• Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. (mdanderson.org)
  • Additionally, the ongoing GINECO/ENGOTov25 Phase 3 trial, PAOLA-1, is testing the effect of LYNPARZA in combination with bevacizumab as a first-line maintenance treatment in women with newly diagnosed advanced ovarian cancer, regardless of their BRCA status. (merck.com)
  • The epithelial lining of the fallopian tube is of critical importance for human reproduction and has been implicated as a site of origin of high-grade serous ovarian cancer. (nature.com)
  • As in ovarian cancer, the use of intraperitoneal (IP) chemotherapy must be considered the current standard treatment option in patients with stage II-IV disease. (medscape.com)
  • In the phase I/II TOPACIO study, women with platinum-resistant/refractory ovarian cancer were assigned to the combination of niraparib (Zejula) and pembrolizumab (Keytruda). (targetedonc.com)
  • In the phase II MEDIOLA, 32 patients with recurrent platinum-sensitive ovarian cancer with germline BRCA mutations in second-line or later therapy were treated with olaparib (Lynparza) and durvalumab (Imfinzi). (targetedonc.com)
  • Investigators had high hopes for the phase JAVELIN 100 Ovarian trial evaluating avelumab (Bavencio) in combination with and/or following platinum-based chemotherapy in previously untreated patients with ovarian cancer. (targetedonc.com)
  • Similarly, the phase III JAVELIN Ovarian 200 trial of avelumab alone or in combination with pegylated liposomal doxorubicin (PLD) failed to provide a statistically significant improvement in overall survival or progression-free survival versus PLD alone in patients with platinum resistant/refractory ovarian cancer, missing its primary endpoint. (targetedonc.com)
  • The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (merckmanuals.com)
  • The addition of farletuzumab (MORAb-003) to carboplatin plus paclitaxel or carboplatin plus pegylated liposomal doxorubicin (PLD) did not demonstrate superiority over placebo plus chemotherapy in patients with platinum-sensitive recurrent ovarian cancer who are in their first relapse and have low cancer antigen (CA)-125 levels, according to data from a phase 2 study presented during the 2021 SGO Virtual Annual Meeting on Women's Cancer . (onclive.com)
  • Farletuzumab, a humanized monoclonal antibody, binds to folate receptor alpha, which is known to be highly expressed in epithelial ovarian cancer and is associated with the malignant potential of the disease. (onclive.com)
  • The agent has previously yielded promising preclinical antitumor activity when evaluated in xenograft ovarian cancer models, and has demonstrated PFS (HR, 0.49) and OS (HR, 0.44) superiority over placebo in patients with ovarian cancer who were in their first platinum sensitive relapse and had low CA-125 in a phase 3 study. (onclive.com)
  • The primary objective of the phase 2 study was to determine whether farletuzumab in addition to carboplatin and paclitaxel or carboplatin plus PLD could demonstrate superiority over placebo in terms of improving PFS in patients with platinum-sensitive ovarian cancer who are in their first relapse and have low CA-125. (onclive.com)
  • Avelumab alone or in combination with chemotherapy versus chemotherapy alone in platinum-resistant or platinum-refractory ovarian cancer (JAVELIN Ovarian 200): an open-label, three-arm, randomised, phase 3 study. (nih.gov)
  • The Canary High Grade Serous Ovarian Cancer (HGSC) study is leveraging the expertise and resources of four institutions to study the microenvironmental factors that can lead fallopian tubes to develop this deadly type of ovarian cancer and thus provide a signal to alert for the presence of early disease. (canaryfoundation.org)
  • Our focus is to define the role of the fallopian tube micro-environment in the development of high grade serous ovarian cancer (fallopian tube being the most common ovarian cancer), with the ultimate objective to find targets for prevention and markers of early disease onset for early detection. (canaryfoundation.org)
  • please see NCCN Guidelines - Ovarian Cancer, Including Fallopian Tube Cancer and Primary Peritoneal Cancer . (hemonc.org)
  • Dr. Godwin's laboratory, which has received funding over the years from the OVERRUN Ovarian Cancer Foundation and the Vicki Welsh Ovarian Cancer Fund, is dedicated to finding better, more reliable methods for the detection of this deadly disease, particularly high-grade serous carcinomas, the deadliest form of ovarian cancer that primarily originates in the fallopian tubes and spreads rapidly. (kucancercenter.org)
