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  • evaluation
  • Evaluation of the synthesized phenanthridine spiropyrans' interactions with G4 DNA was performed with a Thioflavin T displacement assay, circular dichroism, Taq DNA polymerase stop assay, and NMR. (rsc.org)
  • important
  • This revealed that the substitution pattern on the phenanthridine spiropyrans was very important for their ability to bind and stabilize G4 structures. (rsc.org)
  • We further work on the identification of the Trypanosoma brucei resistance mechanism for isometamidium, an important phenanthridine drug against animal trypanosomiasis in sub-Saharan Africa. (gla.ac.uk)