• Ion-channel block can lead to acute and delayed arrhythmias, while biochemical toxicities can result in cell death, abnormal cardiac function, and even heart failure and death. (the-scientist.com)
  • However, pathological conditions can disrupt this intricate mechanosensory system and manifest as potentially life-threatening cardiac arrhythmias. (mdpi.com)
  • His research interests include basic science research in advanced cardiac life support, and atrial fibrillation, the clinical pharmacology of antiarrhythmic drugs, and clinical research on implanted devices, antiarrhythmic drugs, and quality of life in patients with arrhythmias. (torontoheartcentre.ca)
  • Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2019 5 56 (3): 313-319. (cdc.gov)
  • Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2019 10 57 (1): 97-103. (cdc.gov)
  • Our laboratory studies the electrophysiology of cardiac muscle and the generation of arrhythmias. (bristol.ac.uk)
  • Interplay between cardiac function and structure in modulating deadly arrhythmias in the human heart, computer modelling and simulation towards a reduction and replacement of animals in research and safer drugs in human, and advanced mathematical modelling for cardiac tissue and magnetic resonance imaging. (ox.ac.uk)
  • The development of novel non-invasive imaging modalities (Electrocardiographic Imaging, ECGI) for the diagnosis and guided therapy of cardiac arrhythmias. (ox.ac.uk)
  • Cardiac arrhythmias and sudden cardiac death are important late complications of this syndrome. (medscape.com)
  • On the QT' provides clinicians, medical students, drug developers and regulators with a basic review of cardiac electrophysiology, the pharmacology of antiarrhythmic drugs, a review of current regulatory guidelines, how to measure the QT and other ECG manifestations of cardiac repolarization as well as possible future direction in these areas. (crediblemeds.org)
  • By measuring electrical activity in isolated single cardiac myocytes and in excised perfused intact hearts, we aim to better understand the processes underlying cardiac repolarization and their modulation in disease states. (bristol.ac.uk)
  • Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes. (ox.ac.uk)
  • Ma S, Ma J, Guo L, Bai J, Mao S, Zhang M ( 2019 ) Tongguan capsule-derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts. (multichannelsystems.com)
  • Atrial fibrillation (AF) is the most common disturbance of cardiac rhythm and is associated with significantly increased mortality. (bristol.ac.uk)
  • She received her PhD in pharmacology and toxicology from the University of Arizona in 2012 for which she identified cysteine cathepsins as novel targets of UVA-induced photooxidative stress. (the-scientist.com)
  • The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative approaches to support early detection and prediction as well as improved understanding of cardiovascular toxicology and pathobiology. (hesiglobal.org)
  • This award offers Postdoctoral or Early Career researchers working in cardiovascular safety science or a related field, an opportunity to share your research, learn from and network with experts in the toxicology and safety pharmacology fields from academia, regulatory agencies and pharmaceutical companies. (hesiglobal.org)
  • An article that included best practices for use of stem cell cardiomyocytes in cardiac safety assessments was published in Regulatory Toxicology and Pharmacology . (hesiglobal.org)
  • [ 1 ] Beck was the first physician to use DC defibrillation on a human to treat ventricular fibrillation on a 14-year-old during cardiac surgery in 1947. (medscape.com)
  • Written by current leaders in the field, Augoustides and Kaplan's Cardiac Anesthesia Review summarizes critical, must-know cardiac anesthesia knowledge in a concise, quick-review format making this an indispensable review tool for cardiac anesthesiologists and fellows, as well as advanced residents seeking a cardiac fellowship. (icebe.es)
  • From 1983 to 1985, he completed a Fellowship in Cardiac Electrophysiology at Stanford University Medical Centre in California. (torontoheartcentre.ca)
  • The HESI Cardiac Safety Committee seeks Postdoctoral or Early Career researchers working in cardiovascular safety science or a related field for the 2024 Early Career Seminar Award Series . (hesiglobal.org)
  • The effect of blocking the fast inward sodium current causes the phase 0 depolarization of the cardiac action potential to decrease (decreased V max ).It seems still efficacious as an IV antimalarial against Plasmodium falciparum. (explained.today)
  • Transient delivery of electrical current causes a momentary depolarization of most cardiac cells allowing the sinus node to resume normal pacemaker activity. (medscape.com)
  • Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ ( 2019 ) A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia. (multichannelsystems.com)
  • Many in vitro assays exist for the pre-clinical evaluation of hERG-related cardiotoxicity [ 8 ], examples include rubidium-flux assays, radioligand binding assays, in vitro electrophysiology measurements, and fluorescence-based assays [ 9 ]. (springer.com)
  • What we set out to do was to try to solve that problem by building a computer-based pipeline for screening," said Colleen Clancy, a professor in the Department of Physiology and Membrane Biology and the Department of Pharmacology at the UC Davis School of Medicine. (newswise.com)