  • Findings from an exploratory subgroup analysis in the phase 3 INNOVATE-3 trial suggest that Tumor Treating Fields plus paclitaxel may confer a survival benefit in patients who received only 1 prior line of therapy for platinum-resistant ovarian cancer. (cancernetwork.com)
  • Combining Tumor Treating Fields (TTFields) with paclitaxel did not reach the primary end point of overall survival (OS) in the treatment of patients with platinum-resistant ovarian cancer, according to a press release on final results from the phase 3 ENGOT-ov50/GOG-3029/INNOVATE-3 trial (NCT03940196). (cancernetwork.com)
  • Novocure provides update on phase 3 ENGOT-ov50 / GOG-3029 / INNOVATE-3 trial evaluating Tumor Treating Fields therapy in platinum-resistant ovarian cancer. (cancernetwork.com)
  • Dr. Dmitriy Zamarin speaks with Cancer Network about the findings of a phase II trial in platinum-resistant ovarian cancer patients. (cancernetwork.com)
  • In the phase III JGOG 3016 trial, dose-dense weekly paclitaxel (80 mg/m 2 ) plus 6 area under the curve (AUC) of carboplatin had a better median progression-free survival (PFS) compared with the tri-weekly conventional regimen in ovarian cancer patients (28.0 vs. 17.2 months) [ 9 , 10 ]. (e-crt.org)
  • The tube, which connects the peritoneal space to the endometrial cavity, captures the egg after ovulation and transports the sperm from the uterus to the fertilization site in the ampulla (the middle portion of the tube). (medscape.com)
  • The more cephalad ends of the paired paramesonephric ducts are opened to the peritoneal cavity and develop into the fallopian tubes, while the more caudal portion fuses in the lower midline to form the uterovaginal primordium, which later develops into the epithelium and glands of the uterus and cervix. (medscape.com)
  • If one müllerian duct fails to develop (usually associated with lack of development of the mesonephric system on the same side), a unicornuate uterus results, which consists of one uterine horn with only one fallopian tube. (medscape.com)
  • Complete failure of the müllerian system results in the absence of the fallopian tubes, the uterus, the cervix, and most of the vagina (Rokitansky-Küster-Hauser syndrome). (medscape.com)
  • The paired fallopian tubes extend laterally from the cornua of the uterus on each side and end near the ovaries. (medscape.com)
  • The isthmus is short, about 2.5-4 cm, and begins as the tube exits the uterus. (medscape.com)
  • The egg travels down the fallopian tube towards the uterus. (greatdad.com)
  • It helps diagnose fallopian tube occlusions, malformations in the uterus, Asherman's syndrome and pelvic inflammatory disease. (simple-remedies.com)
  • Using this procedure, you can ascertain whether the tubes are open or occluded and whether the occlusion is situated at the junction of the tube and the uterus or at the end of the fallopian tube. (simple-remedies.com)
  • This will reveal whether the fallopian tubes are open or occluded and whether the obstruction is proximal - i.e. at the intersection of the fallopian tube and the uterus or distal - i.e. at the other end of the fallopian tube. (simple-remedies.com)
  • In case the uterus is normal, but the tubes are blocked, there will be no dye spill at the ends of the tubes. (simple-remedies.com)
  • The fluid gradually fills the uterus and fallopian tubes, straightening all the folds, allowing the doctor to examine their structure, and make a conclusion about whether the fallopian tubes are passable or not. (binaclinic.by)
  • Staging fallopian tube cancer involves the removal of both fallopian tubes and of the ovaries, uterus, cervix, infracolic omentum, and retroperitoneal lymph nodes, in addition to peritoneal washings and peritoneal biopsies. (medscape.com)
  • Gestational trophoblastic disease is a group of proliferative disorders originating from trophoblastic tissue in the uterus. (msdmanuals.com)
  • In the second half of the menstrual cycle, the oocyte travels to the uterus through the fallopian tube. (formularywatch.com)
  • PID can lead to inflammation and scarring of the fallopian tubes and uterus, which can affect your menstrual cycle. (carrottopng.com)
  • This can lead to serious complications, such as inflammation of the upper genital organs (fallopian tubes and uterus), which can reduce a woman's fertility. (elitour.org)
  • Fallopian Tubes: Tubes that connect the ovaries to the uterus, where fertilization typically occurs. (zorahealth.co)
  • To aid primary care physicians, emergency medicine physicians, and gynaecologists in the initial investigation of adnexal masses, defined as lumps that appear near the uterus or in or around ovaries, fallopian tubes, or surrounding connective tissue, and to outline recommendations for identifying women w. (bvsalud.org)
