His research concerns the physiology of cancer cells, immunological therapy for blood cancers, and the discovery of bone- and cartilage-forming stem cells in the vertebrate skeleton. (wikipedia.org)
As the understanding of how key molecular pathways work in cancers has increased, so have more-sophisticated therapies been introduced, often used conjunction with the traditional slash, burn and poison approaches. (anti-agingfirewalls.com)
The potential role of p53 as a specific target in modern therapies against cancers is being widely discussed. (encyclopedia.pub)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
Angiogenesis3
Consequently, blocking tumor angiogenesis could prevent the formation of tumor blood vessels and inhibit or slow the growth and spread of tumor cells [ 6 - 8 ]. (biomedcentral.com)
Tumor angiogenesis is a consequence of an imbalance between pro-angiogenic factors, such as the vascular endothelial growth factor (VEGF) family and IL-8/CXCL8, and inhibitors of angiogenesis, including endostatin, angiostatin and other related molecules [ 14 - 16 ]. (biomedcentral.com)
However, the precise regulation and mechanisms of tumor angiogenesis are not yet fully explored and the identification of other novel specific, effective inhibitors of angiogenesis is urgently required to treat patients with cancer. (biomedcentral.com)
Proliferation5
RNA silencing and pharmacologic inhibitors were used to evaluate the functions of CDK7/p38α/MYC/PD-L1 axis in cancer cell proliferation and antiPD-1 therapy resistance. (biomedcentral.com)
Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. (aacrjournals.org)
Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
CUDC-305 inhibited the proliferation of these cancer cell lines with an IC50, ranging from 40 to 900 nmol/L (mean IC50, 220 nmol/L). CUDC-305 shows high affinity for HSP90alpha/beta (IC(50), approximately 100 nmol/L) and HSP90 complex derived from cancer cells (IC(50), 48.8 nmol/L). CUDC-305 exhibits high oral bioavailability (96.0%) and selective retention in tumor (half-life, 20.4 hours) compared with normal tissues. (medkoo.com)
Tumor cell2
N- trans -Feruloyloctopamine (FO), a natural compound, was reported in our previous study to inhibit a tumor cell malignant phenotype by AKT- and EMT-related signals and might be used as a promising drug for HCC treatment. (hindawi.com)
Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. (biomedcentral.com)
Protein7
This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
Our previous report showed that FO inhibits HCC cell invasion via AKT-, mitogen-activated protein kinase- (MAPK-), and EMT-related signals [ 7 ]. (hindawi.com)
DNA-PKcs: A Targetable Protumorigenic Protein Kinase. (jefferson.edu)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. (medkoo.com)
At the molecular level, pitavastatin induced expression of the cyclin dependent kinase (CDK) inhibitor p21 in a cholesterol independent manner, blocked repressive phosphorylation of the Retinoblastoma tumor suppressor protein at CDK targeted sites, and reduced expression of E2F target genes required for progression through the G1/S boundary. (oncotarget.com)
Antitumor2
THZ1 boosted antitumor immunity by recruiting infiltrating CD8 + T cells and synergized with antiPD-1 therapy. (biomedcentral.com)
CUDC-305 exhibits dose-dependent antitumor activity in an s.c. xenograft model of U87MG glioblastoma and significantly prolongs animal survival in U87MG orthotopic model. (medkoo.com)
Pathways2
Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease. (stanford.edu)
Correlating with its efficacy in these various tumor models, CUDC-305 robustly inhibits multiple signaling pathways, including PI3K/AKT and RAF/MEK/ERK, and induces apoptosis. (medkoo.com)
Efficacy1
Natural products have gained attention for a long time in cancer therapy because of their strong efficacy and low toxicity, exhibiting a wide range of biological activities against a variety of diseases, such as infectious diseases and cancer [ 5 ]. (hindawi.com)
Dose-dependent3
Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. (mdpi.com)
Exposure of Capan-2 cells to the aqueous extract of Triphala for 24 h resulted in the significant decrease in the survival of cells in a dose-dependent manner with an IC50 of about 50 μg/ml. (biomedcentral.com)
Studies with pitavastatin in primary patient derived tumor cells and established PDA lines, revealed dose dependent growth inhibition. (oncotarget.com)
Apoptosis3
CDK7 silencing and CDK7 inhibitor THZ1 elicited apoptosis and suppressed tumor growth. (biomedcentral.com)
As a potassium-specific ionophore, beauvericin A increases intracellular calcium concentrations and triggers DNA fragmentation and apoptosis through a calcium dependent caspase 3-sensitive pathway. (medindex.am)
Pretreatment of cells with pifithrin-α or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis. (biomedcentral.com)
Hematologic1
The meeting was attended by ∼70 investigators and included formal presentations, panel group discussions, and two breakout sessions that addressed targeted therapies in hematologic and solid tumors. (aacrjournals.org)
Chemotherapy2
Tumor growth is initially reduced by radiation, surgery, or hormone therapy and later, by pairing them with chemotherapy for advanced cancer. (mdpi.com)
Both chemotherapy and radiation therapy have from the onset been focused on killing cancer cells, in one case by using highly toxic chemicals and in the other case by using focused radiation. (anti-agingfirewalls.com)
Enzymes1
If you choose to take turmeric/curcumin (traditionally, curcumin has been much more widely recognized, but newer research suggests the whole herb has more advantages), look for a product that contains piperine or Bioperine (black pepper extract), which inhibits the enzymes that break down most supplements and medicines in the gut. (blogspot.com)
