• Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. (wikipedia.org)
  • Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. (sens.org)
  • In apocrine secretion, secretory cells accumulate material at their apical ends, and this material then buds off from the cells, forming extracellular vesicles . (wikipedia.org)
  • The secretory cells therefore lose part of their cytoplasm in the process of secretion. (wikipedia.org)
  • 2017. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. . (oregonstate.edu)
  • 2017. Rapamycin and the inhibition of the secretory phenotype. . (oregonstate.edu)
  • Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)
  • Senescent cells continuously secrete a range of molecules that alter their local milieu, the Senescence Associated Secretory Phenotype (SASP). (uu.nl)
  • Senescent cells cause harm through what is known as the senescence-associated secretory phenotype (SASP) , the secretion of signals that spur inflammation, tissue modeling, and alterations in cellular behavior. (fightaging.org)
  • This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
  • She is widely known for her research on how senescent cells influence aging and cancer - in particular the senescence-associated secretory phenotype (SASP). (lifeboat.com)
  • The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders. (bvsalud.org)
  • Soluble urokinase plasminogen activator surface receptor is part of SASP, and has been used to identify senescent cells for senolytic therapy. (wikipedia.org)
  • SASP is the primary cause of the detrimental effects of senescent cells. (wikipedia.org)
  • SASP is heterogenous, with the exact composition dependent upon the senescent-cell inducer and the cell type. (wikipedia.org)
  • SASP is one of the three main features of senescent cells, the other two features being arrested cell growth, and resistance to apoptosis. (wikipedia.org)
  • Although SASP from senescent cells can kill neighboring normal cells, the apoptosis-resistance of senescent cells protects those cells from SASP. (wikipedia.org)
  • Interleukin 1 alpha (IL1A) is found on the surface of senescent cells, where it contributes to the production of SASP factors due to a positive feedback loop with NF-κB. (wikipedia.org)
  • Senescent cells are highly metabolically active, producing large amounts of SASP, which is why senescent cells consisting of only 2% or 3% of tissue cells can be a major cause of aging-associated diseases. (wikipedia.org)
  • SASP factors cause non-senescent cells to become senescent. (wikipedia.org)
  • SASP disrupts normal tissue function by producing chronic inflammation, induction of fibrosis and inhibition of stem cells. (wikipedia.org)
  • Chronic inflammation associated with aging has been termed inflammaging, although SASP may be only one of the possible causes of this condition. (wikipedia.org)
  • SASP factors IL-6 and TNFα enhance T-cell apoptosis, thereby impairing the capacity of the adaptive immune system. (wikipedia.org)
  • SASP factors from senescent cells reduce nicotinamide adenine dinucleotide (NAD+) in non-senescent cells, thereby reducing the capacity for DNA repair and sirtuin activity in non-senescent cells. (wikipedia.org)
  • SASP induction of the NAD+ degrading enzyme CD38 on non-senescent cells may be responsible for most of this effect. (wikipedia.org)
  • SASP induces an unfolded protein response in the endoplasmic reticulum because of an accumulation of unfolded proteins, resulting in proteotoxic impairment of cell function. (wikipedia.org)
  • Next, in aged mice treated with zoledronate or vehicle for 8 weeks, zoledronate significantly reduced circulating SASP factors, including CCL7, IL-1β, TNFRSF1A, and TGFβ1 and improved grip strength. (sens.org)
  • Analysis of publicly available RNAseq data from CD115+ (CSF1R/c-fms+) pre-osteoclastic cells isolated from mice treated with zoledronate demonstrated a significant downregulation of senescence/SASP genes (SenMayo). (sens.org)
  • To establish that these cells are potential senolytic/senomorphic targets of zoledronate, we used single cell proteomic analysis (cytometry by time of flight [CyTOF]) and demonstrated that zoledronate significantly reduced the number of pre-osteoclastic (CD115+/CD3e-/Ly6G-/CD45R-) cells and decreased protein levels of p16, p21, and SASP markers in these cells without affecting other immune cell populations. (sens.org)
  • Moreover, we have found that SASP factors can trigger stemness in healthy and cancer cells. (uu.nl)
  • In healthy cells, we hypothesize that SASP factors prevent differentiation of tissue stem cells and thereby impair tissue rejuvenation (de Keizer Trend Mol Med 2017) Together, this calls for investigation on how senescent and stem cells interact and how mitigation of their negative interplay may improve tissue regeneration during aging and affect migration of therapy-resistant cancer. (uu.nl)
