Phenotype in mice. Medical search. Frequent questions

METHODS: As renal phenotype can be influenced by genetic background, we generated congenic C57BL/6 and FVB/N Ctns(-/-) mice and assayed renal lesions and function by histological and biochemical studies. (cnrs.fr)
RESULTS: C57BL/6 Ctns(-/-) mice showed significantly higher renal cystine levels than the FVB/N strain. (cnrs.fr)
Moreover, C57BL/6 mice presented with pronounced histological lesions of the proximal tubules as well as a tubulopathy and progressively developed chronic renal failure. (cnrs.fr)
CONCLUSIONS: Thus, the C57BL/6 strain represents the first Ctns(-/-) mouse model to show clear renal defects. (cnrs.fr)
In addition to highlighting the influence of genetic background on phenotype, the C57BL/6 Ctns(-/-) mice represent a useful model for further understanding cystinosin function in the kidney and, specifically, in the proximal tubules. (cnrs.fr)
To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa −/− , Xpc −/− and wild-type control female mice in a pure C57BL/6J background were done. (aacrjournals.org)
Approach: 4 wk wild-type (WT, C57BL/6J) male mice were fed control diet (CD) or HFD and received either p16 or control Vivo Morpholino (VM) by tail vein injection 2x during the 16th wk of feeding. (gene-tools.com)
Adopted male and female C57BL/6J mice that fasted for 24 h were included to examine the effect of fasting on myokine expression in slow-twitch soleus and fast-twitch tiabialis anterior (TA) skeletal muscle. (hku.hk)
Akr1d1-/- mice were generated on a C57BL/6 background. (ox.ac.uk)
Causal impact of a full-gene deletion will be investigated in all organ systems by comparing phenotypic characteristics of KO-mice with wild-type control mice of the same genetic C57BL/6N background (Munoz-Fuentes et al. (springer.com)
MI was induced in male C57Bl/6 mice by ligation of the left anterior descending coronary artery. (lu.se)

However, neither treatment improved glucose homeostasis in PLB4 mice, implying that impaired glucose metabolism in this genotype may not be associated with glucagon like peptide 1 (GLP-1) and/or RBP4-mediated pathways. (ulster.ac.uk)
Genotype-Phenotype Correlation of Tracheal Cartilaginous Sleeves and Fgfr2 Mutations in Mice. (cdc.gov)
SMAD6 variants in craniosynostosis: genotype and phenotype evaluation. (cdc.gov)

We have demonstrated that a mouse maternal low-protein diet (LPD) fed exclusively during preimplantation development (Emb-LPD) increases offspring growth but programmes adult cardiovascular and metabolic disease. (manchester.ac.uk)
AKR1D1 knockout mice develop a sex-dependent metabolic phenotype. (ox.ac.uk)
Bile acids and glucocorticoids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unknown. (ox.ac.uk)
Metabolic phenotypes including body weight and composition, lipid homeostasis, glucose tolerance and insulin tolerance were evaluated. (ox.ac.uk)
Akr1d1-/- mice had a sex-specific metabolic phenotype. (ox.ac.uk)
These extensive high-throughput data from IMPC mice provide a promising opportunity to explore genetics causing metabolic heart disease with an important translational approach. (springer.com)
We further detected mild metabolic and mitochondrial impairments in female mdx carrier mice that were exacerbated with high-fat diet feeding. (frontiersin.org)
These results are in line with previous data and suggest that before the onset of myofiber necrosis, mitochondrial and metabolic abnormalities are present within the mdx mouse. (frontiersin.org)
Effects of Deletion of Mutant Huntingtin in Steroidogenic Factor 1 Neurons on the Psychiatric and Metabolic Phenotype in the BACHD Mouse Model of Huntington Disease. (lu.se)
IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)
Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
The International Mouse Phenotyping Consortium, IMPC, has set the goal of systematically "knocking out" each protein-coding genes in the mouse and phenotyping these so-called knockout (KO) mice using highly standardized high-throughput tests (Brown and Moore 2012 ). (springer.com)

