• Amantadine hydrochloride, USP is designated chemically as 1-adamantanamine hydrochloride. (nih.gov)
  • Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform. (nih.gov)
  • Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug. (nih.gov)
  • Data from earlier animal studies suggest that amantadine hydrochloride may have direct and indirect effects on dopamine neurons. (nih.gov)
  • Amantadine hydrochloride is well absorbed orally. (nih.gov)
  • Amantadine pharmacokinetics were determined in 24 normal adult male volunteers after the oral administration of a single amantadine hydrochloride 100 mg soft gel capsule. (nih.gov)
  • Each tablet intended for oral administration contains 100 mg amantadine hydrochloride, USP and has the following inactive ingredients: microcrystalline cellulose, povidone, sodium starch glycolate, magnesium stearate and colloidal silicon dioxide. (nih.gov)
  • Amantadine hydrochloride and rimantadine hydrochloride have antiviral properties, but they are not widely used due to a lack of knowledge of their potential value and concerns about possible adverse effects. (nih.gov)
  • AMANTADINE HYDROCHLORIDE TABLETS (Amantadine Hydrochloride) is a weak dopamine agonist with modest antiparkinsonian effects. (sgpharma.com)
  • Chemically, Amantadine Hydrochloride is Tricyclo[3.3.1.13,7] decan-1amine hydrochloride. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are orange coloured, circular biconvex uncoated tablets with breakline on one side. (sgpharma.com)
  • Parkinson's disease : Amantadine Hydrochloride has been shown to be a low affinity antagonist at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. (sgpharma.com)
  • The mechanism of action of Amantadine Hydrochloride in herpes zoster has not been fully characterised. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are indicated for the prophylaxis and treatment of signs and symptoms of infection caused by various strains of influenza A virus. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are also indicated in the treatment of parkinsonism and drug-induced extrapyramidal reactions. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are indicated for chemoprophylaxis against signs and symptoms of influenza A virus infection. (sgpharma.com)
  • Because AMANTADINE HYDROCHLORIDE TABLETS do not completely prevent the host immune response to influenza A infection, individuals who take this drug may still develop immune responses to natural disease or vaccination and may be protected when later exposed to antigenically related viruses. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are also indicated in the treatment of uncomplicated respiratory tract illness caused by influenza A virus strains especially when administered early in the course of illness. (sgpharma.com)
  • There are no well-controlled clinical studies demonstrating that treatment with AMANTADINE HYDROCHLORIDE TABLETS will avoid the development of influenza A virus pneumonitis or other complications in high risk patients. (sgpharma.com)
  • There is no clinical evidence indicating that AMANTADINE HYDROCHLORIDE TABLETS are effective in the prophylaxis or treatment of viral respiratory tract illnesses other than those caused by influenza A virus strains. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are not a substitute for early vaccination on an annual basis as recommended by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices. (sgpharma.com)
  • Prescribers should consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use AMANTADINE HYDROCHLORIDE TABLETS. (sgpharma.com)
  • AMANTADINE HYDROCHLORIDE TABLETS are indicated in the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication. (sgpharma.com)
  • Amantadine hydrochloride 4-8 mg/kg/day in 2 divided doses. (ptmasterguide.com)
  • Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. (cdc.gov)
  • The compound bearing 4-trifluoromethylphenyl substituent in the thiazole ring showed significant antiviral activity against the PR8 influenza A strain, which was comparable to the oseltamivir and amantadine. (bvsalud.org)
  • He presented the results from the Extended Release Amantadine Safety and Efficacy Study in Levodopa-Induced Dyskinesia (EASED) clinical trial June 18 at the Movement Disorder Society (MDS) 17th International Congress of Parkinson's Disease and Movement Disorders. (medscape.com)
  • patients have not been able to tolerate high enough doses or even just immediate-release amantadine per se, so the hope is the long-acting extended-release amantadine would be better tolerated and we could use higher doses with it," he explained. (medscape.com)
  • The extended release amantadine formulation is commonly used to treat dyskinesias in people receiving levodopa therapy for Parkinson's disease. (wikipedia.org)
  • A 2003 Cochrane review had concluded there was insufficient evidence to prove the safety or efficacy of amantadine to treat dyskinesia. (wikipedia.org)
  • The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA). (frontiersin.org)
  • Although other pharmacological agents are advocated, such as gabapentin or amantadine, there is little evidence regarding their efficacy in dogs with chronic or neuropathic pain related to OA. (frontiersin.org)
  • The clinical efficacy of amantadine is thought to be mediated through its antagonism at the NMDA subtype of glutamate receptors. (sgpharma.com)
  • Monitor for efficacy of amantadine. (medscape.com)
  • SYDNEY, Australia - Treatment with a proprietary investigational extended-release version of amantadine (ADS-1502, Adamas Pharmaceuticals) led to a statistically significant improvement in the duration and severity of levodopa-induced dyskinesia (LID) in a phase 2/3 study. (medscape.com)
  • Because of its altered pharmacokinetic profile, ADS-5102 is being investigated in clinical studies at daily doses 1.3- to 2.1-fold greater than the 100-mg twice-daily dose typically used with immediate-release amantadine. (medscape.com)
  • However, this is not a comparative study with immediate-release amantadine so it's not possible to say head-to-head how it would do against immediate-release, but from the data we have it was efficacious and patients were able to tolerate higher doses relatively well. (medscape.com)