  • Some researchers are more interested in altering SASP , however, trying to minimize or block the damaging factors while leaving senescent cells present. (fightaging.org)
  • Further, a SASP suppression therapy is something that would have to be taken as medicine on a continuing basis, whereas destruction of senescent cells can happen as a single treatment as needed, say once every few years. (fightaging.org)
  • Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. (oregonstate.edu)
  • Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. (oregonstate.edu)
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
  • Epithelial stem cells exhibit increased mitochondrial mutation in aging that affects their progeny in the mucosal epithelium. (open.ac.uk)
  • 2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
  • Cell 2017). (uu.nl)
  • Male young and old senescence-accelerated prone mice (SAMP8), aged 2 and 10 months, respectively, were divided into four groups: non-treated young, non-treated old, old treated with 1 mg/kg/day xanthohumol, and old treated with 5 mg/kg/day xanthohumol. (springer.com)
  • Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
  • To find out, first authors Yuyan Zhu and Huayan Hou crossed PSAPP mice (which overexpress human amyloid precursor protein and presenilin-1 with familial AD-linked mutations) with CD45-knockout mice, and analyzed their progeny at four or eight months of age. (alzforum.org)
  • Mice were killed at 17 or 22 weeks of age, and their kidneys and hearts were examined histologically and by immunohistochemistry. (nih.gov)
  • In recent years, more direct evidence has been established, demonstrations of extended life and improved health in mice resulting from the targeted destruction of senescent cells. (fightaging.org)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
  • By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
  • Moreover, histological analyses demonstrated that age causes a thickness of aortic walls, but this did not occur in G6PD-Tg mice. (bvsalud.org)
  • Moreover, our group has recently evidenced that early-life infection in 5xFAD mice induces a subpopulation of microglial cells with a monocyte-like profile presenting as potential markers genes corresponding to Gal3, and APOE. (lu.se)
  • In this week's Journal of Neuroscience, Jun Tan, University of South Florida, Tampa, and colleagues propose that the tendency of microglia to lean one way or the other depends on CD45, a transmembrane phosphatase found on microglia and some other immune cells. (alzforum.org)
  • The findings held up in vitro, where CD45-sufficient primary microglia gobbled Aβ peptides faster than did their CD45-deficient counterparts, also in confocal imaging studies, which revealed fluorescent Aβ within the cytoplasm of wild-type microglia but remaining on the surface of CD45-deficient cells. (alzforum.org)
  • During aging, microglia seem to shift further toward the harmful phenotype. (alzforum.org)
  • However, microglia can also act as an apoE source under chronic inflammatory conditions or during aging [4-6]. (lu.se)
  • Recent findings have highlighted an increase of the Gal3 gene (lgal3) in apoE4-microglia and upregulated APOE levels, particularly in aged microglia [6]. (lu.se)
  • The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. (lu.se)
  • Transforming growth factor beta family members secreted by senescent cells impede differentiation of adipocytes, leading to insulin resistance. (wikipedia.org)
  • Expression of surface markers and differentiation potential was consistent with ISCT/IFATS standards for the ASC phenotype. (nih.gov)
  • We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Tissue regeneration relies on faithful differentiation of stem cells. (uu.nl)
  • Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. (techscience.com)
  • A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
  • Currently, differentiation protocols generate cells with an immature phenotype. (sloankettering.edu)
  • Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease. (sens.org)
  • It will also illustrate how these novel aging-inducing strategies, with a particular focus on the Neddylation pathway, can be used to accelerate the emergence of late-onset phenotypes in human pluripotent stem cell models of Alzheimer's and Parkinson's diseases. (edu.au)
  • 2023 Theme: "Sex Differences in Aging from Reproductive to Immune System. (jax.org)
  • To test this, we first performed in vitro senescence assays using human lung fibroblasts and DNA repair-deficient mouse embryonic fibroblasts, which demonstrated that zoledronate killed senescent cells with minimal effects on non-senescent cells. (sens.org)
  • Repair of mitomycin-C-induced chromosomal aberrations was impaired in RAD51B/Rad51b-c.92delT human and mouse somatic cells in vitro and in explanted mouse bone marrow cells. (nature.com)
  • Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro . (jneurosci.org)
  • However, during in vitro expansion, MSCs are prone to aging, which largely limits their application. (techscience.com)
  • In order to promote the adult phenotype, stress-inducing agents have been employed in vitro in an attempt to mimic aging. (sloankettering.edu)
  • MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
  • [ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
  • Acute myeloid leukemia (AML), which accounts for 15-20% of all leukemias in childhood, belongs to a heterogeneous group of hematopoietic malignancies of monoclonal origin, which result from the malignant transformation of a stem cell. (bvsalud.org)
  • These neoplasms can manifest with a myeloid, erythroid, or platelet precursor phenotype, or a combination thereof 5 . (bvsalud.org)
  • ApoE interacts with multiple ligands, among them triggering-receptor expressed on myeloid cells 2 (TREM2), which is greatly implicated in neuroinflammation [5]. (lu.se)
  • Exclusion criteria: (1) Acute mixed phenotype leukaemia (excluding ALL with myeloid antigen expression). (who.int)
  • Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, Nakanishi T et al (2000) Telomere reduction in human liver tissues with age and chronic inflammation. (springer.com)
  • Variations in the degree of mosaicism between tissues explained the phenotype. (lu.se)
  • Aging is a complex and multi-dimensional phenotype that affects all tissues of all organisms. (jax.org)
  • However during aging the regenerative capacity of tissues is impaired and the inhibitory mechanism on tissue stem cells are largely unknown When healthy cells are irreparably damaged, they can enter a state called senescence (White et al. (uu.nl)
  • for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)
  • The miR-29a-3p level was decreased, and PTEN level was elevated in laryngocarcinoma tissues and the cancer cell lines. (hindawi.com)
  • At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)
  • Generate a bank of fibroblasts and corresponding induced pluripotent stem cells (iPSCs) that represent the breadth of healthy adult chronological age from a human cohort extensively phenotyped for key physical and functional measures of biological age. (salk.edu)
  • Given the tremendous promise of regenerative medicine to enhance human health and treat disease, Congress included a provision in the 21st Century Cures Act to support a Regenerative Medicine Innovation Project ($30 million distributed over FY17 through FY20) for the funding of clinical research to further the field of regenerative medicine (RM) using adult stem cells, including autologous, non-autologous use as well as eligible induced pluripotent stem cells (iPSC). (nih.gov)
  • Just 2 years later, Falck was pro- of the adult brain was fixed and immuta- moted to department chairman, and he ble and that nerve cells could not be handed over most of his laboratory to his regenerated after damage or death. (lu.se)
  • This condition arises from immature T cells in more than 80% of cases and immature B cells in the remainder of cases. (medscape.com)
  • The pair thought it might be transplanted into rats to relieve Parkinson- to join the medical school at the Univer- possible to implant immature cells into like symptoms, Björklund and former stu- sity of Lund, where he would stay for his damaged brain areas, where the new cells dent Olle Lindvall initiated the first clinical entire career. (lu.se)
  • Among the leukemias, the most prevalent type is acute lymphoblastic leukemia (ALL), which is characterized by accumulation of immature lymphoid cells in the bone marrow 2,3 and accounts for roughly 80% of all cases of leukemia in childhood. (bvsalud.org)
  • This age-related inflammation, also referred to as inflammaging, increases the risk for tissue damage and genetic aberrations that cause cellular transformation and cancer development ( 8 , 9 ). (frontiersin.org)
  • The histology was atypical with pronounced proliferation of endocrine cells comprising >70% of the pancreatic tissue and a small pancreatoblastoma. (lu.se)
  • In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
  • The project will focus on investigating through which mechanisms senescent cells induce pluripotency (I), how such a persistent lock of stemness can impair tissue regeneration (II) and how this may affect tumor therapy resistance (III). (uu.nl)
  • As such, senescent cells have been found to be directly causative for tissue aging and loss of homeostasis (Baar et al. (uu.nl)
  • Drive technology development to create novel organoid and hybrid-cell models to investigate the role of cellular heterogeneity in human tissue and organ aging. (salk.edu)
