Phase induction chemotherapy. Medical search. Frequent questions

This randomized, open-label, phase III clinical trial compared the efficacy between standard CCRT and two different induction chemotherapy (ICT) regimens followed by CCRT. (h12o.es)
The FLT3 inhibitors sorafenib, midostaurin, quizartinib and gilteritinib have been tested in monotherapy in several settings including refractory or relapsed AML (R/R AML), post-transplant maintenance as well as in combination with intensive chemotherapy (ICT) or non-intensity regimens. (dovepress.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Combination chemotherapy regimens, such as FOLFIRINOX and nab-paclitaxel plus gemcitabine, have demonstrated improved survival rates in advanced pancreatic cancer ( 7 , 8 ). (frontiersin.org)
Hence, continued advancements in diagnostic techniques, chemotherapy and radiation therapy regimens, targeted therapy strategies, and cachexia treatments will be critical for improving patient outcomes ( Figure 1 ). (frontiersin.org)
Moreover, 10 of 18 patients were treated with venetoclax, TKI and hypomethylating agent (HMA) regimens, which also associated with a high ORR rate (6 CR, 1 CRi, 3 MLFS), and can be used for induction or salvage therapy. (bvsalud.org)

This study assessed activity and safety of an innovative integration of multimodality treatment-induction chemotherapy (ICT), surgery and radiotherapy (RT)-modulated by histology and response to ICT. (uninsubria.it)
After Dillman study (CALGB 8433), French CEBI 138 study (Le Chevalier et al 1991) and RTOG 8808 study (Sause et al ), chemotherapy has been routinely added to radiotherapy (RT) for unresectable Stage III patients. (oncolink.org)
Patients are stratified according to participating center, timing of prior radiotherapy (early [before day 1, course 4 of chemotherapy] vs late vs no prior radiotherapy), stage of disease at diagnosis (limited vs extensive), and response at study entry (complete vs partial). (knowcancer.com)
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. (studentdoctor.net)
Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)

In patients with newly diagnosed acute myeloid leukemia (AML) with an IDH1 mutation who were ineligible for intensive chemotherapy, the addition of the IDH1 inhibitor ivosidenib to azacitidine significantly improved survival vs azacitidine alone, according to data presented at the 2021 American. (ascopost.com)
The trial did not meet its primary endpoint of statistically significant improvement of OS for patients with AML who are ineligible for intensive chemotherapy at the time of the planned analysis. (biospace.com)

This is a single arm Phase I study of de-intensified hypofractionated radiation therapy for favorable human papilloma virus-associated oropharynx cancer. (centerwatch.com)
Chemotherapy and radiation therapy are the cornerstone of therapy for unresectable pancreatic cancer. (frontiersin.org)

The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
She noted 2 relevant trials that studied concurrent versus sequential immunotherapy-KEYNOTE-189 (NCT02578680), which examined platinum chemotherapy plus pemetrexed with or without pembrolizumab (Keytruda), and KEYNOTE-407 (NCT02775435), which looked at carboplatin plus paclitaxel or nab-paclitaxel (Abraxane) chemotherapy with or without pembrolizumab. (cancernetwork.com)
We have learned a lot in…recent years about the association of chemotherapy with immunotherapy and the tumor microenvironment," said Kelly during her presentation. (cancernetwork.com)

the goal of induction is remission. (oncolink.org)
after a remission, you will enter this second phase of treatment. (oncolink.org)
Be able to state the approximate success rate of chemotherapy for AML (rate of complete remission with induction chemotherapy and cure rate). (hematology.org)

Presently, the standard first-line treatment for advanced pancreatic cancer is gemcitabine-based chemotherapy. (frontiersin.org)

What about induction chemotherapy followed by CRT, would that give better systemic control without losing the advantage of better locoregional provided by concurrent CRT? (oncolink.org)
A series of phase II studies demonstrated the above scheme was feasible, and Median Survival (MS) achieved was similar to that for concurrent CRT and better than sequential CRT. (oncolink.org)

Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum chemotherapy. (aacrjournals.org)

Describe the unique features of acute promyelocytic leukemia (AML M3), including the morphologic appearance of the promyelocyte, hemorrhagic complications, chromosomal abnormality, and treatment with induction therapy and all trans retinoic acid. (hematology.org)
In the past two decades, therapy for newly diagnosed APL has evolved from an all- trans retinoic acid (ATRA)+chemotherapy backbone for all patients to the addition of arsenic trioxide (ATO) to ATRA with omission of chemotherapy in low-risk patients as a new standard of care. (nature.com)

A person typically undergoes a transplant during the consolidation phase. (medicalnewstoday.com)
Chemotherapy for AML is broken down into three phases: induction phase, consolidation (or intensification), and maintenance phase. (oncolink.org)
Therapy of AML commonly consists of an induction phase, followed by a consolidation phase. (hematology.org)
In a phase Ib trial (2215-CL-0103) reported in the Journal of Clinical Oncology, Keith W. Pratz, MD, and colleagues found that incorporation of the FLT3 inhibitor gilteritinib into intensive induction and consolidation chemotherapy and its use as single-agent maintenance therapy were associated. (ascopost.com)
In the phase II SWOG 1318 trial reported in the Journal of Clinical Oncology, Advani et al found that blinatumomab induction and consolidation followed by maintenance with POMP (prednisone, vincristine, mercaptopurine, and methotrexate) produced good outcomes in patients aged ≥ 65 years with newly. (ascopost.com)

or (3) the control arm of induction therapy with combination chemotherapy and pembrolizumab with maintenance pembrolizumab and pemetrexed. (cancernetwork.com)
In advanced adenocarcinoma of GC, gastroesophageal junction cancer (GEJC) and esophageal cancer (EC), the combination of nivolumab and chemotherapy in first-line therapy improves overall survival (OS) in PD-L1 (programmed cell death protein 1)-positive patients with approval in Europe (PD-L1 CPS (combined positivity score) ≥ 5), USA and Taiwan (CHECKMATE-649) and pembrolizumab plus chemotherapy for GEJC and EC in Europe (CPS ≥ 10) and the USA (KEYNOTE-590). (mdpi.com)
In a French phase II basket trial (AcSé Pembrolizumab) reported in The Lancet Oncology, Jean-Yves Blay, MD, and colleagues investigated the activity and safety of pembrolizumab in patients with rare sarcomas. (ascopost.com)
AcSé Pembrolizumab is an ongoing phase II multitumor study investigating the activity of. (ascopost.com)
In the phase II KEYNOTE-B61 trial reported in The Lancet Oncology, Laurence Albiges, MD, PhD, and colleagues found that first-line pembrolizumab plus lenvatinib produced durable responses in patients with advanced non-clear cell renal cell carcinoma. (ascopost.com)

Methods: Patients with untreated, operable sinonasal tumours with selected histotypes (squamous cell carcinoma, intestinal-type adenocarcinoma, sinonasal undifferentiated and neuroendocrine carcinoma, olfactory neuroblastoma) were enrolled in a single-arm, phase II, multicenter clinical trial. (uninsubria.it)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
GRECO-2 is a phase 2, multicenter, randomized, double-blind, placebo-controlled study to determine the effect on overall survival of adding GC4711 to SBRT following 4 months of chemotherapy in subjects with un-resectable or borderline non-metastatic pancreatic cancer. (moffitt.org)
A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
A Phase 2 Single Arm, Multicenter Trial to Evaluate the Efficacy of the BiTE Antibody Blinatumomab in Adult Subjects With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic Leukemia (Alcantara Study) Rochester, Minn. This study seeks adult subjects with R/R Ph+ B-precursor ALL. (mayo.edu)

A phase I trial of docetaxel based induction and concomitant chemotherapy in patients with locally advanced head and neck cancer. (uchicago.edu)

