Phage therapeutics. Medical search. Frequent questions

Researchers from Texas A&M University, Adaptive Phage Therapeutics, the US Navy, and San Diego State University, worked to source and purify phage that could be used to treat Patterson's infection intravenously. (wikipedia.org)
GAITHERSBURG, Md.--( BUSINESS WIRE )-- Adaptive Phage Therapeutics, Inc. , ("APT"), a clinical-stage biotechnology company dedicated to providing therapies to treat infectious diseases, today announced the appointment of Jesse L. Goodman, MD, MPH, to the company's Board of Directors. (sweetrude.net)
Antibiotic resistance is one of our most serious global health threats and Adaptive Phage Therapeutics has emerged as an innovative leader in addressing the challenge," said Jesse L. Goodman, MD, MPH. (sweetrude.net)
Adaptive Phage Therapeutics, Inc. (sweetrude.net)
Adaptive Phage Therapeutics (APT) is a clinical-stage company advancing therapies to treat multi-drug resistant infections. (sweetrude.net)
GAITHERSBURG, Md., January 12, 2023--(BUSINESS WIRE)--Adaptive Phage Therapeutics, Inc., (APT) a clinical-stage biotechnology company advancing the APT phage bank, the world's largest therapeutic phage initiative for treatment of bacterial infectious diseases, today announced the first patient has been dosed in the PHAGE clinical trial, evaluating bacteriophage therapy in adults with cystic fibrosis (CF) who carry Pseudomonas aeruginosa (P. aeruginosa) in their lungs. (biohealthinnovation.org)
At Adaptive Phage Therapeutics, we are committed to developing innovative treatments that address the growing problem of antibiotic resistance," said Greg Merril, CEO of Adaptive Phage Therapeutics. (biohealthinnovation.org)
Adaptive Phage Therapeutics (APT) recently announced that the first patient in an early-stage clinical trial for its investigative bacteriophage therapy has been dosed. (umn.edu)
This work will be carried out in partnership with Mikeljon Nikolich, Ph.D. at the Walter Reed Army Institute of Research (WRAIR) and Adaptive Phage Therapeutics (APT). (jcvi.org)

It has been in practice for just over 100 years in countries such as Russia and Georgia, but due to the recent clinical attention of antibiotic resistance, Western countries have slowly been integrating phage therapy into their medicinal arsenal. (wikipedia.org)

Phage therapy is the method by which bacteriophages (viruses which infect bacteria) are used to treat bacterial infections or reduce bacterial populations. (wikipedia.org)
For more than a century, researchers have considered the potential use of phages as therapeutics, theorizing that mixtures of bacteriophages might be used on their own, or in conjunction with antibiotics, to treat bacterial infections-especially those resistant to antibiotics. (biohealthinnovation.org)
Bacteriophages (phages) are viruses capable of infecting and replicating within bacterial cells. (asm.org)
Bacteriophages - more commonly known as phages - are viruses that infect and kill bacteria. (hemopet.org)
This chapter will give an overview of the different applications of bacteriophages (phages). (caister.com)
Multiple bacteriophages, also known simply as "phages," would be applied as an added treatment for antibiotic-resistant infections, administered at the same time as antibiotics. (missouri.edu)
Non-enveloped bacteriophages are more difficult to tolerate photoinactivation than enveloped phages, which makes them an important model tool to evaluate the efficiency of PDI therapy against viruses that cause diseases in humans. (intechopen.com)

PHAXIAM is developing a portfolio of phages targeting 3 of the most resistant and dangerous bacteria, which together account for more than two-thirds of resistant hospital-acquired infections: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. (fox4kc.com)
Do you know or could you help me find sources, if it is possible for bacteria to acquire and use phage genes for their own benefit after they neutralise phage infection (through CRISPR/CAS for example)? (phagedirectory.com)
The trial is evaluating whether the bacteriophage, or "phage," therapy is safe and able to reduce the amount of bacteria in the lungs of volunteers. (biohealthinnovation.org)
Phages are viruses that can kill or neutralize specific bacteria while leaving non-target bacteria and human cells unharmed. (biohealthinnovation.org)
Our team's research has demonstrated that certain phages specific for Campylobacter can significantly reduce the load of the bacteria carried by poultry. (news-medical.net)
GangaGen is a developer of therapeutics based on phage technology for the control of disease-causing bacteria. (news-medical.net)
Antimicrobial therapeutics are medicines that kill or make it harder for bacteria to grow and multiply in people or animals. (medgadget.com)
Cariou was referring to phage therapy, a controversial treatment that uses a type of virus to defeat bacterial infection.It makes use of one of the oldest enemies of bacteria found in nature. (maisonneuve.org)
The doctor promised that if Summerhayes's bacteria again develops resistance and his antibiotic eventually fails, she'll ask Health Canada to approve phage therapy for him. (maisonneuve.org)
Desperate to find a cure after more than a dozen antibiotics had failed, Strathdee, an infectious disease epidemiologist at the University of California, San Diego, School of Medicine, stumbled upon phage therapy: a mostly forgotten treatment discovered 100 years ago that uses viruses to kill lethal bacteria. (today.com)
Phages are viruses that have naturally evolved to attack bacteria. (today.com)
The trial aims to determine whether the treatment is safe and if it reduces the amount of bacteria in trial volunteers, with investigators gathering data on safety and microbiologic activity, how the phages function in the body, how the therapy affects patients' lung function, and it s impact on overall quality of life. (umn.edu)
Rockville, MD-September 12, 2023- The J. Craig Venter Institute (JCVI), led by Derrick Fouts, Ph.D., has been awarded a five-year, $5.7M grant from the National Institute of Health (NIH) to develop a bacteriophage (or phage) therapeutic cocktail to treat infections caused by the bacteria Klebsiella pneumoniae . (jcvi.org)
Currently, medical professionals often resort to taking a swab of the patient's bacteria, nurturing it in a petri dish, and then testing which phages are able to kill it. (hemopet.org)
Sadly, in some cases, the proper phage to fight an antibiotic-resistant bacteria is found too late to save a patient. (hemopet.org)
On the other hand, the collateral damage to other bacteria or human cells is minimal and the risk of resistance to phages by bacteria is low. (hemopet.org)
Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. (concordbookshop.com)
To help current trials and encourage more research, Hitchcock spent her days tracking down specific phages from the environment - places where bacteria thrived, like in water or sewage. (missouri.edu)
When DNA of the phage integrates into the host bacteria's genetic material, the bacteria develop the capacity to produce this polypeptide toxin. (medscape.com)