  • The infundibulum, from the Latin word meaning funnel, is the funnel-shaped most distal end of the tube and is in close relation to the ovary. (medscape.com)
  • The purpose of this study is to evaluate the response to treatment with Ribociclib and Letrozole in patients with low-grade serous cancer of the ovary, fallopian tube or peritoneum. (mayo.edu)
  • Histologically documented epithelial carcinoma arising in the ovary, fallopian tube, or peritoneum, from Stage II-IV at diagnosis, receiving initial cytoreductive surgery and chemotherapy with at least one platinum -based chemotherapy regimen. (survivornet.com)
  • Outcomes after multiple lines of chemotherapy for platinum-resistant epithelial cancers of the ovary, peritoneum, and fallopian tube. (nih.gov)
  • Major causes of female infertility may include polycystic ovary syndrome (PCOS), chocolate cysts and pelvic inflammatory disease that affects ovary and fallopian tube. (bangkokhospital.com)
  • These cancers refer to the origin of neoplastic diseases affecting the organs of the female reproductive system, and may originate in the breasts, cervix, uterine body, endometrium, ovary, vulva, vagina and fallopian tube. (bvsalud.org)
  • Newly diagnosed patients with advanced-stage ovarian, fallopian tube, or primary peritoneal cancers should always be evaluated by a gynecologic oncologist if possible. (jnccn.org)
  • Earlier this year an amended ODD status was granted to include both fallopian tube and primary peritoneal cancers following the expanded US approval of Lynparza in August 2017 for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer, who are in a complete or partial response to platinum-based chemotherapy. (worldpharmanews.com)
  • In November 2014, the FDA approved bevacizumab (Avastin) for platinum-resistant, recurrent, epithelial ovarian, fallopian tube, or peritoneal cancers in patients who received no more than two prior chemotherapy regimens. (medscape.com)
  • However, investigators have demonstrated precursor cancerous lesions in the fallopian tube (tubal in-situ carcinoma [TIC]) and have provided evolutionary evidence that many advanced serous ovarian cancers originate in the fallopian tubes. (medscape.com)
  • [ 1 , 2 ] Currently, both early-stage and advanced-stage fallopian tube cancers are treated in much the same way as ovarian cancers-that is, with surgery followed by chemotherapy. (medscape.com)
  • Surgery is the initial therapy for stage I-IV fallopian tube cancers. (medscape.com)
  • Only a small percentage of women with epithelial fallopian tube cancers are treated with surgery alone. (medscape.com)
  • no randomized trials have specifically addressed fallopian tube cancers. (medscape.com)
  • Accordingly, the chemotherapy used to treat primary fallopian tube cancers is based on the standard management of ovarian cancers. (medscape.com)
  • Pancreatic cancer is a rare, life-threatening disease that accounts for about 3% of all cancers in the US. (worldpharmanews.com)
  • Ovarian cancers represent several distinct diseases, which are named after the type of cell they come from: epithelial, germ cell and stromal. (kucancercenter.org)
  • Epithelial ovarian cancers, which represent 85 to 90 percent of malignant ovarian cancers, are a complex group of tumors that arise from multiple different precursor tissues, and the most common and deadly subtype (high-grade serous) is thought to originate primarily in the fallopian tubes. (kucancercenter.org)
  • Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing the last platinum therapy. (nih.gov)
  • Patients 18 years and older with epithelial histology of ovarian or primary peritoneal or fallopian tube carcinoma and a life expectancy of at least 12 months were able to enroll on the trial. (cancernetwork.com)
  • Operations on the pelvic organs, including abortion, endometriosis, previous inflammatory processes, and some congenital features of the development of the fallopian tubes can lead to the fact that spermatozoa cannot cause an egg and pregnancy does not occur. (binaclinic.by)
  • Acute inflammatory diseases of the pelvic organs (cervicitis, vaginitis, endometritis and others). (binaclinic.by)
  • Conditions like endometriosis and pelvic inflammatory disease can lead to adhesion or occlusion of the fallopian tube. (anavara.com)
  • Additional eligibility criteria included having up to 5 prior lines of systemic therapy, an ECOG performance status of 0 or 1, and evaluable disease in the abdominal or pelvic region per RECIST v1.1 criteria. (cancernetwork.com)
