Pharmaceutical acetylsalicylic aspirin. Medical search. Frequent questions

Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. (wikipedia.org)
In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. (wikipedia.org)
In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. (wikipedia.org)
The name is ultimately a blend of the prefix a(cetyl) + spir Spiraea, the meadowsweet plant genus from which the acetylsalicylic acid was originally derived at Bayer + -in, the common chemical suffix. (wikipedia.org)
This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. (wikipedia.org)
Reaction between acetic acid and salicylic acid can also form aspirin but this esterification reaction is reversible and the presence of water can lead to hydrolysis of the aspirin. (wikipedia.org)
Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, which melts at 136 °C (277 °F), and decomposes around 140 °C (284 °F). Its acid dissociation constant (pKa) is 3.5 at 25 °C (77 °F). Polymorphism, or the ability of a substance to form more than one crystal structure, is important in the development of pharmaceutical ingredients. (wikipedia.org)
Aspirin: In 1897, German chemist Felix Hoffmann synthesized acetylsalicylic acid, which would later become known as aspirin. (scienceprog.com)
It was used to make chemical called acetylsalicylic acid. (aweber.com)
The common name for acetylsalicylic acid is Aspirin. (aweber.com)
Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug. (sigmaaldrich.com)
Pharmaceuticals containing acetylsalicylic acid (Acylpirin, Aspirin, and Anopyrin etc.) should not be used for 3 weeks before the Labiaplasty - Labia Reduction surgery, as they decrease clotting time of blood. (beautyinprague.com)
The drug is acetylsalicylic acid, more commonly known as aspirin. (wyattresearch.com)
Most pharmaceutical interventions are composed of compounds or biomolecules usually transmitting a single signal to the body: acetyl-salicylic acid, also known as aspirin, the anti-depressant fluxetine, hormones like growth hormone, etc. (senescence.info)
Another example of the importance of medicinal plants for medicine is the story of acetylsalicylic acid which is also known as aspirin. (uu.se)
In 1897 he modified the substance chemically to acetylsalicylic acid whereupon his father's stomach problems were eased. (uu.se)
Acetylsalicylic acid is one of today's most common medicines against pain. (uu.se)
In recent years there has emerged an alternative use for acetylsalicylic acid. (uu.se)
The chemical name for this drug is acetylsalicylic acid. (factfile.org)
Examples of acetylated pharmaceuticals include heroin and acetylsalicylic acid (aspirin). (mjbizdaily.com)
Additionally, salicylic acid is a key precursor in the synthesis of aspirin (acetylsalicylic acid) and other pharmaceutical compounds. (infinitylearn.com)
Answer: Salicylic acid is a key starting material in the synthesis of aspirin (acetylsalicylic acid). (infinitylearn.com)
In this process, salicylic acid reacts with acetic anhydride in the presence of a catalyst, such as sulfuric acid, to form aspirin and acetic acid. (infinitylearn.com)
In this reaction, the hydroxyl group of salicylic acid reacts with acetic anhydride to form an ester, resulting in the production of aspirin. (infinitylearn.com)
The active chemical is acetylsalicylic acid. (dandc.eu)
Aspirin (IUPAC name: acetylsalicylic acid) is used to reduce inflammation by inhibiting biological enzymes and prevent clotting to reduce chance of stroke. (scienceready.com.au)
Aspirin, also known as acetylsalicylic acid, is a popular over-the-counter medication used to relieve pain, reduce inflammation, and lower fever. (pharmadoctor.su)
The best known active agents are the active ingredients in pharmaceuticals such as acetylsalicylic acid in Aspirin or taxol in cancer drugs. (leibniz-wirkstoffe.de)
It trademarked acetylsalicylic acid as aspirin in 1899. (takecare4.eu)
The aspirin we know, acetylsalicylic acid, was developed by Bayer Pharmaceuticals in the late 1890's in Germany and was widely available over the counter beginning about 1915. (whatswrongwithhealthcareinamerica.com)
Aspirin's chemical name is acetylsalicylic acid (ASA). (aopa.org)
Eventually, in 1899, German chemists turned salicylic acid into acetylsalicylic acid. (dhushara.com)
Yahoo News reported, " Asprin (sic) is a valuable tool in improving a plant's immune system because the pharmaceutical contains acetylsalicylic acid, which is chemically similar to the salicylic acid naturally found in plants. (gogardennow.com)
García Rodríguez LA, Cea Soriano L, Hill C, Johansson S. Increased risk of stroke after discontinuation of acetylsalicylic acid: a UK primary care study. (bayeraspirin.com)
We also perform custom synthesis and purification of Acetylsalicylic Acid Impurity F (Aspirin Impurity F) from mg to gm scale. (blogspot.com)
In 2022, the pharmaceutical sector dominated the market due to the rising usage of medications based on salicylic acid for the treatment of various skin conditions, cardiovascular diseases, and Hughes syndrome. (credenceresearch.com)
The market for salicylic acid will see more prosperous chances due to the rising demand for aspirin in the treatment and prevention of dementia and strokes. (credenceresearch.com)
Thermo Fisher Scientific, Shandong Xinhua Longxin Chemical Co. Ltd., Merck & Co. Inc., Zhenjiang Gaopeng Pharmaceutical Co. Ltd., and other regional firms compete fiercely for market share in the salicylic acid sector. (credenceresearch.com)
The addition of a new indication (thrombosis prophylaxis) prompts the World Health Organization (WHO) to include acetylsalicylic acid, the active ingredient in Aspirin™, in its "List of essential medicines" for a second time. (bayer.com)
Peptic ulcer, hypersensitivity to Diclofenac like other non- steroid anti-inflammatory agents, Diclofenac is also contra-indicated in asthmatic patient in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor. (addinpharma.com)
Acetylsalicylic acid is degraded in the environment. (janusinfo.se)
Acetylsalicylic acid has low potential for bioaccumulation. (janusinfo.se)
Acetylsalicylic acid has moderate chronic toxicity. (janusinfo.se)
The use of acetylsalicylic acid (sales data Sweden 2018) has been considered to result in low environmental risk. (janusinfo.se)
Hence, acetylsalicylic acid can be regarded as readily biodegradable. (janusinfo.se)
Persistence: It cannot be excluded that acetylsalicylic acid is persistent, due to the lack of data. (janusinfo.se)
Acetylsalicylic acid and penicillins were eliminated despite their very high consumption and discharge to sewage because they break down very quickly, both in the treatment of wastewater and in natural waters. (janusinfo.se)
Acetylsalicylic acid is colorless or white in crystalline, powder, or granular form. (medscape.com)
paracetamol and acetylsalicylic acid was conducted in 115 out patients with acute plasmodium falciparum malaria. (bvsalud.org)

