Chemicals and Drugs
Phenanthrolines
PhenLigandLigandsComplexesDerivativesAbstractBidentateCopperDonorsOrganicCompoundReactionsSodiumIronContentCoordinationFunctionPropertiesMethodFormsActivityMetalActivitiesRutheniumComplexes of 1,10-phenanthrolineCationicTrisMoietyToxicologyEDTAFollowed by titrationReagentsSupramolecularIonsAcetylacetonateZincDescriptorComplexAcidStudiesTopic
Phen11
  • 1,10-Phenanthroline (phen) is a heterocyclic organic compound. (wikipedia.org)
  • 1,10-Phenanthroline (Phen) is a well-known benchmark ligand and has often been used in the coordination chemistry for the complexation of transition metal ions, such as Fe2+, Ni2+, and Co2+. (thecrucibleonscreen.com)
  • Ferroin is the chemical compound with the formula [Fe(o-phen)3]SO4, where o-phen is an abbreviation for 1,10-phenanthroline, a bidentate ligand. (thecrucibleonscreen.com)
  • Single crystals of [Co(phen)(3)](IO4)(3)center dot 2H(2)O Were obtained by dissolving the yellow coloured precipitated product (obtained by slowly mixing the separately dissolved tris(1,10-phenanthroline)cobalt(III) chloride with sodium periodate in aqueous medium in 1:3 molar ratio) in hot water and allowing it to evaporate slowly at room temperature. (ua.pt)
  • The reaction of 1,10′-phenanthroline (phen), tetrasodium pyrophosphate (Na 4 PPi) and FeCl 2 ·6H 2 O in deionized water yielded the iron(III)-PPi chelate complex, {[Hphen][Fe(phen)(H 2 P 2 O 7 ) 2 ]·2H 2 O} (1). (syr.edu)
  • abstract = "The reaction of 1,10′-phenanthroline (phen), tetrasodium pyrophosphate (Na4PPi) and FeCl2·6H2O in deionized water yielded the iron(III)-PPi chelate complex, {[Hphen][Fe(phen)(H2P2O7)2]·2H2O} (1). (syr.edu)
  • In the present study, we investigated the antitumor effect and associated molecular mechanisms of the copper (II) complex of salicylate phenanthroline [Cu(sal)(phen)] against hepatocellular carcinoma (HCC). (bvsalud.org)
  • English The reactions between equimolar amounts of CuX2 (X = NO3− and CF3SO3−) and two aromatic nitrogen-containing heterocycles differing in the position of nitrogen atoms, 1,7- and 4,7-phenanthroline (1,7- and 4,7-phen), were performed in ethanol/methanol at room temperature. (unifr.ch)
  • This work aimed to evaluate the effects of copper(II), manganese(II) and silver(I) complexes coordinated with 1,10-phenanthroline (phen)/1,10- phenanthroline-5,6-dione (phendione) on Fonsecaea spp. (tudublin.ie)
  • In the present study, Au(III) and Pt(II) complexes of 1, 10-phenanthroline (phen) were synthesized and used as the test compounds. (anadolu.edu.tr)
  • In this study, the stability constants of I : 1 : 1 ternary complexes of Cu(II) with 1,10-phenanthroline (Phen) as the primary ligand, and 2,2'-bipyridyl (Bpy) and some selected a-amino acids [(glycine (Gly), leucine (Leu), glutamine (Gln)] as secondary ligands, were identified in I=0.1 m ionic medium at t=(25 +/- 0.1)degrees C in aqueous solutions, by potentiometry. (uludag.edu.tr)
Ligand5
  • In the title compound, [Co(C 7 H 5 O 2 ) 2 (C 14 H 12 N 2 )], the Co II ion is located on a twofold rotation axis and is chelated by a 2,9-dimethyl-1,10-phenanthroline (dmphen) ligand and two benzoate anions in a distorted octa-hedral geometry. (iucr.org)
  • Phenanthroline, a rigid and planar organic compound with two fused pyridine rings, has been used as a powerful ligand for metals and a binding agent for DNA/RNA. (wayne.edu)
  • What type of ligand is 1/10-phenanthroline? (thecrucibleonscreen.com)