  • Pelvic Inflammatory Disease, or PID, scarring of fallopian tubes, and potentially fatal ectopic pregnancy, as well as conjunctivitis and Chlamydial pneumonia in newborns) (4). (nccid.ca)
  • Conditions like pelvic inflammatory disease, often caused by untreated chlamydia or gonorrhea, can lead to scarring of the fallopian tubes, increasing the risk of ectopic pregnancies and infertility. (todays-woman.net)
  • 11 Pelvic inflammatory disease (PID) is the major cause of infertility worldwide. (formularywatch.com)
  • Pelvic inflammatory disease (PID) is an infection of the reproductive organs, usually caused by sexually transmitted infections (STIs). (carrottopng.com)
  • Before you start therapy, Gynaecologic oncologists and pathologists will cooperate to play out a thorough analytic assessment, which might incorporate a pelvic test, ultrasound, lab or potentially other imaging and blood tests, to decide the sort and phase of cancer. (girnhospital.com)
  • The objective of a cervical screening programme is to prevent invasive cancer of the cervix by detecting and treating pre-invasive disease of the cervix. (annals.edu.sg)
  • A clinical syndrome resulting from the ascending spread of microorganisms from the vagina and endocervix to the endometrium, fallopian tubes, and/or contiguous structures. (cdc.gov)
  • In a nonrandomized, open-label Phase II study, MD Anderson researchers demonstrated that talazoparib, a PARP inhibitor, showed activity in patients with germline BRCA1/2 mutation-positive, early HER2-negative breast cancer. (mdanderson.org)
  • For the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, who are in complete or partial response to platinum-based chemotherapy. (merck.com)
  • PURPOSE: Lenvatinib and pembrolizumab (LEN+PEMBRO) demonstrated clinically meaningful and statistically significant improvements in efficacy versus treatment of physician's choice (TPC) in patients with advanced endometrial cancer (aEC) in the phase 3 Study 309/KEYNOTE-775. (bvsalud.org)
  • PURPOSE: A phase I trial to study the side effects of vaccine therapy in patients with ovarian epithelial, primary peritoneal, or fallopian tube cancer. (survivornet.com)
  • Determine the safety of NY-ESO-1b peptide vaccine and Montanide® ISA-51 in patients with ovarian epithelial, primary peritoneal, or fallopian tube cancer. (survivornet.com)
  • Consensus-based guidelines from the National Comprehensive Cancer Network (NCCN) suggest administering three to six cycles of chemotherapy for stage IA-IC disease and six to eight cycles for stage II-IV disease. (medscape.com)
  • Nemvaleukin alfa is under clinical development by Alkermes and currently in Phase III for Fallopian Tube Cancer. (pharmaceutical-technology.com)
  • According to GlobalData, Phase III drugs for Fallopian Tube Cancer have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. (pharmaceutical-technology.com)
  • Alkermes is a biopharmaceutical company that focuses on the research, development, and commercialization of drugs for the treatment of cancer, neurodegenerative and central nervous system (CNS) diseases. (pharmaceutical-technology.com)
  • Cervical cancer is a preventable disease that affects nearly half a million women worldwide. (annals.edu.sg)
  • Fallopian tube cancer is the least common of gynaecological malignancies. (annals.edu.sg)
  • Efficacy data demonstrated no significant differences between treatment groups for any efficacy parameters, including clinical benefit rate, CRs and PRs, as well as stable disease, time to response [TTR], and duration of response [DOR]," Thomas Herzog, MD, a professor of obstetrics and gynecology and deputy director at University of Cincinnati Cancer Institute, said during a presentation on the findings. (onclive.com)
  • The Fred Hutchinson Cancer Research Center in Seattle, the University of Pennsylvania, the Van Andel Institute in Michigan, and the University of California San Francisco have built the infrastructure to share fallopian tube specimens, experimental and clinical data, and analytical teams. (canaryfoundation.org)
  • The research will be performed in two phases: first, a retrospective phase that involves analysis of previously collected, banked fallopian tube samples with associated clinical information, and second, a prospective study, that includes newly collected samples, each with the goal of identifying what changes in the molecular landscape signal cancer. (canaryfoundation.org)
  • 1) Due to the late onset of symptoms, patients are often diagnosed after the cancer has progressed to locally advanced or metastatic stages of the disease. (worldpharmanews.com)