69-75 By 1899, Bayer had named it "Aspirin" and sold it around the world. (wikipedia.org)
Aspirin is introduced to the pharmaceutical industry in 1899. (factfile.org)

Bayer AG is a chemical and pharmaceutical giant founded in Barmen, Germany in 1863 by Friedrich Bayer and his partner, Johann Friedrich Weskott. (takecare4.eu)
As a baby boomer born in the fifties, I grew up in a family whose medicine cabinet contained two boxes of Bayer® Aspirin, one box each of chewable, orange-flavored baby aspirin and full-strength (325 mg) aspirin. (aopa.org)
In the late 1890s, aspirin made its way to a dye and pharmaceutical company called Bayer, named after the chemist who founded the company. (aopa.org)
It was felt by one of the chemists at Bayer that aspirin was cardiotoxic. (aopa.org)
Bayer ® Aspirin can help save lives. (bayeraspirin.com)
For maximum efficacy, remind patients to continue taking Bayer ® Aspirin with their prescription antiplatelet therapy. (bayeraspirin.com)
Bayer ® Aspirin 81 mg is recommended as part of a secondary prevention regimen-with an enteric coating to help with GI tolerability. (bayeraspirin.com)
Why Bayer ® Aspirin? (bayeraspirin.com)
As early as 1992, Bayer broke ground on a new site in Bitterfeld in eastern Germany, where production of Aspirin™ began in 1994. (bayer.com)
To better equip itself for the challenges of the future, Bayer set up a third pharmaceutical research center, this time in Japan, in addition to the locations in Europe (Wuppertal) and North America (West Haven, Connecticut). (bayer.com)
In 1995 the research center of Japanese pharmaceutical subsidiary Bayer Yakuhin Ltd. was dedicated at Kansai Science City near Kyoto. (bayer.com)

