AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
PityriasisArea Under CurveHalf-LifeDose-Response Relationship, DrugDrug InteractionsAdministration, OralCross-Over StudiesPharmacokineticsMetabolic Clearance RateInfusions, IntravenousMicrodialysisEncyclopedias as TopicHeart-Lung MachineCapillariesGlucuronosyltransferaseMembranes, ArtificialSurgical Procedures, Minimally Invasive
Pharmacokinetics and PharmacodynamicsAntibacterial agentAntimicrobialAntimicrob Agents ChDrugsAntibioticInfectionsAntiretroviral agentsHumansInfectious agentsInhibitorsChemotherapyTherapeuticsReviewMethodsStudiesDiscoveryStudySingle agentPotentialPharmacokineticsPharmacologyMedicinal ChemistryAntimicrobial agentsPharmacokineticEfficacyTriazole antifungal agentAntifungalInhibitorAntibioticSubstancesPathogensChemotherapeutic agentsAntibacterial AgentsOrganismAntibioticsDrugInfectionHumansVitroSusceptibilityInfectiousIntravenousTreatmentDivisionDevelopmentActivityCommonHigh
Pharmacokinetics and Pharmacodynamics3
  • A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson's disease, in healthy volunteers. (sc-ctsi.org)
  • Evaluation of the single-dose pharmacokinetics and pharmacodynamics of apixaban in healthy Japanese and Caucasian subjects. (sc-ctsi.org)
  • Pharmacokinetics and pharmacodynamics of drugs are introduced. (lsue.edu)
Antibacterial agent4
  • Sulfamethoxazole is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. (slabcutse.com)
  • It is also contraindicated in patients with a history of severe hypersensitivity (e.g. anaphylactic reaction) to any other type of betalactam antibacterial agent (penicillins, monobactams and carbapenems). (medico-labs.com)
  • Antibacterial agent-associated pseudomembranous colitis have been reported with nearly all antibacterial agents, including cefuroxime and may range in severity from mild to life threatening. (medico-labs.com)
  • It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in the treatment and prevention of such infections. (wikipedia.org)
Antimicrobial7
  • The discovery was formally announced at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 55th meeting during 17-21 September 2015 at San Diego, California, and published the next year in the Proceedings of the National Academy of Sciences. (wikipedia.org)
  • Antimicrobial Agents and Chemotherapy. (wikipedia.org)
  • The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and development of novel anti-infectives. (frontiersin.org)
  • Interscience Conference on Antimicrobial Agents and Chemotherapy. (epd-llc.com)
  • 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy. (epd-llc.com)
  • Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)
  • Antimicrobial agents should be given as soon as possible, according to the most likely pathogens. (medscape.com)
Antimicrob Agents Ch1
Drugs3
  • This chapter aims to discuss the anti-infective agents to broaden the understanding of the fundamental concepts, practical applications of the drugs prescribed and the necessary care for pregnant women. (eurekaselect.com)
  • Because of the relatively common occurrence of some infections during pregnancy, there is a great importance of studying them, therefore, knowing the classification of the drugs and identifying which agents are safe during pregnancy will both be discussed in this chapter. (eurekaselect.com)
  • Out of the 259 agents that were approved, 75 were first-in-class drugs with new MMOAs, and out of these, 50 (67%) were small molecules and 25 (33%) were biologics. (gotomydoctor.com)
Antibiotic3
  • Patients with sepsis have a high mortality rate, accumulated evidences suggest that an optimal antibiotic administration strategy based on pharmacokinetics/pharmacodynamics (PK/PD) can improve the prognosis of septic patients. (biomedcentral.com)
  • These supports often influence patients' PK, resulting in poor anti-infective efficacy and requiring antibiotic dose adjustment. (biomedcentral.com)
  • Sometimes, the term antibiotic -literally "opposing life", from the Greek roots ἀντι anti , "against" and βίος bios , "life"-is broadly used to refer to any substance used against microbes , but in the usual medical usage, antibiotics (such as penicillin ) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics ) are fully synthetic . (wikipedia.org)
Infections2
  • Hence, there is a need for the accelerated development of new agents to treat and prevent infections caused by AMR pathogens ( WHO, 2021 ). (frontiersin.org)
  • Female mosquitoes ingest circulating MF during a blood meal from animals harboring patent infections, with ingested MF molting to the infective third-stage larvae (L3) within 10-14 days post-blood meal. (biomedcentral.com)
Antiretroviral agents2
  • Efavirenz is a non-nucleoside reverse transcriptase inhibitor indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 infection in adults and in pediatric patients at least 3 months old and weighing at least 3.5 kg. (nih.gov)
  • For use of antiretroviral agents for post-exposure prophylaxis consult the most recent official guidelines, e.g. those of the WHO. (who.int)
Humans1
  • They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (edu.au)