Taking tolcapone in mid-gestation barely caused embryo lethality, however, the mice developed preeclampsia-like phenotypes, including maternal hypertension, proteinuria and fetal growth restriction. (biorxiv.org)
In conclusion, tolcapone causes embryo lethality and growth restriction in early gestation, while in mid-gestation tolcapone causes preeclampsia-like phenotypes in mice with defective trophoblast invasion. (biorxiv.org)
We show that modification of the Tuba1a mRNA sequence results in homozygous lethality and a severe neurodevelopmental phenotype. (ozgene.com)
Studies in mice have struggled with the lethality of Cux1 null variants. (nature.com)

Here, we describe an MTO1-deficient mouse model generated by gene trap mutagenesis that mirrors the human phenotype remarkably well. (uni-koeln.de)
Our results showed that m2 macrophage-like cell transplantation in these mice reduced inflammatory gene expression. (nii.ac.jp)
In this study, we used gastrocnemius skeletal muscle RNA sequencing data from fasting male mice in the Gene Expression Omnibus (GEO) database. (hku.hk)
Fasting reduced Fndc5 and Igf1 gene expression in soleus and TA muscles in both male and female mice without muscle phenotype or gender differences, but Il6, Mstn and Erfe expression was influenced by fasting with fibre type- and gender-dependent effects. (hku.hk)
This phenotype was associated with sexually dimorphic changes in bile acid metabolism and composition but without overt effects on circulating glucocorticoid levels or glucocorticoid-regulated gene expression in the liver. (ox.ac.uk)
The C. elegans gene dpy-19 belongs to the dpy ("dumpy" phenotype) gene class and encodes DPY-19, transmembrane protein with C-linked mannosyltransferase activity. (wikipedia.org)
Because the wa-2 mutation was mapped previously to the vicinity of the EGF/TGF-α receptor (EGFR) gene on mouse chromosome 11, we hypothesized that the wa-2 phenotype might result from a defect in either the expression or activity of EGFR, or both. (houstonmethodist.org)
AceView: gene:dpy-21, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
This gene is associated to a phenotype (DumPY : shorter than wild-type). (nih.gov)
Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)

In this study, we investigate the impact of maternal nutrition on post-implantation trophoblast phenotype and fetal growth. (manchester.ac.uk)
These data demonstrate that early post-implantation embryos modify trophoblast phenotype to regulate fetal growth under conditions of poor maternal nutrition. (manchester.ac.uk)
In this study, we investigated changes in the mechanical phenotype of murine fetal neural progenitor cells (fNPCs) during reprogramming to induced pluripotent stem cells (iPSCs). (lih.lu)

Here, we test the hypothesis that aging phenotype(s) commonly associated with broad category of chronic kidney disease are accelerated in diabetic kidneys and linked to the p66ShcA locus. (hofstra.edu)
The mice underwent chronic polysomnographic electrode implantation (4EEG/2EMG) to assess sleep architecture. (lvhn.org)

To test the in-vivo consequences of constitutive p66 expression in diabetic kidneys, we crossed Akita diabetic mouse with the p66KO mouse. (hofstra.edu)
For our in vivo and ex vivo experiments, we inoculated wild-type mice with TCL1 leukemic cells isolated from Eµ-TCL1 transgenic mice and then monitored disease progression by detecting leukemic cells in peripheral blood. (biomedcentral.com)

To this end, respiration of unrestrained adult and neonatal adenosine A1 receptor knockout mice (A(1)R(-/-)) was measured in a plethysmographic device. (uni-regensburg.de)
To directly assess the role of nNOS in mdz muscle, we generated dystrophin-nNOS double knockout mice by mating nNOS single knockout mice with mdx mice. (johnshopkins.edu)
The double knockout mice are indistinguishable from the rndx mice in terms of dystrophic muscle morphology and sarcolemma membrane damage. (johnshopkins.edu)

Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)
Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)

The histomorphology analysis of placentas from tolcapone treated mice exhibited abnormalities in trophoblast layer and the hampered trophoblast invasion in decidua. (biorxiv.org)

Homozygous mutation at the p66 locus delays or prevents aging phenotype(s) in the kidney that may be precursors to diabetic nephropathy. (hofstra.edu)
As we previously localized TGF-α mRNA to the inner root sheath, this pattern of EGFR expression is consistent with the effect of the wa-2 mutation on hair structure, and together with our previous characterization of TGF-α- deficient mice, reveals a critical role for signaling by this ligand/receptor system in skin. (houstonmethodist.org)

