• Punica granatum is found to contain hydrolysable tannins as major active chemical constituents and phytoconstituents, namely, corilagin, ellagic acid, kaempferol, luteolin, myricetin, quercetin, quercimetrine, and quercetin-3-o-rutinoside which were previously isolated from the fruits of Punica granatum [ 8 ]. (hindawi.com)
  • Methods In this study we evaluated and compare antioxidant, anti-glycative and anti-degenerative actions of two flavones apigenin and luteolin and a flavonol quercetin, in function of their hydroxyl groups arrangement. (unict.it)
  • Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner. (alstuttu.org)
  • As concerns Ca2+ signalling, luteolin and quercetin inhibited Ca2+ influx strongly, although baicalein did slightly. (alstuttu.org)
  • With regard to PKC signalling, luteolin and quercetin inhibited PKC translocation and PKC activity strongly, although baicalein did slightly. (alstuttu.org)
  • It's simply a concentrated amount of the flavonoids Luteolin, Quercetin and Rutin. (blogspot.com)
  • The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)
  • Flavonols and flavones constitute the main two classes of flavonoids, whose antioxidant properties and high biological activity have been proofed both in vitro and in vivo. (raysahelian.com)
  • The flavonoids diversity showed a significant content of luteolin and its derivatives, except for Landoltia punctata that had significant apigenin content. (rsc.org)
  • Besides the natural bioactive properties in plants, flavonoids are phytochemicals with several medically-relevant biological activities such as antiviral, antifungal, antibacterial antihepatotoxic, anti-osteoporotic, antiulcer, anti-proliferative. (rsc.org)
  • Flavonoids of Cy were further characterized by proton nuclear magnetic resonance spectroscopy, O-, C- and O,C-glycosides of luteolin being isolated and identified, namely luteolin 7-O-β-glucopyranoside and luteolin 6-C-β-glucopyranoside (isoorientin), consistent with previous studies, as well as luteolin 2"-O-rhamnosyl-C-(6-deoxy-ribo-hexos-3-ulosyl) (cassiaoccidentalin B), identified for the first time in Cy. (uc.pt)
  • In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators. (alstuttu.org)
  • 5 This plant contains phenolic compound like gallic acid and flavonoids e.g. luteolin and luteolin-7-O-glucoside. (medcraveonline.com)
  • The results demonstrate that some flavonoids are strong inhibitors of 5'-NT activity which can be correlated to their pharmacological effects. (gazi.edu.tr)
  • Therefore, a network pharmacology and molecular docking technology were used to uncover the active compounds and pharmacological mechanism of XQLD on asthma. (researchsquare.com)
  • Considering that AD is a multifactorial disease, nutraceutical compounds offer the advantage of a multitarget approach, tagging different molecular sites in the human brain, as compared with the single-target activity of most of the drugs used for AD treatment. (j-alz.com)
  • In addition, we also discuss the activity of nutraceutical compounds and phytopharmaceuticals formulae, mainly directed to tau protein aggregates mechanisms of action. (j-alz.com)
  • There are 16 species of Boehmeria genus confirmed to have chemical compounds, and 9 species of which reported to exhibit pharmacological activity in the form of extracts and single compound isolates. (phcogj.com)
  • These bioactive compounds and peptides possess different medicinal properties like anti-hypertensive, antioxidative, anti-inflammatory, anticancer, anti-microbial activity and antinociceptive. (biomedcentral.com)
  • The main compounds were luteolin-7-glucoside (cynaroside), chlorogenic acid, and epicatechin in the extracts. (erciyes.edu.tr)
  • Active compounds, oleanolic acid and luteolin in G. tenuifolia are affected by several factors, including climatic change, pathogens and agricultural practices. (springeropen.com)
  • This is the first study to explore the inhibitory effects of compounds from P. frutescens on Trichophyton mentagrophytes and its mechanism of action coupled with the antifungal activity in vitro from network pharmacology, transcriptomics and proteomics. (biomedcentral.com)
  • The top five potential antifungal compounds in P. frutescens screened by network pharmacology are: progesterone, luteolin, apigenin, ursolic acid and rosmarinic acid. (biomedcentral.com)
  • These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. (priceplow.com)
  • Of these compounds, luteolin showed the most potent inhibitory activity (IC(50)=1.5μg/mL). (greenmedinfo.com)
  • On the other hand, some phenolic compounds, which responsible for antioxidant activities of EEAB was determined by liquid chromatography-high resolution mass spectrometry (LC-HRMS). (trdizin.gov.tr)