Infectious agents1
  • However, in this period, physiological changes take place that make the woman more vulnerable to infectious agents. (eurekaselect.com)
Inhibitors1
  • Cell permeable vanX inhibitors as vancomycin re-sensitizing agents. (extherid.com)
Chemotherapy3
  • Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete or partial response to a rituximab product in combination with chemotherapy, as single-agent maintenance therapy. (drugs.com)
  • Non-progressing (including stable disease), low-grade, CD20-positive, B-cell NHL as a single agent after first-line cyclophosphamide, vincristine, and prednisone (CVP) chemotherapy. (drugs.com)
  • For anti-tumor antibiotics, see Chemotherapy § Cytotoxic antibiotics . (wikipedia.org)
Therapeutics2
  • A mucosal model to study microbial biofilm development and anti-biofilm therapeutics. (extherid.com)
  • Many new oncology therapeutics are immunotherapeutic agents. (compbio.com)
Review1
  • Keerty D, Yacoub AT, Nguyen TC, Haynes E, Greene J. First Case of Infective Endocarditis With Streptococcus equinus in an Immunocompetent Patient in North America: A Case Report and Review of Literature. (moffitt.org)
Methods1
  • CBI provides a variety of validated cell lines and specialized methods for the assessment of anti-tumor agents both in vitro and as xenografts. (compbio.com)
Studies1
  • These studies show that the microbiological profile of our ultra-broad-spectrum beta-lactamase inhibitor xeruborbactam in combination multiple beta-lactams exceeds that for other investigational or marketed agents," stated Michael Dudley, PharmD, FIDSA, president and chief executive officer of Qpex Biopharma. (qpexbio.com)
Discovery1
  • Atta-ur- Rahman, M. Iqbal Choudhary , " Frontiers in Anti-Infective Drug Discovery ", Bentham Science Publishers (2018). (benthamscience.com)
Study1
  • Aims: We aimed to study the relation between pharmacokinetics (PK) and pharmacodynamics (PD) of docetaxel in early breast cancer and recommend a target exposure. (unav.edu)
Single agent2
  • Do not use as a single agent or add on as a sole agent to a failing regimen. (nih.gov)
  • Relapsed or refractory, low grade or follicular, CD20-positive B-cell NHL as a single agent. (drugs.com)
Potential2
  • Consider potential for cross-resistance when choosing other agents. (nih.gov)
  • We have evaluated many potential anti-cancer compounds in oncology research models. (compbio.com)
Pharmacokinetics12
  • Clinical implications of pharmacokinetics and pharmacodynamics of fluoroquinolones. (nih.gov)
  • Qigui Li, Mark R. Hickman , " Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy ", Bentham Science Publishers (2015). (benthamscience.com)
  • Research into antimicrobial pharmacokinetics and pharmacodynamics has established surrogate relationships between the 2 that correlate with outcomes such bacterial eradication or clinical cure. (medscape.com)
  • Given the pharmacokinetics of this agent, the drug concentration probably will remain above the MIC of the organism beyond the time necessary to achieve an optimal pharmacodynamic effect. (medscape.com)
  • Using our knowledge of pharmacokinetics and pharmacodynamics allows us to optimize antimicrobial choice and dose to ensure the best use of our dwindling anti-infective resources. (medscape.com)
  • In this webinar, William Hope talks about the role of pharmacokinetics and pharmacodynamics for antimicrobial drug development. (gardp.org)
  • Her work focuses on the pharmacokinetics of ampicillin in the neonate, as well as determining the population pharmacokinetics and pharmacodynamics of lamivudine in HIV-infected infants. (ucsd.edu)
  • Biochemical Pharmacology publishes original research findings and review articles related to the elucidation of cellular and tissue function(s) at the biochemical and molecular levels, the modification of cellular phenotype(s) by genetic, transcriptional/translational or drug/compound-induced modifications, as well as the pharmacodynamics and pharmacokinetics of xenobiotics and drugs, the latter including both small molecules and biologics. (elsevier.com)
  • This is based on both the pharmacokinetics and pharmacodynamics of the medications themselves, along with the hepatic and renal function of the patient since most medications are metabolized and/or cleared in these organs. (pulmonologyadvisor.com)
  • Also, not enough information about pharmacokinetics and pharmacodynamics is available, so the optimal dose should be determined to use these antibiotics to prevent the toxic effects of this antibiotic. (modernmedlab.com)
  • In current study, additionally to their pharmacokinetics and pharmacodynamics, we have presented current knowledge about the genes and two-component systems that may cause such resistance to polymyxin and colistin. (modernmedlab.com)
  • This first-in-human study aimed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of MHV370 in healthy adults, as well as the effects of food consumption on a single dose of MHV370. (charite-research.org)
Pharmacology3
