CamptothecinTopoisomerase I InhibitorsDNA Topoisomerases, Type IHalf-LifeArea Under CurveAntineoplastic Agents, PhytogenicPharmacokineticsMetabolic Clearance RateAdministration, OralBiological AvailabilityInjections, IntravenousTopotecanDrug InteractionsDose-Response Relationship, DrugInfusions, IntravenousTopoisomerase InhibitorsTissue DistributionChromatography, High Pressure LiquidAntineoplastic AgentsCamptothecaCross-Over StudiesDrug Administration ScheduleDNA DamageFood-Drug InteractionsEnzyme InhibitorsProdrugsTeniposideNeoplasmsBiotransformationTopoisomerase II InhibitorsKineticsModels, BiologicalOrganosilicon CompoundsRubiaceaeAphidicolinTumor Cells, CulturedDrug Screening Assays, AntitumorMaximum Tolerated DoseEtoposideOrganic Chemistry PhenomenaApoptosisCytochrome P-450 CYP3ACell Line, TumorP-GlycoproteinKB CellsTime FactorsDrug CarriersDNA Topoisomerases, Type IIInfusions, ParenteralRitonavirDrug ResistanceAnti-Bacterial AgentsDNADNA, SuperhelicalDouble-Blind MethodInjections, IntramuscularBileAmsacrineDrug Resistance, NeoplasmChemistry, PharmaceuticalDrug Dosage CalculationsAntifungal AgentsCapsulesCell SurvivalDNA CleavageDelayed-Action PreparationsAnti-Infective AgentsRats, Sprague-DawleyDrug CombinationsKetoconazoleChromatography, LiquidLeukemia L1210Therapeutic EquivalencyTriazolesCephalosporinsDNA ReplicationDrug Therapy, CombinationStereoisomerismAbsorptionIridoid GlucosidesDNA RepairDrug Evaluation, PreclinicalEllipticinesTreatment OutcomeMidazolamMolecular StructureAnti-HIV AgentsDoxorubicinNeutropeniaProtein BindingTabletsPolyethylene GlycolsDrug Delivery SystemsInjections, SubcutaneousDrug StabilityHIV Protease InhibitorsLactonesHealthy VolunteersMacaca fascicularisIntercalating Agents