• Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. (pharmacycode.com)
  • A 2015 systematic review compared perphenazine with other antipsychotic drugs: As a member of the phenothiazine type of antipsychotics, perphenazine shares in general all allergic and toxic side-effects of chlorpromazine. (wikipedia.org)
  • The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Buscopan. (janusinfo.se)
  • Use of any photosensitizing medications within the past 6 months of Screening, including psoralens, sulfonamide drugs, tetracycline antibiotics, thiazide diuretics, phenothiazines, coal tar and derivatives, and tricyclic antidepressants. (who.int)
  • Treatment includes phenothiazine tranquilizers (chlorpromazine, phenothiazine), anticonvulsants, and beta-blockers as needed along with supportive therapy. (vin.com)
  • Chemically, it is classified as a piperazinyl phenothiazine. (wikipedia.org)
  • Perphenazine (4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol), a piperazinyl phenothiazine, having the chemical formula, C 21 H 26 CIN 3 OS. (nih.gov)
  • phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2. (chemspider.com)
  • A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2. (chemspider.com)
  • The TGA recently reviewed this issue following a coronial hearing of a fatal case involving a 74-day old infant being given over-the-counter (OTC) promethazine oral liquid, a phenothiazine derivative that is a long-acting antihistamine with mild atropine-like anticholinergic effects and some anti-serotonin effects. (tga.gov.au)
  • In such disorders caution should be exercised in administering Tigan, particularly to patients who have recently received other CNS-acting agents (phenothiazines, barbiturates, belladonna derivatives). (linkedlifedata.com)
  • Physostigmine Salicylate (physostigmine salicylate injection) Injection is a derivative of the Calabar bean , and its active moiety, physostigmine, is also known as eserine. (rxlist.com)
  • Prochlorperazine is a propylpiperazine derivative of phenothiazine. (drugs.com)
  • Amoxapine, the N -demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). (genelabs.com)
  • Toxicities to morphine derivatives are included. (vin.com)
  • A derivative of morphine (thought to be less addictive than morphine but effective as an analgesic). (vin.com)
  • CPZ, a phenothiazine drug, has a pharmacologic profile that suggests that it might be useful in prevention and treatment of postoperative nausea and vomiting (PONV). (ispub.com)
  • Recently, heterocyclic phenothiazine ( PT ), originally used in drug applications [ 29 , 30 ], has been adopted as a novel electron donor in organic dye because PT contains electron-rich sulfur-nitrogen heteroatoms and its ring has sterically hindered nonplanar butterfly conformation. (hindawi.com)
  • Phenothiazines are detected by a spot urine test. (bmj.com)
  • The present report focuses on the advancement of aza-Diels-Alder reaction for the synthesis of optically active and inactive quinoline derivatives. (heterocycles.jp)
  • Thorazine is a neuroleptic of the group of aliphatic phenothiazine derivatives. (iufro.org)
  • Like other phenothiazines, it exerts an antiemetic effect through a depressant action on the chemoreceptor trigger zone. (drugs.com)
  • Since phenothiazines may prolong the electrocardiogram QT interval and cause dangerous arrhythmias, we focussed on this side effect. (ispub.com)
  • Meanwhile, the steric effect of phenothiazine-based ( PT1-3 ) dyes was also investigated. (hindawi.com)
  • The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. (sumobrain.com)
  • A new phenothiazine derivative--thioridazine. (nih.gov)
  • Thioridazine, a new phenothiazine derivative for chronic schizophrenia]. (nih.gov)
  • The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine. (nih.gov)
  • Thioridazine hydrochloride is 2-methylmercapto-10-[2-(N-methyl-2-piperidyl) ethyl] phenothiazine. (nih.gov)
  • The basic pharmacological activity of thioridazine is similar to that of other phenothiazines, but is associated with minimal extrapyramidal stimulation. (nih.gov)
  • Thioridazine, also known as mellaril-S or mellerette, belongs to the class of organic compounds known as phenothiazines. (hmdb.ca)
  • Until the controversy surrounding the interaction of chlorpromazine and dimethoxymethylamphetamine in man is resolved, acute- toxic reactions elicited by this particular amphetamine derivative might best be managed by a drug' of the benzodiazepine class. (erowid.org)
  • Tranquilizers with more than a very short-lived sedative effect did not exist until 1952 when the Frenchmen Delay and Deniker introduced our first neuroleptic drug , the phenothiazine derivative chlorpromazine. (nobelprize.org)
  • These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring. (hmdb.ca)
  • For example, methylene blue is a cationic tricyclic phenothiazine salt (see Figure). (millennialscientific.com)
  • Use of any photosensitizing medications within the past 6 months of Screening, including psoralens, sulfonamide drugs, tetracycline antibiotics, thiazide diuretics, phenothiazines, coal tar and derivatives, and tricyclic antidepressants. (who.int)
  • Compazine ( prochlorperazine ) is an antiemetic (to control nausea and vomiting ) and first-generation piperazine phenothiazine antipsychotic medication. (medicinenet.com)
  • Piperazine derivatives of phenothiazine. (farmasco.info)
  • The synthesis, structure and biological activity of phenothiazine derivative. (ejpmr.com)