  • Dr. Best specializes in the clinical pharmacology of antiretroviral agents, with expertise in antiretroviral therapeutic drug monitoring, treatment of HIV-infected pregnant women and children, and antiretroviral central nervous system penetration. (ucsd.edu)
  • Dr. Tremoulet studies the pharmacology of anti-infective agents. (ucsd.edu)
  • A secondary objective is to establish partnerships among anti-microbial pharmacologists, microbiologists and animal modelers to bridge the gap between antimicrobial pharmacology and its application to fundamental and translational research for the clinical management of drug resistance. (nih.gov)
Medicinal Chemistry2
  • Current Medicinal Chemistry: Anti-Infective Agents 2005 . (nih.gov)
  • He has 40 scientific publications and patents in the areas of synthetic and medicinal chemistry, and anti-viral research. (nih.gov)
Antimicrobial agents10
  • The development of drug-resistant bacteria and the necessity for unique antimicrobial agents, directed to the search of new habitats to screen the production of anti-infective substances. (springer.com)
  • The discovery was formally announced at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 55th meeting during 17-21 September 2015 at San Diego, California, and published the next year in the Proceedings of the National Academy of Sciences. (wikipedia.org)
  • Antimicrobial Agents and Chemotherapy. (wikipedia.org)
  • However, to do so effectively, one needs to understand the pharmacokinetic and pharmacodynamic properties of the antimicrobial agents in question. (medscape.com)
  • For concentration-dependent antimicrobial agents such as fluoroquinolones and aminoglycosides, Cmax/MIC or AUC/MIC most closely correlates with clinical and microbiological outcomes. (medscape.com)
  • For time-dependent antimicrobial agents such as beta-lactams, the percentage of time during the dosing interval that the drug concentration remains above the MIC of the organism is the measure that most closely predicts outcomes. (medscape.com)
  • The purpose of this FOA is to support antimicrobial pharmacokinetic and pharmacodynamic (PK/PD) studies of drug combinations or sequentially administered (sequenced) antimicrobial agents in relevant in vitro and animal models to enhance understanding of the host, drug and microbial factors that contribute to the emergence of antimicrobial drug resistance in clinically relevant pathogens with a goal of minimizing the potential for development of resistance. (nih.gov)
  • Resistance is a natural and inevitable event in microbial populations that are exposed to antimicrobial agents and is starting to limit the effectiveness of available drugs for the treatment of bacterial, viral fungal and parasitic infectious diseases. (nih.gov)
  • Since the introduction of antimicrobial agents as standard medical practice and in veterinary applications, indiscriminate use and incomplete therapies have resulted in a substantial increase in antimicrobial resistance in the U.S. and globally. (nih.gov)
  • Major targets of antimicrobial agents. (microbiologyclass.net)
Pharmacokinetic1
  • 1. Pharmacokinetic studies, pharmacodynamics/exploratory trials. (nih.gov)
Efficacy2
  • Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). (lookformedical.com)
  • Applications that focus on preclinical and pilot clinical studies on bioavailability, toxicity, and efficacy of cancer therapeutic agents are reviewed in ATA. (nih.gov)
Triazole antifungal agent3
  • Fluconazole, a triazole antifungal agent, is a potent and specific inhibitor of fungal sterol synthesis. (mims.com)
  • Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS. (lookformedical.com)
  • A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. (lookformedical.com)
Antifungal8
  • Antifungal agents. (lookformedical.com)
  • An imidazole antifungal agent that is used topically and by intravenous infusion. (lookformedical.com)
  • Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. (lookformedical.com)
  • A fluorinated cytosine analog that is used as an antifungal agent. (lookformedical.com)
  • The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. (lookformedical.com)
  • A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL. (lookformedical.com)
  • An imidazole derivative that is commonly used as a topical antifungal agent. (lookformedical.com)
  • A synthetic antifungal agent. (lookformedical.com)
Inhibitor3
  • Efavirenz is a non-nucleoside reverse transcriptase inhibitor indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 infection in adults and in pediatric patients at least 3 months old and weighing at least 3.5 kg. (nih.gov)
  • He and his collaborators have advanced numerous compounds into preclinical and clinical development, including ciluprevir (BILN 2061), the first HCV NS3 protease inhibitor to demonstrate anti-viral activity in humans. (nih.gov)
  • Tazobactam/piperacillin (TAZ/PIPC) is an anti-pseudomonal broad spectrum penicillin combined with a beta-lactamase inhibitor, tazobactam (TAZ) at a ratio of 1 (TAZ):8 (PIPC). (journalmc.org)
Antibiotic1
  • Once the specific pathogen has been identified, narrow the antibiotic agent according to organism and susceptibility testing. (pulmonologyadvisor.com)
Substances2
