NeutrophilsMacrophagesBactericidal activityPolymorphonuclear leukocytesMonocytesInflammationMacrophageRespiratory burstCytokine productionNeutrophilicMulticellular organismsPhagocytesAdhesionSecretionBacteriaParticlesMicroorganismsTissueFunctionalMoleculesResponsesPhenomenonPatientsDestructionActivationCellsWorkAspectsProcessAnimalsAdditionMovement
Neutrophils4
- In multicellular organisms, and more particularly in animals with a well-developed immune system, phagocytosis is mostly performed by specialized, professional phagocytes: macrophages, dendritic cells (DCs), and neutrophils. (frontiersin.org)
- However, during the acute phase of inflammation , particularly as a result of bacterial infection , neutrophils leave the vasculature and migrate toward the site of inflammation in a process called chemotaxis . (bionity.com)
- Neutrophils undergo a process called chemotaxis that allows them to migrate toward sites of infection or inflammation. (bionity.com)
- TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro , hemorrhagic necrosis of tumors in vivo , increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. (biolegend.com)
Macrophages3
- Cell biology of phagocytosis has been mainly established on bone marrow-derived tissue macrophages. (frontiersin.org)
- Phagocytosis of invading pathogens by macrophages is a key component of this initial response. (uspharmacist.com)
- Morphine has been shown to negatively impact macrophage function by impairing the proliferation of macrophage progenitor cells, inhibiting cytokine secretion leading to decreased chemotaxis, hindering the ability of macrophages to directly phagocytize pathogens, and inhibiting nitric oxide production. (uspharmacist.com)
Bactericidal activity3
- CD15 has been implicated in adhesion, as well as chemotaxis, phagocytosis, and bactericidal activity. (biolegend.com)
- CD15 antigen is important for direct carbohydrate-carbohydrate interaction and plays a role in mediating phagocytosis, bactericidal activity and chemotaxis. (exposed-skin-care.net)
- DS patients also present a T cell immunodeficiency causing functional defects of polymorphonuclear leukocytes, reduced chemotaxis, diminished phagocytic ability, defective oxidative response and abnormal bactericidal activity 3 . (bvsalud.org)
Polymorphonuclear leukocytes1
- Anomalies of chemotaxis and phagocytosis by polymorphonuclear leukocytes have been observed. (lu.se)
Monocytes1
- However, SWCNT suppressed chemotaxis of primary human monocytes in a standard chemotaxis assay. (cdc.gov)
Inflammation1
- Together with inflammation, phagocytosis composes the first line of defense against multicellular organisms by the innate immune system. (frontiersin.org)
Macrophage3
- Investigation of P. levii virulence factors ( 6 , 7 ) indicated that this microorganism is able to synthesize an anti-IgG 2 protease ( 8 ) and to reduce macrophage chemotaxis, phagocytosis, and oxidative burst. (cdc.gov)
- Such "silent" clearance is mediated by the innate immune system via polarized monocyte/macrophage populations that use a range of PRRs and soluble molecules to promote binding and phagocytosis of ACs. (aston.ac.uk)
- 1993. Role of alveolar macrophage chemotaxis and phagocytosis in pulmonary clearance responses to inhaled particles: Comparisons among rodent species. (cdc.gov)
Respiratory burst1
- However, phagocytosis can also activate the respiratory burst, which produces toxic reactive oxygen species (ROS). (frontiersin.org)
Cytokine production2
- For example, SP-A and SP-D stimulate phagocytosis and chemotaxis and regulate cytokine production by multiple immune cells. (fz-borstel.de)
- however, there is evidence that there is reduced interleukin (IL)-8 and keratinocyte-derived cytokine production, resulting in impaired chemotaxis. (uspharmacist.com)
Neutrophilic2
- The agent activated T-cell differentiation, T-cell recognition of peptide-MHC complexes, induced changes in intracellular composition of cyclic nucleotides, and activated neutrophilic chemotaxis and phagocytosis. (nih.gov)
- Increased oxidant, free radical scavenging, and neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing support immunological health. (concordia.style)
Multicellular organisms2
- Chemotaxis , a kind of taxis , is the phenomenon in which bodily cells, bacteria , and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. (wikidoc.org)