  • The protocol is fast and easy-to-use, and isolates very abundant yields of nuclear extract from mammalian cells or tissue samples. (abcam.com)
  • Even a small number of senescent cells, say 1% of the cells in an organ, can alter tissue structure and the behavior of normal cells to a great enough degree to produce disease symptoms. (fightaging.org)
  • In this and similar ways all of the fundamental forms of cell and tissue damage that cause aging are linked together, feeding from one another, making up a web of interacting forms of damage and consequences. (fightaging.org)
  • Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. (bvsalud.org)
  • Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in the adaptive immune cell populations and phenotypes. (medrxiv.org)
  • In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. (ox.ac.uk)
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
  • Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
  • More recently, cellular senescence has been considered as an additional cause of age-related tumorigenesis. (frontiersin.org)
  • Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
  • At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
  • By the time that the SENS rejuvenation research proposals were first formalized, more than three decades later, a little after the turn of the century, the research community had a much better understanding of cellular senescence as a phenomenon, as well as a good deal of indirect evidence to show that (a) senescent cells accumulated with age, and (b) their presence contributed to age-related disease and dysfunction. (fightaging.org)
  • It is an interesting point to consider that a range of diseases, age-related and otherwise, may provoke greater cellular senescence as a part of the progression of pathology, even though cellular senescence is not one of the main root causes of these condition. (fightaging.org)
  • Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. (ox.ac.uk)
  • In humans, aging-related diseases, including cardiovascular diseases, cancer and type 2 diabetes, pose a huge health and economic burden, which will continue to increase as the aging population is expected to double by 2030. (jax.org)
  • Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
  • During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)
  • This project is part of RESCUE, a multidisciplinary, intersectoral and interdisciplinary PhD training programme in Regenerative Medicine and Stem Cells organised by UMC Utrecht (coordinator) and Utrecht University. (uu.nl)
  • The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
  • Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
  • Dr Saurat is recognized for her expertise in the study of neurodegenerative diseases using human pluripotent stem cells. (edu.au)
  • Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. (oregonstate.edu)
  • Disruption of immune cell functions and responses plays a significant role in the etiology of many aging-related diseases. (jax.org)
  • Aging is associated with a deregulation of biological systems that lead to an increase in oxidative stress, inflammation, and apoptosis, among other effects. (springer.com)
  • XN was shown to modulate inflammation, apoptosis, and oxidative stress in aged livers, exerting a protective effect in hepatic alterations. (springer.com)
  • The mev-1(kn1) mutants are hypersensitive to oxidative stress and age precociously, probably because of elevated superoxide anion production in mitochondria. (ironmagazine.com)
  • SDB is a common disorder that results in oxidative stress and inflammation and is associated with several age-related health disorders. (lifeboat.com)
  • In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. (jci.org)
  • Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)
  • HIV-associated immune dysfunction and inflammation have been suggested to contribute to this age advancement and increased risk of comorbidities. (frontiersin.org)
  • We observed that age advancement in all three groups combined was associated with a monocyte immune phenotypic profile related to inflammation and a T cell immune phenotypic associated with immune senescence and chronic antigen exposure. (frontiersin.org)
  • The identified monocyte and T cell immune phenotypic profiles that were associated with age advancement, were strongly related to inflammation, chronic antigen exposure and immune senescence. (frontiersin.org)
  • In the general population aging is associated with immunological changes resulting in low grade inflammation and deterioration of the innate and adaptive immune system in the elderly ( 10 - 13 ). (frontiersin.org)
  • Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
  • People with HIV on successful antiretroviral therapy show signs of premature aging and are reported to have higher rates of age-associated comorbidities. (frontiersin.org)
