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  • vasculature
  • This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. (europa.eu)
  • skeletal muscle cells
  • This study aimed to investigate the role of GPR41 in modulating basal and insulin-stimulated glucose uptake in insulin-sensitive cells including adipocytes and skeletal muscle cells. (jove.com)
  • Previous studies in L6 skeletal muscle cells have shown that insulin-induced activation and assembly of insulin receptor substrate 1 (IRS1) and p85? (jove.com)
  • Here we show that nexilin, a F-actin binding protein implicated in the pathogenesis of familial dilated cardiomyopathies, preferentially binds to IRS1 over IRS2 to influence glucose transport in skeletal muscle cells. (jove.com)
  • Moreover, the selective binding of nexilin to IRS1 and not IRS2 may contribute to the differential specificity of IRS isoforms in the modulation of GLUT4 trafficking in skeletal muscle cells. (jove.com)
  • survival
  • Due to these findings, other aspects were deeply investigated to increase the survival of injected stem cells into pathological muscle. (frontiersin.org)
  • IBMX treatment improved cell survival and migration, engraftment into the SC niche and repair of dystrophic muscle. (uottawa.ca)
  • stem cell niches
  • In this review, the distribution of telocytes in different stem cell niches will be explored, highlighting the intimate relationship between the two types of cells and their possible functional relationship. (springer.com)
  • occurs
  • Protein synthesis is the most energy-consuming process within the cell and, not surprisingly, it occurs at low rates in quiescent stem cells. (iospress.com)
  • Single cell imaging studies suggest that transcription is not continuous and occurs as discrete pulses of gene activity. (jove.com)
  • 1-3 In recent years, with the development of new visualization methods, it has become possible to follow transcription as it occurs in real time in single living cells. (jove.com)
  • tissue
  • We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. (europa.eu)
  • Bani D, Formigli L, Gherghiceanu M, Faussone-Pellegrini M. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. (springer.com)
  • CD34+ stromal cells/fibroblasts/ fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. (springer.com)
  • Characteristic is the progressive loss of muscle mass which has been attributed, at least in part, to the inability of muscle stem cells to efficiently regenerate tissue lost as the result of the disease. (frontiersin.org)
  • In addition, age and disease affect the tissue environment, in which the cells are infused or injected. (ahajournals.org)
  • 1 However, it has recently been shown that a decrease in stem cell function plays a primary role in the pathogenesis of multiple diseases and tissue aging. (ahajournals.org)
  • In addition, differences in CTC quality between healthy donor blood spiked with cells from tissue culture versus patient blood samples are highlighted. (jove.com)
  • fibrosis
  • We propose that muscle degeneration and fibrosis provokes altered vascularization and immune responses, which eventually affect negatively stem cell functions. (europa.eu)
  • homeostasis
  • Glucose homeostasis is primarily controlled by the endocrine hormones insulin and glucagon, secreted from the pancreatic beta and alpha cells, respectively. (jove.com)
  • Our results show that, during normal prostate homeostasis, sequentially proliferating cells are detected at a rate that is consistent with a stochastic process. (jove.com)