  • 4. Badshah, S.L. and A. Naeem, Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance. (millennialscientific.com)
  • Besides their antipsychotic activity, phenothiazines have a significant antimicrobial effect as well, since they can enhance the bactericidal function of macrophages and inhibit efflux pumps. (iiarjournals.org)
  • The antimicrobial activity of a series of benzothiazolyl-10H-phenothiazine derivatives against Gram positive Bacteria ( Staphylococcus aureus and Bacillus cereus ), Gram negative Bacteria ( Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa ) and fungus Candida albicans respectively, was screened using diffusion method and minimal inhibitory concentrations (MIC) were assessed by broth serial dilution procedure. (ubbcluj.ro)
  • The triazole substituted phenothiazine has been of keen interest biological activity such as antimicrobial, anti inflammatory. (ejpmr.com)
  • A cyanoacrylate moiety was added at the C(3) position of the phenothiazine as an electron acceptor, and a triarylamine moiety was attached at the C(7) position as an electron donor. (elsevierpure.com)
  • In 1885, two years after Bernthsen first managed to produce phenothiazine, he also succeeded in describing the structure of methylene blue ( 1 ). (iiarjournals.org)
  • Millennial Scientific has used methylene blue as a representative phenothiazine compound and developed a solid phase extraction (SPE) method using its all-carbon reverse phase media. (millennialscientific.com)
  • The reagent oxidizes the derivative to a cationic free radical, with which it then forms a coloured salt. (handlebar-online.com)
  • 3. Phenothiazine substituted Ru(bpy)3 2+ derivative as highly selective "turn-ON" luminescence chemodosimeter for Cu2+. (gcwtvm.ac.in)
  • In general, most acute physiological and psychologi-cal effects of the naturally occurring anticholinergic (belladonna and stramonium) derivatives can be adequately reversed by physostigmine. (erowid.org)
  • A series of organic dyes containing a phenothiazine central unit were synthesized and were used effectively in the fabrication of dye-sensitized solar cells (DSSCs). (elsevierpure.com)
  • Chloroquine and its derivative, hydroxychloroquine sulfate, were initially used as malarial prophylaxis. (aao.org)
  • Prolonged use of the chloroquine derivatives typically results in a pigmentary maculopathy. (aao.org)
  • The exact mechanism of chloroquine derivative toxicity is unknown, though they are known to have an affinity for binding to melanin and concentrating in the RPE and uvea. (aao.org)
  • The imaging changes induced by chloroquine derivatives are nonspecific and often a multimodal imaging approach is utilized with the results interpreted in the appropriate clinical context. (aao.org)
  • A known hypersensitivity to phenothiazines, comatose or greatly depressed states due to central nervous system depressants and, in cases of existing blood dyscrasias, bone marrow depression and pre-existing liver damage. (sdrugs.com)
  • 4-21) the third pulmozyme is approved for oral use or in many oral liquids 75 prepared by combi- sisting of a multifactorial condition involving age- nervous system depressants 509 table 10-4 phenothiazine derivatives descbol the hydrogen bonds the release process. (stonecottagegardens.com)
  • Phenothiazines are unanimously one of the most versatile compounds from the view of biological activity. (iiarjournals.org)
  • This is why phenothiazines are basic compounds in pharmacology. (iiarjournals.org)
  • Since then, several antipsychotic phenothiazine compounds have been used in clinical practice, although research conducted in the last couple of decades indicated that phenothiazine compounds could have an important role in other fields of medicine as well, such as in the treatment of tumorous, infectious, or neurodegenerative diseases ( 3 ). (iiarjournals.org)
  • Trial use of melleril, a new derivative of phenothiazine in psychiatric clinical practice]. (nih.gov)
  • Phosphomolybdic acid is used as reagent for colorimetric determination of phenothiazine derivatives in various pharmaceutical products. (handlebar-online.com)
  • Some biological activity of aryloxypropanolamins of bisphenol derivatives. (ijpsonline.com)
  • The magnitude of Ca-dependent drug binding to activator correlated with the ability of the drugs to inhibit phosphodiesterase activation and binding of phenothiazine derivatives paralleled clinical antipsychotic activity. (erowid.org)
  • 9. In phenothiazines the modifi cation that leads to lower incidence of EPS, possibly due to increased central anti-muscarinic activity, is a. (remixeducation.in)
  • Phenothiazines are effective in treating emesis, possibly because of their effects in the dopaminergic mesolimbic system. (medscape.com)
  • Finally, phenothiazines can also be effective in the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. (iiarjournals.org)
  • No specific antagonists are yet available for central aberrations induced by phencyclidine or the tetrahydrocannabinol derivatives of marijuana. (erowid.org)
  • The best performance was found in compound NSPt-C6, in which a hexyl group was attached at the N(10) of phenothiazine and a thiophenylene at the C(7) position. (elsevierpure.com)
  • A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. (hmdb.ca)
  • Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents. (nih.gov)
  • Clinical experiences with the new phenothiazine derivative, melleril]. (nih.gov)
  • Therapeutic experiences with a new phenothiazine derivative melleril]. (nih.gov)