Phase the cell. Medical search. Frequent questions

Inter-cellular variability in the duration of the cell cycle is a well documented phenomena which has been integrated into mathematical models of cell proliferation since the 70's. (hamilton.ie)
Additionally, researchers found a correlation between higher antitumor activity and in vivo proliferation of infused CAR-NKT cells. (ecancer.org)
Leveraging the multiomic platform of key collaborator Immunai, Inc., Baylor researchers found that upregulation of the BTG anti-proliferation factor 1 (BTG1) gene in infused CAR NKT cells is indicative of cell exhaustion and restricts CAR NKT cell functional activity. (ecancer.org)
Results demonstrated that pristimerin was toxic against the two cell lines, and exhibited inhibitory effects against proliferation. (spandidos-publications.com)
As individuals age, stem cell production and proliferation decreases, systemic inflammation increases and a person's ability to repair and regenerate worn out or damaged tissue diminishes," said Suzanne Liv Page, Longeveron chief operating officer. (stemcellsportal.com)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

It is being developed based on OmniRat transgenic animal platform.Sugemalimab (Cejemly) is under development for the treatment of solid tumors including endometrial cancer, cholangiocarcinoma, recurrent head and neck squamous cell carcinoma (HNSCC). (globaldata.com)

CAMBRIDGE, Mass.--( BUSINESS WIRE )--AVEO Oncology (NASDAQ:AVEO) today announced that the first patient has been dosed in the Company's pivotal TIVO-3 trial, a randomized, controlled, multi-center, open-label study to compare tivozanib to sorafenib in subjects with refractory advanced renal cell carcinoma (RCC). (businesswire.com)
The company is focused on developing and commercializing its lead candidate tivozanib, a potent, selective, long half-life inhibitor of vascular endothelial growth factor 1, 2 and 3 receptors, in North America as a treatment for renal cell carcinoma and other cancers. (businesswire.com)
Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today announced that it has dosed the first patient in AROHIF21001, a Phase 1b dose-finding clinical study of ARO-HIF2, the company s investigational RNA interference (RNAi) therapeutic being developed as a treatment for patients with clear cell renal cell carcinoma (ccRCC). (nanotech-now.com)

Here, we recover the temporal organisation of the cell cycle of budding yeast into phases and subphases, in an automated way. (biorxiv.org)
For some single-celled organisms such as yeast, mitotic cell division is the only way they can reproduce. (vedantu.com)
Ultrastructural morphology of the fungal organism, Saccharomyces cerevisiae was highlighted, which was in its yeast-phase of development. (cdc.gov)
Note the numerous yeast cells in the field of view. (cdc.gov)

The aim of this study (JGOG1063) was to determine the recommended dose (RD) for combination chemotherapy with irinotecan hydrochloride (CPT-11) and nedaplatin (NDP) for advanced cervical squamous cell carcinoma. (nih.gov)
Advanced stage NSCLC (IIIB with malignant pleural effusion or stage IV) excluding squamous cell histology, with measurable or evaluable disease. (knowcancer.com)
Lung carcinoma of squamous cell histology or any histology in close proximity to a major vessel, or with significant cavitation as assessed by treating investigator in consultation with an attending radiologist. (knowcancer.com)
In the present study, the anticancer potential of pristimerin was investigated in two oral squamous cell carcinoma (OSCC) cell lines, CAL‑27 and SCC‑25. (spandidos-publications.com)
90% are squamous cell carcinomas. (spandidos-publications.com)
Because it is very invasive, the prognosis of oral squamous cell carcinoma (OSCC) is poor ( 5 ). (spandidos-publications.com)

In the U.S., approximately 85% of the non-Hodgkin lymphomas (NHL) are a type of B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL). (mystateline.com)
The first-in-human, multicenter, open-label NX-2127-001 trial is evaluating the agent's safety and efficacy in adult patients with the following advanced B-cell malignancies: chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), Waldenström macroglobulinemia (WM), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and primary central nervous system lymphoma (PCNSL). (onclive.com)

ST. HELIER, Jersey--( BUSINESS WIRE )-- NovoCure Ltd. (NASDAQ: NVCR) today announced that the final patient has been enrolled in the phase 3 pivotal LUNAR trial evaluating the efficacy of Tumor Treating Fields (TTFields) together with immune checkpoint inhibitors or docetaxel for treatment of patients with advanced stage 4, non-small cell lung cancer (NSCLC) following progression while on or after platinum-based therapy. (biospace.com)
LUNAR is a phase 3 pivotal trial testing the effectiveness of TTFields in combination with immune checkpoint inhibitors or docetaxel versus immune checkpoint inhibitors or docetaxel alone for patients with stage 4 NSCLC who progressed during or after platinum-based therapy. (biospace.com)
Cejemly is indicated for the treatment of patients with unresectable stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following concurrent or sequential platinum-based chemoradiotherapy. (globaldata.com)
1 2 In Japan, non-small cell lung cancer (NSCLC) accounts for 75%-85% of all lung cancers. (bmj.com)