Aim: To assess feasibility, complications and efficacy of induction chemotherapy followed by standard chemoradiotherapy in patients with bulky anal canal cancer. (uniroma1.it)
A041501, A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (a Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL Rochester, Minn. (mayo.edu)

A Phase III Randomized Trial of Steroids + Tyrosine Kinase Inhibitor Induction with Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults. (kucancercenter.org)
I first discussed the case of Makayla Sault in the context of the story of a First Nations girl with cancer, whose fate was almost certainly sealed when a Canadian judge ruled that she could pursue "traditional" treatment in lieu of curative chemotherapy for her lymphoblastic leukemia, even though what she and her family were choosing had nothing to do with traditional aboriginal healing. (scienceblogs.com)
A Phase II Study of Daratumumab-Hyaluronidase for Chemotherapy-Relapsed/Refractory Minimal Residual Disease (MRD) in T Cell Acute Lymphoblastic Leukemia (T-ALL Rochester, Minn., Jacksonville, Fla. (mayo.edu)
EA9181, A Phase III Randomized Trial of Steroids+Tyrosine Kinase Inhibitor Induction With Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults Rochester, Minn. This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. (mayo.edu)
This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)
Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia. (mayo.edu)

Catálogo en línea Koha › Detalles para: A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. (h12o.es)
Induction Chemotherapy Followed by Chemoradiotherapy Compared with Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non-Small. (oncolink.org)

This research study is studying the combination of venetoclax and chemotherapy as a possible treatment for acute myelogenous leukemia (AML). (dana-farber.org)
The majority of patients (6/7) had tumor downsizing after induction treatment. (uniroma1.it)
Doctors may also recommend this treatment to those with relapsed or resistant AML after they undergo re-induction chemotherapy. (medicalnewstoday.com)
Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. (studentdoctor.net)
Is laryngeal preservation (LP) with induction chemotherapy (ICT) safe in the treatment of hypopharyngeal SCC? (studentdoctor.net)
While the use of immune checkpoint inhibitors, as a monotherapy and in combination with chemotherapy, has demonstrated benefits for patients with NSCLC, the key to unlocking the full therapeutic potential for these treatments, said Kelly, an associate director for clinical research at the University of California Davis Comprehensive Cancer Center, lies in the timing of treatment initiation. (cancernetwork.com)
Immune checkpoint inhibition is a new standard of targeted therapy in the treatment of advanced or metastatic gastric cancer (GC) and is represented in various combinations with and without chemotherapy in every therapy line within clinical trials. (mdpi.com)
For adult patients, many acute lymphocytic leukemia treatment plans include an aggressive and long-term regimen of chemotherapy (chemo) to destroy cancer cells in the blood. (moffitt.org)
In the phase III CONTACT-03 trial reported in The Lancet, Sumanta Pal, MD, FASCO, and colleagues found that the addition of atezolizumab to cabozantinib did not improve outcomes in patients with renal cell carcinoma whose disease progressed on or after prior immune checkpoint inhibitor treatment. (ascopost.com)
In a phase III trial (LASER301) reported in the Journal of Clinical Oncology, Byoung Chul Cho, MD, PhD, and colleagues found that lazertinib improved progression-free survival vs gefitinib in the first-line treatment of EGFR-mutated advanced non-small cell lung cancer (NSCLC). (ascopost.com)
Chemotherapy is the main treatment for ALL and is given according to a treatment plan (often called a protocol or regimen). (nhsinform.scot)
For far too long, people with AML had very few treatment options, aside from very intense chemotherapy. (biospace.com)
Our review focuses on recent advances in the control and treatment of these diseases with particular reference to diagnosis, chemotherapy, vaccines, vector and environmental control. (who.int)

Establish the phase II recommended dose of daily afatinib administered with weekly carboplatin/paclitaxel and twice-daily ribavirin for patients with stage IVA/IVB oropharynx squamous cell cancer. (jnccn.org)