  • The use of Lynparza in pancreatic cancer is being assessed in the ongoing Phase III POLO trial, which is testing Lynparza as maintenance monotherapy vs placebo in patients with germline BRCA-mutated metastatic pancreatic cancer whose disease has not progressed following 1st-line platinum-based chemotherapy. (worldpharmanews.com)
  • POLO is a Phase III, randomised, double-blinded, placebo-controlled trial to evaluate the efficacy and safety of Lynparza tablets (300 mg twice daily) as maintenance monotherapy compared with placebo, in patients with germline BRCA-mutated metastatic pancreatic cancer whose disease has not progressed following 1st-line platinum-based chemotherapy. (worldpharmanews.com)
  • Even when present at lower levels, which is often the case when cancer is in its earliest phases, small extracellular vesicles serve as a promising biomarker for early detection," Dr. Godwin said. (kucancercenter.org)
  • We see treatment exposure and number of prior therapies are relevant and can drive outcomes, and we will leverage these data as we explore and identify new opportunities to treat this deadly disease," David O'Malley, MD, professor of Obstetrics and Gynecology at The Ohio State University Wexner College of Medicine and director of the Division of Gynecologic Oncology at The James Comprehensive Cancer Center, concluded. (cancernetwork.com)
  • Laboratory scientists are investigating the connections between autoimmune diseases and the mechanisms that help cancer grow and spread without being detected by the immune system. (benaroyaresearch.org)
  • Cancer is an umbrella term for a variety of diseases in which abnormal cells divide uncontrollably. (benaroyaresearch.org)
  • The goal of our research is to better understand mechanisms of sensing and repair during diseases like cancer, infections, and neurodegenerative disorders. (benaroyaresearch.org)
  • Methodology This double-blind, placebo (PBO)-controlled, phase 3 trial evaluated niraparib in pts with newly diagnosed, advanced, high-grade serous or endometrioid ovarian, primary peritoneal, or fallopian tube cancer with a complete or partial response to first-line CT. (bmj.com)
  • Recurrent, advanced, platinum resistant ovarian, fallopian tube, and primary peritoneal cancer and must have a histological diagnosis of a high-grade serous histology. (survivornet.com)
  • Doubling of cancer antigen 125 (CA-125) level on 2 successive measurements may be considered as meeting the definition of disease progression b) Have received at least 2 lines of prior therapy including a platinum-based regimen if eligible and a poly-ADP ribose polymerase ( PARP ) inhibitor if BRCA 1/2 mutated. (survivornet.com)
  • This randomized phase II/III trial studies how well pegylated liposomal doxorubicin hydrochloride with atezolizumab and/or bevacizumab work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back. (clinicaltrialsgps.com)
  • It is not yet known which combination will work better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer. (clinicaltrialsgps.com)
  • This phase I study was conducted to determine the maximum tolerated dose and the recommended phase II dose of weekly administered Genexol-PM combined with carboplatin in patients with gynecologic cancer. (e-crt.org)
  • This open-label, phase I, dose-escalation study of weekly Genexol-PM included 18 patients with gynecologic cancer, who were equally divided into three cohorts of dose levels. (e-crt.org)
  • Because of the disseminated nature of the disease, primary peritoneal cancer is treated with surgical debulking and chemotherapy. (medscape.com)
  • Disparities between Uptake of Germline BRCA1/2 Gene Tests and Implementation of Post-test Management Strategies in Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients. (cdc.gov)
  • Complex coordinated contractions of the musculature are thought to be important for movement of the ovum from the distal end to the proximal end of the tube, while at the same time aiding in the movement of sperm from the proximal end to the distal end of the oviduct. (medscape.com)
  • The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
  • In a distal blockage, there is hydrosalpinx with dilatation of the fallopian tube mainly due to a previous infection. (anavara.com)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
  • After the infectious process, the patency of the fallopian tubes can be assessed no earlier than in 2-3 weeks. (binaclinic.by)