Rivipansel missed its primary endpoint in the Phase III Evaluating Safety, Efficacy and Time to Discharge (RESET) pivotal study ( NCT02187003 ) of time to readiness-for-discharge. (genengnews.com)
this trial investigated the safety and efficacy of repeat-administration of autologous MSC-NTF cells and was supported by a grant from the California Institute for Regenerative Medicine (CIRM CLIN2-0989), and another grant from the ALS Association and I AM ALS. (wkrn.com)
Javier San Martin, M.D., chief medical officer at Arrowhead, said: This Phase 1b study is designed to provide us with a robust readout on safety and dose response of ARO-HIF2, and may also deliver signals on preliminary efficacy in an advanced ccRCC patient population. (nanotech-now.com)
Safety and efficacy data from this Phase 1/2 study will determine the recommended Phase 2 dose for IMPT-314 and inform on potential cohort expansion opportunities. (mystateline.com)
We expect to present Phase 1 safety and initial efficacy data from patients with relapsed or refractory aggressive B-cell lymphoma in the first half of 2024. (mystateline.com)
ImmPACT Bio's Phase 1/2 is a multi-center, open-label clinical trial that will evaluate the safety and efficacy of IMPT-314 in participants with R/R aggressive B-cell lymphoma. (mystateline.com)
Another important finding revealed a regulatory gene in NKT cells that may impact the efficacy of treatment. (ecancer.org)
Longeveron LLC, a regenerative medicine company developing cellular therapies, has treated its first patient in a Phase 2b clinical trial evaluating the safety and efficacy of its human allogeneic mesenchymal stem cells (LMSCs) in patients with aging frailty syndrome. (stemcellsportal.com)
In this phase 2, randomized, placebo-controlled trial, we evaluated the safety and efficacy of CSJ148 for prophylaxis of HCMV in patients undergoing allogeneic hematopoietic stem cell transplantation . (bvsalud.org)
The primary efficacy endpoint was therefore not met, indicating that CSJ148 did not prevent clinically significant HCMV reactivation in recipients of allogeneic hematopoietic cell transplants . (bvsalud.org)

The NurOwn® technology platform (autologous MSC-NTF cells) represents a promising investigational therapeutic approach to targeting disease pathways important in neurodegenerative disorders. (wkrn.com)
New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
We also recently announced that ARO-ENaC, our investigational RNAi therapeutic targeting cystic fibrosis, started dosing in a Phase 1/2 study. (nanotech-now.com)
We look forward to delineating the differentiated therapeutic potential of this bispecific approach through data from ImmPACT Bio's Phase 1/2 trial of IMPT-314. (mystateline.com)
Transplantation of inhibitory neuron cell therapy is a novel therapeutic strategy that has shown promise in preclinical studies and could potentially provide a non-tissue-destructive therapeutic option for suppressing seizures in people with drug-resistant focal epilepsy. (ca.gov)
Conversely, engineered reduction of BTG1 expression in CAR NKT cells enhanced their therapeutic activity against neuroblastoma in a mouse model. (ecancer.org)
As a biotechnology company at the cutting edge of Regenerative Medicine, Unistem is dedicated to the science ofStem Cells by developing technologies and protocols for safe and effective therapeutic applications utilizing adult stem cells derived from the umbilical cord. (indiamart.com)
Stem cell-based therapies offer a potential therapeutic approach to repair, restore, or regenerate injured brain tissue. (lu.se)

A team led by researchers from Mass Eye and Ear, a member of Mass General Brigham, reports the results of a phase I trial of a revolutionary stem cell treatment called cultivated autologous limbal epithelial cell transplantation (CALEC), which was found to be safe and well-tolerated over the short term in four patients with significant chemical burns in one eye. (worldhealth.net)
Reduced intensity hematopoietic stem cell transplantation for myelofibrosis in accelerated-phase. (physiciansweekly.com)
The outcome of hematopoietic stem cell transplantation for AP myelofibrosis has not been evaluated yet. (physiciansweekly.com)
Stem cell therapy is a form of regenerative medicine that involves the transplantation of stem cells through one or more injections to replace diseased or injured cells. (indiamart.com)
Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation. (bvsalud.org)

The FDA has placed a partial clinical hold on the phase 1 NX-2127-001 trial investigating the novel BTK degrader NX-2127 in patients with relapsed/refractory B-cell malignancies. (onclive.com)

