• The committee (that I also chaired) that prepared the latest report examined the current and future role of pharmacogenetics - the study of how people's genetic makeup determines their response to drugs - both in the discovery and development of new drugs, and in providing safer and more personalised treatment to patients. (scidev.net)
  • Franca R, Stocco G, Favretto D, Giurici N, Decorti G, Rabusin M. Role of Pharmacogenetics in Hematopoietic Stem Cell Transplantation Outcome in Children. (mdpi.com)
  • Thought you might appreciate this item(s) I saw at Pharmacogenetics and Genomics. (lww.com)
  • Pharmacogenetics and Genomics. (lww.com)
  • Distinct stages of translational genomics from discovery phase to an evaluation of health impacts on individuals or populations have been defined, and a recent systematic review of the literature from 2012 to 2013 shows that many of the studies that address clinical utility and the implementation of genomic medicine apply to pharmacogenetics, particularly for cancer patients. (futurelearn.com)
  • In the future, advances gleaned from pharmacogenetics research will provide information to guide doctors in getting just enough of the right medicine to a person--the practice of "personalized medicine. (spineuniverse.com)
  • In theory, pharmacogenetics - the subfield of personalized medicine that focuses on how people with different DNA variants respond to drugs - is supposed to solve this problem. (wordnik.com)
  • Researchers hope that pharmacogenetics will lead to therapies in which the active ingredient and dosage are tailored to a patient's individual genetic dispositions (see personalized medicine ). (bayer.com)
  • This course overviews the basic principles of molecular diagnostics and pharmacogenetics and the applications of the emerging technologies in personalized medicine. (uclaextension.edu)
  • RESEARCH TRIANGLE PARK, N.C. & LONDON--(EON: Enhanced Online News)--Quintiles, the world's leading biopharmaceutical services company, and London Genetics, an expert in the use of pharmacogenetics in drug discovery and development, today announced a strategic alliance to offer the biopharmaceutical industry innovative pharmacogenetics solutions to advance personalized medicine. (fiercebiotech.com)
  • In partnership with Sun Life Financial and Assurex Health, a wholly owned subsidiary of Myriad Genetics, Inc., CAMH is studying how pharmacogenetics can improve mental healthcare. (sunlife.ca)
  • The PGRN welcomes individuals, groups, or teams in pharmacogenetics, human genetics, or pharmacology and related fields to apply for affiliate membership. (nih.gov)
  • London Genetics Limited (LGL), a not-for-profit company, is an expert in the use of pharmacogenetics in clinical drug discovery and development. (fiercebiotech.com)
  • In 1962, I read a description of the acetylator trait in Werner Kalow's (1962) new book on pharmacogenetics while I was an NIH fellow in human genetics at the Galton Laboratory, University College, London. (aspetjournals.org)
  • Naturally occurring genetic variants in enzymes that control the body's ability to metabolize drugs a field known as pharmacogenetics play a critical role in governing the safety and effectiveness of many drugs. (wordnik.com)
  • A crude form of pharmacogenetics is already applied in medicine because we know that certain genetic variants that affect drug metabolism are more prevalent in populations from some parts of the world than others. (futurelearn.com)
  • Although pharmacogenetics research is still early in its development, the initial results suggest that detection of molecular variants associated with psychotropic drug response may soon be possible. (psychiatrictimes.com)
  • Pharmacogenetics is likely to play a central role in the personalization of treatment, to stratify patients based on their likelihood of response to both standard agents (i.e., gemcitabine/nucleoside transporters) and targeted treatments (i.e., epidermal growth factor receptor gene mutations and/or amplification and tyrosine kinase inhibitors), Thus, molecular analysis should be implemented in the optimal management of the patient affected by pancreatic adenocarcinoma. (aacrjournals.org)
  • The aim of this review is to provide an overview of currently available data regarding the pharmacogenetics of membrane transporters that may be involved in the interindividual variability of the response to tacrolimus. (springermedizin.de)
  • Pharmacogenetics research has shown that a simple blood test given to these patients ahead of time--in which a laboratory can "read" the sequence of a particular defective gene involved in drug metabolism--can accurately predict how much medicine they should receive. (spineuniverse.com)
