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  • kinase
  • Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene. (wikipedia.org)
  • When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
  • biology
  • Coico also studied with Myron Melamed, a GSMC professor of biology and scientist with an international reputation, who had co-authored the seminal cytometry publication in Science, "Spectrophotometer: New Instruments for Ultra-rapid Cell Analysis," with Louis Kamentsky of Columbia University's IBM Watson Laboratory) and Marc E. Weksler, a professor of medicine and eventual Irving Sherwood Wright Professor of Geriatrics at Weill Cornell. (wikipedia.org)
  • Lents is noted for his work in cell biology, genetics, and forensic science, as well as his popular science writing and blogging on the evolution of human biology and behavior. (wikipedia.org)
  • Lents has published research reports in the area of cell and cancer biology, genetics, forensic science, as well as the teaching and learning of science, particularly evolution. (wikipedia.org)
  • His early work focused on the cell cycle and cancer biology, particularly the G1 to S phase transition. (wikipedia.org)
  • 1998
  • 1998). The cell cycle hypothesis of AD also attempts to explain for the characteristic senile plaques and the neurofibrillary tangles of AD pathology. (wikipedia.org)
  • eukaryotes
  • Non-proliferative (non-dividing) cells in multicellular eukaryotes generally enter the quiescent G0 state from G1 and may remain quiescent for long periods of time, possibly indefinitely (as is often the case for neurons). (wikipedia.org)
  • different
  • Analysis of the activities of key phosphatidylcholine and phosphatidylethanolamine biosynthetic enzymes in subcellular fractions obtained from MCF-7 cells at different cell cycle phases revealed that there was robust activity of key enzymes in the fractions prepared from MCF-7 cells in G2/M phase. (biomedsearch.com)
  • The ratio of cells within the different phases can be calculated using this assay supplemented by visible evidence from photomicrographs. (tebu-bio.com)
  • Heat production of Reuber H35 rat hepatoma cells and murine C1300 neuroblastoma cells at different stages of the cell cycle were measured microcalorimetrically. (uu.nl)
  • The duration of G1 is highly variable, even among different cells of the same species. (wikipedia.org)
  • The cell cycle hypothesis of AD proposes that the disease is caused by aberrant re-entry of different neuronal populations into the cell division cycle, following a 2-hit hypothesis (Nagy et al. (wikipedia.org)
  • cytoplasm
  • During the final stage, cytokinesis, the chromosomes and cytoplasm separate into two new daughter cells. (wikipedia.org)
  • M phase is itself composed of two tightly coupled processes: karyokinesis, in which the cell's chromosomes are divided, and cytokinesis, in which the cell's cytoplasm divides forming two daughter cells. (wikipedia.org)
  • In 1971, two independent teams of researchers (Yoshio Masui and Clement Markert, as well as Dennis Smith and Robert Ecker) found that frog oocytes arrested in G2 could be induced to enter M phase by microinjection of cytoplasm from oocytes that had been hormonally stimulated with progesterone. (wikipedia.org)
  • neurons
  • Neurons typically remain in G0, a nondividing, nonreplicating phase of the cell cycle. (wikipedia.org)
  • 2005). Thus, the cell-cycle hypothesis of Alzheimer's disease considers AD as a disease of deregulation of the cell cycle in neurons. (wikipedia.org)
  • Many subscribers to the 2-hit hypothesis of AD argue that the best strategy towards AD prevention appears to be the prevention of neurons from leaving G0 phase and entering the abnormal G1 associated with AD. (wikipedia.org)
  • somatic
  • In the sense that DNA replication must occur if genetic material is to be provided for the progeny of any cell, whether somatic or reproductive, the copying from DNA to DNA arguably is the fundamental step in the central dogma. (wikipedia.org)
  • gene
  • Complete hydatidiform moles consist only of paternal DNA, and thus the cells lack p57 expression as the gene is paternally imprinted (silenced). (wikipedia.org)
  • The SAMHD1 protein is also known as: AGS5: Aicardi- Goutières syndrome type 5 DCIP: Dendritic cell-derived IFNG-induced protein2 Mg11: Interferon-gamma-inducible protein HDDC1: HD domain containing 1 MOP-5: Monocyte protein 5 SAMH1_HUMAN SBBI88 CHBL2 The gene encoding human SAMHD1 was originally identified in a human dendritic cell cDNA library as an orthologue of a mouse gene IFN-γ-induced gene Mg11. (wikipedia.org)
  • Other studies showed that lack of Daxx gene caused a higher apoptotic rate in embryonic stem cells. (wikipedia.org)