This approval is significant because data from our VIALE-A trial has shown that newly-diagnosed patients, who cannot undergo intensive chemotherapy, lived longer when treated with VENCLEXTA plus azacitidine than those treated with azacitidine alone," said Mohamed Zaki , M.D., Ph.D., vice president and global head of oncology development, AbbVie. (biospace.com)
10 AML typically worsens quickly, and due to age or comorbidities, not all patients are eligible to receive intensive chemotherapy. (biospace.com)

Targeted drug therapy may also be suitable if AML does not respond to chemotherapy. (medicalnewstoday.com)
Be able to describe the principle goals of each phase of therapy. (hematology.org)
In a single-institution, phase I, first-in-human trial reported in The Lancet Oncology, Cowan et al found that the combination of the γ-secretase inhibitor (GSI) crenigacestat and B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy was tolerable and produced a high. (ascopost.com)
A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3 Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/ITD AML (BMT CTN 1506) Rochester, Minn., Scottsdale/Phoenix, Ariz. (mayo.edu)
At the time of venetoclax and TKI-based therapy, 5 patients were initially diagnosed, with Ph + acute myeloid leukemia (AML) (n = 1) and mixed phenotype acute leukemia (MPAL) (n = 4), 7 patients had chronic myeloid leukemia at blastic phase (CML-BP), and the remaining 6 patients had relapsed or refractory to prior therapy. (bvsalud.org)

Dicycloplatin can inhibit the proliferation of tumor cells via the induction of apoptosis. (wikipedia.org)
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mayo.edu)

A significant portion of patients with acute myelogenous leukemia (AML) can now be cured with chemotherapy. (hematology.org)
Children who get chemotherapy to treat some types of cancer have an increased risk of developing leukemia later on. (texaschildrens.org)

Doctors may use a combination of chemotherapy drugs, such as cytarabine, and an anthracycline drug, such as daunorubicin. (medicalnewstoday.com)

Patients with un-resectable or borderline pancreatic cancer still have poor outcomes, with both toxicity and disease progression during induction chemotherapy limiting the number eligible for surgery. (moffitt.org)

As reported in The Lancet by Becker et al, an interim analysis of a European phase II study (ADMEC-O) showed that adjuvant nivolumab was associated with a numeric benefit in disease-free survival vs observation in patients with completely resected Merkel cell carcinoma. (ascopost.com)

Five completed the scheduled induction chemotherapy and all patients completed the programmed concomitant chemoradiotherapy. (uniroma1.it)

Dicycloplatin is a chemotherapy medication used to treat a number of cancers which includes the non-small-cell lung carcinoma and prostate cancer. (wikipedia.org)
1 "For a majority of our patients who do not have oncogenic-driven cancers, there is now overwhelming and compelling data for the role of immune checkpoint inhibitors, either with chemotherapy or as monotherapy in the first-line setting," acknowledged Kelly. (cancernetwork.com)
Jakob JA, Kies MS, Glisson BS, Kupferman ME, Liu DD, Lee JJ, El-Naggar AK, Gonzalez-Angulo AM, Blumenschein GR . A Phase II study of Gefitinib in Patients with Advanced Salivary Gland Cancers. (mdanderson.org)

SCALOP: Results of a randomized phase II study of induction chemotherapy followed by genicitabine (G) or capecitabine (Cap) based chentoradialion (CRT) in locally advanced pancreatic cancer (LANPC). (ox.ac.uk)

Results: Seven patients with bulky anal canal cancer were evaluable for this pilot phase of the study. (uniroma1.it)
We aimed to study mature outcomes from a randomised, multicentre, phase II study of (223)Ra. (researchgate.net)
randomised, multicentre, phase II study of 223 Ra. (researchgate.net)
We conducted a dose-escalation study to identify the maximum tolerated dose (MTD) of ganetespib in patients with chemotherapy-naïve MPM. (aacrjournals.org)
A third trial, the currently enrolling phase III INSIGNIA study (NCT03793179), aims to specifically address the sequencing debate. (cancernetwork.com)
This is a single-institution phase I study with an expansion cohort. (jnccn.org)
3. Written informed consent from the patient and/or the parent/legal guardian inclusion criteria for randomisation A will be defined on completion of the externally sponsored phase 1b study. (who.int)
Exclusion criteria for randomisation A will be defined on completion of the externally sponsored phase 1b study. (who.int)