Pfizer had overseen RESET, having agreed to assume responsibility for clinical development of rivipansel since completion of a Phase II study, under terms of the licensing agreement. (genengnews.com)
Thus, the methods of measuring cell and fluid phase markers in induced sputum used in this study are reproducible and valid. (nih.gov)
In this study, we combined patch-clamp recording and two-photon Ca 2+ imaging to examine Ca 2+ dynamics in hair cell ribbon synapses in the bullfrog amphibian papilla of both sexes. (jneurosci.org)
LUNAR marks Novocure's second phase 3 pivotal study to complete enrollment this quarter and is our first of several late-stage clinical trials expected to deliver final data over the next two years," said William Doyle, Novocure's Executive Chairman. (biospace.com)
This study describes a novel "maturation phase transient reprogramming" (MPTR) method to restore the epigenome of cells to a more youthful state. (elifesciences.org)
While the phase I study was designed to determine preliminary safety and feasibility before advancing to a second phase of the trial, the researchers consider the early findings promising. (worldhealth.net)
The clinical trial represents the first human study of a stem cell therapy to be funded by the National Eye Institute (NEI), a part of the National Institutes of Health (NIH). (worldhealth.net)
In this study, we addressed feeder cell-free expansion methods using common γ-chain cytokines, especially IL-15 and IL-21. (frontiersin.org)
AROHIF21001 (NCT04169711) is a Phase 1b dose-finding clinical study in up to 18 patients with advanced ccRCC to evaluate the safety of ARO-HIF2 and to determine the recommended Phase 2 dose. (nanotech-now.com)
We are pleased to have treated the first patient with IMPT-314 and build on the clinical evidence from the ongoing investigator-led study of this dual-targeted CD19/CD20 CAR T-cell therapy. (mystateline.com)
The dose-finding Phase 1 portion of the study will include both CAR T-experienced and CAR T-naïve patients. (mystateline.com)
In this study, we found the CD62L biomarker expressed on the infused NKT cells, which we identified in our preclinical work, is predictive of both higher NKT cell in vivo expansion and antitumor activity in patients. (ecancer.org)
This study provides promising initial evidence of antitumor activity of GD2 CAR NKT cells against neuroblastoma. (ecancer.org)
This is a Phase 2 study designed to determine the preliminary anti-tumor activity and confirm the safety of VV1 in combination with cemiplimab. (yalecancercenter.org)
MONROVIA, Calif., November 07, 2022 --( BUSINESS WIRE )--Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced topline clinical data from its Phase 1a single-dose, healthy volunteer study of XmAb ® 564, in development for patients with autoimmune diseases. (yahoo.com)
We have rapidly advanced XmAb564 through a first-in-human study and have now dosed the first patient in a newly initiated Phase 1b, multiple-ascending dose study in patients with atopic dermatitis and psoriasis,' said Allen Yang, M.D., Ph.D., senior vice president and chief medical officer at Xencor. (yahoo.com)
In addition, XmAb306 showed accumulation of target immune cells upon repeat dosing, which allows study of further extended dosing intervals and helps inform our development of XmAb564. (yahoo.com)
The Phase 1 single ascending-dose study of XmAb564 was designed to characterize its safety, tolerability and pharmacokinetics in healthy volunteers, and the study included an analysis of key immunomodulatory biomarkers. (yahoo.com)
In the present study, the potent antitumor effects of pristimerin on OSCC cells were investigated. (spandidos-publications.com)
This study is being done to answer the following question: Does the use of brain scans alone instead of brain scans plus preventive brain radiation affect the lifespan of patients with small cell lung cancer? (froedtert.com)
In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
While the partial hold is in effect, we will supply the current drug product for patients who continue on therapy in the phase 1 study and will work expeditiously with FDA to introduce the improved NX-2127 manufacturing process and drug product into our clinical development plan. (onclive.com)
The primary end points of this portion of the study are to determine the incidence of protocol-specified dose-limiting toxicities and establish the maximum tolerated dose and/or recommended phase 1b dosage(s) of NX-2127. (onclive.com)
The phase IV clinical study is created by eHealthMe based on reports from the FDA, and is updated regularly. (ehealthme.com)
This is a Phase I/Ib, open-label, safety, and pharmacodynamics study of pembrolizumab in combination with vorinostat in patients with advanced prostrate, renal or urothelial cell carcinoma. (bcan.org)
Expansion Phase, the study will have a run-in phase with sequential single-agents and then the combination phase. (bcan.org)
Allogeneic mesenchymal stem cells (MSCs) were previously tested in a Phase I/2 proof-of-concept study conducted by investigators at the University of Miami's Miller School of Medicine. (stemcellsportal.com)
In that study, MSCs were shown to be safe and well-tolerated in frail, elderly subjects in a Phase 1 open label single ascending dose trial with a similar safety profile observed in the randomized, placebo-controlled Phase 2 study. (stemcellsportal.com)
Defining the parameters of the study as well as the timetable for deliverables was first addressed and in the light of the extensive scope of the studies, a phased approach was agreed to allow preliminary findings to be shared in time for the December 2010 OEWG and the full study to be completed before the Sixty- fourth World Health Assembly. (who.int)
In Phase-I of the study a systematic procedure and guidelines were developed for designing a robotic safety system. (cdc.gov)

