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  • TCPS
  • 90% of VICs found in standard in vitro culture conditions are aVICs, as these cells appear to undergo a rapid transformation to an aVIC phenotype when cultured on tissue culture polystyrene (TCPS) in growth medium. (ahajournals.org)
  • On the PEGDMA-DEGDMA system, cells exhibited a more differentiated phenotype on the stiffest surface indicated by elevated osteocalcin compared with TCPS. (naver.com)
  • Relationship
  • To investigate on the gene-relationship between NGF, BDNF, and Osteocalcin we compared by RT-PCR the transcript levels of Ngf, Bdnf and Osteocalcin as well as of their receptors p75NTR/NTRK1, NTRK2 , and Gprc6a in brain, bone, white/brown adipose tissue (WAT/BAT) and reproductive organs of 3 months old female and male mice. (frontiersin.org)
  • mechanisms
  • The inability to preserve a healthy VIC phenotype during in vitro studies has hampered the elucidation of mechanisms involved in calcific aortic valve disease. (ahajournals.org)
  • Possible mechanisms for the osteoclerotic bone phenotype include factors produced by PCa, such as bone morphogenetic protein (BMP), transforming growth factor-β, insulin-like growth factor, fibroblast growth factor, and platelet-derived growth factor ( 19 ). (aacrjournals.org)
  • cardiovascular
  • Background: Circulating osteocalcin (OC), a marker which is central in bone mineralization, may be involved in the atherosclerotic process and influence the risk of developing cardiovascular disease (CVD). (le.ac.uk)
  • Aims: We conducted a systematic review and meta-analysis of published observational evidence, to assess and quantify the associations of circulating OC (total, undercarboxylated, and carboxylated OC) with cardiovascular outcomes (clinical CVD endpoints and intermediate cardiovascular phenotypes). (le.ac.uk)
  • Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. (hindawi.com)
  • Molecular
  • Villafán-Bernal JR, Sánchez-Enríquez S, Muñoz-Valle JF (2011) Molecular modulation of osteocalcin and its relevance in diabetes (review). (springer.com)
  • partially
  • This myofibroblastic phenotype was partially reversed within 4 days, and fully reversed within 9 days, following application of a combination of a fibroblast media formulation with culture on collagen coatings. (ahajournals.org)
  • Specifically, osteocalcin exists as fully carboxylated or partially carboxylated forms and completely uncarboxylated. (frontiersin.org)
  • Expression
  • Changes in the expression levels of osteocalcin, Ngf , or Bdnf genes may mutually affect the expression levels of the others. (frontiersin.org)
  • These results indicate a Dex induced phenotype drift of the tenocytes by reducing scleraxis expression. (biomedcentral.com)
  • Expression of genes like Runx2, Collagen-1, Osteocalcin and the microRNAs 328 and 339, were performed using Q-PCR. (intechopen.com)
  • DEX increased leptin, Ob-Ra and Ob-Rb expression in a dose-dependent manner while decreasing expression of osteocalcin. (medsci.org)
  • In the presence of leptin, Cbfa1 and osteonectin expression showed no significant change, whereas osteocalcin expression was decreased. (medsci.org)
  • patients
  • Analysis of large groups of patients versus normal/reactive samples has highlighted the existence of aberrant MC phenotypes in SM, which are essential for the diagnosis of the disease. (jove.com)
  • protein
  • In the osteocalcin (OC) gene promoter, both independent positive and negative regulatory elements, as well as others with contiguous [TATA/glucocorticoid-responsive elements (GRE)] or overlapping [TATA/GRE, vitamin D-responsive enhancer elements (VDRE)/AP-1, and OC box/AP-domains, are sites for modifications in protein-DNA interactions. (umassmed.edu)