• The effect of selected benzo[c]phenanthridine and protoberberine alkaloids from plants of Papaveraceae family [2] on stability of parallel (sequence from c- kit oncogene promoter) and anti-parallel (human telomeric sequence) GQ was studied. (muni.cz)
  • Quaternary Benzo[c]phenanthridine. (merlot.org)
  • Appropriately substituted benzo[i]phenanthridines structurally related to nitidine, a benzo[c]phenanthridine alkaloid with antitumor activity, are active as topoisomerase I-targeting agents. (elsevier.com)
  • Studies on benzo[i]phenanthridines have indicated analogues that possess a 2,3-methylenedioxy moiety and at least one and preferably two methoxyl groups at the 8- and 9-positions, such as 8,9-dimethoxy-2,3-methylenedioxybenzo[i]phenanthridine, 2, are active as topoisomerase I-targeting agents. (elsevier.com)
  • Tetramethoxylated benzo[i]phenanthridines, wherein the 2,3-methylenedioxy moiety is replaced with methoxyl groups at the 2- and 3-position, are inactive as a topoisomerase I-targeting agent. (elsevier.com)
  • The observation that 2,3-dimethoxylated benzo[i]phenanthridines can actually exhibit enhanced activity prompted the present study in which several 8-substituted 2,3-dimethoxybenzo[i]phenanthridines were prepared and their pharmacological activities evaluated. (elsevier.com)
  • Substituted benzo[i]phenanthridines that have incorporated within their structure an 8,9-methylenedioxy group can exhibit topoisomerase I-targeting activity. (elsevier.com)
  • Evaluation of anticancer activities of benzo phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line. (medicdebate.org)
  • While the effects of benzo[c]phenanthridine alkaloids (QBA), known mainly as sanguinarine and chelerythrine, on the inhibition of some kinds of cancer cell proliferation have been established, the effect on oral squamous cell is not known. (medicdebate.org)
  • Two 2,3,9,10-Tetraoxygenated benzo[c]phenanthridine alkaloids, 1 2, originally reported as zanthoxyline and broussonpapyrine, respectively, were synthesized using the Pd-mediated intramolecular aryl-Aryl coupling reaction as the key step. (elsevier.com)
  • Total synthesis of several benzo[c]phenanthridine alkaloids was accomplished via an aryl-aryl coupling reaction using a novel Pd reagent prepared from Pd(OAc) 2 DPPP, and Bu 3 P. This is a versatile method for the coupling reactions of not only aryl triflates and arenes but also aryl halides and arenes. (elsevier.com)
  • Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc) 2 , DPPP, and Bu 3 P . Synthesis , (2), 237-241. (elsevier.com)
  • abstract = "Total synthesis of several benzo[c]phenanthridine alkaloids was accomplished via an aryl-aryl coupling reaction using a novel Pd reagent prepared from Pd(OAc)2 DPPP, and Bu3P. (elsevier.com)
  • Evaluation of molluscicidal activities of benzo[c]phenanthridine alkaloids from Macleaya cordata (Willd) R. Br. (hindawi.com)
  • Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV," Phytotherapy Research , vol. 16, no. 1, pp. 84-87, 2002. (hindawi.com)
  • This research focuses on the development of a facile synthetic methodology of benzo[c]phenanthridines. (amrita.edu)
  • 7-Hydroxynitidine, a modified benzo[c]phenanthridine alkaloid, is shown to have strong cytotoxic activity against HeLa S3 cells. (amrita.edu)
  • Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. (biomedsearch.com)
  • Part I. A new synthesis of phenanthridine homologues and derivatives Gilbert T. Morgan, Leslie Percy Walls, J. Chem. (wikipedia.org)
  • A Heck cyclisation approach is described for the rapid synthesis of a library of natural product-like small molecules, based on the phenanthridine core. (rsc.org)
  • Reema Abu Khalaf*, Dalal Masalha and Dima Sabbah, "DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design, and Synthesis", Current Computer-Aided Drug Design (2019) 15: 1. (eurekaselect.com)
  • We have developed an efficient protocol for the synthesis of C-glycosylated phenanthridines. (figshare.com)