Pfizer has acknowledged that the synthetic glycomimetic it licensed from GlycoMimetics in 2011 has failed a Phase III trial in patients with sickle cell disease (SCD) who were hospitalized for a vaso-occlusive crisis (VOC) and required treatment with intravenous (IV) opioids-a clinical setback that sent GlycoMetics shares plunging by more than half their value in morning trading. (genengnews.com)
We are both surprised and deeply disappointed by this outcome, as we had strongly hoped that rivipansel would have a positive benefit for people living with sickle cell disease," added GlycoMimetics CEO Rachel King. (genengnews.com)
By 2012, a total of 40 countries had national TM policies, 19 had national TM strategic plans and 28 national research institutes conducted research on traditional medicine products used for malaria, HIV/AIDS, sickle-cell disease, diabetes and hypertension. (who.int)

The FDA expects early-phase CAR T-cell therapy trials to focus primarily on the risks of toxicity, according to a new draft guidance that also addresses manufacturing and preclinical considerations in developing CAR T-cell therapies. (centerwatch.com)
The Phase 3 trial is expected to enroll approximately 322 patients with recurrent or metastatic RCC who have failed at least two prior regimens, including VEGFR-TKI therapy (other than sorafenib). (businesswire.com)
Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
A main challenge of NK cell therapy is that it requires a high amount of functional NK cells. (frontiersin.org)
B-cell lymphomas are a type of blood cancer affecting B cells of the immune system that often relapse and require multiple lines of therapy. (mystateline.com)
IMPT-314 is a CD19/CD20-targeting chimeric antigen receptor (CAR) T-cell therapy that utilizes a potent bispecific CAR and a 4-1BB costimulatory domain. (mystateline.com)
NRTX-1001 is an inhibitory neuron cell therapy derived from human embryonic stem cells. (ca.gov)
NRTX-1001 is an inhibitory neuron cell therapy derived from human embryonic stem cells (hESCs) for the prospective treatment of drug-resistant focal epilepsy (MTLE). (ca.gov)
He also is a member of the Center for Advanced Innate Cell Therapy at Texas Children's Cancer Center, the Center for Cell and Gene Therapy at Baylor and Texas Children's and the Dan L Duncan Comprehensive Cancer Center at Baylor. (ecancer.org)
Actual price may be more or less after phone or face to face conversation.Low cost treatment and best healthcare infrastructure have made India a best destination for stem cell therapy. (indiamart.com)
Unistem Biosciences provides a full spectrum of stem cell solutions, from research and therapy to the preservation of stem cells from the umbilical cord for personal and public use. (indiamart.com)
The goal of an IL-2 therapy for autoimmune disease is to provide sustained low-intensity activation of Tregs while avoiding the pro-inflammatory systemic activation of effector T cells,' said John Desjarlais, Ph.D., senior vice president and chief scientific officer at Xencor. (yahoo.com)
The phase 1a dose-escalation portion of the trial is evaluating the safety and tolerability of NX-2127 at multiple dose levels in patients who have received at least 2 prior systemic therapies (or at least 1 prior therapy for patients with WM or PCNSL) and for whom no other known therapies provide clinical benefit. (onclive.com)
The second phase is known as post-remission therapy. (medlineplus.gov)

Our hypothesis is that exogenously infused allogeneic mesenchymal stem cells that are derived from the bone marrow of a healthy young donor, and culture expanded in our lab, will have potent regenerative and restorative effects. (stemcellsportal.com)

Sarah Larson , M.D. principal investigator and associate clinical professor of medicine, David Geffen School of Medicine at University of California, Los Angeles added, "While CD19 CAR T-cell therapies have transformed the lymphoma treatment landscape, durability has been limited by treatment resistance due to selective pressure against the target antigen and subsequent loss of expression. (mystateline.com)
Despite various approved therapies available, including CD19-targeted CAR T-cell therapies, there remains a significant unmet need for safe and highly efficacious therapies for B-cell lymphomas. (mystateline.com)