  • Antioxidant activity and phenolic compounds of ginger (Zingiber officinale Rosc. (trdizin.gov.tr)
  • Rutin, naringin, hyperosid, (+/-)catechin, caffeic acid and rosmarinic acid had no inhibitory effect on the 5'-NT activity. (gazi.edu.tr)
  • It has high antimicrobial activity, can against common food contaminant microorganism. (vitamingrup.com)
  • A study published by Nutrients stated " curcumin , a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. (dogcancerfoundation.org)
  • The unique characteristics of their basic skeleton and the nature and position of the substituents have attracted and stimulated vigorous investigations as a consequence of an enormous biological potential, that manifests itself as (among other properties) antioxidant, anti-inflammatory, antiviral, antimicrobial, and anticancer activities. (unime.it)
  • Therefore, rigorous research activities are being carried out around the globe to develop alternative methods for treatment of infectious diseases caused by multi-drug resistant (MDR) bacteria, these include using of bacteriophages, phage lytic enzymes, bacteriocins, antimicrobial peptides or herbal medicines. (microbiologyjournal.org)
  • Antioxidant and antimicrobial activities of four Astragalus species growing wild in Turkey, Turk. (trdizin.gov.tr)
  • Antidiabetic activity was evaluated by Aldose reductase, α -amylase and PTP1B inhibition assays in in vitro and Alloxan-induced diabetes in rats was used as an in vivo model. (hindawi.com)
  • In bioactivity studies, MEPG and VAD have showed potent antidiabetic activity in α -amylase, aldose reductase, and PTP1B inhibition assays with IC 50 values of 1.02, 2.050, 26.25 μ g/mL and 0.284, 0.788, 12.41 μ g/mL, respectively. (hindawi.com)
  • Luteolin is the most active compound in the NO (48.19±0.18%) and AGEs (60.06±0.52%) inhibition, in function of a low torsion angle (16.3°) between the 3-OH moiety and C'6 carbon atom. (unict.it)
  • Its anti-inflammatory activity was correlated with the inhibition of p38 mitogen-activated protein kinase (MAPK) and c-jun NH2-terminal kinase (JNK) 1/2 signaling pathways. (uc.pt)
  • Moreover, it was verified, for the first time, that Cy extract inhibited the chymotrypsin-like activity of proteasome, with the consequent inhibition of the nuclear factor (NF)-kB, a transcription factor that regulates the expression of numerous inflammatory mediators. (uc.pt)
  • Among the three fractions, PAF strongly contributed to the inhibition of proteasome activity triggered by Cy extract. (uc.pt)
  • The anti-inflammatory activity,the % of inhibition of paw edema of crude methanol extract showed the highest activity in leaf (58.24% inhibition) at 100µg/ml, in bark (40.80% inhibition) at 200µg/ml.The analgesic activity, the effect of each extractive at two different concentration (100 & 200µg/ml) on the response of mice was measured. (medcraveonline.com)
  • The most potent activity was also found in crude methanolic fraction (CME) showed in leaf highest % of inhibition (25.93 at 100µg/ml) and in bark highest % of inhibition (33.33 at 100µg/ml) after standard (Diclofenac-Na). (medcraveonline.com)
  • The inhibition of antioxidant activity in plasmodium may contribute to killing the malaria causing parasites. (ncats.io)
  • Purification and characterization of carbonic anhydrase enzyme from black sea trout (Salmo trutta Labrax coruhensis) kidney and inhibition effects of some metal ions on the enzyme activity, Environ. (trdizin.gov.tr)
  • Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities. (bvsalud.org)
  • and on the study of secondary metabolites in plant foods, exploring the molecular mechanisms that explain their activity. (researchgate.net)
  • This article reviewed the natural source and pharmacokinetics of AG and systematically summarized the pharmacological activities and potential mechanisms of AG in treating diverse diseases in order to promote the development of AG as a functional food, in doing so providing references for its clinical application in disease therapy. (frontiersin.org)
  • Luteolin has been found to induce apoptosis in cancer cells using several mechanisms. (dogcancerfoundation.org)
  • Through in vitro antifungal assays screening the compound with efficacy, transcriptomics and proteomics were performed to investigate the pharmacological mechanisms of the effective compound against Trichophyton mentagrophytes . (biomedcentral.com)
  • In addition, these inhibitors were used to verify phosphorylation of AKT, GSK3beta, and ERK1/2 and to confirm mechanisms regulated by luteolin in JAR and JEG-3 cells. (ewha.ac.kr)