Find out the interesting information about one of the most widely used drugs in the world in Facts about Aspirin . (factfile.org)
Do you want to comment on facts about aspirin ? (factfile.org)

API full form in pharma is Active Pharmaceutical Ingredient. (salvavidaspharmaceutical.in)

Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. (wikipedia.org)
A that time, the main purpose of aspirin was to treat gout and rheumatic fever. (factfile.org)
Aspirin is used as an anti-inflammatory agent for the treatment of soft tissue and joint inflammation and vasculitides such as acute rheumatic fever and Kawasaki disease. (medscape.com)

The history of aspirin starts in the days of Hippocrates, the father of modern medicine, 2,400 years ago. (aopa.org)

Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. (wikipedia.org)
A new series of NSAIDs in which aspirin is joined by an ester linkage to furoxan moieties, with different ability to release NO, were synthesized and tested for NO-releasing, antiinflammatory, antiaggregatory, and ulcerogenic properties. (uhi.ac.uk)
Non-aspirin NSAIDs are licensed for the relief of pain and inflammation arising from rheumatic disease. (bris.ac.uk)
The MeSH heading "osteoarthritis" was combined with the generic names of the 17 non-aspirin NSAIDs licensed in the UK for the management of OA in general practice. (bris.ac.uk)
The search of Embase used the term "osteoarthritis" if present in the abstract, title or keywords, and was combined with the generic names of the 17 non-aspirin NSAIDs, only if they were mentioned in the title, abstract or keywords. (bris.ac.uk)
SELECTION CRITERIA: All double blind, randomised controlled trials, in the English language, comparing the efficacy of two non-aspirin NSAIDs in the management of osteoarthritis of the knee, were selected. (bris.ac.uk)
Studies which compared one "trial" NSAID with one "reference" NSAID were included provided they were non-aspirin NSAIDs available in the UK and were licensed for the treatment of OA by general practitioners. (bris.ac.uk)

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis. (sigmaaldrich.com)
In the 1920s, aspirin rose to fame as an anti-inflammatory, analgesic, and antipyretic. (aopa.org)
The prevalence of aspirin-containing analgesic products makes these agents, found in virtually every household, common sources of unintentional and suicidal ingestion. (medscape.com)

Pfizer is a world-famous pharmaceutical and biotechnology company. (wealthybyte.com)
Being one of the oldest pharmaceutical firms, Pfizer Inc. is set to dominate the industry with its Covid pills. (wealthybyte.com)

Dr. Craven started giving his older patients aspirin to prevent myocardial infarction (heart attacks). (aopa.org)
2. García Rodríguez LA, Cea-Soriano L, Martín-Merino E, Johansson S. Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care. (bayeraspirin.com)

The risk of having ovarian cancer can be reduced up to 20 percent if the women take aspirin daily. (factfile.org)
The children with flu symptoms, chicken pox and other viral disease should not take aspirin because it can increase the risk of having Reye's syndrome. (factfile.org)
Should I Take Aspirin To Prevent Stroke or Heart Attack? (theskepticalcardiologist.com)

The damaged intestinal lining in celiac patients is already sensitive, and the introduction of aspirin could potentially exacerbate the situation. (pharmadoctor.su)

However, the potential issue could lie in the fillers or binders used in the production of aspirin tablets, which could contain gluten. (pharmadoctor.su)