Strikingly, Xpa −/− and Xpc −/− mice also showed a phenotypical difference in terms of tumor spectrum. (aacrjournals.org)
In response to transforming growth factor (TGF)-β, interferon (IFN)-β, or interleukin (IL)-35, neutrophils shift from the N1 to the N2 phenotype and support tumor progression [ 4 ]. (biomedcentral.com)
In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)
In a glioma mouse model, CD44 was restricted to hypoxic and perivascular tumor regions, and in human glioma, a hypoxia signature correlated with CD44. (lu.se)

Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)

Therefore, using a mouse model, we tested a hypothesis that inhaled OD induces neuroinflammation and sensory-motor deficits. (cdc.gov)

In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression under the control of the human K14 promoter. (nuigalway.ie)

We report that expression of human CD4 molecule in mCD4/8 -/− mice rescues thymocyte development and completely restores the T cell compartment in peripheral lymphoid organs. (elsevierpure.com)
Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity. (bvsalud.org)

The ketogenic diet has been shown to preserve motor function in aged mice by activation of mitochondrial biogenesis, oxidative metabolism and antioxidant capacity. (jain-foundation.org)
Reactive oxygen species (ROS) metabolism was substantially increased in Wild Type (WT)-MSCs in HG media in association with increased cell death by apoptosis and acquisition of the senescent phenotype. (hofstra.edu)
Beyond that, we are linking metabolism to the heart and describing phenotypes that emerge in a set of known genes, when knocked out in mice, such as the leptin receptor ( Lepr ), leptin ( Lep ), and Bardet-Biedl syndrome 5 ( Bbs5 ). (springer.com)

We recently reported that brain-specific human β-secretase 1 (BACE1) knock-in (PLB4), a mouse model of sporadic Alzheimer's disease (AD), also develops a severe diabetic phenotype characterised by impaired glucose homeostasis, decreased insulin sensitivity and a fatty liver phenotype. (ulster.ac.uk)
The skin of Wnt5a TG mice was not psoriatic, but characterized with normal proliferation and homeostasis of epidermis. (nuigalway.ie)

The specific CB2 cannabinoid receptor agonist JWH-133 induced cognitive improvement in double AβPP/PS1 transgenic mice, a genetic model of Alzheimer's disease. (nih.gov)
In conclusion, these data indicate that the adenosine A(1) receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice. (uni-regensburg.de)

These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). (lu.se)
In CRC patient tissues and xenografts from mouse model, presence of increased amount of M2 macrophages was observed. (lu.se)

We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
Our findings highlight the importance of maintaining the wild-type coding sequence when engineering mouse lines and the impact of synonymous genetic variation. (ozgene.com)
Homozygous knockout mutants ( Cux1 − / − ) died shortly after birth due to underdeveloped lungs and respiratory failure [ 13 ], and only in outbred genetic backgrounds some mice survived to adulthood. (nature.com)

Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. (escholarship.org)
Lastly, inhibition of the strong autophagic program observed in adolescent mdx male mice via administration of the autophagy inhibitor leupeptin did not improve skeletal muscle pathology. (frontiersin.org)

Here, we describe a detailed protocol for the detection and quantification of key neuropathological changes in Alzheimer's mouse models. (nih.gov)

Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. (lu.se)