  • The ultrafast nonadiabatic dynamics of a prototypical Cu(I)-phenanthroline complex, [Cu(dmp)2]+ (dmp = 2,9-dimethyl-1,10-phenanthroline), initiated after photoexcitation into the optically bright metal-to-ligand charge-transfer (MLCT) state (S3) is investigated using quantum nuclear dynamics. (ncl.ac.uk)
  • Photoinduced DNA Cleavage and Photocytotoxic of Phenanthroline-Based Ligand Ruthenium Compounds. (nih.gov)
Ligands2
  • Luman, C.R. and Castellano, F.N. (2003) "Phenanthroline Ligands" in Comprehensive Coordination Chemistry II. (wikipedia.org)
  • The six nitrogen atoms, originating from three 1,10-phenanthroline ligands (each bidentate) show distorted octahedral geometry around the central Co(III) metal ion. (ua.pt)
Complexes1
  • Silver(I) 1,10-Phenanthroline Complexes Are Active against Fonsecaea P" by Ingrid S. Sousa Ingrid S. Sousa, Tatiana D.P. Vieira et al. (tudublin.ie)
Derivatives2
  • Alkyllithium reagents form deeply colored derivatives with phenanthroline. (wikipedia.org)
  • Optical properties of new 5-(4-phenylethynyl)-substituted-1,10-phenanthroline derivatives. (univ-grenoble-alpes.fr)
Abstract1
  • abstract = "An AlPO4 zeotype has been prepared using the aromatic diamine 1,10-phenanthroline and some of its methylated analogues as templates. (southwales.ac.uk)
Bidentate1
Copper1
  • The copper (II) complex of salicylate phenanthroline inhibits proliferation and induces apoptosis of hepatocellular carcinoma cells. (bvsalud.org)
Donors3
  • In terms of its coordination properties, phenanthroline is similar to 2,2'-bipyridine (bipy) with the advantage that the two nitrogen donors are preorganized for chelation. (wikipedia.org)
  • We recently discovered that phenanthroline could be used as a nucleophilic catalyst to access high yielding and diastereoselective α-1,2-cis glycosides through the coupling of hydroxyl acceptors with α-glycosyl bromide donors. (wayne.edu)
  • The phenanthroline catalysis system is applicable to a number of furanosyl bromide donors to provide the challenging 1,2-cis substitution products in good yield with high anomeric selectivity. (wayne.edu)
Organic2
  • It is a white solid that is soluble in organic solvents….1,10-Phenanthroline. (thecrucibleonscreen.com)
  • Ba(TMHD) 2 (phenanthroline) 2 is used as an intermediate for preparing the precursors of metal-organic sources by dissolving in tetrahydrofuran (THF). (ereztech.com)
Compound1
  • As compared with pure 1T-MoS2, the compound with a phenanthroline interlayer provides greater activity and better current-voltage efficiency in electrocatalytic hydrogen evolution after heating treatment owing to stabilization of the 1T phase. (ipmnet.ru)
Reactions1
  • Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric acid, and an oxidizing agent, traditionally aqueous arsenic acid or nitrobenzene. (wikipedia.org)
Sodium1
  • A rapid, accurate method for the determination of iron using hydroxylamine hydrochloride, sodium acetate buffer, and 1,10-phenanthroline is described. (thecrucibleonscreen.com)
Iron2
  • The principle is based on the reduction of trivalent iron by hydroxylammonium chloride, formation of a bivalent iron/1,10-phenanthroline complex in a buffered system. (iso.org)
  • Formation of the iron(II)-1,10-phenanthroline complex in a buffered medium at a pH between 3.5 and 4.2. (iso.org)
Content1
  • The alkyllithium content of solutions can be determined by treatment of such reagents with small amounts of phenanthroline (ca. 1 mg) followed by titration with alcohols to a colourless endpoint. (wikipedia.org)
Coordination1
  • The function of the phenanthroline unit is to coordinate to metal ions, which can in turn coordinate to other molecules, and allow us to build up complex architectures taking advantage of the coordination characteristics of the metal ions. (europa.eu)