  • Recent reports show that CKD presents as a clinical model of premature aging. (hindawi.com)
  • I would like to further dissect the aging process in multiple cell lineages using an inducible model system of Hutchinson-Gilford Progeria Syndrome, a premature aging disorder. (sloankettering.edu)
  • Sanz A, Stefanatos RK (2008) The mitochondrial free radical theory of aging: a critical view. (springer.com)
  • Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. (bvsalud.org)
  • POI is a disorder associated with female infertility that affects about 1% of women before the age of 40 years. (nature.com)
  • ALL affects people of all ages but more often children. (medpagetoday.com)
  • It usually affects people over the age of 60 years. (medicalnewstoday.com)
  • Age-related macular degeneration (AMD) affects a person's central vision. (medicalnewstoday.com)
  • Aging dramatically affects the incidence of late-onset diseases, prompting questions about the potential link between cellular age and neurodegeneration. (edu.au)
  • Adipose derived stromal cells (ASCs) are a rich and convenient source of cells for clinical regenerative therapeutic approaches. (nih.gov)
  • This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. (cdc.gov)
  • Apocrine secretion is less damaging to the gland than holocrine secretion (which destroys a cell) but more damaging than merocrine secretion ( exocytosis ). (wikipedia.org)
  • The results demonstrated that trolox can resist aging, promote proliferation, and enhance PGE-2 secretion of MSCs without affecting their surface marker expression. (techscience.com)
  • In this study, we screened the bioactive molecules that can specifically enhance the secretion of a PGE-2 of MSCs and identified trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) as an inhibitor of MSC aging in long-term culture. (techscience.com)
  • Setting aside debates over methodologies and treatments, it is certainly the case that initial results from clearance of senescent cells have invigorated the field, pulling in greater funding and effort. (fightaging.org)
  • The effect of antioxidant trolox on biological characteristics of MSCS, including aging, proliferation, and gene expression, was examined. (techscience.com)
  • Childhood cancer corresponds to a group of diseases characterized by the uncontrolled proliferation of atypical cells, which may occur anywhere in the body 1 . (bvsalud.org)
  • An inflammatory monocyte immune phenotypic profile associated with age advancement in HIV-negative individuals, while the monocyte profile in blood donors and people with HIV was more reflective of loss of function. (frontiersin.org)
  • These age-related immunological changes resemble those seen during treated HIV-1 infection and include high levels of soluble inflammatory proteins, high levels of monocyte and T cell activation, T cell exhaustion and senescence, and low levels of naïve T cells ( 14 - 25 ). (frontiersin.org)
  • GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
  • APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge. (lu.se)
  • A paracrine pro-inflammatory phenotype developed in senescing cells. (bvsalud.org)
  • Partial least squares regression (PLSR) was used to explore associations between biological age advancement and immunological changes in the T cell and monocyte compartment in people with HIV (n=40), comparable HIV-negative individuals (n=40) participating in the Comorbidity in Relation to AIDS (COBRA) cohort, and blood donors (n=35). (frontiersin.org)
  • A cohort of 1030 healthy human adults (45.9% females, and 54.1% males) from 50 to 98 years of age was used. (bvsalud.org)
  • Previous studies revealed that inhibition of miR-744-3p could restore PTEN expression, and then suppressed laryngeal squamous cell carcinoma progression [ 20 ], suggesting that upregulation of PTEN could contribute to cancer development. (hindawi.com)
  • Other conditions associated with acanthocytosis include abetalipoproteinemia, McLeod phenotype, and treatment with the lung cancer drug alectinib. (medscape.com)
  • 2016. Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. . (oregonstate.edu)
  • The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. (oregonstate.edu)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
  • Aging strongly correlates with the development and incidence of chronic respiratory diseases, including cancer and idiopathic pulmonary fibrosis, but is most strongly linked with development of chronic obstructive pulmonary disease. (karger.com)
  • In cancer cells, this makes them more resistant to treatment. (uu.nl)
  • The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging, and cancer. (aacrjournals.org)