  • Objective This study reviewed the phytochemistry, ethnopharmacological, and pharmacological potentials of Vernonia amygdalina. (shu.ac.uk)
  • Portulaca olerace: a review of phytochemistry and pharmacological effects. (raysahelian.com)
  • Consumption of flavanol -rich cocoa inhibit several measures of platelet activity including, epinephrine - and ADP-induced glycoprotein IIb/IIIa and P-Selectin expression, platelet microparticle formation, and epinephrine-collagen and ADP-collagen induced primary hemostasis. (raysahelian.com)
  • The ability of luteolin to inhibit angiogenesis , to induce apoptosis , to prevent carcinogenesis in animal models, to reduce tumor growth in vivo and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid has cancer chemopreventive and chemotherapeutic potential. (dogcancerfoundation.org)
  • As for depigmenting activity, both extracts were able to inhibit tyrosinase. (bvsalud.org)
  • Hence, it is worthwhile to isolate and elucidate the bioactive principles that are responsible for the better activity that is underway. (medcraveonline.com)
  • While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations, and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. (tigerfitness.com)
  • This review analyzes the biochemical, pharmacological, and biological properties of Citrus flavones, emphasizing their occurrence in Citrus spp. (unime.it)
  • Biochemical and pharmacological studies revealed that the anti-inflammatory effect of luteolin was accompanied by down-regulation of extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt and Src. (alstuttu.org)
  • The nephroprotective activity of the luteolin was tested and it showed significant improvement in biochemical parameters and histopathological change. (rjpdft.com)
  • These findings suggest that MEPG and VAD possess significant antidiabetic activity in both in vitro and in vivo models. (hindawi.com)
  • Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L. (erciyes.edu.tr)
  • HPLC analysis revealed that the quantity of oleanolic acid and luteolin in in vitro shoots, tissue culture plants in the greenhouse, wild type plants and commercial crude drug varied depending upon the source. (springeropen.com)
  • 2013. Antitumor activity of Portulaca oleracea polysaccharides against cervical carcinoma in vitro and in vivo. (raysahelian.com)
  • The cytotoxicity and the anti-inflammatory properties of luteolin and its glycosides were evaluated in LPS-stimulated mouse macrophages. (uc.pt)
  • Resistance to apoptosis stands as a roadblock to the successful pharmacological execution of anticancer drug effect. (researchgate.net)
  • Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)
  • Product Name: Luteolin, Luteolin Extract Powder. (vitamingrup.com)
  • Chemical characterization by HPLC/PDA/ESI-MSn identified chlorogenic acid (CGA) as the main phenolic acid of the Cy extract, which was partially responsible for the inhibitory effect on the proteasome activity. (uc.pt)
  • T. divaricata flower methanolic extract (TDFME) was screened for antiulcer activity versus aspirin and ethanol induced gastric ulcers at three doses--125, 250, and 500 mg/kg--orally using misoprostol as a standard. (afpm.org.my)
  • METHODS: The test extract was screened for anti-ulcer activity by Aspirin induced ulcerogenesis in pyloric ligation and ethanol induced gastric ulcers at three doses - 125, 250, and 500 mg/kg, p.o. using Ranitidine 50 mg/kg and Misoprostol 100 μg/kg as standard drug in respective models. (afpm.org.my)
  • The methanol extract exhibited the highest radical scavenging activity. (erciyes.edu.tr)
  • Ethyl acetate extract showed strongest a-amylase inhibitory activity, while the best a-glucosidase inhibitory effect recorded for the methanol extract. (erciyes.edu.tr)
  • Purslane extract fed mice showed higher activity upon induction by new environmental stimuli, lower anxiety and higher novelty-seeking behavior in the open field tasks, and significantly improved learning and memory ability in step-through compared with d-gal-treated mice. (raysahelian.com)
  • Purslane extract significantly increased superoxide dismutase (SOD) activity and decreased the malondialdehyde (MDA) level. (raysahelian.com)
  • Meanwhile, purslane extract also could up-regulate telomere lengths and telomerase activity in PHAS-fed groups. (raysahelian.com)
  • Pharmacological properties of preparations based on Astragalus extract (Review), Pharm. (trdizin.gov.tr)
  • We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. (erciyes.edu.tr)