EDMONTON, ALBERTA, CANADA, November 21, 2023 / EINPresswire.com / -- An Edmonton-based biotechnology company leading the discovery of novel peptide therapeutics, 48Hour Discovery, has achieved a significant milestone by reaching $5 million in total revenue since its inception in 2017. (nbc4i.com)

Background curves represent a qualitative measure of the overall interest, research, and use of phage therapy (yellow) and antibiotics (blue), showing how the introduction of antibiotics and the critical review of the early phage therapy studies coincided to bring phage therapy research and development to an almost complete standstill around the 1940s. (asm.org)

Under the terms of the agreement, Bicycle will utilize its proprietary phage platform to discover Bicycles to be developed into BRCs. (biospace.com)
Bicycle will use its proprietary phage platform to discover and develop bicyclic peptides, and Bayer will be responsible for, and fund, all further preclinical and clinical development, manufacturing, and commercialisation activities. (shlegal.com)

Prior antimicrobial therapeutic approaches have been "fixed," while pathogens continue to evolve resistance to each of those therapeutics, causing those drug products to become rapidly less effective in commercial use as antimicrobial resistance (AMR) increases over time. (sweetrude.net)
The investigational phage therapeutic, WRAIR-PAM-CF1, was developed by the Walter Reed Army Institute of Research (WRAIR) and is licensed to and manufactured by APT. (biohealthinnovation.org)
Supported with a three-year, $1.2 million grant from the UCSD chancellor, the new Center for Innovative Phage Applications and Therapeutics (IPATH) is applying "the same principles of clinical evaluation and development to phage therapy that would be applied to any other therapeutic entity," says center co-director Robert Schooley, a physician and infectious disease specialist at UCSD. (nature.com)
Phages replicate through two primary life cycles, the dynamics of which have important implications for their therapeutic application. (asm.org)
Individual chapters discuss the relationship between risk and vulnerability, threat agent dispersal through the environment, threat agent sensor development, the use of phage display for detection and therapeutic intervention, and an overview of recognized threats and their toxic effects. (routledge.com)
The therapeutic will be based on a five-phage cocktail, which has already been shown to be effective against 53 out of 100 strains on our test panel. (jcvi.org)

The company is building on an innovative approach based on the use of phages, natural bacterial-killing viruses. (krqe.com)
The researchers hope their open-access tool can be used by other scientists, policymakers and public health officials to prioritize viruses for further study, surveillance and risk-reducing activities, such as possibly developing vaccines or therapeutics before a disease spills over. (livescience.com)
Phages are viruses that only infect specific bacterial host cells. (jcvi.org)

The patents empower 48Hour Discovery to harness their chemically modified phage display technology to its fullest potential and drive further commercialization opportunities for the company. (nbc4i.com)

In the version of this article initially published, we listed 13 companies that were developing phage therapies a decade ago and stated that only a few are still active today. (nature.com)

APT's PhageBank™ approach leverages an ever-expanding library of bacteriophage (phage) that collectively provide evergreen broad spectrum and polymicrobial coverage. (sweetrude.net)
Felix d'Herelle first coined the term "bacteriophage" ( 4 ), literally meaning "bacterium eater," and began using phages to treat bacterial infections in human patients ( Fig. 1 ). (asm.org)

A new preprint by Martin Plymouth, Stephanie Lynch and colleagues investigates the attitudes of Australian infectious diseases physicians towards phage therapy . (phagedirectory.com)
The rising incidence of infectious diseases globally is a major driver of the antimicrobial therapeutics market. (medgadget.com)