  • The big challenge computationally is the system that we studied is pretty large," said study co-author Igor Vorobyov, an assistant professor in the Department of Physiology and Membrane Biology and the Department of Pharmacology at the UC Davis School of Medicine. (newswise.com)
  • Zhang YH, Wu W , Sun HY, Deng XL, Cheng LC, Li X, Tse HF, Lau CP, Li GR. Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases. (ucsd.edu)
  • A blocker of the funny/HCN channels (ivabradine) approved in 2005 has proved efficacious in the treatment of coronary artery disease and heart failure by reducing cardiac frequency (and hence metabolic demand). (wikipedia.org)
  • Pediatric cardiology is accountable for the diagnosing of inborn coronary failure, performing arts diagnostic procedures like echocardiograms, cardiac catheterizations and electrophysiology studies. (cardiologymeeting.com)
  • Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going? (simula.no)
  • Kussauer S, David R, Lemcke H ( 2019 ) hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us. (multichannelsystems.com)
  • The WISE workshop was convened to review results from the Women's Ischemic Syndrome Evaluation (WISE) study and other studies of ischemic heart disease to examine the nature and scope of gender differences in both chronic and acute cardiac ischemia, in terms of clinical manifestations, detection, and treatment. (ahajournals.org)
  • There is a substantial body of scientific literature about the presentation of acute cardiac ischemia (ACI) in women, including acute myocardial infarction (AMI) and unstable angina pectoris, which can lead to AMI. (ahajournals.org)
  • She previously worked as a postdoctoral scientist for two years in GlaxoSmithKline's Safety Pharmacology group, where her research focused on developing and validating an electrophysiology assay using human induced pluripotent stem cell-derived cardiomyocytes for cardiac safety screening. (the-scientist.com)
  • Turn to the trusted team of Drs. Joel A. Kaplan and John G.T. Augoustides for focused, comprehensive guidance on topics relevant to certification examinations for adult cardiac anesthesiology practitioners. (icebe.es)
  • Resume the dose that was used prior to initiating the CYP3A4 inhibitor 2 to 3 days after discontinuation of the strong inhibitor [see Drug Interactions (7.1) , Clinical Pharmacology (12.3) ]. (guidelinecentral.com)
  • in patients with moderate or severe hepatic impairment (Childs-Pugh categories B and C), since alfuzosin blood levels are increased in these patients [ see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3) ]. (sdrugs.com)
  • with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since alfuzosin blood levels are increased [ see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ]. (sdrugs.com)
  • Caution should be exercised when Fual extended-release tablets are administered in patients with severe renal impairment [ see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3) ]. (sdrugs.com)
  • Fual extended-release tablets are contraindicated for use in patients with moderate or severe hepatic impairment [ see Contraindications (4), Use in Specific Populations (8.7) and Clinical Pharmacology (12.3) ]. (sdrugs.com)
  • Although the pharmacokinetics of Fual extended-release tablets have not been studied in patients with mild hepatic impairment, caution should be exercised when Fual extended-release tablets are administered to such patients [ see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3) ]. (sdrugs.com)
  • Cardiology and neurology pharmacology lectures. (midwestern.edu)
  • Dr. Paul Dorian is the Department Director, Division of Cardiology, University of Toronto and Staff Cardiac Electrophysiologist at St. Michael's Hospital. (torontoheartcentre.ca)
  • He is Professor of Medicine in the Division of Cardiology and in the Division of Clinical Pharmacology at the University of Toronto, and a Staff Scientist at the Li Ka Shing Knowledge Institute. (torontoheartcentre.ca)
  • Develop fast computational toolkits to reproduce the heart structure and function, including ionic dynamics and activation (electrophysiology), contraction and pump blood (mechanics) and scar growth and remodelling (biochemistry), and search key mechanisms in myocardial infarction (MI), aiming to aid clinical management and drug development for MI. (ox.ac.uk)
  • Eisenmenger syndrome refers to any untreated congenital cardiac defect with intracardiac communication that leads to pulmonary hypertension, reversal of flow, and cyanosis. (medscape.com)
  • This was the first description of a link between a large congenital cardiac shunt defect and the development of pulmonary hypertension. (medscape.com)
  • Originally described in association with a large VSD, Eisenmenger syndrome can also manifest with a patent ductus arteriosus (PDA) or, less frequently, with other congenital cardiac anomalies, such as atrioventricular septal defects (AVSDs) and atrial septal defects (ASDs). (medscape.com)
  • Amend N, Thiermann H, Worek F, Wille T ( 2019 ) The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicol Lett 308:1-6. (multichannelsystems.com)
  • In 1979, he and collaborators discovered the so-called "funny" (or "pacemaker") current in cardiac pacemaker cells, a new mechanism involved in the generation of cardiac spontaneous activity and autonomic regulation of heart rate. (wikipedia.org)
