Loading...
  • cytoplasm
  • P element also encodes a suppressor of transposition, which accumulates in the cytoplasm during the development of cells. (wikipedia.org)
  • He began working at the Institut de Biologie Physicochimique (the Rothschild Institute) in Paris, and later worked at the CNRS at Gif-sur-Yvette, where he studied the contribution of cytoplasm to the cell phenotype and pursued the interactions between nuclear and cytoplasmic genetic endowments necessary to the yielding of an intact, functioning (albeit single-celled) organism. (wikipedia.org)
  • developmental
  • In contrast to the uniformly penetrant mPanIN phenotype observed following developmental activation of Kras G12D in the Pdx1 -expressing progenitor cells, the Pdx1 -expressing population in the mature pancreas (predominantly islet β cells) appears to be relatively resistant to the effects of oncogenic Kras . (pnas.org)
  • plasticity
  • The E to M transition (EMT), associated with the loss of cell-cell adhesion and the gain of invasive traits, is considered to be a hallmark of plasticity within a stem cell population and is particularly relevant for tumors. (pnas.org)
  • Here, we combine numerical simulations of a large Boolean model for the EMT-MET network with the analysis of a wide set of bulk and single-cell gene expression data to reconstruct the topography underlying E/M plasticity. (pnas.org)
  • To identify determinants of plasticity in lung cancer we exposed eight different cell lines to TGFβ1 to induce EMT and stimulate modulation of CD133+ CICs. (ovid.com)
  • recombination
  • The acinar cell derivation of the mPanINs was established through lineage tracing in reporter mice, and by microdissection of lesional tissue demonstrating Cre -mediated recombination events. (pnas.org)
  • The hybrid dysgenesis syndrome is marked by temperature-dependent sterility, elevated mutation rates, and increased chromosome rearrangement and recombination. (wikipedia.org)
  • mice
  • In mice given methylnitrosourea treatment, the bone marrow became hypocellular and there was a drastic decrease in the number of leukocytes and platelets, thereby indicating an impaired reproductive capacity of hematopoietic stem cells. (nii.ac.jp)
  • This finding on human cells may shed light on the unusual heterogeneity observed in mice where NK cells with monocytic and thymic phenotypes have been discerned. (springer.com)
  • tested this notion by using Sleeping Beauty transposons to help insert sequences into mice with sickle cell anemia so they can produce the enzymes need to counteract their anemia. (wikipedia.org)
  • This sequence was then added inserted into a plasmid and introduced into the cells of the mice. (wikipedia.org)
  • The mice that receive the insertion showed a fivefold increase in the expression of HO-1, which in turn reduced blood vessel blockage from sickle-cell anemia. (wikipedia.org)
  • mutations
  • Osteosarcoma-derived transmitochondrial cell hybrids (cybrids) carrying XTC.UC1 mitochondrial DNA (mtDNA) were generated to discriminate whether the energetic failure depended on mitochondrial or nuclear DNA mutations. (aacrjournals.org)
  • However, the functional relevance of these mutations on the biochemical phenotype has not been investigated. (aacrjournals.org)
  • Human Cells
  • Publications] Ishibashi,T.: 'Intracellular localization and function of DNA repair methyltransferase in human cells' Mutation Res.315・3. (nii.ac.jp)
  • partial
  • However, down-regulated pluripotency gene expression and failure to form teratoma indicated that the CRC-iPC cells had only attained partial pluripotency. (biomedcentral.com)
  • Slug triggers the steps of desmosomal disruption, cell spreading, and partial separation at cell-cell borders, which comprise the first and necessary phase of the EMT process. (wikipedia.org)
  • tissues
  • We propose a general mapping strategy that can be used for other pathways, providing a useful tool to visualize the ever increasing number of gene expression data obtained from single cells and tissues. (pnas.org)
  • Almost 80% of human malignancies originate from E tissues, and a transition toward an M phenotype is usually associated with more aggressive potential ( 2 ⇓ ⇓ - 5 ). (pnas.org)
  • receptors
  • Expression of the Fc receptor remains controversal since Fc receptors may be absent on some NK cells depending on their organ origin. (springer.com)
  • Specificity
  • Grieder and Blackburn, "The Telomere Terminal Transferase of Tetrahymena Is a Ribonucleoprotein Enzyme with Two kinds of Primer Specificity", 51 Cell 887, 1987. (freepatentsonline.com)
  • No conclusion can be reached on the basis of cloned cells as to the problem of clonal distribution of NK-like specificity. (springer.com)