Aspirin does have pain and anti-inflammatory properties, but it is very hard on the stomach, liver, and kidneys. (aweber.com)
White Willow bark has the salicin, but also has flavonoids, which have powerful anti-inflammatory properties without the aggressive side effects of the pharmaceutical. (aweber.com)
WITHDRAWN: Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee. (bris.ac.uk)
Aspirin, being a non-steroidal anti-inflammatory drug (NSAID), can cause irritation to the stomach lining, leading to discomfort, pain, or even ulcers in some cases. (pharmadoctor.su)

In 1971, Dr. John Vane discovered that aspirin worked on prostaglandin synthesis. (aopa.org)

Which Kind of Baby Aspirin Should I Take To Prevent Heart Attack? (theskepticalcardiologist.com)
The skeptical cardiologist recently asked his Eternal Fiancée to grab a bottle of baby aspirin while she was at the local Walgreen's. (theskepticalcardiologist.com)

The synthesis of aspirin is classified as an esterification reaction. (wikipedia.org)

Just like any other drug, aspirin also has side effect if you consume the higher dose. (factfile.org)
Should you take low dose aspirin every day? (whatswrongwithhealthcareinamerica.com)
Over the subsequent decades, numerous trials of aspirin use in patients with a variety of forms of heart disease were conducted, and the "big picture" showed that daily use of low-dose aspirin in coronary patients cut the rate of death, heart attack and stroke combined by about 22% relative to non-use. (whatswrongwithhealthcareinamerica.com)
If you have risk factors for coronary disease and no history of ulcers or other bleeding issues, I would seriously consider taking low dose aspirin daily. (whatswrongwithhealthcareinamerica.com)
could be avoided, if patients followed their doctors' recommendations for post-MI preventive measures like a low-dose aspirin regimen. (bayeraspirin.com)
Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. (bayeraspirin.com)
Low-dose aspirin helps to prevent thrombosis. (medscape.com)
One teaspoon of 98% methyl salicylate contains 7000 mg of salicylate, the equivalent of nearly 90 baby aspirins and more than 4 times the potentially toxic dose for a child who weighs 10 kg. (medscape.com)

On the condition of FDA approval, sales of Maxigesic® IV could start soon, with an exclusive license and distribution agreement already signed between Hyloris' partner AFT Pharmaceuticals and Hikma Pharmaceuticals, a leading supplier of complex, injectable hospital products in the U.S. (marketscreener.com)

All the products described present an antiinflammatory trend, maximized in derivatives 12, 16, and 17, they are devoid of acute gastrotoxicity, principally due to their ester nature, and show an antiplatelet activity primarily determined by their ability to release NO. They do not behave as aspirin prodrugs in human serum. (uhi.ac.uk)
A randomised, double-blind, multinational study to prevent major vascular events with Ticagrelor compared to Aspirin(ASA) in patients with acute ischaemic stroke or Transient Ischemic Attack (TIA). (clinicaltrialsregister.eu)
SOCRATES - Acute Stroke Or Transient IsChaemic Attack TReated with Aspirin or Ticagrelor and Patients OutcomeS]. (clinicaltrialsregister.eu)

A precursor to aspirin found in the bark of the willow tree (genus Salix) has been used for its health effects for at least 2,400 years. (wikipedia.org)

The Guinness Book World of Records picked aspirin as the highest selling drug in the world in 1950. (factfile.org)
In 1950 he published an article in Annals of Western Medicine and Surgery showing that zero of 400 patients given aspirin had a heart attack. (aopa.org)

We supply a wide range of aspirin-related impurities and degradation products, as well as our ISO17034-accredited API. (lgcstandards.com)

In 1940, Karl Link became interested in researching aspirin and he found that it has anticoagulant activity. (aopa.org)
The anticoagulant effect of aspirin is seen by working on the platelets in blood to keep them from forming clots. (aopa.org)

Regulated Information - Liège, Belgium - 1 September 2022 - Hyloris Pharmaceuticals SA (Euronext Brussels: HYL) , a specialty biopharma company committed to addressing unmet medical needs through reinventing existing medications, today reported its condensed consolidated financial results for the six-month period ending 30 June 2022, along with a year-to-date business update and an outlook. (globenewswire.com)

Like flour mills, factories producing aspirin tablets must control the amount of the powder that becomes airborne inside the building, because the powder-air mixture can be explosive. (wikipedia.org)

