelin-expressing flank tumors. (aacrjournals.org)
  • tyrosine
  • GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity . (genecards.org)
  • In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. (genecards.org)
  • We report here the identification and characterization of a kinase, triacylglycerol accumulation regulator1 (TAR1), that is a member of the yeast ( Saccharomyces cerevisiae ) Yet another kinase1 (Yak1) subfamily in the dual-specificity tyrosine phosphorylation-regulated kinase family in a green alga ( Chlamydomonas reinhardtii ). (plantphysiol.org)
  • expression
  • GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
  • In N-deficient conditions, global changes in expression levels of N deficiency-responsive genes in N assimilation and tetrapyrrole metabolism were noted between tar1-1 and wild-type cells. (plantphysiol.org)
  • Previously identified factors affecting the levels of TAG accumulation, the transcription factor NRR1, and metabolic enzymes PGD1, PDAT1, ADP-Glc pyrophosphorylase, and isoamylase were reported by characterizing mutants with aberrant TAG accumulation in N-deficient conditions, but no regulatory factors involved in protein modification leading to global changes in gene expression in different stress conditions (i.e. (plantphysiol.org)
  • Maternal wun2 RNA was found to be concentrated in pole cells and pole cell-specific expression of wun2 rescues the pole cell death phenotype of the maternal wun2 mutant, suggesting that wun2 activity in pole cells is required for their survival. (sdbonline.org)
  • While several studies correlated increased expression of the histone code reader Spin1 with tumor formation or growth, little is known about physiological functions of the protein. (diagenode.com)
  • The majority of long noncoding RNAs (lncRNAs) is still poorly characterized with respect to function, interactions with protein-coding genes, and mechanisms that regulate their expression. (diagenode.com)
  • The cause of the hypofunction seemed to be multifactorial and was associated with upregulation of intrinsic T-cell inhibitory enzymes (diacylglycerol kinase and SHP-1) and the expression of surface inhibitory receptors (PD1, LAG3, TIM3, and 2B4). (aacrjournals.org)
  • genetic
  • The identification of this mutation and phenotype will facilitate molecular diagnosis, carrier screening, and genetic counseling in the Yemenite Jewish population. (arvojournals.org)
  • Mutation
  • The causative mutation was detected by direct sequencing of the underlying gene, and its prevalence in additional affected and unaffected Yemenite Jews was determined. (arvojournals.org)
  • Sequences
  • To gain insight into both PLC-γ evolution and structure-function relationships within the Drosophila PLC-γ encoded by small wing ( sl ), we cloned and sequenced the PLC-γ homologs from Drosophila pseudoobscura and D. virilis and compared their gene structure and predicted amino acid sequences with PLC-γ homologs in other animals. (genetics.org)
  • Targets
  • PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. (utsouthwestern.edu)
  • genome
  • Although other Wnt genes are present in the fly genome, they do not appear to have major roles in development (reviewed in L ogan and N usse 2004 ). (genetics.org)
  • activates
  • In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. (genecards.org)
  • mechanisms
  • Several mechanisms of action have been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches. (diagenode.com)
  • domain
  • The kinase domain of TAR1 showed auto- and transphosphorylation activities. (plantphysiol.org)
  • each domain is presumed to have arisen once and then been spread both by gene duplication and by being co-opted into existing genes by exon shuffling via retrotransposition, illegitimate recombination, or long interspersed nuclear element-mediated 3′ transduction ( L ong 2001 ). (genetics.org)
  • novel
  • Many proteins with novel functions were created by exon shuffling around the time of the metazoan radiation. (genetics.org)
  • different
  • Phospholipase C-γ (PLC-γ) is typical of proteins that appeared at this time, containing several different modules that probably originated elsewhere. (genetics.org)
  • Two distinct PLC-γ homologs encoded by different genes-PLC-γ1 and PLC-γ2-are present in mammals, whereas all invertebrates described to date have only a single homolog. (genetics.org)