Before standard chemoradiotherapy, patients received induction chemotherapy with 3 cycles of 75 mg/m2cisplatin and 750 mg/m25-fluorouracil. (uniroma1.it)
This involves giving chemotherapy in cycles followed by a period of rest in between to allow the body to recover. (medicalnewstoday.com)

Early studies with induction including 6-mercatopurine (6-MP) alone or in combination with steroids, methyl-glyoxal guanyl hydrazine and/or methotrexate led to poor results. (nature.com)

In patients with relapse disease, we see that they were given often induction chemotherapy, and then they went through sometimes transplant and then a maintenance phase. (ajmc.com)
Lower maternal educational level was associated with increased frequency of mucositis, as were induction chemotherapy and maintenance chemotherapy after relapse. (bvsalud.org)

A standard 3 + 3 phase I dose-escalation design will be used. (jnccn.org)

Be able to identify the complications of induction chemotherapy for AML. (hematology.org)

Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)

Furthermore, with ATRA-ATO combinations, chemotherapy may safely be omitted in low-risk patients. (nature.com)

This phase involves providing a person with low doses of chemotherapy or other drugs for months to years. (medicalnewstoday.com)

As reported in The New England Journal of Medicine by Masahiro Tsuboi, MD, and colleagues, the planned final overall survival analysis of the phase III ADAURA trial has shown a significant benefit with osimertinib vs placebo in patients with resected EGFR-mutant non-small cell lung cancer (NSCLC). (ascopost.com)

Conclusion: Induction chemotherapy has the potential to become a standard approach in patients with bulky human papillomavirus-negative anal canal cancer. (uniroma1.it)

The most commonly used chemotherapy regimen was the BFM-95 protocol. (bvsalud.org)

However, by abandoning chemotherapy and choosing Clement's quackery instead of Makayla's best shot at a cure, Makayla and her family reduced her chances of survival from 70% to zero. (scienceblogs.com)
The trial was designed to have 80% power to detect a 40% increase in median survival, from about 13mo to 18.2 mo with the addition of induction chemo using a one-tailed log-rank test conducted at a 0.025 level of significance. (oncolink.org)

Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. (studentdoctor.net)

All patients underwent chemotherapy either Induction chemotherapy following surgery or chemotherapy after surgery. (who.int)

Doctors may give targeted drugs along with chemotherapy. (medicalnewstoday.com)

and first-, second-, and third-line chemotherapy for metastatic or recurrent disease. (medscape.com)
46 (23%) patients were diagnosed with LABC, and had undergone chemotherapy first for downstage of the disease. (who.int)

Anatomy9

Organisms2

Diseases65

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment83

Phenomena and Processes26

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science6

Health Care32

Regimens6

Radiotherapy5

Ineligible for intensive chemotherapy2

Radiation therapy2

Immunotherapy3

Remission3

Gemcitabine1

Concurrent2

Platinum chemotherapy1

Trans retinoic acid2

Consolidation5

Pembrolizumab5

Multicenter5

Docetaxel1

Efficacy2

Lymphoblastic6

Chemoradiotherapy alone2

Treatment13

Carboplatin1

Intensive2

Therapy5

Tumor2

Leukemia2

Cytarabine1

Eligible1

Adjuvant1

Concomitant chemoradiotherapy1

Cancers3

Locally advanced1

Study8

Cycles2

Steroids1

Relapse2

Dose1

Complications1

Bone1

Combinations1

Years1

NSCLC1

Conclusion1

Commonly1

Survival2

Cancer1

Surgery1

Drugs1

Disease2