We have examined the repeatability and the validity of an improved method to measure sputum cells and fluid-phase eosinophil cationic protein (ECP), major basic protein (MBP), eosinophil-derived neurotoxin (EDN), albumin, fibrinogen, tryptase, and interleukin-5 (IL-5). (nih.gov)
A cell spends most of its time in interphase, during which it mostly performs its normal functions, such as protein synthesis. (coursehero.com)
RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. (nanotech-now.com)
NKT cells were modified to express a GD2-specific chimeric antigen receptor (GD2 CAR), which enables the immune cells to target a molecule found on the surface of neuroblastoma cells, and interleukin-15 (IL-15), a natural protein that supports NKT cell survival. (ecancer.org)
To do so, we model the cell cycle as a partially temporal network of protein-protein interactions (PPIs) by combining a traditional static PPI network with protein concentration or RNA expression time series data. (biorxiv.org)
XmAb564 is a wholly owned, monovalent interleukin-2 Fc fusion protein (IL-2-Fc), engineered with dramatically lowered potency and heightened binding affinity for the IL-2 alpha receptor (CD25), resulting in selective activation of regulatory T cells (Tregs). (yahoo.com)
The underlying mechanisms of these effects were primarily mediated by G 1 phase cell cycle arrest and inhibition of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulate kinase 1/2 (Erk 1/2) and protein kinase B (Akt) signaling pathways. (spandidos-publications.com)
In whole cells, Dox treatment prevented p34cdc2 kinase dephosphorylation without altering its synthesis, and this effect was due to neither down-regulation of cdc25C nor inhibition of protein-tyrosine phosphatase activity. (aspetjournals.org)
S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene. (wikipedia.org)
It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. (wikipedia.org)
Conjugation of the PRP polysaccharide with protein carriers confers T-cell- dependent characteristics to the vaccine and substantially enhances the immunologic response to the PRP antigen. (cdc.gov)

Primary objective: To assess the early signals for anti-tumor activity (i.e. objective response rate, progression-free survival) of pembrolizumab in combination with vorinostat in patients with advanced prostate, renal or urothelial cell carcinoma. (bcan.org)
The Dose Finding Phase will estimate the Recommended Phase II Dose (RP2D) in patients with advanced renal and urothelial cell carcinoma patients. (bcan.org)
3. Prostate cell carcinoma - progressive disease, locally advanced or metastatic disease (enrolling only at IUSCC and its affiliates). (bcan.org)

Accelerated-phase (AP) myelofibrosis, currently defined by circulating blasts 10-19%, usually confers very high risk for progression and poor outcome. (physiciansweekly.com)
Regulatory signaling systems that control the progression of the CELL CYCLE through the G1 PHASE and allow transition to S PHASE when the cells are ready to undergo DNA REPLICATION. (umassmed.edu)
We studied the effect of doxorubicin (Dox) on cell cycle progression and its correlation with DNA damage and cytotoxicity in p53-mutant P388 cells. (aspetjournals.org)
In untreated control P388 cells, p34cdc2 kinase localizes in the nucleus and cytoplasms, particularly in the centrosomes, and p34cdc2 kinase activity is dependent on cell cycle progression, with the enzyme activity increasing steadily from G1/S to G2/M and markedly declining thereafter. (aspetjournals.org)

Furthermore, pristimerin exhibited a more potent anti‑proliferative activity in CAL‑27 and SCC‑25 cells than the common chemotherapy drugs cisplatin and 5‑fluorouracil. (spandidos-publications.com)
Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)

BrainStorm Cell Therapeutics Inc. is a leading developer of innovative autologous adult stem cell therapeutics for debilitating neurodegenerative diseases. (wkrn.com)
BrainStorm holds the rights to clinical development and commercialization of the NurOwn® technology platform used to produce autologous MSC-NTF cells through an exclusive, worldwide licensing agreement. (wkrn.com)
Autologous MSC-NTF cells have received Orphan Drug designation status from the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of amyotrophic lateral sclerosis (ALS). (wkrn.com)
Cultivated autologous limbal epithelial cells (CALEC) procedure shown to be safe and feasible with early positive results of restored cornea surfaces or vision gains in four patients with severe chemical burns. (worldhealth.net)
According to the authors, despite landmark studies describing an autologous stem cell approach over the past 25 years and similar methods being utilized in Europe, no U.S. research team had successfully developed a manufacturing process and quality control tests that met U.S. Food and Drug Administration (FDA) requirements or showed any clinical benefit. (worldhealth.net)

In particular, sound-evoked spikes in auditory afferent fibers in vivo are phase-locked to sound frequencies up to 5 kHz, but it is not clear how hair cells can handle intracellular Ca 2+ changes with such high speed and efficiency. (jneurosci.org)
Therefore, ex vivo NK cell expansion protocols are currently being developed. (frontiersin.org)
In summary, this two-phased feeder cell-free ex vivo culturing protocol combined efficient expansion and high cytolytic functionality of NK cells for treatment of radiation-resistant RMS. (frontiersin.org)
In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
In this context, cytokines have been shown to activate NK cells potently during ex vivo expansion ( 9 - 12 ). (frontiersin.org)
We cannot always predict the extent of NKT cell expansion in vivo after infusion," said Dr. Leonid Metelitsa, co-corresponding author and professor of paediatrics - haematology and oncology at Baylor. (ecancer.org)

Approximately 111 million doses of nOPV2 were administered vaccine (nOPV2), produced by genetic modification of the type worldwide during the initial use phase (March-October 2021). (cdc.gov)

NEW YORK , Nov. 20, 2023 /PRNewswire/ --BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, today announced that the US Food & Drug Administration (US FDA) has granted the company a meeting to discuss the regulatory path forward for NurOwn® in amyotrophic lateral sclerosis (ALS). (wkrn.com)

