• Digoxin is a cardiac glycoside with direct inotropic effects, as well as indirect effects, on the cardiovascular system. (medscape.com)
  • Cardiac digitalis is also called digoxin and cardiac glycoside. (stackexchange.com)
  • Digoxin is a cardiac glycoside used in the management of particularly atrial fibrillation and in heart failure. (oushodsheba.com)
  • IV digoxin can only be given to patients who have not received cardiac glycosides in the preceding 2 wk. (oushodsheba.com)
  • Mechanism of action of digoxin (Lanoxin) reviewed: animation and excerpts of a pharmacology textbook on the pharmacological effects of this cardiac glycoside for heart failure. (pharmacologycorner.com)
  • The leaves of Digitalis Purpurea are the source of Digitoxin and Digoxin, which are cardiac glycosides. (howmed.net)
  • Our purpose was to determine the effect of progressive i.v. infusion of either ASI-222, a polar aminocardenolide agent, or digoxin, a neutral cardenolide, on cardiac sympathetic, efferent vagal, and carotid sinus nerve activity. (elsevierpure.com)
  • Digoxin or ASI-222 were infused into anesthetized dogs at dose rates which caused cardiac arrhythmias in about 2 hr. (elsevierpure.com)
  • Digoxin and ASI-222 produce different profiles of changes in cardiac autonomic nerve activity and appear to differ in autonomic reflex receptor interactions. (elsevierpure.com)
  • Forskolin, a diterpene derivative of the Indian plant Coleus forskhohlii , proved to be a marked positive inotropic and vasodilatory compound in animal experiments with a mechanism of action distinct from catecholamines, cardiac glycosides, and phosphodiesterase-inhibiting compounds. (lww.com)
  • Master's Degree in Pharmacology and Toxicology is a form of organization proposed graduate of Faculty of Pharmacy of Craiova. (umfcv.ro)
  • Currently, Romanian medical and pharmaceutical research is largely based on clinical studies and less on investment in creating new drugs, which require specialists with interdisciplinary field of Pharmacology and Toxicology. (umfcv.ro)
  • The specific objective of the Master in Pharmacology and Toxicology consists in the formation and development of complementary skills preparation of initial medical and pharmaceutical students in order to improve efficiency of health services, high quality in terms of medical or research activity. (umfcv.ro)
  • Master's program budget in Pharmacology and Toxicology is part of the budget of the Faculty of Pharmacy UMF Craiova, the latter being the institution which has legal personality. (umfcv.ro)
  • For example, diuretics lower plasma [K+] and thus increase sensitivity for cardiac glycosides. (trc-p.nl)
  • Potentially Fatal: Electrolyte imbalances such as hypokalaemia and hypomagnesemia (e.g. admin of potassium-losing diuretics, corticosteroids) can increase the risk of cardiac toxicity. (oushodsheba.com)
  • In today's pharmacology , only these are called diuretics. (zxc.wiki)
  • Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D. Patients should be monitored with regard to electrocardiogram (ECG) and serum calcium levels. (com.bd)
  • Since these drugs' safety and efficacy in humans are already known and proven, they may readily go through clinical validation and be made available to patients more quickly," said the first author of the study, who is also a professor in the Department of Pharmacology at the University of Montreal. (drugdiscoverytrends.com)
  • Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. (pharmacycode.com)
  • Chemistry - A cardiac glycoside, digitoxin occurs as a bitter tasting, odorless, white to pale buff colored, microcrystalline powder. (elephantcare.org)
  • Journal of Pharmacology and Experimental Therapeutics , 253 (1), 180-184. (elsevierpure.com)
  • Rebagay, WR & Caldwell, RW 1990, ' Different patterns of autonomic nerve activity produced by a polar vs. a neutral cardiac glycoside ', Journal of Pharmacology and Experimental Therapeutics , vol. 253, no. 1, pp. 180-184. (elsevierpure.com)
  • For the American Society for Pharmacology and Experimental Therapeutics newsletter, see The Pharmacologist . (atozwiki.com)
  • Symptoms: Hyperkalaemia, cardiac arrhythmias and heart block. (oushodsheba.com)
  • sympathetic nerve activity remained depressed even through the onset of cardiac arrhythmias. (elsevierpure.com)
  • This is because digitalis poisoning is associated with cardiac disturbances: ventricular tachycardia, ventricular fibrillation, SA block and AV block. (stackexchange.com)
  • The mechanism of action of digitalis-like preparations based on inhibition of myocardial NA+/K+-ATPase as well as of cardiac conducting tissue. (stackexchange.com)
  • Digitalis agents react with various peripheral reflex receptor areas (i.e., carotid artery baroreceptors and cardiac mechanoreceptors) to alter autonomic nerve activity. (elsevierpure.com)
  • Agoxin 0.25 mg is a cardiac glycoside used in the management of particularly atrial fibrillation and in heart failure. (medeasy.health)
  • Cardiac dysfunction was observed as a decrease in mean arterial pressure (MAP), heart rate (HR), left ventricular rate of peak positive and negative pressure change {(+) and (-) LV dP/dt} and elevated left ventricular end diastolic pressure (LVEDP) following ISP administration. (scialert.net)
  • While compounds of both groups can be used to influence the cardiac output of the heart, cardenolides are more commonly used medicinally, primarily due to the widespread availability of the plants from which they are derived. (wikipedia.org)
  • Clinical pharmacokinetics is a branch of pharmacology that studies the clinical aspects of absorption , distribution, metabolism, and excretion of drugs . (pharmacologymentor.com)
  • Drug acting on cardiovasular system: cardiac glycosides, Anti hypertensive, anti arrhythmic and anti anginal drugs. (gen.in)
