Phenanthrene metabolites in urine. Medical search. Frequent questions

This change was greatest for firefighters assigned to attack and search with 2.3, 5.6, 3.9, and 1.4-fold median increases in pyrene, phenanthrene, naphthalene, and fluorene metabolites. (cdc.gov)
Compared to interior attack, transitional attack resulted in 50% less uptake of pyrene (p = 0.09), 36% less uptake phenanthrene (p = 0.052), and 20% less uptake of fluorene (p (cdc.gov)
Urinary concentrations of PAH metabolites, specifically monohydroxylated PAHs (OH-PAHs), have been used as biomarkers of human exposure to select PAHs including naphthalene, fluorene, phenanthrene, and pyrene. (cdc.gov)
Ten monohydroxy-PAHs (OH-PAHs) were analyzed in urine samples, consisting in the principal metabolites of naphthalene (NAP), fluorene (FLU), phenanthrene (PHE), and pyrene (PYR). (polito.it)
Urine samples from 100 subjects were collected and concentrations of monophenolic metabolites of naphthalene, fluorene, phenanthrene, and pyrene and the nicotine metabolites cotinine and trans-3′-hydroxycotinine were measured Pevonedistat using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to assess PAH and ETS exposures. (alkpathway.com)

Median concentrations of PAH metabolites in urine increased from pre-firefighting to 3-h post firefighting for all job assignments. (cdc.gov)
Metabolites of naphthalene were found at the highest concentrations (P50 values of 892 and 4300 ng/g creatinine for 1- and 2-OH-NAP, respectively) followed by the three OH-FLUs (P50 values of individual compounds in the range of 58.2-491 ng/g creatinine), the four OH-PHEs (P50 values in the range of 30.5-145 ng/g creatinine), and 1-OH-PYR (P50 value of 82.8 ng/g creatinine). (polito.it)
Median concentrations of the single metabolites in smokers were from 1.4 fold (for 4-OH-PHE) to 14 fold higher (for 3-OH-FLU) than those observed in non-smokers. (polito.it)
samples of non-occupationally exposed non-smoker adult subjects and to establish relationships between airborne exposures and urinary concentrations in order to (a) assess the suitability of the studied metabolites as biornarkers of PAH and ETS, (b) study the use of 3-ethenypyridine as ETS tracer and (c) link ETS scenarios with exposures to carcinogenic PAH and VOC. (alkpathway.com)
Concentrations of urinary metabolites were 0.44 (1.70) ng/mL for 1-hydroxypyrene and 0.88 (5.28) ng/mL for cotinine. (alkpathway.com)
Concentrations of urinary metabolites of nicotine were lower than in most previous studies, suggesting very low exposures in the ETS-exposed group. (alkpathway.com)

Urine was analyzed for metabolites of polycyclic aromatic hydrocarbons (PAHs) and breath was analyzed for volatile organic compounds (VOCs) including benzene. (cdc.gov)
1-Hydroxyphenanthrene is a phenanthrol and a human metabolite of phenanthrene that can be detected in urine of persons exposed to PAHs. (wikipedia.org)
Upon entering the body, PAHs are readily metabolized and eliminated in urine. (cdc.gov)
The specific analytes measured in this method are monohydroxylated metabolites of PAHs (OH-PAHs), namely 1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 3-hydroxyfluorene, 1-hydroxyphenanthrene, 2- & 3-hydroxyphenanthrene, and 1-hydroxypyrene. (cdc.gov)
Polycyclic aromatic hydrocarbons (PAHs) are compounds of interest due to their widespread presence (e.g., their metabolites are detected in up to 100% of the Canadian population) and their toxicological potential. (gwfnet.net)
PAHs and cotinine markers in the urine samples (n = 97) of participants from two regions from the Mackenzie Valley (Dehcho and Sahtú) was completed by liquid and gas chromatography coupled with mass spectrometry. (gwfnet.net)

0.05) increases from pre- to post-fire for some metabolites of VOCs (e.g., benzene, toluene) and naphthalene were found. (cdc.gov)

As a contribution to knowledge of the stereochemical configuration of the 1:2-dihydroxy-1:2-dihydro-naphthalene and - anthracene, metabolites of the respective aromatic hydrocarbons isolated by Young(8) and by Boyland(1) from rat and rabbit urine, the cis- and trans- forms of the diols (V) and (VI) have been synthesised. (gla.ac.uk)

and, ii) smoking status (self-reported status and adjusted on urine cotinine level). (gwfnet.net)

To better understand the absorption of combustion byproducts during firefighting, we performed biological monitoring (breath and urine) on firefighters who responded to controlled residential fires and examined the results by job assignment and fire attack tactic. (cdc.gov)

The presence of a parent drug or its metabolites in blood or urine may help confirm exposure in suspect cases. (merckvetmanual.com)

Biological monitoring was done for creatinine-adjusted levoglucosan in urine pre- and post-shift. (cdc.gov)