A translational consequence of this mouse model may be to caution against anaesthesia-related cardiac arrhythmias which may be fatal in patients. (uni-koeln.de)
We aim to study if E-MNC transplantation can reduce SG inflammation in a mouse model of SS. (nii.ac.jp)
This study delineates the clinical presentation in an extended cohort and investigates the molecular mechanism underlying the disorder in a Cux1 +/− mouse model. (nature.com)
In a mouse model of dysferlinopathy (Bla/J) we found that a continuous 3-month ketogenic diet starting right before the disease onset (5-month-old mice) improves motor function and muscle strength to the levels observed in WT mice. (jain-foundation.org)
We also investigated whether a reduction in dietary carbohydrate improves muscle perform in a mouse model of dysferlinopathy (Bla/J). We fed pre-symptomatic mice either a ketogenic diet (low carbohydrate-high fat), an isocaloric control diet (high carbohydrate-low fat), or regular chow for three months. (jain-foundation.org)
Yet, the mouse shares a similar developmental trajectory to the human heart and a comparable four-chamber morphology that greatly enhances its translational value as a model organism, despite the substantial differences in size (Krishnan et al. (springer.com)
Sleep phenotype in the Townes mouse model of sickle cell disease. (lvhn.org)
CONCLUSIONS: The presence of decreased total NREM sleep associated with reduced arousals, in the absence of OSAS, suggests a distinctive underlying sleep phenotype in a mouse model of SCD. (lvhn.org)
Using TCR alpha and beta repertoire sequencing for T-cell subsets, as well as single-cell RNAseq and TCRseq, we track the concentrations and phenotypes of individual T-cell clones in response to primary and secondary yellow fever immunization - the model for acute infection in humans - showing their large diversity. (elifesciences.org)
Here we examined the potential anti-cancer effect of the NF-κB inhibitor parthenolide (PTL) and its water soluble analogue dimethylaminoparthenolide (DMAPT) on tumour progression and metastasis in the TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model of prostate cancer. (edu.au)
We examined the effects of exposure to BD on the mouse lung metabolome in the genetically heterogeneous collaborative cross outbred mouse model. (utmb.edu)
In this work, we used an Eµ-TCL1 mouse model of human CLL. (biomedcentral.com)
Mitoapocynin attenuates organic dust exposure-induced neuroinflammation and sensory-motor deficits in a mouse model. (cdc.gov)
These in creating a mouse model for occupational asthma using HDI findings suggest that respiratory response to TDI depends on (hexamethylene diisocyanate), in which the sensitized mice prior frequency and concentration of dermal sensitization in mice. (cdc.gov)

Xpc −/− mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa -deficient or wild-type mice. (aacrjournals.org)
Xpa −/− mice showed a significant elevation in liver tumors. (aacrjournals.org)
Additionally, Xpc -deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa −/− mice, whereas in both models mutant frequency is increased in liver. (aacrjournals.org)
At 30 weeks of age, male, but not female, Akr1d1-/- mice were more insulin tolerant and had reduced lipid accumulation in the liver and adipose tissue yet had hypertriglyceridemia and increased intramuscular triacylglycerol. (ox.ac.uk)
Here, the changes in molecular pathways associated to the development and progression of HT1-driven liver disease that remains uncorrected under NTBC therapy were investigated using whole transcriptome analyses on the livers of Fah- and Hgd-deficient mice under continuous NTBC therapy and after seven days of NTBC therapy discontinuation. (edgehill.ac.uk)
Most importantly, a set of 25 genes related to liver disease and HCC development was identified that was differentially regulated in HT1 vs. AKU mouse livers under NTBC therapy. (edgehill.ac.uk)

To gain insights into the neuropathogenesis of Cohen syndrome , we systematically characterized brain changes in Vps13b-mutant mice and compared murine findings to 235 previously published and 17 new patients diagnosed with VPS13B-related Cohen syndrome . (bvsalud.org)

Ectoplacental cone explants were isolated at day 8 of gestation from female mice fed either normal protein diet (NPD: 18% casein), LPD (9% casein) or Emb-LPD and cultured in vitro. (manchester.ac.uk)

In neonatal mice, the respiratory response to hypoxia was surprisingly similar in both genotypes. (uni-regensburg.de)
This article is a brief introduction to the study of CMT and correlates the most common different genotypes and phenotypes. (medscape.com)

Remarkably, depending on the type of neoplastic disease, the phenotype and functions of neutrophils appear different. (biomedcentral.com)

Many animal models are used to perform research on SS, including the MRL/lpr mouse and the non-obese diabetic (NOD) mouse. (nii.ac.jp)
Hence, we here aimed to assess if targeted anti-diabetic therapies (Liraglutide and Fenretinide) would attenuate the diabetic and behavioural phenotype of these mice. (ulster.ac.uk)
Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent. (hofstra.edu)

In order to better understand the locomotor networks, we have used different transgenic mice for anatomical characterization of one of these interneuron groups, called V2 interneurons. (ox.ac.uk)
Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral phenotypes with females less affected. (bvsalud.org)

Six-week-old male TRAMP mice received PTL (40 mg/kg in 10% ethanol/saline), DMAPT (100 mg/kg in sterile water), or vehicle controls by oral gavage thrice weekly until palpable tumour formation. (edu.au)
PTL did not slow overall tumour development, while the ethanol/saline vehicle used to administer PTL unexpectedly induced an aggressive metastatic tumour phenotype. (edu.au)
Mice were administered with either saline, fluorescent lipopolysaccharides (LPSs), or OD extract intranasally daily for 5 days a week for 5 weeks. (cdc.gov)
The saline or OD extract-exposed mice received either a vehicle or MA (3 mg/kg) orally for 3 days/week for 5 weeks. (cdc.gov)