Function1
Properties3
  • The synthesis and optical properties of a novel family of 5-substituted-1,10-phenanthroline derivs. (univ-grenoble-alpes.fr)
  • The effects on optical properties, of the substitution with electro-withdrawing or -donating substituents in the 5th position of the 1,10-phenanthroline are investigated. (univ-grenoble-alpes.fr)
  • These findings indicate that the particular interaction of Pd(II) with phenanthroline confers the best pharmacokinetic and pharmacodynamic properties that make this class of DNA intercalators remarkable inhibitors, even of the resistant cell growth. (unimore.it)
Method1
Forms1
  • 1,10-Phenanthroline forms a stable complex with Fe(II) ion called ferroin, which is used as an indicator in Fe(II) salt titrations. (thecrucibleonscreen.com)
Activity1
  • 1,10-Phenanthroline is an inhibitor of metallopeptidases, with one of the first observed instances reported in carboxypeptidase A. Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. (wikipedia.org)
Metal1
  • Substituents at the 2,9 positions confer protection for the attached metal, inhibiting the binding of multiple equivalents of the phenanthroline. (wikipedia.org)
Activities1
  • Magnesium ions were required for the ATPase activities of both BchH and BchI+D, and these activities were inhibited 50% by 2 mM o-phenanthroline. (lu.se)
Ruthenium1
  • In addition wild-type PYP ( PYP WT), PYP R52G and ALBP were successfully modified with a (η 6 -arene) ruthenium( II ) phenanthroline complex via a maleimide linker. (rsc.org)
Complexes of 1,10-phenanthroline2
  • Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline. (uams.edu)
  • Two highly sensitive spectrophotometric methods have been developed for the determination of olanzapine (OLP) in pharmaceuticals using cerium(IV) and iron(II) complexes of 1,10-phenanthroline and 2,2´x-bipyridyl as reagents. (uni-mysore.ac.in)
Cationic2
  • Cationic palladium phenanthroline complexes catalyze the cycloisomerization of functionalized 1,5- and 1,6-dienes to form cyclopentenes which possess a trisubstituted olefin in good yield and with good selectivity. (organic-chemistry.org)
  • The reactions between allyl compounds CH2CHCH2Fn bearing electron-withdrawing functional (Fn) groups and cationic {Pt(aryl)(1,10-phenanthroline)}+ fragments generated in situ are described. (unina.it)
Tris2
  • Here, the growth-inhibitory effects of tris-(1,10-phenanthroline) iron (II) complex ([Fe(phen) 3 ] 2+ ), a known commercially available cheap chemical substance, were examined. (nih.gov)
  • Inquire TRIS(4 7-DIPHENYL-1 10-PHENANTHROLINE) (cas: 123148-15-2 ) online by filling out the inquiry form, we will get back to you within 24 hours! (musechem.com)
Moiety2
  • The emission is strongly dependent on the typical structure of the starting precursor for ZnO synthesis, where one phenanthroline moiety is attached with zinc acetylacetonate hydrate complex. (iisc.ac.in)
  • Elegant syntheses have been reported recently for fully conjugated diad systems incorporating the 1,10-phenanthroline moiety as the bidentate ligand and we have described the first molecular rack (molrac) in which two units of the same ligand are spatially separated. (edu.au)
Toxicology1
  • An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to o-Phenanthroline (66-71-7). (nih.gov)
EDTA1
  • IMP + EDTA + 1,10-phenanthroline, μg/mL. (cdc.gov)
Followed by titration1
  • The alkyllithium content of solutions can be determined by treatment of such reagents with small amounts of phenanthroline (ca. 1 mg) followed by titration with alcohols to a colourless endpoint. (wikipedia.org)