  • 7 The present study was started to identified the pharmacological parameter of extracts from mature leaves and barks of S. caseolaris because that it may contains substances with potential therapeutic uses and these could serve a basis of precursors for synthesis of useful drugs. (medcraveonline.com)
  • Compared to the control group, the mouse in the group treated with purslane extracts by 1 g/d had significantly higher activities of phosphofructokinase, lactate dehydroenase and higher levels of ATP in the cortices, especially under the hypoxic environment for 24 hours. (raysahelian.com)
  • The current study provides validation of Psidium guajava and Madhuca indica extracts and fractions for its anti-PD activity and could be a valuable source for the treatment of PD in future. (jptcp.com)
  • The potential activity for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait (Weiss and Hait, 1977). (biomedjournal.com)
  • Next, we established effects of luteolin in the presence of pharmacological inhibitors of PI3K/AKT, ERK1/2 MAPK, and mTOR on proliferation of JAR and JEG-3 cells. (ewha.ac.kr)
  • We describe for the first time the presence in duckweeds of 5- O -( E )-caffeoylquinic acid ( 1 ), 3- O -( E )-coumaroylquinic acid ( 2 ), luteolin-7- O -glucoside- C -glucoside ( 3 ), 4- O -( E )-coumaroylquinic acid ( 4 ), luteolin-6- C -glucoside-8- C -rhamnoside ( 5 ), and luteolin-8- C -glucoside-6- C -rhamnoside ( 6 ). (rsc.org)
  • PDEs consists of a superfamily with 11 subfamilies, which have been characterized on the basis of amino acid sequence, substrate specificity, pharmacological properties and allosteric regulation. (biomedjournal.com)
  • The oleanolic acid and luteolin contents were found to be significantly higher (16.89 mg/g and 0.84 mg/g, respectively) in 3-month old tissue culture raised plants in greenhouse compared to commercially available crude drug (6.51 mg/g, 0.13 mg/g, respectively). (springeropen.com)
  • The contents of oleanolic acid and luteolin in the tissue culture raised plants in the greenhouse were significantly higher than the marketed crude drug demonstrating the practical application of the tissue culture technology. (springeropen.com)
  • The key findings of the present study manifested that rosmarinic acid, a medicinal compound extracted from P. frutescens , had pharmacological activity in inhibiting the growth of Trichophyton mentagrophytes by affecting its enolase expression to reduce metabolism. (biomedcentral.com)
  • The efficacy of V. amygdalina in ameliorating diseases is attributed to its antioxidant activity and ability to improve the antioxidant system. (shu.ac.uk)
  • Antioxidant activity of cauliflower (Brassica oleracea L.), Turk. (trdizin.gov.tr)
  • Antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(β-D-glucopyranosyl)-hederagenin, Phytother. (trdizin.gov.tr)
  • Antioxidant activity. (bvsalud.org)
  • We compared viability of JAR and JEG-3 cells in response to luteolin alone or in combination with other chemotherapeutic drugs (etoposide, cisplatin, and paclitaxel) and found that luteolin has synergistic effects with the conventional chemotherapeutic drugs as an anticancer agent. (ewha.ac.kr)
  • We review in-depth important medicinal plants that have been already investigated for therapeutic uses against AD, focusing on a diversity of pharmacological actions. (j-alz.com)
  • This study predicted the main ingredients, potential drug targets and pharmacological mechanism of XQLD on asthma from a new sight, as well as provided a promising approach for the research of chemical basis and pharmacology in Traditional Chinese medicine (TCM). (researchsquare.com)
  • The objective of this review is to provide an overview of chemical and pharmacological characteristics of Boehmeria genus based on research studies. (phcogj.com)
  • Results amassed in the present study add on to a growing body of literature on the multi-pharmacological potency of B. tripartita which can be applied to bio-products development geared towards management of common diseases. (erciyes.edu.tr)
  • en=Castor bean}} ==Properties== Reference: Dravya - Substance, Rasa - Taste, Guna - Qualities, Veerya - Potency, Vipaka - Post-digesion effect, Karma - Pharmacological activity, Prabhava - Therepeutics. (ayurwiki.org)
  • One of the major challenges of medical sciences has been finding a reliable compound for the pharmacological treatment of Alzheimer's disease (AD). (j-alz.com)
  • Luteolin is a natural compound known for its anticancer effects on various human cancers by regulating signal transduction cascades. (ewha.ac.kr)
  • Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from fruit rinds of Punica granatum . (hindawi.com)
