• CONCLUSIONS: Targeting TLR4 inhibition could be a potential therapeutic strategy to protect RGCs from COH damage. (bvsalud.org)
  • Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
  • In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
  • Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease. (ucdavis.edu)
  • Cold-Induced Platelet Aggregation in Vivo and Its Inhibition by a Nonionic Surface Active Substance," Thrombosis Research, vol. 2, pp. 331-342 (1973). (everypatent.com)
  • In addition, Ganoderma lucidum can antagonize the multidrug resistance of tumor cells to chemotherapy drugs, and reduce the damage to the body caused by radiotherapy and chemotherapy. (ganoherb.com)
  • Moreover, while there are several DNA-PK inhibitors currently being evaluated in the clinical trials in attempt to increase the efficacy of radiotherapy or chemotherapy, multiple functions and subcellular localization of DNA-PKcs in various types of cells may further complicate the effects at the cellular and organismal level. (molcells.org)
  • Therefore, most patients receive radiotherapy and temozolomide (TMZ) combined with chemotherapy after surgery. (biomedcentral.com)
  • Here, using pharmacological inhibitors, we investigate a role for V-ATPase during non-canonical autophagy. (babraham.ac.uk)
  • The DNA repair field is a vibrant one, and the stage is ripe for scrutinizing the potential treatment efficacy and future clinical applications of the pharmacological inhibitors of HR enzymes as mono- or combinatorial therapy regimes. (springeropen.com)
  • It can protect vascular endothelial cells against oxidative stress-induced inflammatory damage. (ganoherb.com)
  • In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
  • Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)
  • UV irradiation represents a major challenge to genomic integrity throughout the evolution of terrestrial organisms, resulting in the development of specific mechanisms that govern the cellular response to UV-induced DNA damage. (rupress.org)
  • The specific changes on the DNA upon UV exposure are different from those induced by γ irradiation, mostly resulting in chemical modifications of single DNA strands such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts ( Balajee and Bohr, 2000 ). (rupress.org)
  • The irradiation and chemotherapy drugs that are used to destroy cancer cells also damage healthy cells. (elifesciences.org)
  • TAp63α is kept in an inactive and exclusively dimeric state but undergoes rapid phosphorylation-induced tetramerization and concomitant activation upon detection of DNA damage. (elifesciences.org)
  • The development of resistance to cancer therapeutics represents a major hindrance to the successful pharmacological treatment and eradication of tumors in patients. (biomedcentral.com)
  • We studied the transcriptional role of p53 during nerve growth factor-induced differentiation of the PC12 line into neuron-like cells. (biomedcentral.com)
  • The propolis extract was shown to possess the capacity to protect sperm membrane from the deleterious action of oxidative attack, reducing TBARS formation and LDH release. (propoleo.cl)
  • 2020. 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor, lowers L-NAME-induced hypertension through suppression of angiotensin-converting enzyme in rats. (ucdavis.edu)
  • The aim of the study was to evaluate the effect of Musa sapientum methanolic fruit extract on volume of gastric juice and pepsin activity in aspirin induced peptic ulcer in albino rats. (ijpsr.com)
  • The study aimed to evaluate the effect of Musa sapientum methanolic fruit extract on the volume of gastric juice and pepsin activity in aspirin induced peptic ulcer in albino rats. (ijpsr.com)
  • The effect of propolis along with paclitaxel on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats. (propoleo.cl)
  • More recently, Zimmerman and Zimmerman (1990/1991) concluded that 'cannabis mutagenicity remains unclear', but argued that there was evidence that 'cannabinoids induce chromosome aberrations in both in vivo and in vitro studies' (p19). (druglibrary.org)
  • We conclude that Tip60 enables UV-induced DDR signaling even in the absence of p53, whereas preaccumulated p53 suppresses UV-induced DDR by reducing the levels of BRCA1. (rupress.org)
  • Ganoderma lucidum can inhibit the inflammation of the digestive tract induced by drugs and fungal infections, improve the immune function of the intestinal mucosa, and regulate the imbalance of intestinal flora. (ganoherb.com)
  • On the other hand, their therapeutic use for other purposes would be limited in patients with impaired immune systems, a restriction which would potentially preclude their use as anti-emetic agents in cancer chemotherapy, or as appetite stimulants and mood enhancers in patients with AIDS. (druglibrary.org)