  • Reports describing experiments conducted with natural product mixtures, plant or animal extracts will not be considered for publication unless the structures and concentrations of all component substances are known, and the agents can be easily obtained by others wishing to replicate the study. (elsevier.com)
  • Substances or chemical agents that affect biological or living systems. (schleiden-eifel.de)
Pathogens1
  • Resistance limits the market life of antimicrobial drugs, while limited markets exist for agents only active against resistant pathogens. (cdc.gov)
Chemotherapeutic agents1
  • He obtained his PhD in Biochemistry from Northwestern University in 2008 where he studied protein structure-based drug design of novel chemotherapeutic agents. (chi-peptalk.com)
Antibacterial Agents1
Organism3
  • Pharmacodynamics describes the interaction between the antimicrobial agent and the infecting pathogen (what the drug does to the infecting organism). (medscape.com)
  • However, ciprofloxacin as a single agent probably cannot be used to treat most serious infections with this organism because of its inability to achieve adequate concentrations at the site of infection. (medscape.com)
  • In contrast, if the same organism exhibits a 4-mg/L MIC to piperacillin-tazobactam (Zosyn®), it is exquisitely susceptible and is likely to be treatable by this agent alone for even serious infections. (medscape.com)
Antibiotics1
  • A computer-assisted management program for antibiotics and other antiinfective agents. (nih.gov)
Drug7
  • Atta-ur-Rahman , " Frontiers in Clinical Drug Research: Anti-Infectives ", Bentham Science Publishers (2017). (benthamscience.com)
  • While working at the interface between Drug Discovery and Early Development at Novartis, DuPont Pharmaceuticals, and Pfizer Dr. Anderson contributed to IND's and investigator brochures in therapeutic the areas of oncology CVMED, CNS, and antibacterial/anti-infectives. (nih.gov)
  • A compound drug consisting of strong agent), antibacterial drugs and enzyme inhibitors. (nih.gov)
  • Applications focused on early stages of drug discovery involving synthesis, validation/optimization of new anti-cancer therapeutic agents and in vivo evaluation of new drugs are reviewed in DMPC. (nih.gov)
  • Applications that focus on the mechanism of action of novel anticancer agents and the impact of drug properties on anti-cancer drug function may be reviewed in MCTA. (nih.gov)
  • The drug belongs to the group of cerebroactive drugs, has anti-ischemic, antioxidant, membrane-stabilizing and nootropic properties. (mysalve.com)
  • The probability of changing the pharmacodynamics of piracetam under the influence of other drugs is low, since 90% of the drug is excreted unchanged in the urine. (mysalve.com)
Infection1
  • The goal of antimicrobial therapy is to correctly identify infection and then select the most appropriate anti-infective that can sufficiently treat the infection. (pulmonologyadvisor.com)
Humans1
Vitro1
  • In vitro, CVF anti-HIV-1 activity showed increased HIV inhibition over baseline following TFV-eluting IVR use, from a median of 7.1% to 84.4% in TFV/LNG, 15.0% to 89.5% in TFV-only, and -27.1% to -20.1% in placebo participants. (cdc.gov)
Susceptibility1
  • Minimum inhibitory concentrations (MICs) can be very useful in selecting the best antimicrobial agent for a given patient with known culture and susceptibility results. (medscape.com)
Infectious1
  • However, interference of antioxidant constituents of blood plasma takes precedence in our analysis and therefore the application of ozone therapy for these purposes is largely dismissed for autohemotherapy as a direct action of the elimination of various infectious agents. (scirp.org)
Intravenous1
  • To this end, her research has concentrated on developing a scoring method to identify IVIG-resistant Kawasaki Disease patients and identifying the role of IgG glycosylation to determine the anti-inflammatory mechanism of intravenous immunoglobulin. (ucsd.edu)
Treatment1
  • Pyrazinamide is an antitubercular , anti- infective agent that is FDA approved for the treatment of the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents . (wikidoc.org)
Division1
  • Dr. Murphy deferred to Dr. John Alexander of the FDA Anti-Infectives Review Division, who explained that if a group decides to change the labeling for dosing for particular children, the information along with its sources must be compiled. (nih.gov)
Development1
  • Development and impact of a computerized pediatric antiinfective decision support program. (nih.gov)
Activity1
  • We further evaluated TFV pharmacodynamics (PD) through ex vivo CVF activity against both human immunodeficiency virus (HIV)-1 and herpes simplex virus (HSV)-2, and LNG PD using cervical mucus quality markers and serum progesterone for ovulation inhibition. (cdc.gov)
Common1
  • The most common measure used to define antimicrobial pharmacodynamics is the organism's MIC. (medscape.com)
High1
  • Clinical isolates of P. gingivalis strains with high dipeptidyl peptidase 4 (DPP4) expression also had a high capacity for biofilm formation and were more infective. (inra.fr)