  • Furthermore, in alloxan-induced diabetes model MEPG (200 and 400 mg/kg, p.o.) and VAD (10, 25, and 50 mg/kg, p.o.) have showed significant and dose dependent antidiabetic activity by maintaining the blood glucose levels within the normal limits. (hindawi.com)
  • Apart from these medicinal uses, various parts of the plant have been scientifically proved for antidiabetic activity [ 21 ]. (hindawi.com)
  • However, the effect and pharmacological mechanism of 4-terpineol in HPH rats remain unexplored. (bvsalud.org)
  • Collectively, these results showed that luteolin plays an important role in the treatment of human choriocarcinoma cells by inhibiting the PI3K/AKT/mTOR/SREBP cascade and expression of lipogenic genes. (ewha.ac.kr)
  • The bioflavonoids possess a broad-spectrum of pharmacological activities. (unict.it)
  • Purification and characterization of the carbonic anhydrase enzyme from horse mackerel (Trachurus trachurus) muscle and the impact of some metal ions and pesticides on enzyme activity. (trdizin.gov.tr)
  • Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. (alstuttu.org)
  • The gravity of the impact of renal failure on human health is well known and as there is no specific tretment for renal failure, the current study was undertaken to evaluate the effect of luteolin. (rjpdft.com)
  • Nephroprotective Effect of Luteolin against Gentamicin-induced Nephrotoxicity in Albino Rats. (rjpdft.com)
  • It should be noted that interferons display antiviral activity in HSV-1-infected AD patients. (j-alz.com)
  • Taxifolin shows promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders Taxifolin has been found to act as an agonist of the adiponectin receptor 2 (AdipoR2). (wikipedia.org)
  • Luteolin is a natural flavonoid found in many plants. (vitamingrup.com)
  • Luteolin has also been found to destroy the ability of cancer cells to replicate their DNA and cut off their blood supply making it more difficult for the cancer cells to spread (metastasize) to other portions of the body. (dogcancerfoundation.org)
  • Currently, edible plants are found to have biological and pharmacological activities and are used in various domains. (rjpdft.com)
  • After that, the phytochemicals were molecular docked in Auto dock 4.2 to see if they had any pharmacological activity. (journalgazett.com)
  • Several studies on G. tenuifolia have demonstrated its pharmacological values of antioxidation, anti-inflammation, immunomodulation, and cytotoxicity on several human cancer cell lines. (springeropen.com)
  • However, the effects of luteolin on human placental choriocarcinoma are not known. (ewha.ac.kr)
  • scavenging effects, ferric ions (Fe3+) and cupric ions (Cu2+ ) reducing abilities, and metal (Fe2+) chelating activity were realized. (trdizin.gov.tr)
  • Until carefully controlled, well-designed human efficacy and safety studies are performed, ALSUntangled does not support the use of luteolin or any luteolin-containing products in patients with ALS. (alstuttu.org)
  • Ancient books of Traditional Chinese Medicine and modern pharmacological studies have shown that it has potential anti-fungi activity. (biomedcentral.com)
  • We also determined levels of SREBP1 and SREBP2 expression to investigate regulatory functions of luteolin in lipid metabolism in JAR and JEG-3 cells. (ewha.ac.kr)
  • In the gestational period, the administration of M- and N-cholinolytic drugs to pregnant female rats for 3 days caused a significant change in the activity of brain monoaminergic system in the 20-day-old rats fetuses. (sgma.info)
  • Anti-inflammatory activity of some Iraqi plants using intact rats. (jptcp.com)
  • Despite the vast pharmacological activities of V. amygdalina, more human clinical trials are needed to identify effective and safe doses for treatment of various diseases. (shu.ac.uk)
  • the level of NADPHDH activity was significantly reduced with the introduction of concanavalin A on the 13th day of pregnancy and cyclophosphamide on the 15th day of pregnancy. (sgma.info)
  • Expression levels of both SREBP1 and SREBP2 mRNAs were significantly reduced, but only SREBP1 protein was influenced by luteolin. (ewha.ac.kr)
  • In this study, Sonneratia caseolaris was evaluated for its anti-inflammatory, analgesic andthrombolytic activities using different systems assay. (medcraveonline.com)
  • Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. (alstuttu.org)
  • The antifungal activity of the candidates was detected by a broth microdilution method. (biomedcentral.com)
  • Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn. (jpionline.org)
  • Home » JPHI » Vol 13, Issue 4 » Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn. (jpionline.org)
  • 1.Pandey SN, Mittal P, Singh G. Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn. (jpionline.org)