  • The Phase 1 clinical study is expected to begin enrollment this year and is being funded by the National Institute of Allergy and Infectious Diseases (NIAID), an institute within the National Institutes of Health (NIH). (bluewillow.com)
  • In the transatlantic CLEAN-PCD study, an international team led Dr Felix Ringshausen, senior physician at the Department of Pneumology and Infectious Diseases at Hannover Medical School (MHH), has now investigated a new treatment approach. (mhh.de)
  • This and other reviews in the series will contribute to advancing Canadian practice by providing information necessary to identifying commonalities in the practice of PN, challenges relating to specific diseases / infectious agents, and proposed strategies to address them. (nccid.ca)
  • Hydrosalpinx is distally blocked, dilated, fluid-filled fallopian tube caused by infectious diseases. (drmaggiejuacupuncture.com)
  • Not only to identify fertility problems, premarital screening also enables women to assess general health status, detect infectious diseases and screen hereditary conditions that may affect the future offspring. (bangkokhospital.com)
  • This report provides updated uniform criteria* for state health department personnel to use when reporting the nationally notifiable infectious diseases listed in Part 1 of this report. (cdc.gov)
  • Fallopian tube carcinomas were once believed to be rare. (medscape.com)
  • The fallopian tube is an essential component of the normal reproductive process. (medscape.com)
  • This chapter addresses the management of weight related to three phases of a woman's reproductive years - precon-ception, during pregnancy and postpartum - for adult wom-en with obesity. (bvsalud.org)
  • Although these reproductive periods are addressed separately, it is important to consider that these phases re. (bvsalud.org)
  • The inserts for the hysteroscopic sterilization system available in the United States are placed bilaterally into the fallopian tubes and require 3 months for adequate fibrosis and scarring leading to bilateral tubal occlusion. (cdc.gov)
  • HIPEC after neoadjuvant chemotherapy and interval debulking is associated with development of platinum-refractory or -resistant disease. (nih.gov)
  • The major indications of fallopian tube recanalization are blockages in the proximal and middle portions of the fallopian tube. (anavara.com)
  • Fallopian tube recanalization (FTR) is a non-surgical procedure performed to clear blockages of the fallopian tube. (anavara.com)
  • The procedure needs to be carried out during the follicular phase of the cycle. (simple-remedies.com)
  • It is performed under fluoroscopic guidance during the follicular phase of the menstrual cycle after the cessation of menses. (anavara.com)
  • The purpose of the follicular phase is to develop a follicle capable of undergoing ovulation. (formularywatch.com)
  • At the beginning of the follicular phase there is a rise in FSH levels on the first day of the cycle, which prompts a reduction in progesterone and estrogen levels at the end of the previous cycle. (formularywatch.com)
  • Most pregnancies occurred after deviations from FDA directions, which include placement in the early follicular phase of the menstrual cycle, imaging at 3 months to document proper placement, and use of effective alternative contraception until documented occlusion (Level of evidence: II-3, fair, direct). (cdc.gov)
  • Treatments include anti-inflammatory drugs, drugs to suppress ovarian function and endometrial tissue growth, surgical ablation and excision of endometriotic implants, and, if disease is severe and no childbearing is planned, hysterectomy alone or hysterectomy plus bilateral salpingo-oophorectomy. (msdmanuals.com)
  • Luteal phase deficiency (LPD) is a condition in which there is either no enough progesterone production or poor endometrial response. (drmaggiejuacupuncture.com)
  • One of the leading causes of female infertility is the obstruction of the fallopian tubes. (binaclinic.by)
  • Tube infertility is practically untreatable and there is a very little chance of natural conception. (binaclinic.by)
  • Affectations of the fallopian tube account for the most common cause of female infertility. (anavara.com)
  • Infertility due to male factors, fallopian tube factors, or unknown causes. (who.int)
  • Compare the objective tumor response rate, progression-free survival, and disease control in patients treated with these regimens. (knowcancer.com)
  • Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
  • Patients are followed at day 30, every 9 weeks until disease progression, and then every 6 months thereafter. (knowcancer.com)