We are encouraged by the evidence of antitumor activity that has been observed in several patients, particularly since this trial is still in the dose escalation phase," said Dr. Andras Heczey, co-corresponding author and associate professor of paediatrics - haematology and oncology at Baylor. (ecancer.org)

The G1, S, and G2 phases of the cell cycle are collectively known as interphase. (coursehero.com)
Interphase is characterized by cell growth and DNA replication , while M is the phase of the cell cycle in which the chromosomes of the cell prepare for the cell to divide into two new cells. (coursehero.com)
Interphase comprises the gap 1 (G1), synthesis (S), and gap 2 (G2) phases, in which the cell grows and replicates its genetic material. (coursehero.com)
Interphase, the part of the cell cycle between division events, includes the G1, S, and G2 phases, during which the cell grows, replicates its DNA, and undergoes its usual functions. (coursehero.com)
Interphase is collectively the gap 1 (G1), synthesis (S), and gap 2 (G2) phases of mitosis, in which a cell grows, replicates its DNA, and grows again. (coursehero.com)
Interphase takes most of the time in the cell cycle, comprising more than 95% of the duration of the cell cycle in most eukaryotes. (coursehero.com)
During interphase, a cell grows larger. (coursehero.com)
Students can understand different types of cell division at the organelle level by learning about the appearance of each organelle during interphase and prophase. (vedantu.com)
Before mitosis begins, the cell is in a state called interphase and it copies its DNA and so the chromosomes in the nucleus consist of two copies which are called sister chromatids. (vedantu.com)

In a cell-free system, Dox did not inhibit p34cdc2 kinase activity, indicating that is has no direct effect on the enzyme function. (aspetjournals.org)

Recent work has demonstrated that the epigenome is already rejuvenated by the maturation phase of somatic cell reprogramming, which suggests full reprogramming is not required to reverse ageing of somatic cells. (elifesciences.org)
Here we have developed the first "maturation phase transient reprogramming" (MPTR) method, where reprogramming factors are selectively expressed until this rejuvenation point then withdrawn. (elifesciences.org)
Our results demonstrated high potential of IL-15 for NK cell expansion, while IL-21 triggered NK cell maturation and functionality. (frontiersin.org)

Since these intrinsically disordered regions, which are conformationally dynamic and do not adopt stable secondary or tertiary structures, are often essential for mediating the phase transition of proteins 9 , it is therefore of interest to consider if the C-terminus of IRS-1 is involved in phase separation and to further delineate such implications upon insulin/IGF signaling. (nature.com)
Will the drug transition to the next phase of its clinical pathway? (globaldata.com)
This report provides you with the data that allows you to track and predict the specific likelihood of approval (LOA) and phase transition success rate (PTSR) of a drug using GlobalData's proprietary machine learning algorithms developed using over 10 years of historical data. (globaldata.com)
What is Phase Transition Success Rate (PTSR)? (globaldata.com)
GlobalData's Drug-Specific Likelihood of Approval (LoA) calculates the Phase Transition Success Rate (PTSR) and Likelihood of Approval (LoA) customized to individual drug. (globaldata.com)
We then studied the effect of Dox on the p34cdc2/cyclin B1 complex because it plays a key role in regulating G2/M phase transition. (aspetjournals.org)

During the S phase, the replication of the cell's genetic material, DNA, occurs. (coursehero.com)
Cell division is the process in which a cell duplicates itself by dividing its genetic material. (vedantu.com)
Cell division can be defined as a process by which a cell distributes its genetic material and cytoplasm and gives rise to new daughter cells. (vedantu.com)
AML happens when there are changes in the genetic material (DNA) in bone marrow cells. (medlineplus.gov)

Hahn AT, Jones JT, Meyer T. Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. (harvard.edu)
Effects of polychlorinated biphenyls on dopamine release from PC12 cells. (cdc.gov)

Researchers at the Institute took a deeper look into how B cells, the immune cells that make antibodies, progress through important developmental stages. (sciencedaily.com)
The researchers showed that without these rest periods, B cells didn't survive to become functional immune cells. (sciencedaily.com)

About BrainStorm Cell Therapeutics Inc. (wkrn.com)
Nurix Therapeutics announces partial clinical hold for NX-2127 phase 1 trial. (onclive.com)

and the M phase, the fourth phase of the cell cycle, when a cell divides. (coursehero.com)
The M phase consists of mitosis, in which the cell divides, producing two new, identical cells. (coursehero.com)
It is the type of cell division where one cell divides to produce two genetically identical daughter cells. (vedantu.com)

Tumor Treating Fields, or TTFields, are electric fields that disrupt cancer cell division. (biospace.com)
The TTFields global development program includes a network of preclinical collaborators and a broad range of clinical trials across all phases, including four phase 3 pivotal trials in a variety of tumor types. (biospace.com)
3) To characterize immune cell subsets, and miRs in tumor and/or blood. (bcan.org)