  • Pharmacogenetics of Adverse Drug Reactions. (routledge.com)
  • Pharmacogenetics is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. (wikipedia.org)
  • Pharmacogenetics is the scientific discipline seeking to improve the response to drug therapies (better clinical efficiency and reduction of side effects) by taking into consideration the genetic characteristics of the patient. (clinicaltrials.gov)
  • Johnson, a clinical pharmacist at the University of Florida, studies this gene-drug relationship, known as pharmacogenetics , with a focus on cardiovascular diseases. (wordnik.com)
  • The advancement of pharmacogenetics will continue to further our knowledge of disease-drug interactions and pathogenesis. (ovid.com)
  • The science that studies the relationship between a person's genetic dispositions and the body's individual response to a drug is called pharmacogenetics. (bayer.com)
  • Clinical pharmacogenetics determines whether individual differences in the expression of a protein or enzyme affect the metabolism of a drug. (aafp.org)
  • Pharmacogenetics has many possible applications in the drug treatment of cardiovascular diseases. (bmj.com)
  • Second, pharmacogenetics may be useful for dose adaptations for specific drugs in patients with aberrant drug metabolism. (bmj.com)
  • The lack of consistency in what we accept in bioequivalence and in pharmacogenetics of drug metabolising enzymes is discussed and illustrated with the example of nortriptyline. (springer.com)
  • Psychiatric pharmacogenetics refers to the use of genetic testing to predict the effectiveness of pharmacotherapy for individuals with psychiatric illnesses, including alcohol, drug and addiction problems. (practicalrecovery.com)
  • Researchers from Baylor College of Medicine recently published an article that reviews psychiatric pharmacogenetics for drug and alcohol treatment (Haile, Kosten & Kosten, 2008). (practicalrecovery.com)
  • Psychiatric pharmacogenetics has great potential for improving drug and alcohol treatment outcome in the future. (practicalrecovery.com)
  • Pharmacogenetics involves the use of molecular genetic informa-tion to predict drug effectiveness and drug-induced adverse events. (psychiatrictimes.com)
  • Pharmacogenetics provides a number of distinct advantages in the search for informative correlates of psychotropic drug response. (psychiatrictimes.com)
  • The emerging field of pharmacogenetics aims at predicting the drug response based on an individual's genetic profile, thus helping clinicians to tailor effective treatments. (uclaextension.edu)
  • Germline pharmacogenetics describes genetic variations associated with drug response or drug disposition that may predispose a patient to be at risk for drug-related toxicity, nonstandard dose requirements, or lack of therapeutic benefit. (arupconsult.com)
  • Note: the metabolic phenotype predicted by pharmacogenetics may be altered by drug-drug interactions (eg, a CYP2C9 normal metabolizer could become a poor metabolizer if the patient takes a medication that inhibits CYP2C9). (arupconsult.com)
  • In this paper, we review key studies in cardiovascular pharmacogenetics that reveal genetic variations underlying the outcomes of drug treatment in cardiovascular disease. (up.ac.za)
  • Nevertheless we experience a lack of enthusiasm in the implementation of pharmacogenetics, especially when compared with for instance adaptation of drug dosing to liver or renal function or bodyweight for children. (springer.com)
  • Neslihan Aygun Kocabas, "Catechol-O-Methyltransferase (COMT) Pharmacogenetics in the Treatment Response Phenotypes of Major Depressive Disorder (MDD)", CNS & Neurological Disorders - Drug Targets (2012) 11: 264. (eurekaselect.com)
  • Pharmacogenetics, the study of influence of genetic factors on drug action and metabolism, is used for predicting adverse reactions of drugs. (ptcommunity.com)
  • The field of pharmacogenetics has been around since the 1950's, and as new information has slowly accumulated about additional gene and drug interactions, it has begun to be utilized across multiple health care specialties. (lineagen.com)
  • For more detailed information about specific gene variant and drug interactions and further education about pharmacogenetics, we highly recommend visiting the PharmGKB website . (lineagen.com)
  • Pharmacogenetics is believed to account for inter-ethnic differences (e.g., between patients of Asian, Caucasian and African descent) in adverse events and efficacy profiles of many widely used drugs in cancer chemotherapy. (wikipedia.org)
  • Pharmacogenetics is a very useful and important tool in predicting which drugs will be effective in various patients. (wikipedia.org)