  • Approximately 20% of the white population is homozygous for a recessive point mutation of the FUT2 gene, which leads to the absence of A, B, and H antigen expression, also called the nonsecretor phenotype. (cdc.gov)
  • The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers were related to chronic antigen stimulation and immune senescence in HIV-negative individuals. (frontiersin.org)
  • The cause of the accentuated and/or accelerated aging in people with HIV remains to be fully elucidated, with factors like HIV associated chronic immune activation and dysfunction, ART toxicity and the higher prevalence of traditional risk factors each having been implicated to contribute to age-associated comorbidity development ( 8 , 9 ). (frontiersin.org)
  • We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)
  • This now enables investigation of how parameters such as clonal expansion relate to gene expression phenotypes [ 28 ], thereby providing novel insights not accessible by bulk sequencing (e.g. (nature.com)
  • The distinction in significant genes between total lifetime CAPS score and the anxious arousal symptom dimension of PTSD highlights a potential biological difference in the mechanism underlying the heterogeneity of the PTSD phenotype. (cdc.gov)
  • The overarching goal of the SD-NSC Human Cell Models of Aging Core is to create and make available powerful, new human cell-based models to enable studies into the molecular and cellular heterogeneity of human aging. (salk.edu)
  • If one of these atypical reproductive cells contributes to the genetic makeup of a child, the child will have an extra chromosome 18 in each of the body's cells. (medlineplus.gov)
  • There is some evidence for age-associated degeneration of neurons and glia of the enteric nervous system, although enteric neuronal losses are likely not to be nearly as extensive as previously believed. (open.ac.uk)
  • Aging enteric neurons have been shown to exhibit a senescence-associated phenotype. (open.ac.uk)
  • This presentation will detail the whole genome CRISPR/Cas9 and large scale in silico drug screening approaches we took to develop methods for measuring and manipulating cellular age in pluripotent stem cell derived neurons. (edu.au)
  • Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)
  • however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
  • Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
  • This two-day meeting brings together leading scientists from across disciplines (immunology, aging, genomics, and computational biology) with shared interests in using systems immunology to understand aging and aging-related diseases. (jax.org)
  • This paper reports the incidence of sickle cell diseases, other haemoglobinopathies and haemoglobinopathy carriers over a 12-month period using high performance liquid chromatography as a primary screening method. (who.int)
  • Furthermore, we describe for the first time the importance of gut-derived AAA catabolites in the aging process describing novel biomarkers that could contribute to better understand this physiological process but also age-related diseases. (bvsalud.org)
  • Therefore, we demonstrated that the T and B cells can be activated normally and exhibit functional features. (medrxiv.org)
  • In mammals, functional analysis of the individual RAD51 paralogues in cell lines has shown similar but non-redundant contributions in DNA repair processes such as HR efficiency, RAD51 nuclear focus formation, sensitization to mitomycin C (MMC) and protection of perturbed replications forks [ 11 ]. (nature.com)
  • Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)
  • Researchers, led by scientists at the University of Colorado School of Medicine, have found basic molecular processes used by the Zika virus to "hijack" the cells that it infects and potentially how it makes molecules that are directly linked to disease. (news-medical.net)
  • Recent advances in genomic technologies (e.g., single cell transcriptomics and epigenomics) enable precise description of molecular and cellular changes associated with aging in human cells as well as in model organisms, including the mouse. (jax.org)
  • Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)
  • The natural aging process is marked by molecular changes that occur during development, maturation, and decline. (karger.com)
  • The cellular and molecular changes exhibited by the aging gut cells also vary. (open.ac.uk)
  • Unlike iPSC-based reprogramming processes that can erase epigenetic and transcriptional signatures of aging, direct-conversion approaches can better maintain molecular signatures of aging in resultant cell types. (salk.edu)
  • Boghosian-Sell L, Mewar R, Harrison W, Shapiro RM, Zackai EH, Carey J, Davis-Keppen L, Hudgins L, Overhauser J. Molecular mapping of the Edwards syndrome phenotype to two noncontiguous regions on chromosome 18. (medlineplus.gov)