The chemical structures of metabolites were elucidated by comparing the retention time, accurate molecular mass, and fragmentation patterns of analytes with those of PPD. (westminster.ac.uk)

There were not many significant correlations between either personal exposures to PAH and their urinary metabolites, or of the latter with ETS markers. (alkpathway.com)

The MAK Collection for Occupational Health and Safety, Biomonitoring Methods, Vol. 6 (article) PAH Metabolites in Bile Fluids of Dab (Limanda limanda) and Flounder (Platichthys flesus): Spatial Distribution and Seasonal Changes. (wikipedia.org)

Blood, urine and food samples were obtained for later analysis, while questionnaire and 3-day diet information was recorded. (nutritionstudies.org)

On the other hand, low correlation was observed between the PAH metabolite 2-naphthol and the parent PAH, gas-phase naphthalene. (alkpathway.com)

Most human hospitals, emergency clinics, and some veterinary diagnostic laboratories have illicit drug screens available and can check for the presence of illicit drugs or their metabolites in different body fluids. (merckvetmanual.com)

Studies show that certain PAH metabolites interact with DNA and are genotoxic, causing malignancies and heritable genetic damage in humans. (cdc.gov)
However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)

The model fungus Cunninghamella elegans produces, in the case of the biodegradation of phenanthrene, a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). (wikipedia.org)
In the case of (V) optical resolution of the transcompound into its d and 1l- forms shows that the former is identical with the dihydride obtained by Young through catalytic hydrogenation of the naphthalene metabolite. (gla.ac.uk)
In the case of (VI) the physical properties of the synthetic dl-trans- compound indicate its identity with the dihydride of the optimally inactive anthracene metabolite described by Boyland. (gla.ac.uk)

Advances in Medicine and Biology, Vol. 93 Yamazaki, H., Chowdhury, G. and Guengerich, F.P. Activation of Thalidomide to Reactive Metabolites by Autoinduced Human Cytochrome P450 3A Enzymes, with Substrate Cooperativity, and Implications for Development of Analogs. (shoyaku.ac.jp)

Any individual who has failed the naloxone challenge test or who has a positive urine screen for opioids. (opioidsolutions.org)

The results showed that phase I metabolites are monooxygenation, dioxygenation and oxidative dehydrogenation metabolites, and phase II metabolic pathways were demonstrated to be cysteine conjugation and glucuronidation. (westminster.ac.uk)

Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)

Urine specimens are processed, stored, and shipped to the Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention for analysis. (cdc.gov)

This change was greatest for firefighters assigned to attack and search with 2.3, 5.6, 3.9, and 1.4-fold median increases in pyrene, phenanthrene, naphthalene, and fluorene metabolites. (cdc.gov)
Compared to interior attack, transitional attack resulted in 50% less uptake of pyrene (p = 0.09), 36% less uptake phenanthrene (p = 0.052), and 20% less uptake of fluorene (p (cdc.gov)
Examples include phenanthrenes, naphthalene, and pyrene. (cdc.gov)
19. DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers. (nih.gov)
[ 6 ] While not specific for tobacco, 1-OH-pyrene was very suitable for high throughput assay, and phenanthrene tetraol was felt to be a surrogate for benzo(a)pyrene, which was believed to be a major DNA adducting PAH leading to cancer in humans, since the two are metabolized by similar pathways. (medscape.com)
Urinary PAH biomarkers for naphthalene, fluorene, phenanthrene, and pyrene were detected in all workers and were higher for post-shift samples than those collected pre-shift. (cdc.gov)
Impact Of Phenanthrene Co-Administration On The Toxicokinetics Of Benzo[A]Pyrene In Humans. (oregonstate.edu)

Results: PAH levels in the worker breathing zones were highest for naphthalene, acenaphthene, and phenanthrene, with geometric means of 52.1, 11.4, and 9.8 µg/m3, respectively. (cdc.gov)
0.05) increases from pre- to post-fire for some metabolites of VOCs (e.g., benzene, toluene) and naphthalene were found. (cdc.gov)

The primary endpoints to distinguish between classes of smoke exposure included expired CO, urinary phenanthrene tetraol (an indicator of exposure to polycyclic aromatic hydrocarbons in smoke inhalation), and a urinary mercapturic acid, 3-HPMA, metabolite of acrolein (an inhaled volatile organic compound which the investigators characterize as a cardiopulmonary toxicant). (hcplive.com)

2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite of estrone and estradiol. (hmdb.ca)
Parallel experiments with rat liver microsomes indicated that the major metabolite formed from acenaphthene by rat liver microsomes was 1-acenaphthenone. (lookformedical.com)

PAH elimination occurs via urine and feces, and urinary metabolites are eliminated within a few days (Ramesh et al. (cdc.gov)
4. Aromatic and polycyclic hydrocarbons in air and their urinary metabolites in coke plant workers. (nih.gov)