  • Fusing combinations of these elements, derived from different kingdoms, has resulted in production of diverse hybrid factors having defined DNA-binding specificity and transcriptional activation function for the target organism in question. (genetics.org)
  • derivation
  • To assess the bioenergetic efficiency of mitochondria, we analyzed the thyroid oncocytic follicular cell line XTC.UC1 and compared it with other non-oncocytic lines of follicular cell derivation. (aacrjournals.org)
  • thus
  • Thus, in the mouse promonocytes have been characterized as NK cells with a defined spectrum of susceptible target cells. (springer.com)
  • differentiate
  • Specifically, the project has identified that prostate cancer cells differentiate into a neuronal-like state in response to androgen deprivation therapy. (napier.ac.uk)
  • these are multipotent stromal cells that can differentiate into a variety of cell types. (wikipedia.org)
  • effector
  • This problem has become amenable recently with the help of monoclonal antibodies and by cloning of effector cells. (springer.com)
  • Cloning of effector cells, though fashionable and widely applied, has not yet resolved the Chamaeleon-like phenoyype. (springer.com)
  • express
  • Emerging evidence shows that the EMT is a multiple-step process where cells express a mix of markers, both characteristic of E and M cells ( 6 ⇓ - 8 ). (pnas.org)
  • However, other findings point to a considerable heterogeneity which shows that NK cells express Thy-1 antigens as well as Ly related antigens characteristic for the T cell lineage. (springer.com)
  • murine
  • In a case of hybrid resistance, the parental bone marrow (BM) graft is rejected by F1 generation in murine model. (wikipedia.org)
  • molecular
  • The concept of "landscape" in the context of dynamical systems theory represents a high-dimensional space, in which each cell phenotype is considered as an "attractor" that is determined by interactions between multiple molecular players, and is buffered against environmental fluctuations. (mdpi.com)
  • Restoration of Telomeres in Human Papoillomavirus-Immortalized Human Anogential Epithelial Cells," Molecular and Cellular Biology 14:961-969 (1994). (freepatentsonline.com)
  • constitutively
  • Further characterization showed that MCP compounds restore actin stress fibers and cause flat reversion in NIH 3T3 cells transformed with H-Ras (V12) but not in NIH 3T3 cells transformed with constitutively active Raf-1 (RafΔN). (mysciencework.com)
  • lineage
  • Because carcinogens can adversely impact multiple cell types in the pancreas, the lineage fidelity from cell-of-origin to eventual neoplasia is hard to preserve ( 9 ). (pnas.org)
  • transcription
  • A hybrid transcription factor comprising a fusion of the DNA-binding domain of Saccharomyces cerevisiae GAL4 and the transcription activation domain of maize C1 was expressed in stably transformed Arabidopsis. (genetics.org)
  • Together these studies establish that DNA-binding domains from heterologous factors can bind to synthetic promoters containing appropriate binding sites on naked DNA templates introduced into plant cells, and nonplant activation domains can productively interact with the transcription machinery of the plant when covalently linked to a DNA-binding domain. (genetics.org)
  • For two-hybrid screening, the transcription factor is split into two separate fragments, called the DNA-binding domain (DBD or often also abbreviated as BD) and activating domain (AD). (wikipedia.org)
  • Furthermore
  • Furthermore, MCP110 caused G1 enrichment of A549 cells with the decrease of cyclin D level. (mysciencework.com)
  • Furthermore, the enzymatic activity of complexes I and III was dramatically decreased in these cells compared with controls, in conjunction with a strongly enhanced production of reactive oxygen species. (aacrjournals.org)
  • nucleotide
  • 8-Oxo-dGTP (8-oxo-7,8-dihydrodeoxyguanosine triphosphate) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causee mutation. (nii.ac.jp)
  • activation
  • These results highlight potent and specific effects of MCP compounds on cancer cells with intrinsic Ras activation. (mysciencework.com)
  • On the other hand, Slug cannot trigger the second phase, which includes the induction of cell motility, repression of the cytokeratin expression, and activation of vimentin expression. (wikipedia.org)
  • It means activation of NK cell. (wikipedia.org)
  • vivo
  • No conclusive evidence has so far been provided for the in vivo operation of these cells. (springer.com)
  • change
  • action potential The local voltage change across the cell wall as a nerve impulse is transmitted. (wikipedia.org)