  • Data from the phase III EORTC 55971 trial 1 and the CHORUS trial 2 suggest that progression-free survival (PFS) and OS are equivalent between up-front chemotherapy and up-front surgery ( Table 1 ). (jnccn.org)
  • Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.We report the final prespecified analysis for overall survival (OS), along with updated progression-free survival (PFS) and objective response rate (ORR), and safety from the open-label, randomized, phase III Study 309/KEYNOTE-775. (bvsalud.org)
  • Patients receive NY-ESO-1b peptide vaccine emulsified with Montanide® ISA-51 subcutaneously once every 3 weeks on weeks 1, 4, 7, 10, and 13 in the absence of disease progression or unacceptable toxicity. (survivornet.com)
  • Patients are followed at 3 weeks (week 16) and then every 6-12 weeks for 2 years or until disease progression. (survivornet.com)
  • Those with prior disease progression on treatment with weekly paclitaxel for recurrent disease or brain metastasis or leptomeningeal spread of the tumor were not able to enroll on the trial. (cancernetwork.com)
  • Pts were considered to be at a high risk for disease progression based on their clinical characteristics. (bmj.com)
  • a) Platinum resistant disease is defined as progression of disease within six months of platinum regimen. (survivornet.com)
  • In all arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. (clinicaltrialsgps.com)
  • A radiomics method based on MR FS-T2WI sequence for diagnosing of autosomal dominant polycystic kidney disease progression. (cdc.gov)
  • The FDA grants ODD status to medicines intended for the treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the US. (worldpharmanews.com)
  • In the congenital disease primary ciliary dyskinesia (PCD), the function of the cilia is particularly severely disturbed and self-cleaning no longer works. (mhh.de)
  • Efficacy outcomes by surgical timing, either primary debulking surgery (PDS) or interval debulking surgery (IDS), and postoperative residual disease status, either no visible residual disease (NVRD) or visible residual disease (VRD), are shown in table 1 . (bmj.com)
  • While discovering an infection can cause relationship strife, leaving a disease like gonorrhea untreated can impact future fertility chances . (thoughtcatalog.com)
  • Preference is now given to the term 'STI' (sexually transmitted infection) because not all infected individuals develop symptomatic disease, although they carry the potential to develop symptoms and to transmit infection to others. (nccid.ca)
  • One of the first things you should do when planning for a pregnancy or upon finding out you are pregnant is to get a full health check-up, which should include sexually transmitted disease and infection testing . (todays-woman.net)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
  • They can ensure you're free from diseases and conditions which could impact your fertility. (thoughtcatalog.com)
  • The guide will start with an overview of the anatomy of fertility-the essential elements that must operate well for conception to occur-and then, with this understanding, walks through the phases of preconception preparation, step-by-step. (banyanbotanicals.com)
  • A new antibody-drug conjugate, mirvetuximab soravtansine, has been approved for use in a subset of patients with platinum-resistant disease. (jnccn.org)
  • Among 36 patients with platinum-resistant disease, 6 patients had partial response (PR) and 12 had stable disease. (targetedonc.com)
  • No more than 3 lines of prior therapy for the treatment of platinum resistant disease is permitted. (survivornet.com)
  • Single-agent treatment is the preferred approach for patients with platinum-resistant disease or for patients with intermediate platinum-sensitive disease with a short time to recurrence of 6-12 months. (medscape.com)
  • Affected people suffer from chronic respiratory diseases such as bronchitis, pneumonia or dilatation of the lower airways (bronchiectasis) from an early age. (mhh.de)
  • The tubes sit within the abdominal cavity and are suspended by the mesosalpinx, a free edge of the superior portion of the broad ligament that contains the blood supply and nerves. (medscape.com)
  • If the tubes are patent, then the dye will fill the tubes and spill out into the abdominal cavity. (simple-remedies.com)
  • In fact, most patients with stage I disease are treated with adjuvant chemotherapy because of the luminal structure of the organ and the risk of shedding cells out of the tubes and into the abdominal cavity. (medscape.com)
  • In this phase people are likely to develop jaundice (yellowing of the skin and eyes, hence the name 'yellow fever'), dark urine and abdominal pain with vomiting. (speedpix.com)