- In multicellular organisms, chemotaxis is critical to development as well as normal function. (wikidoc.org)
Phagocytes2
- Phagocytosis has been traditionally studied in pathological conditions, leading to the assumption that microglia have to be activated in order to become efficient phagocytes. (frontiersin.org)
- Adherence reaction mediated through the CR receptors on phagocytes lead to stimulation of phagocytosis, activation of metabolism and secretory function and movement of phagocytes into the inflammatory site. (dadamo.com)
Adhesion1
- BTK's role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion. (medscape.com)
Secretion1
- The second group of receptors reacts with small complement fragments (C4a, C3a, C5a) as well as with C1q, Ba, Bb and factor H. Stimulation of these receptors results in various biological effects (chemotaxis, secretion of vasoactive amines, mediators of the inflammatory and anaphylactic reaction etc. (dadamo.com)
Bacteria1
- Although migration of cells was detected from the early days of the development of microscopy ( Leeuwenhoek ) , erudite description of chemotaxis was first made by T.W. Engelmann (1881) and W.F. Pfeffer (1884) in bacteria and H.S. Jennings (1906) in ciliates . (wikidoc.org)
Particles1
- Phagocytosis removes foreign particles from the lymph as it moves from the interstitial spaces to the bloodstream. (healthjade.net)
Microorganisms1
- Phagocytosis of invading microorganisms by immune cells was first discovered by the father of cellular immunology Ilya Metchnikoff in 1882, for which he was awarded the Nobel Prize. (frontiersin.org)
Tissue1
- The present review will summarize the current state of the literature regarding the role of microglial phagocytosis in maintaining tissue homeostasis in health as in disease. (frontiersin.org)
Functional1
- More importantly, the functional consequences of microglial phagocytosis remain largely unexplored. (frontiersin.org)
Molecules1
- Common mechanisms of recognition, engulfment, and degradation of the different types of cargo are assumed, but very little is known about the shared and specific molecules involved in the phagocytosis of each target by microglia. (frontiersin.org)
Responses2
- Chemotaxis is one of the most basic cell physiological responses. (wikidoc.org)
- Foreign substances filtered by the lymph nodes are trapped by (a)_____ _____ ______. (b)_____ then destroy some foreign substances by phagocytosis and (c)_____ bring about the destruction of others by immune responses. (easynotecards.com)
Phenomenon1
- Overall, phagocytosis is considered a beneficial phenomenon, since it eliminates dead cells and induces an anti-inflammatory response. (frontiersin.org)
Patients1
- La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
Destruction1
- The explanation for the advanced periodontal destruction may include the disturbance in NE chemotaxis. (bvsalud.org)
Activation1
- Calcium supplements signaling is definitely associated with primary events of immunity which include chemotaxis account activation and phagocytosis. (biologyexperimentideas.net)
Cells1
- Phagocytosis is a term coined from the Greek to describe the receptor-mediated engulfment and degradation of dead cells and microbes. (frontiersin.org)
Work1
- On November 3 , 2006 , Dr. Dennis Bray of University of Cambridge was awarded the Microsoft European Science Award for his work on chemotaxis on E. coli . (wikidoc.org)
Aspects1
- The most important aspects in quality control of chemotaxis assays were described by H. Harris in the 1950s. (wikidoc.org)
Process2
- Phagocytosis is a Greek-derived term which literally means the cellular process of eating. (frontiersin.org)
- The Nobel Prize Laureate E. Metchnikoff also contributed to the study of the field with investigations of the process as an initial step of phagocytosis . (wikidoc.org)
Animals1
- In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis . (wikidoc.org)
Addition1
- In addition, microglia phagocytoses brain-specific cargo, such as axonal and myelin debris in spinal cord injury or multiple sclerosis, amyloid-β deposits in Alzheimer's disease, and supernumerary synapses in postnatal development. (frontiersin.org)
Movement1
- Chemotaxis is called positive if movement is in the direction of a higher concentration of the chemical in question, and negative if the direction is opposite. (wikidoc.org)