  • Pharmaceutics: Parenterals Pharmacology & Medicinal Chemistry: Synthesis, SAR & Metabolism of drugs acting on ANS. (gpatindia.com)
  • Pharmaceutics: Drug Delivery Systems: NDDS (complete NDDS) Pharmacology & Medicinal Chemistry of: Drugs Acting on Central Nervous System - Local & General anaesthetics, narcotic & non-narcotic analgesics Pharmacognosy: Alkaloids Microbiology: Application of microorganism in Bio-conversions & in pharmaceutical industry. (gpatindia.com)
  • Pharmaceutics: Aerosols & Pharmaceutical calculation Pharmacology & Medicinal Chemistry of: Drugs Acting on Central Nervous - antiepilaptics, Sedatives & hypnotics, CNS Stimulents, antiparkinsonian & Psychopharmacological agents. (gpatindia.com)
  • These drugs are normally used to treat other diseases, such as heart failure, cardiac arrhythmia, and infections. (drugdiscoverytrends.com)
  • Among the drugs selected for validation in various types of cancer cells were notably cardiac glycosides and antibiotics, whose epigenetic effects were previously unknown. (drugdiscoverytrends.com)
  • The scientists also observed a "class effect," since half of the drugs were cardiac glycosides. (drugdiscoverytrends.com)
  • We need more research on drugs that target intracellular calcium signalling, such as cardiac glycosides and antibiotics. (drugdiscoverytrends.com)
  • Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. (wikipedia.org)
  • hellebore) Cardiac glycosides affect the sodium-potassium ATPase pump in cardiac muscle cells to alter their function. (wikipedia.org)
  • Cardiac glycosides, however, inhibit this pump by stabilizing it in the E2-P transition state, so that sodium cannot be extruded: intracellular sodium concentration therefore increases. (wikipedia.org)
  • With regard to potassium ion movement, because both cardiac glycosides and potassium compete for binding to the ATPase pump, changes in extracellular potassium concentration can potentially lead to altered drug efficacy. (wikipedia.org)
  • The studies include Na+, K(+)-ATPase activity and its isoforms as well as the cellular uptake of these cardiac glycosides. (nih.gov)
  • These data suggest that differential expressions of Na+, K(+)-ATPase activities and its isoforms in BRO and B16 cells as well as cellular drug uptake may be important determinants of tumor cell sensitivity to cardiac glycosides. (nih.gov)
  • Cardiac glycosides bind to the Na+/K+-ATPase pump and inhibit its action. (trc-p.nl)
  • It acts directly on cardiac muscle, increasing myocardial systolic contractions. (medscape.com)
  • Thought you might appreciate this item(s) I saw in Journal of Cardiovascular Pharmacology. (lww.com)
  • Consultation with a cardiac electrophysiologist or knowledgeable clinician is recommended prior to antiarrhythmic drug initiation. (medscape.com)
  • The origins of clinical pharmacology date back to the Middle Ages , with pharmacognosy and Avicenna 's The Canon of Medicine , Peter of Spain 's Commentary on Isaac , and John of St Amand 's Commentary on the Antedotary of Nicholas . (atozwiki.com)
  • This alters the electrical activity of the heart and decreases cardiac conduction velocity (dromotropic effect). (trc-p.nl)
  • Magnesium sulfate , given i.v., is a useful alternative when β-mimetics are contraindicated, but must be carefully titrated because its nonspecific calcium antagonism leads to blockade of cardiac impulse conduction and of neuromuscular transmission. (manualofmedicine.com)
  • Answer: when the heart cannot pump out the required amount of blood for the whole body it makes heart failure but still heart and body tried compensate to make balance or homeostasis this is the compensatory mechanism to maintain the cardiac function. (topassignmentexperts.com)
  • In addition treatment with T. terrestris decreased the leakage of CK-MB and LDH enzymes from myocardium, there was a significant improvement in cardiac function as evidenced by correction of MAP, HR, LVEDP and contractility and relaxation. (scialert.net)
  • But, I have gathered a lot of Pharmacy(Like Pharmacology, Pharmaceutics and analysis etc. ) books which are downloadable only. (pharmaclub.in)
  • This is consistent with epidemiological studies showing less cancer in patients treated with cardiac glycosides, and less aggressive cancers in patients that did have cancer," he said. (drugdiscoverytrends.com)
  • Most commonly found as secondary metabolites in several plants such as foxglove plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment. (wikipedia.org)
  • Pharmacology, a biomedical science , deals with the research, discovery, and characterization of chemicals which show biological effects and the elucidation of cellular and organismal function in relation to these chemicals. (atozwiki.com)
  • Cardiac glycosides have a narrow therapeutic window and therapeutic drug monitoring is therefore often necessary. (trc-p.nl)
  • The Teaching Resource Centre (TRC) Pharmacology Database is a teaching website for a better understanding of drug mechanisms, primarily focussing on (bio)medical or students Biopharmaceutical Sciences. (trc-p.nl)
  • The word pharmacology is derived from Greek φάρμακον , pharmakon , "drug, poison " and -λογία , -logia "study of", "knowledge of" [3] [4] (cf. the etymology of pharmacy ). (atozwiki.com)
  • milkweed): oleandrin Adonis vernalis (Spring pheasant's eye): adonitoxin Kalanchoe daigremontiana and other Kalanchoe species: daigremontianin Erysimum cheiranthoides (wormseed wallflower) and other Erysimum species Cerbera manghas (suicide tree): cerberin Periploca sepium: periplocin some species of Chrysolina beetles, including Chrysolina coerulans, have cardiac glycosides (including Xylose) in their defensive glands. (wikipedia.org)
  • Caitlin Risener, a Ph.D. candidate in Emory's Molecular and Systems Pharmacology graduate program and the Center for the Study of Human Health, is first author of the current paper. (leisurenewshubb.com)