  • 2020) showed that CRC incidence rates increase by 30% every 5 years of age in individuals aged 50 and over ( 5 ). (frontiersin.org)
  • The estimated overall incidence of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma in Europe is 1.28 per 100 000 individuals annually, with significant age-related variations (0.53 at 45-54 years, ∼1.0 at 55-74 years and 1.45 at 75-99 years). (medscape.com)
  • The overall incidence of sickle cell disease among 22 200 screened neonates was 0.04% (0.07% for UAE citizens and 0.02% for non-UAE citizens). (who.int)
  • The incidence of sickle cell trait was 1.1% overall (1.5% for UAE citizens and 0.8% for non-UAE citizens). (who.int)
  • The age of peak incidence is 2-5 years, and approximately 60% of cases occur before the age of 20. (bvsalud.org)
  • However, it hasn't been well studied with respect to epigenetic aging. (lifeboat.com)
  • To our knowledge, this study is the first empirical study that has linked sleep-disordered breathing with epigenetic age acceleration," Xiaoyu Li, ScD, of Brigham and Women's Hospital and Harvard Medical School in Boston, Massachusetts, told Medscape Medical News . (lifeboat.com)
  • Aging intestinal smooth muscle cells exhibit a number of changes in the signalling pathways that regulate contraction. (open.ac.uk)
  • 00:00:00] Supercentenarians and remarkable age records exhibit patterns indicative of clerical errors and pension fraud. (howardluksmd.com)
  • Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
  • Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individual, reflecting both past and current immune responses. (nature.com)
  • Recent advances in single-cell sequencing enable recovery of the complete adaptive immune receptor sequences in addition to transcriptional information. (nature.com)
  • These data suggest that varying exposures to lifestyle and infection-related factors may be associated with specific changes in the innate and adaptive immune system, that all contribute to age advancement. (frontiersin.org)
  • Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
  • Practical considerations such as the necessary cost and time required to generate and analyze each single-cell sequencing sample has been a limitation to performing large-scale experiments (i.e., with many samples). (nature.com)
  • Future studies should be clear about methods used to analyze PTSD status, as phenotypes based on PTSD symptom dimensions may yield different gene sets than combined CAPS score analysis. (cdc.gov)
  • Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
  • Here, we recovered transcriptome and immune repertoire information for polyclonal T follicular helper cells following lymphocytic choriomeningitis virus (LCMV) infection, CD8+ T cells with binding specificity restricted to two distinct LCMV peptides, and B and T cells isolated from the nervous system in the context of experimental autoimmune encephalomyelitis. (nature.com)
  • While the monocyte and T cell immune phenotypic profile within the HIV-negative individuals reflected those observed in the combined three groups, a distinct profile related to immune dysfunction, was observed within blood donors and people with HIV. (frontiersin.org)
  • In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
  • Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)
  • The increase of vascular arginase activity during aging causes endothelial dysfunction. (bvsalud.org)
  • Of note, the HBGA binding profile is P genotype-dependent ( 4 ), and rotavirus infection correlates with the secretor and partial secretor phenotype (i.e., with active FUT2 gene status) ( 5 , 6 , 9 ). (cdc.gov)
  • Adjustment for lifetime smoking, age, and NATI genotype did not alter the findings. (cdc.gov)
  • We corrected for sex, age, genotype-derived principal components and surrogate variables. (cdc.gov)
  • In this study, the effect of trolox on biological characteristics and aging of MSCs is further investigated. (techscience.com)
  • The miR mimics or inhibitor was transfected into laryngocarcinoma cell lines M4E and Hep2 for the investigation of the biological functions (proliferative, invasion, migratory rates, and apoptotic rates) of this miRNA. (hindawi.com)
  • The main objective of the present study was to describe the changes in plasma metabolome associated with biological aging and the role of sex in the metabolic regulation during aging. (bvsalud.org)
  • Exosome (Exo) (30-200 nm) is a small single-membrane vesicle and exists in almost all mammalian cells [ 12 , 13 ]. (hindawi.com)
  • Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
  • Results: The sample was largely composed of boys (58.3%), ages 5-9 years. (bvsalud.org)
  • A high-throughput untargeted metabolomic analysis was applied in plasma samples to detect hub metabolites and biomarkers of aging incorporating a sex/gender perspective. (bvsalud.org)