High fat/high cholesterol diet (HFD) feeding increases biliary senescence, DR, and biliary insulin-like growth factor-1 (IGF-1) expression in mice. (gene-tools.com)
Graded reduction of BubR1 expression in mouse embryonic fibroblasts causes increased aneuploidy and senescence. (elsevierpure.com)

We analyze brain CUX1 expression and susceptibility to epilepsy in Cux1 +/− mice. (nature.com)

Finally, in situ hybridization analysis demonstrated expression of EGFR predominantly in the outer root sheath of active hair follicles in neonatal mice. (houstonmethodist.org)

It is still unclear which molecular factors and cell types are involved in shaping neutrophil function and phenotype in the CLL microenvironment. (biomedcentral.com)
To investigate the interrelation between Treg and neutrophils in the leukemia microenvironment, we performed experiments using TCL1-injected DEREG mice with Treg depletion or RAG2KO mice with adoptively transferred TCL1 cells alone or together with Treg. (biomedcentral.com)
Additionally, we show that Treg depletion and IL-10 neutralization induce changes in the leukemia microenvironment, partially restoring the "healthy" phenotype of neutrophils. (biomedcentral.com)

Using established methods, we isolated a highly purified population of stem cell antigen-1 positive mesenchymal stem cells (Sca-1+ MSCs) from kidneys of Wild Type (WT) and p66 Knock Out (KO) mice. (hofstra.edu)

We evaluated p16 inhibition on NAFLD phenotypes and biliary E2F1/FOXO1/IGF-1 signaling. (gene-tools.com)

In summary, disease-causing CUX1 variants result in a non-syndromic phenotype of developmental delay and intellectual disability. (nature.com)

To reconstitute the human immune system in mice, transgenic mice expressing human CD4 and human major histocompatibility complex (MHC) class II (DQw6) molecules in an endogenous CD4- and CD8-deficient background (mCD4/8 -/− ), after homologous recombination, have been generated. (elsevierpure.com)
Human CD4 + DQw6 + double transgenic mice are tolerant to DQw6 and the DQw6 molecule functions in antigen presentation, effectively generating a human MHC class II-restricted T cell response to streptococcal M6C2 peptide. (elsevierpure.com)
These data show that both the hCD4 and DQw6 molecules are functional in mCD4/ 8-/− mice, fully and stably reconstituting this limb of the human immune system in mice. (elsevierpure.com)
The remaining mice have a normal lifespan and display the core phenotypes of the human disease , including microcephaly , growth delay, hypotonia , altered memory , and enhanced sociability. (bvsalud.org)
Exposing the human nude phenotype. (lu.se)

We analyzed both the phenotype and activity of neutrophils isolated from the spleens of TCL1 leukemia-bearing mice. (biomedcentral.com)

The obtained results underline the plasticity of the neutrophil phenotype, observed under the influence of leukemic cells alone and depending on the presence of Treg. (biomedcentral.com)

In this manuscript we compare two Tuba1a mouse models, both of which express wild-type TUBA1A protein but employ different codon usage. (ozgene.com)
PLB4 mice and wild-type (WT) controls were administered Liraglutide or Fenretinide for ten consecutive weeks alongside vehicle-treated mice. (ulster.ac.uk)
We found that the mice fed with a ketogenic diet maintained or improved their strength or motor coordination performance to the level shown by the wild type mice. (jain-foundation.org)
Natural aging of wild-type mice is marked by decreased expression of BubR1 in multiple tissues, including testis and ovary. (elsevierpure.com)

In some individuals, this phenotype ameliorates with age, resulting in a clinical catch-up and normal IQ in adulthood. (nature.com)

It provides an opportunity for students to analyze amino acid data and draw conclusions about the evolution of coat-color phenotypes in the rock pocket mouse. (berkeley.edu)

Physiological (body weight and mass composition, glucose tolerance, serum hormone concentration), behavioural (locomotor activity) and molecular assessments were performed in mice pre- and post-treatment. (ulster.ac.uk)