  • By identifying in 1979 the If ("funny") pacemaker current in the sinus node, Dario DiFrancesco challenged the prevailing theory and proposed a novel mechanism to explain the origin of cardiac rhythm. (wikipedia.org)
  • Based on the discovery of the new "funny" channels, carrying an inward (mixed Na+ and K+) current and activating on hyperpolarization, he modified the concept of cardiac pacemaking by demonstrating that the universally accepted "pacemaker" theory of the time, attributed to the deactivation of an outward potassium current (IK2) in Purkinje fibres, was wrong and had to be turned upside-down. (wikipedia.org)
  • Newswise - Death from sudden cardiac arrest makes headlines when it strikes athletes. (newswise.com)
  • The leading risk factors for sudden cardiac arrest are a past attack and the presence of disease. (newswise.com)
  • We find that istaroxime treatment ameliorates the in vivo Ca2+ dysregulation, rescues the cellular action potential duration alternans, while it improves cardiac relaxation. (bvsalud.org)
  • As well as in cardiomyocytes, it opened a new field of research in neurons, where a similar current (hyperpolarization activated Ih) was described soon after the cardiac If. (wikipedia.org)
  • Canine cardiomyocytes treated with PI3K inhibitors show an increased action potential duration and reduced cardiac repolarizing currents. (bvsalud.org)
  • This group is working to understand and characterize use of stem cell-derived cardiomyocytes in cardiac safety assessments. (hesiglobal.org)
  • This mutation triggers cardiac contractile dysfunction and arrhythmogenesis by affecting intracellular Ca2+ dynamics. (bvsalud.org)
  • A major interest of our group are the mechanisms by which GPCR hormones modulate cardiac cellular electrophysiology. (bristol.ac.uk)
  • The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. (bvsalud.org)
  • This project using a common model of arterial hypertension is examining changes associated with hypertension in the electrophysiology of the atrium that might contribute to the incidence of AF. (bristol.ac.uk)
  • Development of the syndrome represents a point at which pulmonary hypertension is irreversible and is an indication that the cardiac lesion is likely inoperable (see the image below). (medscape.com)
  • Is advanced ECG & Pharmacology the same as ACLS? (code1web.com)
  • Very often we are asked if the advanced ECG and Pharmacology course is the same as the ACLS course. (code1web.com)
  • ACLS will improve your ability to recognize and treat cardiopulmonary arrest and to manage immediate post cardiac arrest. (code1web.com)
  • The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface ECG. (explained.today)
  • In particular, hormones such as endothelin have been associated with pathological changes in cardiac function. (bristol.ac.uk)
  • Function and Pharmacology. (ucsd.edu)
  • Cardiac function is modulated by neurotransmitters and hormones that exert their effects via G-protein-coupled receptors on the membrane surface. (bristol.ac.uk)
  • With the intention of protecting clinical trial participants and patients, the International Conference of Harmonization published a guideline (S7B) recommending that "all new drugs" should be tested pre-clinically for hERG sensitivity and cardiac safety before submitting an application to regulatory reviews [ 7 ]. (springer.com)
  • The discovery of the "funny" current and the new proposal of a cardiac pacemaking model raised keen interest in the scientific community and was followed by a fast-increasing number of studies investigating its properties. (wikipedia.org)
  • The current review summarizes the development of the patch clamp technique in cardiac electrophysiology with special focus on the potential applications in integrative physiology. (unideb.hu)
  • Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
  • The awareness of the proarrhythmic risk of PI3K inhibitors was raised because PI3K is also involved in regulating signaling toward cardiac ion channels. (bvsalud.org)
  • Over the decades, many peer-reviewed articles have proven that the MEA technology is indeed a very powerful tool in electrophysiology research and the technology around the MEA has improved significantly. (multichannelsystems.com)
  • Selected candidates will receive a $500.00 USD award and be invited to present their research on a public webinar with HESI Cardiac Safety Committee scientists and other invited guests. (hesiglobal.org)
  • For long-term (greater than 5 microsecond) simulations of the relatively slow entry of the drug into cardiac cells, the scientists also made use of Anton 2 , a special-purpose supercomputer for biomolecular simulation designed and constructed by D. E. Shaw Research (DESRES) and hosted by Pittsburgh Supercomputing Center (PSC). (newswise.com)
  • You can record from neuronal or cardiac cultures, stem cells, or brain or cardiac slices. (multichannelsystems.com)
  • Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes in the mechanical environment and transducing these signals into electrical responses, which can adjust a variety of cardiac parameters such as heart rate and contractility. (mdpi.com)
  • CLINICAL PHARMACOLOGY Mechanism Of Action UCDs are inherited deficiencies of enzymes or transporters necessary for the synthesis of urea from ammonia (NH3, NH4+). (clustermed.info)