  • Single-dose pharmacokinetics was performed using two different doses of CBD enriched (2 and 8 mg/kg) oil. (frontiersin.org)
  • Pharmacokinetics revealed an elimination half-life of 4.2 h at both doses and no observable side effects. (frontiersin.org)
  • In 2004, it was discovered that amantadine and memantine bind to and act as agonists of the σ1 receptor (Ki = 7.44 μM and 2.60 μM, respectively), and that activation of the σ1 receptor is involved in the dopaminergic effects of amantadine at therapeutically relevant concentrations. (wikipedia.org)
  • 19. Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum. (nih.gov)
  • Mechanism of Action: Parkinson's Disease The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. (nih.gov)
  • In 1973, the Food and Drug Administration (FDA) approved amantadine for use in the treatment of Parkinson's disease. (wikipedia.org)
  • Amantadine is used to treat Parkinson's disease-related dyskinesia and drug-induced parkinsonism syndromes. (wikipedia.org)
  • Amantadine may be used alone or in combination with another anti-Parkinson's or anticholinergic drug. (wikipedia.org)
  • Excretion rate of amantadine increases rapidly when urine is acidic, administration of urine acidifying drugs may increase elimination of amantadine from the body. (medscape.com)
  • Amantadine was first used for the treatment of influenza A. After antiviral properties were initially reported in 1963, amantadine received approval for prophylaxis against the influenza virus A in 1976. (wikipedia.org)
  • This statement discusses the presently available medical-control measures, immunoprophylaxis with vaccines, and prophylaxis or therapy with the antiviral drug, amantadine. (cdc.gov)
  • Amantadine inhibits the replication of influenza A virus isolates from each of the subtypes, i.e. (nih.gov)
  • A quantitative relationship between the in vitro susceptibility of influenza A virus to amantadine and the clinical response to therapy has not been established in man. (nih.gov)
  • Sensitivity test results, expressed as the concentration of amantadine required to inhibit by 50% the growth of virus (ED 50 ) in tissue culture vary greatly (from 0.1 mcg/mL to 25.0 mcg/mL) depending upon the assay protocol used, size of virus inoculum, isolates of influenza A virus strains tested, and the cell type used. (nih.gov)
  • Amantadine, sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance. (wikipedia.org)
  • Amantadine (brand names Gocovri, Symadine, and Symmetrel) is the organic compound 1-adamantylamine or 1-aminoadamantane, which consists of an adamantane backbone with an amino group substituted at one of the four tertiary carbons. (wikipedia.org)
  • 1. Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells. (nih.gov)
  • Although amantadine has not been shown to possess direct anticholinergic activity in animal studies, clinically, it exhibits anticholinergic-like side effects such as dry mouth, urinary retention, and constipation. (nih.gov)
  • In addition, amantadine may also exert some anticholinergic activity. (sgpharma.com)
  • Plasma acetylamantadine accounted for up to 80% of the concurrent amantadine plasma concentration in 5 of 12 healthy volunteers following the ingestion of a 200 mg dose of amantadine. (nih.gov)
  • Eight years later, form of amantadine appropriate dose for dosemeasuring spoon or. (grey-panthers.it)
  • To resolve the dose of patients that are us we eat young health for the men we notice on the pharmacokinetics of our anything and frequency pets of how to get them very. (grantroaddaycare.com)
  • As concentration increases, toxicity seems to be more prevalent, however, absolute values of amantadine concentrations associated with adverse effects have not been fully defined. (nih.gov)
  • Treatment with ADS-1502 did not lead to clinical worsening of PD by standard measures, and reported adverse events were consistent with PD and the known amantadine safety profile, the researchers say. (medscape.com)
  • CDC also issued related web-based resources for health professionals concerning the indications for using antiviral agents for influenza, dosage, pharmacokinetics, side effects, antiviral-drug-resistant strains of influenza, and background information. (immunize.org)
  • The low overnight amantadine plasma concentration may reduce the insomnia, sleep disturbances, and vivid dreams associated with immediate-release amantadine. (medscape.com)
  • Amantadine probably does not inhibit monoamine oxidase (MAO) enzyme. (wikipedia.org)
  • More recent studies have demonstrated that amantadine is a weak, non-competitive NMDA receptor antagonist (K 1 = 10µM). (nih.gov)
  • Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. (wikipedia.org)
  • In certain cases, amantadine is also known to prevent virus assembly during virus replication. (nih.gov)
  • Amantadine reduced duration of fever by one day (95% CI 0.7 to 1.2). (nih.gov)
  • Influenza A variants with reduced in vitro sensitivity to amantadine have been isolated from epidemic strains in areas where adamantane derivatives are being used. (nih.gov)
  • There appears to be a relationship between plasma amantadine concentrations and toxicity. (nih.gov)
  • As plasma concentrations of amantadine increase, there is a greater risk for toxicity. (wikipedia.org)
  • Mechanism of Action: Antiviral The mechanism by which amantadine exerts its antiviral activity is not clearly understood. (nih.gov)
  • Amantadine targets the influenza A M2 ion channel protein. (wikipedia.org)
  • Host cells in tissue culture readily tolerated amantadine up to a concentration of 100 mcg/mL. (nih.gov)
  • Across other studies, amantadine plasma half-life has averaged 16 ± 6 hours (range: 9 to 31 hours) in 19 healthy volunteers. (nih.gov)
  • Change in Random really hot I times at Torrey Tang, Haihua Huang scientifically studied ingredients, ProstAid by Naturade talking to him, the pharmacokinetics of roxithromycin in healthy much Rogaine voltaren resinat online bestellen healthy prostate and in glucose of flashbulb must have. (grey-panthers.it)
  • The study was criticised for not achieving steady state before assessing pharmacokinetics and thus possibly underestimating interaction (See reference number 3). (vibore.com)
  • www.drugguide.com/ddo/view/Davis-Drug-Guide/51035/6/amantadine. (drugguide.com)