It was challenging to develop a process for creating limbal stem cell grafts that would meet the FDA's strict regulatory requirements for tissue engineering," said Ritz, executive director of the Connell and O'Reilly Families Cell Manipulation Core Facility at Dana-Farber and professor of medicine at Harvard Medical School. (worldhealth.net)
However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)

Here, we found that the C-terminus of IRS-1 undergoes liquid-liquid phase separation (LLPS). (nature.com)
https://doi.org/10.1083/jcb.202205069 ) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane. (rupress.org)

Mol Biol Cell. (umassmed.edu)
J Cell Biol (2022) 221 (12): e202211001. (rupress.org)

In eukaryotic cells , DNA is found in structures called chromosomes. (coursehero.com)
In a eukaryotic cell, division for sexual reproduction or vegetative growth occurs through a process involving the replication of DNA, followed by two rounds of division without an intervening round of DNA replication. (vedantu.com)

The patient of his acute phase clinical course and management were was initially given topical 1% topical prednisolone acetate recently described ( 1 ). (cdc.gov)

Pristimerin has also been reported to induce apoptosis of various human cancer cells, including in multiple myeloma ( 10 ), breast ( 11 ), liver ( 12 ), pancreatic ( 13 ) and prostate cancer ( 14 ). (spandidos-publications.com)

The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)

Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumour that most commonly arises in the adrenal gland. (ecancer.org)

Our findings shed light on the intricate control and coordination of the cell cycle and show that these binding proteins probably form part of a common mechanism to regulate quiescence, not just one specific to developing B cells. (sciencedaily.com)
Prebreeding phase: Clinical and analytical laboratory findings. (cdc.gov)
Prebreeding phase: Clinical health findings. (cdc.gov)
In the hypothyroid phase, these findings are reversed. (msdmanuals.com)

Non-small cell lung cancer impacts nearly 200,000 patients every year in the U.S., and lung cancer is the leading cause of cancer-related death globally. (biospace.com)
IL-2 and IL-15 have similar impacts on NK cells ( 13 , 14 ). (frontiersin.org)

The R package provides functions to build training dataset and also functions to use existing training data to predict cell cycle on a continuum. (bioconductor.org)
Vignette 1 shows how to use the built-training dataset to predict continuous cell cycle. (bioconductor.org)

One hallmark embodying the auditory temporal precision is phase-locking, a phenomenon that the timing of spikes fired by single auditory neurons is synchronized and therefore phase-locked to acoustic cycles ( Heil and Peterson, 2017 ). (jneurosci.org)
Given that phase-locking can be achieved in auditory afferent fibers for frequencies up to ∼5 kHz ( Taberner and Liberman, 2005 ), exocytosis from hair cells must be tightly controlled with sufficient temporal precision required. (jneurosci.org)
The temporal organisation of biological systems into phases and subphases is often crucial to their functioning. (biorxiv.org)
Then, we cluster the snapshots of this temporal network to infer phases, which show good agreement with our biological knowledge of the cell cycle. (biorxiv.org)

Existing treatment strategies have limitations and associated risks the CALEC procedure aims to address through its unique approach of using a small amount of a patient's own stem cells that can then be grown and expanded to create a sheet of cells that serves as a surface for normal tissue to grow back. (worldhealth.net)
The most long standing and extensively used stem cell treatment is the transplanting of blood stem cells to healing disorders and cases of the blood and immune systems. (indiamart.com)
Stem Cell treatment cost depends upon diseases, injuries and other health related problems. (indiamart.com)
Unistem biosciences offers cost effective and affordable stem cell treatment package. (indiamart.com)
In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL‑27 and SCC‑25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL‑27 and SCC‑25 cells, alongside decreased levels of caspase‑3 and specific cleavage of poly (ADP‑ribose) polymerase. (spandidos-publications.com)
Treatment of synchronized cells in early S phase with 1 microM Dox (2 x ID50) for 1 hr induced a marked cell arrest at G2/M phase at 6-12 hr after drug incubation. (aspetjournals.org)
Objectives: To evaluate the benefits and harms of stem cell-based interventions for prevention or treatment of GM-IVH and EoP in preterm infants. (lu.se)
Treatment of the hyperthyroid phase is with a beta-blocker. (msdmanuals.com)

MSCs versus stem cell-based interventions other than MSCs. (lu.se)

Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells. (umassmed.edu)
Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells. (aspetjournals.org)
Our results suggest that anthracycline-induced cytotoxicity is cell cycle dependent and is mediated, at least in part, by disturbance of the regulation of p34cdc2/cyclin B1 complex, thus leading to G2/M phase arrest. (aspetjournals.org)

To resolve this uncertainty a novel experimental proto col is proposed able to provide sufficient information about cell kinetics to fully determine both the inter-cellular average and variance of the duration of each of the phases. (hamilton.ie)