Male Akr1d1-/- mice were challenged with a high fat diet (60% kcal from fat) for 20 weeks. (ox.ac.uk)
Male Akr1d1-/- mice were not protected against diet-induced obesity and insulin resistance. (ox.ac.uk)
Male and female mutant mice have defects in meiotic chromosome segregation and are infertile. (elsevierpure.com)
In this study, we detected aberrant mitochondrial morphology, reduced cristae number, and large mitochondrial vacuoles from both male and female mdx mice prior to the onset of muscle damage. (frontiersin.org)

URL: http://ras.jes.su/dan/s086956520003288-9-1-en (circulation date: 03.10.2023). (jes.su)

Laminin α1 reduces muscular dystrophy in dy2J mice. (lu.se)

Cux1 heterozygous ( Cux1 +/ − ) animals are fertile and display no obvious phenotypes, but an in-depth analysis of the consequence of heterozygosis has never been pursued [ 13 ]. (nature.com)

The sophisticated expression pattern of myokines would partially explain the complicated cross-talk between skeletal muscle and other organs in different genders and muscles phenotypes, and it is worth further investigation. (hku.hk)

Furthermore, we show that the mechanical phenotype of iPSCs is comparable with that of embryonic stem cells. (lih.lu)

Mice were exposed to 3 concentra-tions of BD for 10 days (2, 20, and 200 ppm), and lung tissues were analyzed using high-resolution mass spectrometry-based metabolomics. (utmb.edu)
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. (nih.gov)

In contrast, mice that had received prior application(s) using protocols involving dermal application and subsequent of TDI, even if only on day 7, exhibited the following: ventilatory intranasal administration of TDI. (cdc.gov)

Tolcapone was administrated to pregnant mice at the dose of 60 mg/kg/day (H-Tol) or 30 mg/kg/day (L-Tol), in the early gestation or the mid-gestation. (biorxiv.org)

There is no cure for SS, however, our approach using enhanced peripheral blood mononuclear cells (EMNC), improves radiation-injured SGs in mice. (nii.ac.jp)
At the organ level, tissue stem cells antagonize senescent phenotypes, by replacing old dysfunctional cells. (hofstra.edu)
They also reveal that pluripotent cells can differentiate towards a more compliant phenotype, which challenges the view that pluripotent stemcells are less stiff than any cells more advanced developmentally. (lih.lu)
OD exposure is known to induce a pro-inflammatory phenotype in microglial cells. (cdc.gov)
Systemically, ivacaftor leads to higher frequencies of circulating Ly6C + and Ly6C hi cells compared to vehicle-treated MI mice. (lu.se)
Our data indicate that the stem cell marker CD44 modulates the hypoxic response of glioma cells and that the pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2α through interaction with CD44, independently of oxygen. (lu.se)

In contrast, neurological examination was largely normal in Mto1-deficient mice. (uni-koeln.de)
In Cux1 +/ − mice, we found delayed growth, histologically normal brains, and increased susceptibility to seizures. (nature.com)
In this study, using adult mice maintained under standard diet, we demonstrate that Socs3 deficiency in the mediobasal hypothalamus (MBH) reduces food intake, protects against body weight gain, and limits adiposity, suggesting that Socs3 is necessary for normal body weight maintenance. (jneurosci.org)

Anatomy29

Organisms19

Diseases13

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Psychiatry and Psychology2

Phenomena and Processes104

Disciplines and Occupations1

Information Science4

Health Care6

C57BL11

Genotype3

Metabolic11

International Mouse Phenotyping Consortium2

Lethality4

Gene11

Fetal3

Chronic2

Vivo2

Knockout mice3

BACHD2

Trophoblast1

Mutation2

Tumor4

Transgenic mouse1

Hypothesis1

Overexpression1

Rescues2

Metabolism3

Homeostasis2

Receptor2

Macrophages2

Genetic3

Pathology2

Alzheimer's1

Reconstitution1

Model14

Liver6

Murine1

Female mice1

Genotypes2

Neoplastic1

Diabetic3

Characterization2

Saline4

Senescence2

Epilepsy1

Neonatal mice1

Microenvironment3

Methods1

Biliary1

Variants1

Human5

Neutrophils1

Plasticity1

Wild-type4

Ameliorates1

Conclusions1

Glucose1

Male4

20231

Muscular dystrophy1

Consequence1

Muscles1

Embryonic1

Tissues2

Protocols1

Gestation1

Cells6

Normal3