  • In particular, stem cells, including mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), and induced pluripotent stem cells (iPSCs), and immune cells, such as T-cells and Natural Killer (NK) cells, have been favored candidates for regenerative medicine and cell-based cancer immunotherapy, respectively. (biomedcentral.com)
  • Primary amyloid is not associated with any other diseases but is a disease entity of its own, conventionally requiring chemotherapy treatment. (qualifyingconditions.com)
  • The development of resistance to chemotherapies represents a significant barrier to successful cancer treatment. (biomedcentral.com)
  • 7. Protect gastric mucosa and prevent liver damage. (ganoherb.com)
  • Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. (elifesciences.org)
  • Our experimental evidence demonstrated that the natural drug under investigation is able to protect genomic DNA by damage induced by benzo[a]pyrene, hydrogen peroxide (H(2)O(2)) and hydrogen peroxide in combination with adenosine 5'-diphosphate (ADP) and ferrous sulfate (FeSO(4)), determining a significant reduction of the intracellular oxidants. (propoleo.cl)
  • The major drawback of such strategies is that they can induce I/R injury to the residual liver parenchyma [4, 12]. (123dok.net)
  • Astragalus may help to reduce some of the side effects of chemotherapy and radiation therapy. (theheartysoul.com)
  • Instead of oral administration, probiotics can also be delivered locally at tumor sites, which can reduce non-specific pharmacological effects on non-tumor tissues. (metabiom.org)
  • We hypothesize that ovarian cancer cells will induce human ovarian TVM expression. (nih.gov)
  • recruits CD8+ T cells, granulocytes, and macrophages to the infection area and induces the release of TNF-related apoptosis-inducing ligand (TRAIL) from neutrophils. (metabiom.org)
  • Along this line, nanoparticle (NP) delivery systems can enhance the immunogenicity of antigens by protecting them from degradation and increasing their uptake by antigen-presenting cells, as well as offering co-delivery with adjuvants. (univ-nantes.fr)
  • For example, pharmacological studies have proved that Ganoderma lucidum has the functions of strengthening the heart, resisting myocardial ischemia, improving myocardial microcirculation, and regulating blood lipids and blood rheology. (ganoherb.com)
  • Whilst vector administration in these studies was conducted with pharmacological interventions or in neonatal animals, rAAV8 vectors appear more efficient at crossing the blood vessel barrier and transducing heart and skeletal muscle of adult mice and hamsters (Wang et al. (justia.com)
  • Ganoderma lucidum can improve gastric ulcers caused by alcohol, drugs, stress, pyloric ligation and other incentives. (ganoherb.com)
  • Modern research has proven that Ganoderma lucidum and its active components have a wide range of pharmacological effects. (ganoherb.com)
  • 5. The role of lowering blood pressure, regulating blood lipids and protecting the heart. (ganoherb.com)
  • In mouse white adipose tissue, PDK4 expression was proven to get induced by acti vation of p38MAPK, which we identified to become signifi cantly up regulated with fasting and, to a lesser extent, with insulin neutralization. (nartpathway.com)
  • As well as the enzyme complexes directly responsible for LC3 lipidation in all contexts, we show the RALGAP complex is important for M2-induced, but not ionophore drug-induced, LC3 lipidation. (babraham.ac.uk)
  • The Ku proteins foster direct ligation of the broken DNA ends by the specialized ligase complex Dnl4-Lif1 [ 12 ]. (springeropen.com)
  • This complex can execute a blunt end ligation reaction on clean DNA ends, i.e. 3′-OH and 5′-phosphate groups. (springeropen.com)
  • At the end of administration, ATQ and PQ at three doses induced decreased PG, increased ACTH, increased adrenal weight and size, and pathological lesions in the adrenal gland and ovary, including vasodilation and hyperemia in the adrenal cortex and medulla as well as hyperplasia and vacuolar degeneration, ovarian corpus luteum surface hyperemia, numerous but small corpus luteum, and disordered follicle development. (bvsalud.org)
  • L-dopa is now rarely used by itself, but rather in combination with carbidopa (Sinemet) or benserazide (Madopar) that protects it from breaking down before it reaches the brain tissue. (digitalnaturopath.com)
  • From our results, we conclude that propolis is a potent antioxidant and, when given in combination with paclitaxel, offers maximum protection against DMBA induced mammary carcinogenesis. (propoleo.cl)