  • This reaction tolerates various functional groups, and enables ready synthesis of complex oligosaccharide-based phenanthridines. (figshare.com)
  • Synthesis of Electron-Deficient Tetrahydro- and Dihydroimidazo[1,2-f]phenanthridines by Microwave-Mediated IMDAF Reactions. (uio.no)
  • PhI(OAc)2-mediated synthesis of 6-(trifluoromethyl)phenanthridines by oxidative cyclization of 2-isocyanobiphenyls with CF3SiMe3 under metal-free conditions. (semanticscholar.org)
  • Three novel 3,8-disubsituted-6-phenyl phenanthridine derivatives 3-5 have been designed, synthesized and characterized. (eurekaselect.com)
  • Objective: This study aims to develop a pharmacophore model of DPP-IV inhibitors and to evaluate phenanthridines as a novel scaffold for inhibiting DPP-IV enzyme. (eurekaselect.com)
  • Conclusion: Phenanthridines may serve as potential lead compound for developing new DPP-IV inhibitors as a promising anti diabetic agent. (eurekaselect.com)
  • The first data in support of this notion were result showing that novel hexahydrobenzo.a.phenanthridine dopaminergic ligands [i.e., dihydrexidine (DHX) and its analogs] activated post-synaptic, but not pre-synaptic, D2-like receptors. (elsevier.com)
  • Similar to the acridines and phenanthridines, these fluorescent probes are popular choices as a nuclear counterstain for use in multicolor fluorescent labeling protocols. (fsu.edu)
  • Tetrafuranos-4-yl and pentapyranos-5-yl radicals, generated from K 2 S 2 O 8 -mediated oxidative decarboxylation of furan- and pyranuronic acids, undergo attack to 2-isocyanodiphenyls and ensuing homolytic aromatic substitution to provide diverse C-glycosylated phenanthridines in satisfactory yields without resort to transition metals. (figshare.com)
  • 2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and its 11,12-dihydro derivative were among the more potent analogues evaluated with regard to topoisomerase I-targeting activity and cytotoxicity. (elsevier.com)
  • LaVoie, Edmond J. / 2,3-Dimethoxybenzo[i]phenanthridines : Topoisomerase I-targeting anticancer agents . (elsevier.com)
  • Further studies revealed that 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine, 7a, is more potent than 2 as a topoisomerase I-targeting agent. (elsevier.com)
  • In addition, the influence of varying substituents at the 2- and 3-positions within the A-ring of these 8,9-methylenedioxybenzo[i]phenanthridines on their relative potency as topoisomerase I-targeting agents and cell proliferation as determined using the MTT assay was investigated. (elsevier.com)
  • LaVoie, Edmond J. / 8,9-Methylenedioxybenzo[i]phenanthridines : Topoisomerase I-targeting activity and cytotoxicity . (elsevier.com)
  • The C-glycosylated phenanthridine derived from β-cyclodextrin has been prepared, which might be potential in medicinal and biological chemistry due to its flexible conformation. (figshare.com)
  • First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. (springer.com)
  • The binding of phenanthridine dyes to tripler poly(dT)*poly(dA). (chalmers.se)
  • The influence of NH 2 , CN, CH 2 OH, OBn, OCH 3 , OH, and NHCOCH 3 substituents at the 8-position on the relative activity of these 2,3-dimethoxybenzo[i]phenanthridines was examined. (elsevier.com)
  • Structure-activity studies were performed to examine the influence of saturation at the 11,12-positions of several substituted 8,9-methylenedioxybenzo[i]phenanthridines. (elsevier.com)
  • No measurable activity for the bovine kidney enzyme was observed with phenanthridine or methotrexate as substrates. (uncg.edu)
  • N-Substituted tetrahydroimidazo[1,2-f]phenanthridines (TIPs) and dihydroimidazo[1,2-f]phenanthridines (DIPs) display a variety of interesting properties, but the structural variation in the compounds have, up till now, been only the N-substituent. (uio.no)
  • Now, I haven't a clue what a phenanthridine alkaloid is, but (just like the average beer-swilling Saturday night out during my student days) it's known to cause confusion, poor coordination, drooling, abdominal pain, vomiting, diarrhoea and seizures. (home.blog)