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  • peripheral blood
  • The presence of SRCs in peripheral blood was not associated with detection of long-term culture-initiating cells, consistent with the notion that SRCs are more primitive than long-term culture-initiating cells. (jci.org)
  • However, when using this AM, the BMCs are contaminated with peripheral blood with the result that there are more than 20% of T cells in the BMCs, which in turn leads to the induction of GvHD. (omicsonline.org)
  • CD34
  • Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene. (wikipedia.org)
  • The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. (wikipedia.org)
  • CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. (wikipedia.org)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • primitive
  • As ML-ICs and SRCs were both detected in blood of AC-SCD patients only, these assays may both measure primitive progenitors. (jci.org)
  • tissue
  • Migration of transferred cells has been studied mainly by tissue biopsies in humans or harvesting organs in animals to determine the presence of donor cells. (aacrjournals.org)
  • Organs are composites of tissue types with diverse developmental origins, and they rely on distinct stem and progenitor cells to meet physiological demands for cellular production and homeostasis. (nih.gov)
  • Skeletal tissue is composed of lineage restricted tissue progenitors. (nih.gov)
  • After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
  • In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had been. (wikipedia.org)
  • citation needed] A Nature Insight review defines niche as follows: "Stem-cell populations are established in 'niches' - specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. (wikipedia.org)
  • It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. (wikipedia.org)
  • Adipose tissue is a rich source of MSCs (or adipose-derived mesenchymal stem cells, AdMSCs). (wikipedia.org)
  • Marrow adipose tissue (MAT) increases in states of low bone density -osteoporosis, anorexia nervosa/ caloric restriction, skeletal unweighting, anti-diabetes therapies). (wikipedia.org)
  • Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT's thermogenic role. (wikipedia.org)
  • The phenomena of mechanically dissociated cells aggregating and reorganizing to reform the tissue they were obtained from subsequently led to the development of the differential adhesion hypothesis by Malcolm Steinberg. (wikipedia.org)
  • With the advent of the field of stem cell biology, the potential of stem cells to form organs in vitro was realized early on with the observation that when stem cells form teratomas or embryoid body, the differentiated cells can organize into different structures resembling those found in multiple tissue types. (wikipedia.org)
  • demonstrate a generalized method for organ bud formation from diverse tissues by combining pluripotent stem cell-derived tissue-specific progenitors or relevant tissue samples with endothelial cells and mesenchymal stem cells. (wikipedia.org)
  • Adult mesenchymal stem cells (MSCs) are being used by researchers in the fields of regenerative medicine and tissue engineering, to artificially reconstruct human tissue which has been previously damaged. (wikipedia.org)
  • Lymphopoiesis is now usually used interchangeably with the term "lymphocytopoiesis" - the making of lymphocytes - but other sources may distinguish between the two, stating that "lymphopoiesis" additionally refers to creating lymphatic tissue, while "lymphocytopoiesis" refers only to the creation of cells in that tissue. (wikipedia.org)
  • assays
  • Stem cells can also be identified by functional assays. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • 14 Additional alternatives of lineage branching based on these results have been proposed, 15 , 16 but differences in markers chosen for cell isolation and the use of different in vitro assays to test lineage restriction make these studies difficult to reconcile. (bloodjournal.org)
  • tissues
  • Isolation and molecular characterization of rare cells ( e.g. circulating tumor and stem cells) within biological fluids and tissues has significant potential in clinical diagnostics and personalized medicine. (mcponline.org)
  • Symptoms caused by blood cancer cells infiltration into tissues: Lymphadenopathy Joint pain Swelling of the gums Hepatoslenomegaly Headache and vomiting: blood cancer infiltration into the wear performance of the central nervous system. (wikipedia.org)
  • They suggested that the less mature tissues, or organ buds, generated through the self-organized condensation principle might be the most efficient approach toward the reconstitution of mature organ functions after transplantation, rather than condensates generated from cells of a more advanced stage. (wikipedia.org)
  • Mesenchymal stem cells have the capacity to become any type of fully developed cell, which can contribute to replacing muscle tissues or internal organs. (wikipedia.org)
  • Molecular
  • Importantly, this model closely recapitulates the phenotypes found in FA patients and may be useful as a preclinical platform to evaluate the molecular pathogenesis of spontaneous BMF and MDS in FA and novel gene transfer protocols for FA. (iupui.edu)
  • Molecular mechanisms of B-cell neoplasias were investigated together with Binder, Trepel and Dierks, the pathogenic significance of granulocytes in Graft-versus-host disease with Zeiser and his colleagues. (wikipedia.org)
  • The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
  • lymphocytes
  • B cells are derived from a common lymphoid progenitor (CLP) cell (lin − c- kit low Sca-1 low IL-7R + ) ( 1 ), which is limited in its ability to develop into T lymphocytes but is fully capable of developing into B cells. (pnas.org)
  • In patients with MS, autoreactive lymphocytes such as T and B cells cause damage to the CNS by attacking myelin proteins. (wikipedia.org)
  • Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). (wikipedia.org)
  • Nomenclature, the system of naming things properly, is not trivial in this case because although lymphocytes are found in the bloodstream and originate in the bone marrow, they principally belong to the separate lymphatic system which interacts with the blood circulation. (wikipedia.org)
  • This is in contrast to the adult where all lymphocytes originate in the bone marrow. (wikipedia.org)
  • fate
  • However, many critical questions pertaining to the regulation of B cell fate determination and early B cell development remain unanswered. (pnas.org)
  • To track the cellular fate of stem and progenitor cells, which express C/EBPα, we developed a mouse model expressing Cre recombinase from the Cebpa promoter and a conditional EYFP allele. (bloodjournal.org)
  • Subsequent experimentation revealed the plasticity of marrow cells and how their fate is determined by environmental cues. (wikipedia.org)
  • marker
  • At least 0.2% of all cells expressing the neuronal marker, NeuN, were BM-derived 4 mo after BM transplantation (BMT). (rupress.org)
  • Retrovirally transduced hematopoietic colonies expressed high levels of GFP as determined by direct visualization with phase contrast and fluorescence microscopy ( Fig. 1, A and B ). Nontransduced clonogenic progenitors showed no detectable fluorescence ( Fig. 1, C and D ), indicating the specificity of GFP as a marker for genetically modified hematopoietic cells. (rupress.org)
  • For example, "chief" cells express the stem cell marker Troy. (wikipedia.org)
  • pluripotent
  • It is at present unclear whether bone marrow stem cells overcome their intrinsic restrictions upon exposure to nervous system environment ("transdifferentiation"), or are truly pluripotent stem cells capable of supplying the adult CNS with neurons and glia. (rupress.org)
  • Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. (wikipedia.org)
  • They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent-iMSC, also called an induced multipotent progenitor cell-iMPC) or unipotent-(iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)
  • As many as 1 in 100 cells collected during amniocentesis has been shown to be a pluripotent mesenchymal stem cell. (wikipedia.org)
  • When pluripotent stem cells are used for the creation of the organoid, the cells are usually, but not all the time, allowed to form embryoid bodies. (wikipedia.org)
  • However, foetal stem cells attained from the amniotic fluid are more stable and more plastic than their adult counterparts making it easier for them to be reprogrammed to a pluripotent state. (wikipedia.org)
  • osteogenic
  • Although those cells which expressed the markers were able to differentiate into muscle, adipogenic, osteogenic, nephrogenic, neural and endothelial cells, this did not necessarily occur from a homogenous population of undifferentiated cells. (wikipedia.org)
  • antigen
  • The Duffy antigen is located on the surface of red blood cells, and is named after the patient in which it was discovered. (wikipedia.org)
  • The Duffy antigen gene was the fourth gene associated with the resistance after the genes responsible for sickle cell anaemia, thalassemia and glucose-6-phosphate dehydrogenase. (wikipedia.org)
  • distinct
  • In particular in intestinal crypt, two distinct groups of SCs have been identified: the "border stem cells" located in the upper part of the niche at the interface with transit amplifying cells (TAs), and "central stem cells" located at the crypt base. (wikipedia.org)
  • clinical
  • Here we review the perfusion method (for harvesting BMCs) and IBM-BMT (for their transplantation) and show that this combination will become a powerful new clinical strategy for allogeneic BMT. (omicsonline.org)
  • As a member of the clinical (Director Bayard Clarkson) and laboratory teams (Director Malcolm A.S. Moore), he carried out a systematic analysis of all patients with acute myeloid leukemia (AML) treated at MSKCC, defining the prognostic and predictive parameters of cell cytology, cell growth in vitro and enzymatic markers. (wikipedia.org)
  • Ectopic
  • Our results indicate that miR-150 most likely down-regulates mRNAs that are important for pre- and pro-B cell formation or function, and its ectopic expression in these cells blocks further development of B cells. (pnas.org)
  • Ectopic expression of miR-181a in hematopoietic stem cells leads to an increase in the production of CD19 + B cells and to a decrease of CD8 + T cells ( 24 ). (pnas.org)
  • D ) Pentachrome stain of cross-section of ectopic bone derived from transplantation of population a-3. (nih.gov)
  • E ) Cross-sectional fluorescence image of ectopic bone in D showing spongy bone marrow stroma derived from transplantation of population a-3. (nih.gov)
  • During aging, bone quantity declines and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and liver. (wikipedia.org)
  • acute
  • Among those affected, the majority develops cancer, most often acute myelogenous leukemia, and 90% develop bone marrow failure (the inability to produce blood cells) by age 40. (wikipedia.org)
  • citation needed] As FA is now known to affect DNA repair, specifically nonhomologous end joining, and given the current knowledge about dynamic cell division in the bone marrow, finding patients are more likely to develop bone marrow failure, myelodysplastic syndromes, and acute myeloid leukemia (AML) is not surprising. (wikipedia.org)
  • By using all techniques available at the time for phenotypic characterization of leukemia cells, he was successful in discovering and describing novel subentities of acute leukemias. (wikipedia.org)
  • Acute biphenotypic leukaemia is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability differentiating into both myeloid and lymphoid lineages. (wikipedia.org)