  • Another newfound use of pharmacogenetics involves the use of Vitamin E. The Technion Israel Institute of Technology observed that vitamin E can be used to in certain genotypes to lower the risk of cardiovascular disease in patients with diabetes, but in the same patients with another genotype, vitamin E can raise the risk of cardiovascular disease. (wikipedia.org)
  • Some suggest preemptive pharmacogenetics testing might be useful in treating elderly patients. (forbes.com)
  • Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. (routledge.com)
  • Conclusion The contribution of pharmacogenetics to tailor-made pharmacotherapy, which especially might be of value for patients deviating from the average, has not yet reached the position it seems to deserve. (springer.com)
  • Understanding the pharmacogenetics of anti-diabetes medications will provide critical baseline information for the development and implementation of genetic screening into therapeutic decision making, and lay the foundation for "individualized medicine" for patients with T2D. (pubmedcentralcanada.ca)
  • Third Wave Technologies Inc. has announced that it has signed a pharmacogenetics collaboration agreement with Laboratory Corporation of America┬« Holdings (LabCorp┬«) to develop a companion diagnostic to help physicians personalize treatment for heart failure patients. (technologynetworks.com)
  • 2 - 4 By addressing genetic variability in therapeutic response, pharmacogenetics (PGx) promises to reduce the risk of ADRs. (aappublications.org)
  • Pharmacogenetics is the research of genetic variations in metabolic routes which can affect personal reactions to drugs, both in terms of therapeutic effect as well as negative effects. (omicsonline.org)
  • Understanding the genetic basis of an individual's response to therapeutic drugs (pharmacogenetics) is a unique area of research with significant translational impact for medicine. (washington.edu)
  • The impact of pharmacogenetics on examples like tramadol, clopidogrel, coumarins and abacavir is described. (springer.com)
  • Leah LaRue '10, a recognized leader in pain medication management, is extending the focus of her work to include the innovative field of pharmacogenetics, a type of genetic testing that shows how genetic variability impacts individual responses to medications. (stlcop.edu)
  • I speak about the importance of medication safety, and I also explain how pharmacogenetics may improve medication safety. (stlcop.edu)
  • What adds to the merit of this study is the pharmacogenetics analysis that was done on the European American subsample, which represents the majority of the sample (83% of medication group, 93% of placebo group). (psychiatrictimes.com)
  • These findings provide a much-needed extension of previous studies of naltrexone pharmacogenetics to individuals of Asian descent, an ethnic group more likely to express the minor allele putatively associated with improved biobehavioral and clinical response to this medication. (pubmedcentralcanada.ca)
  • Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become routine for the clinical practice. (routledge.com)
  • This review will focus on the pharmacogenetics of CYP1B1 in relation to hormone-mediated cancers and provide an assessment of cancer risk based on CYP1B1 polymorphisms and expression. (aacrjournals.org)
  • This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. (wiley.com)
  • This new approach, known as pharmacogenetics , could lead to diagnostic testing to guide the treatment of depression, replacing the current "trial-and-error" method. (wordnik.com)
  • This brief communication will focus on the recently completed randomized, controlled trials by Drs Kranzler and Oslin that studied the utility of pharmacogenetics in predicting treatment outcome for subjects with alcohol use disorders. (psychiatrictimes.com)
  • Pharmacogenetics traditionally is the research of germline mutations e.g., single-nucleotide polymorphisms. (omicsonline.org)
  • They learned about the nature of information being stored in the Pharmacogenetics Knowledge Base (PharmGKB), and the efforts being taken to ensure people's privacy. (nih.gov)
  • Dr. James Kennedy of the Tanenbaum Centre for Pharmacogenetics at the Centre for Addiction and Mental Health (CAMH) in Toronto says research in this innovative field can significantly improve healthcare. (sunlife.ca)
  • Pharmacogenetics is the extremely exciting new field of medicine that asks why.Each of us has a unique genetic make-up. (thedowneypatriot.com)
  • The symposium honored Wendell W. Weber for over 35 years of leadership and scientific advancement in pharmacogenetics and was highlighted by his overview of the historical development of the field. (aspetjournals.org)