This is my 2018 post updating guidance on aspirin usage in light of the ASPREE trial. (theskepticalcardiologist.com)

Lower doses of aspirin have also been shown to reduce the risk of death from a heart attack, or the risk of stroke in some circumstances. (foodchem.md)
https//www.stroke.org/en/life-after-stroke/preventing-another-stroke. (bayeraspirin.com)
Does Aspirin Have A Role In Stroke Prevention In Atrial Fibrillation Or Is It Time To Start Stopping It? (theskepticalcardiologist.com)
For decades the skeptical cardiologist and his cardiology brethren and sistren have prescribed aspirin to prevent stroke in patients with atrial fibrillation. (theskepticalcardiologist.com)

This marked the basic completion of Bayer's Europe/North America/Japan "pharmaceutical research triad. (bayer.com)
To mark the 100th birthday of Aspirin™ on March 6, professional mountaineers wrap Bayer's former high-rise headquarters building in Leverkusen, transforming it into the world's biggest Aspirin™ pack and earning the company three entries in the Guinness Book of Records. (bayer.com)

Aspirin plays a critical role in dual antiplatelet therapy. (bayeraspirin.com)
Preventive aspirin and other antiplatelet medication use among U.S. adults aged ≥40 years: data from the national health and nutrition examination survey, 2011-2012. (bayeraspirin.com)

Related furazan derivatives, aspirin, its propyl ester, and its gamma-nitrooxypropyl ester were taken as references. (uhi.ac.uk)

Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. (wikipedia.org)
Logically, then, you would expect aspirin taken regularly to reduce the risk of heart attacks and strokes and increase the risk of bleeding, and this is a situation in which what seems logical is also true. (whatswrongwithhealthcareinamerica.com)
Dr. Craven also showed that aspirin prevented strokes. (aopa.org)
Additionally, growing aspirin use to treat and prevent diseases like strokes and dementia among the aging population is anticipated to fuel market expansion throughout the forecast period. (credenceresearch.com)

While aspirin has many actions, the one of most importance to its use for cardiovascular disease is its ability to prevent platelets from sticking together. (whatswrongwithhealthcareinamerica.com)
In absolute terms, if 1000 patients took aspirin and 1000 did not, the aspirin users suffered 25 fewer major cardiovascular events - at a cost of 4 major bleeding events. (whatswrongwithhealthcareinamerica.com)
The bottom line was that daily aspirin use reduced the rate of major cardiovascular events from 61.4 per 10,000 person-years to 57.1 - a modest but statistically valid reduction. (whatswrongwithhealthcareinamerica.com)
The 70s and 80s were the heyday of clinical trials showing the use of aspirin in cardiovascular disease could save lives. (aopa.org)
Adherence to therapies for secondary prevention of cardiovascular disease: a focus on aspirin. (bayeraspirin.com)
Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial. (bayeraspirin.com)

Regeneron Pharmaceuticals, Inc. was established in 1988. (wealthybyte.com)
This trial, called ISIS-2 was reported back in 1988 and showed that aspirin did reduce the rate of death and vascular complications when given over the short-term, and that it seemed to have few serious side effects given this way. (whatswrongwithhealthcareinamerica.com)

69-75 Aspirin is available without medical prescription as a proprietary or generic medication in most jurisdictions. (wikipedia.org)
It is therefore crucial to have a discussion with a healthcare provider before starting or stopping any medication, including aspirin. (pharmadoctor.su)

Aspirin is usually well tolerated in most individuals and is considered safe for long-term use at low doses. (pharmadoctor.su)

Differential Scanning Calorimetry (DSC) is the most commonly used Thermal Analysis method for pharmaceutical applications and - along with thermogravimetric analysis - also mentioned in various pharmacopeias such as USP, Ph. (pharmaceutical-business-review.com)