  • In another phase III study, MITO-7, the combination of weekly paclitaxel (60 mg/m 2 ) and carboplatin (3 AUC) was better tolerated than the tri-weekly regimen, with favorable quality-of-life scores and reduced frequency of grade 3-4 toxicities [ 11 ]. (e-crt.org)
  • Among the most important are platinum sensitivity, the status of BRCA and homologous recombination deficiency (HRD), and the changing indications for PARP inhibitors in recurrent disease and maintenance. (jnccn.org)
  • In a Phase II study, MD Anderson researchers showed that a regimen of neoadjuvant and adjuvant treatment with checkpoint inhibitors nivolumab, a PD-1 inhibitor, and relatlimab, a LAG-3 inhibitor, was safe and effective in patients with resectable clinical stage III melanoma. (mdanderson.org)
  • Dr. Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories, said, "Building on the strong data we've seen with LYNPARZA to date, the data from SOLO-1 reinforce LYNPARZA's ability to provide meaningful disease control with a well-characterized safety and tolerability profile. (merck.com)
  • Wilson Disease Prevalence: Discrepancy Between Clinical Records, Registries and Mutation Carrier Frequency. (cdc.gov)
  • PCD is a rare disease and affects about one in 10,000 newborns in Germany. (mhh.de)
  • Similar to the respiratory disease cystic fibrosis, thick mucus accumulates in the airways. (mhh.de)
  • PCD is a severe disease that severely limits life," says Dr. Ringshausen, head of the special outpatient clinics for bronchiectasis disease, PCD and cystic fibrosis and first author of the study. (mhh.de)
  • In luteal phase defect, there is no enough progesterone produced which shows either low progesterone or too much fluctuation of progesterone levels. (drmaggiejuacupuncture.com)
  • Minimally invasive laparoscopic surgery is an advanced surgical treatment of gynecologic diseases. (bangkokhospital.com)
  • During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. (mayo.edu)
  • Therefore, this new organoid model closely mimics the normal physiology and anatomy of the human fallopian tube epithelium and provides a starting point for future investigations into the regulatory mechanisms involved in its cellular renewal and pathology. (nature.com)
  • In a proximal blockage of the fallopian tubes, there is usually the presence of debris which forms a plug in the proximal tube. (anavara.com)
  • The inflammation of the fallopian tube increases the likelihood of the procedure failing. (anavara.com)
  • This has been attributed be to the sluicing out of the fallopian tubes, opening up some small occlusion or cleansing debris that was not allowing conception. (simple-remedies.com)
  • Finally, chlamydia (a sexually transmitted disease) can be responsible for the appearance of vaginitis. (elitour.org)
  • Approval was based on results from the Phase III AURELIA study, which showed that adding bevacizumab to chemotherapy significantly improved progressive-free survival (PFS) and overall response rate (ORR). (medscape.com)
  • It can, however, be caused by bacteria, fungi or even sexually transmitted parasites or diseases. (elitour.org)
  • Exome sequencing and targeted gene panels: a simulated comparison of diagnostic yield using data from 158 patients with rare diseases. (cdc.gov)
  • In newly diagnosed patients with advanced disease, neoadjuvant chemotherapy can be considered if upfront surgery is felt not to be advisable. (jnccn.org)
  • However, historically, the best outcomes have been reported when upfront surgery that leaves no residual disease can be achieved, 3 - 5 and upfront surgery should be considered for patients in whom optimal cytoreduction can be safely achieved. (jnccn.org)
  • Thirteen patients had stable disease lasting at least 4 months. (targetedonc.com)
  • It is not uncommon for patients to suffer for a long time before the disease is even clearly diagnosed. (mhh.de)
  • This is especially true for patients with metastatic disease where the benefits of current treatment options are very limited. (worldpharmanews.com)
  • A small percentage of patients, however, enter a second, more toxic phase within 24 hours of recovering from initial symptoms. (speedpix.com)
  • Bariatric surgery should be considered for patients with severe obesity (body mass index (BMI) ≥ 35 kg/m2) and obesity-related diseases, or BMI ≥ 40 kg/m2 without obesity-related diseases. (bvsalud.org)
  • Cilia are also found in sperm and in the fallopian tubes, which is why PCD is often associated with an unfulfilled desire to have children. (mhh.de)