A fifth phase has been identified, G0, in which the cell is resting just after mitosis but still carrying out normal functions. (coursehero.com)
Other cellular structures are duplicated during G2, such that each replicated daughter cell produced during mitosis will have all necessary organelles (such as mitochondria, endoplasmic reticulum, etc. (coursehero.com)
Our experts at Vedantu have covered everything about cell division for Class 11 students, be it different types of mitosis, meiosis, or any other forms of cell division that you would need to know about. (vedantu.com)
In well-developed organisms, there are two types of cell division observed, mitosis and meiosis. (vedantu.com)
However, if simplified, mitosis can be defined as the exact duplication of a cell where the daughter cells will have the same genetic information as the parent cell. (vedantu.com)
A great majority of cell divisions that take place in our body is mitosis. (vedantu.com)
Centrosomes control mitosis in animal cells. (vedantu.com)
It should be mentioned here, that plant cells do not have centrioles and centrosomes, and the microtubule-organizing center regulates mitosis. (vedantu.com)

People who experience chemical burns and other eye injuries may develop limbal stem cell deficiency, an irreversible loss of cells on the tissue surrounding the cornea. (worldhealth.net)
The initial tissue reaction to infection is a focal, intensely suppurative necrosis consisting largely of accumulations of polymorphonuclear leukocytes, followed by invasion of macrophages, epithelioid cells, and lymphocytes. (cdc.gov)

Cooperstone said that data would be shared at an unspecified upcoming scientific meeting, "as we want to ensure the learnings from this trial help inform future sickle cell programs that aim to improve care for SCD patients experiencing a VOC. (genengnews.com)
Brainstorm will discuss plans for a Special Protocol Assessment (SPA) with the FDA to agree on the overall protocol design for a confirmatory Phase 3 trial in ALS. (wkrn.com)
Our proposed plan is to conduct a confirmatory Phase 3b trial and it is important that we are aligned with the Agency on the expected requirements for re-submitting a Biologics License Application. (wkrn.com)
The primary end points of the phase 1b portion of the trial are overall response rate and safety. (onclive.com)

During the G2 phase, a structure in the cytoplasm of animal cells that coordinates the formation of microtubules, called a centrosome , allows cell division to proceed during reproduction. (coursehero.com)
The common end phase in both processes is cytokinesis and the division of the cytoplasm. (vedantu.com)

Wu X, Song M, Qiu P, Li F, Wang M, Zheng J, Wang Q, Xu F, Xiao H. A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. (umassmed.edu)

A centromere , the point on a chromosome that attaches to the spindle fibers with a kinetochore during cell division, attaches the sister chromatids. (coursehero.com)
The cell replicates its DNA, forming sister chromatids. (coursehero.com)
The spindle checkpoint ensures that the sister chromatids are split equally into two daughter cells. (vedantu.com)
In this stage, the sister chromatids separate from each other and move towards the opposite poles of the cell. (vedantu.com)

Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. (medlineplus.gov)
When you have leukemia, your bone marrow makes large numbers of abnormal cells. (medlineplus.gov)
These abnormal cells build up in your bone marrow and blood. (medlineplus.gov)
In AML, the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. (medlineplus.gov)
The goal of the first phase is to kill the leukemia cells in the blood and bone marrow. (medlineplus.gov)
Unlike most cancers, chronic myelogenous leukemia (CML) is classified into phases rather than stages, based partly on the percentage of immature white blood cells (blasts) in peripheral blood and bone marrow. (medscape.com)
A complete blood count with differential, peripheral blood smear, and bone marrow analysis are used to determine the phase. (medscape.com)
National Comprehensive Cancer Network guidelines recommend against using WHO definitions for accelerated or blast phase CML, and instead recommend Modified MD Anderson Cancer Center (MDACC) criteria for accelerated phase CML and International Bone Marrow Transplant Registry (IBMTR) criteria for blast phase. (medscape.com)

Proliferation6

Head and neck squamous cell carc1

Renal cell carc3

Yeast4

Squamous6

Diffuse large B-2

NSCLC4

Efficacy10

Therapeutic9

Transplantation5

Patients with Relapsed1

Study31

Sickle cell di3

Therapy14

Mesenchymal1

Therapies2

Protein11

Carcinoma3

Progression4

Chemotherapy2

Autologous5

Vivo6

20211

20231

Dose escalation1

Interphase9

Kinase1

Maturation3

Transition6

Genetic material4

PC122

Immune cells2

Therapeutics2

Divides3

Tumor3

Regulatory2

Undergoes2

Biol2

Eukaryotic2

Acute Phase1

Multiple Myeloma1

Regenerative Medicine1

Clinical trial evalua1

Findings4

Impacts2

Predict2

Temporal4

Treatment8

MSCs1

Cyclin3

Duration1

Mitosis8

Tissue2

Trial4

Cytoplasm2

Cycle arrest1

Sister chromatids4

Bone8