Arrest1
Because its discovery, the c Abl family of tyrosine kinases, which includes c Abl and Abl relevant gene , has been shown to be very conserved across species and possesses been implicated in the wide number of cellular HER2 mutation processes including regulation of the actin cytoskeleton, regulation on the cell cycle, and apoptotic cell cycle arrest response to pressure. (pkc-inhibitors.com)
Receptor1
The Abelson non receptor tyrosine kinase gene was initial recognized as the mammalian homolog from the oncogenic gene products from the Abelson murine leukemia virus. (pkc-inhibitors.com)
Cells6
Through his findings, he had shown the roles of cells in cancer therapy. (wikipedia.org)
Herein, genome-wide transcriptome profiling (RNA-Seq) was used to screen the differentially expressed genes (DEGs) in FO-treated Huh7 cells, with the aim of uncovering the pharmacologic pattern. (hindawi.com)
At the single channel level, 6 reduces availability of LVA calcium DNA-dependent RNA polymerase programs HEK 293 cells were transiently transfected with Cav3. (mdmsignaling.com)
However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)
Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
Furthermore, overexpressing URG4/URGCP increased - whereas knockdown of URG4/URGCP decreased - VEGFC expression, NF-κB transcriptional activity, the levels of phosphorylated (but not total) IκB kinase (IKK) and IκB-α, and expression of TNFα, IL-6, IL-8 and MYC in HCC cells. (biomedcentral.com)
Mutant1
NF-κB was inhibited by overexpressing degradation-resistant mutant inhibitor of κB (IκB)-α. (biomedcentral.com)
Ablation1
Moreover, CDK7 ablation specifically suppressed p38α/MYC-associated genes, and THZ1 inhibited MYC transcriptional activity through downregulating p38α. (biomedcentral.com)
Regulation1
Similarly, marked modifications occur in the larger phosphoprotein clusters involving cytoskeleton and neuronal structures, membrane stabilization, and kinase regulation in the late elderly.Present findings may increase understanding of human brain proteostasis modifications in the elderly in the subpopulation of individuals not having AD neuropathological change and any other neurodegenerative change in any telencephalon region. (ibecbarcelona.eu)
Activity4
Further, THZ1 suppressed PD-L1 expression by inhibiting MYC activity. (biomedcentral.com)
In addition, inside a long lasting in vitro research on a CML CP model we now have established a practical link of p210BCR cox1 inhibitor ABL TK activity with centrosome amplification and clonal evolution. (pkc-inhibitors.com)
MDM2 binds to and inhibits TP53 activity. (medscape.com)
The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
Growth2
The Abl loved ones of kinases has been proven to perform a significant role in neuronal growth and the latest studies have shown that c Abl, precisely, may perhaps be an important player in neurodegenerative conditions. (pkc-inhibitors.com)
Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. (medkoo.com)
Pathway1
DNA damage increases TP53 levels through an ATM-dependent pathway. (medscape.com)
Vivo2
Flow cytometry was performed to detect the status of the immune microenvironment after CDK7 inhibition and antiPD-1 therapy in vivo. (biomedcentral.com)
Even so, IM therapy didn't counteract development of centrosome amplification, but IM induced centrosomal and or cytogenetic alterations in various bcr abl bad cell line models and in vivo. (pkc-inhibitors.com)
Patients1
Secondary benefits included the application of crisis health-related services (EMS), Several they would birth fee, along with endovascular therapy in eligible patients. (narturalproducts.com)
Blood1
Maximal voluntary contraction (MVC) torque, range of motion (ROM), and muscle soreness, as well as blood parameters [creatine kinase (CK) and interleukin-6 (IL-6)], were assessed immediately before and after and 1, 2, 3, and 5 days after eccentric exercise. (bvsalud.org)
Effective1
These data suggest that the combined CDK7 inhibitor THZ1 and antiPD-1 therapy can be an effective treatment in NSCLC. (biomedcentral.com)
Drugs1
Prominent among the hits were members of the statin class of HMG-CoA reductase inhibitors, cholesterol lowering drugs that are also being evaluated in cancer. (oncotarget.com)
Calcium1
Consequently, the present study was performed to investigate if the inhibitory effects of L type calcium channel caused by H2S was dependent on the disulfide bridge or sulfhydryl group. (mdmsignaling.com)
Lesions2
Lesion-directed treatment is one option in the setting of single lesions and can include cryotherapy, laser therapy, curettage, and dermabrasion. (jcadonline.com)
Metronomic (that is, low-dose and long-term) photodynamic therapy (mPDT) for treating internal lesions requires the stable fixation of optical devices to internal tissue surfaces to enable continuous, local light delivery. (regenerativemedicine.net)
Future2
This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
The aim of this article is to summarize topics discussed at this workshop and highlight conclusions as to the immediate and long-term future of epigenetic therapy in cancer. (aacrjournals.org)
Potential1
URG4/URGCP may represent a potential target for anti-angiogenic therapy in HCC. (biomedcentral.com)
Study1
This study demonstrated the interaction between the MMP3 rs522616 polymorphism and sex in recovery of muscle strength after eccentric exercise.NEW & NOTEWORTHY Sex differences were identified in the AUC of creatin kinase (CK) and interleukin 6 (IL-6) after eccentric exercise, both of which were greater in men. (bvsalud.org)
Function1
The function of c Abl is dependent on its subcellular localization. (pkc-inhibitors.com)
Response1
The shape of the current response kept unaffected, ATP-competitive Chk inhibitor consistent with the entire cell dimensions. (mdmsignaling.com)