We analyzed urine samples from 331-709 participants from each ethnic group in this study for metabolites of phenanthrene, a surrogate for carcinogenic polycyclic aromatic hydrocarbon exposure. (nih.gov)
Exposure biomarkers that will be longitudinally measured in all participants include urinary hydroxy-polycyclic aromatic hydrocarbons, volatile organic chemical metabolites, metals/metalloids, levoglucosan, and cotinine. (nih.gov)
9. Occupational exposure to polycyclic aromatic hydrocarbons in a graphite-electrode producing plant: biological monitoring of 1-hydroxypyrene and monohydroxylated metabolites of phenanthrene. (nih.gov)

The analytical procedure involves enzymatic hydrolysis of glucuronidated/sulfated OH-PAH metabolites in urine, extraction by on-line solid phase extraction, and separation and quantification using isotope dilution high performance liquid chromatography-tandem mass spectrometry (on-line SPE-HPLC-MS/MS) (Wang et al. (cdc.gov)
Urine metabolites were extracted after enzymatic hydrolysis by solid-phase extraction with styrene-divinylbenzene resin. (lookformedical.com)

While many of the molecules present in cigarette smoke or their metabolites theoretically could be used as markers of exposure, some offer special advantages. (medscape.com)
Using highly sensitive assays for these potential markers of exposure, Dr. Hecht and colleagues [ 7 ] have been able to demonstrate that urine of smokers contains significantly increased levels. (medscape.com)
Moreover, the level of the markers correlated with urinary cotinine, a metabolite of nicotine, providing validation of their ability to quantify tobacco exposure. (medscape.com)
In addition, first void morning urine samples were collected every 4 weeks (immediately prior to dose change in the taper group) for measurement of biomarkers of smoke exposure. (hcplive.com)

Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol at the receptor level. (drugbank.com)

Negligible amounts of codeine and its metabolites are found in the feces. (nih.gov)

noma induction in mice by, 341 Benzo(b)fluoranthene see Benz(e)acephenanthrylene Benzo(/)fluoroanthene carcinogenic properties in ci smoke from, 265 P *Barette Benzo(c)phenanthrene carcinogenic properties in cigarette smoke from, 265 Benzo(rst)pentaphene carcinogenic properties in cigarette smoke from, 265 3,4-Benzopyrene see Benzo(a)pyrene Benzo(a)pyrene ability of smoking mothers to hydroxy). (nih.gov)

mechanism(s) of interactions of xenobiotics and/or their metabolites with cellular macromolecules resulting in toxicity. (nih.gov)

2-hydroxyestrone is not significantly uterotrophic, whereas other hydroxylated estrogen metabolites including 2-hydroxyestradiol, 16a-hydroxyestrone, estriol, 4-hydroxyestradiol, and 4-hydroxyestrone all are. (hmdb.ca)

Internal dose was estimated by quantifying select PAH metabolites in pre- and post-shift urine samples using on-line solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. (cdc.gov)

Studies show that certain PAH metabolites interact with DNA and are genotoxic, causing malignancies and heritable genetic damage in humans. (cdc.gov)

The drug is excreted primarily in the urine, largely as inactive metabolites and small amounts of free and conjugated morphine. (nih.gov)
Both parent drug and metabolites are excreted primarily by the kidney (53% to 79% of the dose), however, urinary excretion of unchanged naltrexone accounts for less than 2% of an oral dose and fecal excretion is a minor elimination pathway. (nih.gov)

Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)

Significant interactions between individual phthalate metabolites and pregnancy complications were observed. (emory.edu)

For these reasons, stable metabolites of molecules contained in smoke, particularly those excreted in the urine, are particularly appealing. (medscape.com)

DACH-platin, an active metabolite of the platinum-based antineoplastic agent oxaliplatin, is highly hydrophobic and toxic when administered systemically. (blogspot.com)

Urinary monohydroxylated phenanthrenes and hydroxypyrene - the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. (wikipedia.org)

Urine specimens are processed, stored, and shipped to the Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention for analysis. (cdc.gov)

Anatomy1

Organisms2

Chemicals and Drugs5

Phenomena and Processes1

Health Care1

Fluorene5

Concentrations6

PAHs6

VOCs1

Aromatic hydrocarbons1

Cotinine1

Firefighters1

Exposure1

Biological1

Analytes1

Exposures1

Methods1

Samples1

Parent1

Body1

Studies2

Case3

Human1

Positive1

Results1

Risk1

Analysis1

Pyrene7

Naphthalene2

Tetraol1

Major metabolite2

Urinary metabolites2

Polycyclic3

Enzymatic hydrolysis2

Exposure4

Estrone1

Feces1

Carcinogenic1

Macromolecules1

Estriol1

Solid phase extr1

Genotoxic1

Primarily2

Organic1

Pregnancy1

Smoke1

Highly1

Effects1

Division1