Who Created The First Pharmaceutical Drugs? (scienceprog.com)
The history of pharmaceutical drugs is a fascinating journey that takes us back thousands of years. (scienceprog.com)
The development of pharmaceutical drugs has been a continuous process, with each generation building upon the knowledge and discoveries of those who came before them. (scienceprog.com)
In this article, we will explore the origins of pharmaceutical drugs, the key figures and civilizations that contributed to their development, and the impact of these discoveries on the world today. (scienceprog.com)
The development of modern pharmaceutical drugs can be traced back to the Middle Ages when alchemists and apothecaries began to experiment with new methods of extracting and purifying medicinal substances. (scienceprog.com)
The 19th and 20th centuries saw an explosion of new pharmaceutical drugs, as scientists and researchers made groundbreaking discoveries in chemistry, biology, and medicine. (scienceprog.com)
The development of new pharmaceutical drugs is a complex and expensive process, often requiring years of research, testing, and regulatory approval. (scienceprog.com)
Pharmaceutical companies play a crucial role in this process, as they invest significant resources into the research and development of new drugs. (scienceprog.com)
Many of the cannabinoids have proven medicinal effectiveness, and biotech companies around the world are actively researching how to identify the cannabinoids and turn them into pharmaceutical drugs. (wyattresearch.com)
In order to produce the cannabinoids used in all the marijuana-derived prescription drugs, you have to produce "pharmaceutical grade" marijuana. (wyattresearch.com)

At the pharmaceutical company where Hoffman was employed, they tested the substance on animals and this is thought to be the first time that animal trials were used in the pharmaceutical industry. (uu.se)
Another chemist by the name of Hoffman reformulated aspirin for better absorption. (aopa.org)

The first true pharmaceutical drug, however, is often credited to the German physician and botanist, Friedrich Serturner. (scienceprog.com)
In July, the United States Food and Drug Administration (FDA) informed Hyloris' development partner, AFT Pharmaceuticals, via a Complete Response Letter (CRL), that it was unable to complete its review of the NDA for Maxigesic® IV and provided specific recommendations needed to address the application's deficiency. (globenewswire.com)
Even though aspirin is good for our health, you should never give this medical drug to the children. (factfile.org)
Drug repurposing means that a pharmaceutical is used for a different purpose than the one it was originally developed and approved for. (dandc.eu)
Aspirin is one of the best examples for drug repurposing. (dandc.eu)
To date, there is no pharmaceutical treatment specifically for coronavirus, so drug repurposing offers rays of hope. (dandc.eu)
After revisiting aspirin indications earlier this month I received a few excellent questions that prompted me to delve further into the mysteries of this remarkable anti-platelet drug. (theskepticalcardiologist.com)
Aspirin is a unique drug, the prototypical two-edged sword of pharmaceuticals. (theskepticalcardiologist.com)
Greater investment inflows and a surge of activity, especially in the field of drug and biomarker discovery, is fuelling the growth of global lipid analysis - lipidomics - making it a standard research tool in academic, pharmaceutical and biotechnology sectors. (chromatographyonline.com)
For patient education information, see the First Aid and Injuries Center, as well as Aspirin Poisoning, Drug Overdose, Activated Charcoal, and Poison Proofing Your Home. (medscape.com)

Reaction mechanism Formulations containing high concentrations of aspirin often smell like vinegar because aspirin can decompose through hydrolysis in moist conditions, yielding salicylic and acetic acids. (wikipedia.org)

Rxn chemical is offering world largest supplier if impurity and pharmaceutical reference standard compound having all data analysis. (blogspot.com)

Nextleaf said it has started searching for commercialization partners of its cannabinoid acetylation patents, focusing on pharmaceutical companies seeking novel cannabinoid-derived products for clinical trials and turnkey pharmaceutical production. (mjbizdaily.com)

One of the first large-scale trials on which we now depend to inform medical decision-making looked at adding aspirin to the medications given patients presenting to hospitals with suspected heart attacks. (whatswrongwithhealthcareinamerica.com)
In 1948 an otorhinolaryngologist, L. L. Craven, was using aspirin in gum (Aspergum®) for his tonsillectomy patients. (aopa.org)
He later published another article based on a study of 8,000 patients taking aspirin. (aopa.org)

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