Reagents1
  • 1. The reagents, 3-butyn-1-ol and 2.0 M ethylmagnesium bromide in tetrahydrofuran , were purchased from Aldrich Chemical Company, Inc. The ethylmagnesium bromide concentration can be easily checked by titration with menthol using 1,10-phenanthroline as indicator. (orgsyn.org)
Supramolecular1
  • Copper(I) phenanthroline complexes and supramolecular systems containing fullerenes: Photophysics, photochemistry and potential applications in sustainable energy technologies. (unibo.it)
Ions3
  • The preorganized ligand 1,10-phenanthroline-2,9-dicarboxylic acid (PDA) was synthesized and subjected to purity verification for studies into its formation constants with various aqueous metal-ions as well as its metal-ligand complex crystal structure. (uncg.edu)
  • The cis-aqua-chloro-bis(N,N'-1,10-phenanthroline-5,6-dione)cobalt(II) nitrate trihydrate (3) and the cis-aqua-bromobis(N,N'-1,10-phenanthroline-5,6-dione)cobalt(II) trifluoro-methanesulfonate tetrahydrate (4), crystalize in the same space group with a similar arrangement of the complex ions. (chalmers.se)
  • The separation of these metal ions as their 4,7-diphenyl-1,10-phenanthroline (bathophenanthroline) chelates on an Inertsil ODS column was investigated by using acetonitrile-water (80/20, v/v) containing 0.06 M perchloric acid as mobile phase and diode array spectrophotometric detection at 250-650 nm. (elsevierpure.com)
Acetylacetonate2
  • We report yellow-red emission from ZnO nanoparticles synthesized within 5 min of microwave irradiation by using zinc acetylacetonate phenanthroline as the starting precursor material. (iisc.ac.in)
  • Two new octa-coordinated red emitting complexes of the type [Ln(acac) 3 (Br 2 -phen)] [acac: acetylacetonate, Br 2 -phen: 4,7-dibromo-1,10-phenanthroline, Ln: Sm(III) and Eu(III)] have been synthesized and characterized. (elsevierpure.com)
Zinc1
  • 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium. (wikipedia.org)
Descriptor1
  • Phenanthrolines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Complex5
  • This has been synthesized by reacting a Robson type macrocyclic precursor dicopper(II) complex [Cu2L(H2O)2](ClO4)2 (1) and 1,10-phenanthroline in ethanol. (uea.ac.uk)
  • Formation of the iron(II)-1,10-phenanthroline complex in a buffered medium. (iso.org)
  • Herein we track the wavepacket dynamics of a prototypical [Cu(2,9-dimethyl-1,10-phenanthroline) 2 ] + complex using TR-XANES. (ncl.ac.uk)
  • Formation of the iron(II)-1,10-phenanthroline complex in a buffered (pH value between 3.5 and 4.2). (iso.org)
  • A new spirocyclic phosphazene derivative has been synthesized from the reaction of 1,10-phenanthroline-5,6-diol with hexachlorocyclotriphosphazatriene in suitable conditions and the Ru(II) complex of the ligand was prepared and characterized. (yildiz.edu.tr)
Acid1
  • Phenanthroline may be prepared by two successive Skraup reactions of glycerol with o-phenylenediamine, catalyzed by sulfuric acid, and an oxidizing agent, traditionally aqueous arsenic acid or nitrobenzene. (wikipedia.org)
Studies2
  • NMR studies of the hydration of the Co(III)(1,10-phenanthroline-5,6-dione)(3)(3+) ion in water and DMSO are also presented. (chalmers.se)
  • Solution ESR, electronic, and ESI-MS spectral studies suggest that 1,10-phenanthroline replaces coordinated water in 1, giving 2. (uea.ac.uk)
Topic1
  • This graph shows the total number of publications written about "Phenanthrolines" by people in UAMS Profiles by year, and whether "Phenanthrolines" was a major or minor topic of these publications. (uams.edu)