This includes the exploration of alternative sources such as natural products, peptides, and phage therapy. (medgadget.com)
Phage, expressing melanoma cDNA express the proteins/peptides on their capsid are "recognized" by the immobilized antibodies are retained in the column, and subsequently eluted for DNA sequencing. (mayo.edu)
These peptides demonstrate promise as potential cancer therapeutics due to their selectivity, cost-effectiveness, ease of synthesis, low antigenicity, and excellent tissue penetration. (utu.fi)
Prof. Travassos' pioneering work uncovered on the potential of peptides derived from microbiological sources, such as those obtained using phage display techniques. (utu.fi)

Dr. Fouts commented, "Phage therapies have been around since the early 1900s but fell out of fashion with the development of effective antibiotic treatments. (jcvi.org)

CAMBRIDGE, England & BOSTON--( BUSINESS WIRE )-- Bicycle Therapeutics Limited (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide ( Bicycle ® ) technology, today announced that it has entered into a strategic collaboration agreement with Novartis to develop, manufacture and commercialize Bicycle ® radio-conjugates (BRCs) for multiple agreed upon oncology targets. (biospace.com)
This collaboration builds on the groundbreaking clinical work we have been doing in the toxin conjugate field and provides new and additional validation for this unique technology," said Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. (biospace.com)
Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. (biospace.com)
Law firm Stephenson Harwood LLP has advised Bicycle Therapeutics plc on its recent strategic collaboration agreement with Bayer to discover and develop Bicycle radioconjugates for multiple oncology targets. (shlegal.com)

In addition to being an active clinician, his prior leadership roles, including serving as the FDA's Chief Scientist, as Director of the FDA's Center for Biologics Evaluation and Research (CBER), and as co-chair of the United States Task Force on Antimicrobial Resistance make him an invaluable expert in the development of novel antimicrobial therapeutics. (sweetrude.net)
Increased global demand for these antibiotics, particularly in developing countries is expected to propel growth of the global antimicrobial therapeutics market over the forecast period. (medgadget.com)
This has led to the development of newer antimicrobial therapeutics, which are expected to drive market growth over the forecast period. (medgadget.com)
However, growing antimicrobial resistance is a major factor expected to hamper growth of the global antimicrobial therapeutics market over the forecast period. (medgadget.com)
The emergence and spread of antimicrobial resistance is a significant driver for the development of new antimicrobial therapeutics. (medgadget.com)
There is a continuous need for new and improved antimicrobial therapeutics to address unmet medical needs. (medgadget.com)
Technological advancements contribute to the expansion of the antimicrobial therapeutics market by facilitating the discovery of novel compounds and enhancing treatment options. (medgadget.com)
Applying precision medicine principles to antimicrobial therapeutics can help optimize treatment regimens, improve patient outcomes, and reduce the unnecessary use of broad-spectrum antibiotics. (medgadget.com)

We disconnected a clever phage, DRA88, which has a wide host range among S. aureus microorganisms. (alliedacademies.org)

Since establishing in 2018, IPATH has been led by Co-directors Strathdee and Schooley, and have set out to lay the foundation for an academic center on the forefront of translational phage therapy research. (wikipedia.org)
This news follows last year's launch of a phage translational research center at the University of California, San Diego (UCSD), another sign of optimism in this old but controversial approach for treating bacterial infections. (nature.com)

Virulent or obligate lytic phages infect and quickly kill their bacterial host cell, whereas temperate or lysogenic phages may either stably integrate into their host's genome or enter into the lytic life cycle. (asm.org)

Temperate phages are capable of protecting their host from phage reinfection and may change the bacterial phenotype through the expression of viral genes, a process known as lysogenic conversion ( 1 ). (asm.org)
Toxin production is encoded on the tox gene, which, in turn, is carried on a lysogenic beta phage. (medscape.com)

Our group has explored the use of genomic RNA/phage display libraries derived from primary human malignant melanoma cells as a means of identifying antibody detectable targets on cancer cells (cancer vaccines or antibody guided therapeutics). (mayo.edu)
These include the use of whole virulent phages as antibacterials, recent advances in the development and applications of genetically modified phages, the use of phages as delivery vehicles and vaccines, and recent developments in the study and use of purified endolysins. (caister.com)

As issues of product consistency, standardization and specificity are being tackled, can phage therapeutics-long oversold and overhyped-finally realize their antibacterial potential? (nature.com)
Phage specificity and the limited research done to date have their drawbacks. (hemopet.org)

After eight weeks of phage therapy, in conjunction with 12 weeks of antibiotics, no evidence of Acinetobacter baumannii was found in Patterson's body following June 6, 2016. (wikipedia.org)
Although phage therapy was first implemented almost a century ago, it was brought to a standstill after the successful introduction of antibiotics. (asm.org)
Finally, we discuss the benefits of phage therapy beyond the clinical perspective, including opportunities for scientific outreach and effective education, interdisciplinary collaboration, cultural and economic growth, and even innovative use of social media, making the case that phage therapy is more than just an alternative to antibiotics. (asm.org)
FIG 1 Timeline of major events in the history of research on phages, phage therapy, and antibiotics. (asm.org)
Unlike antibiotics - which usually cover a broad spectrum of bacterial infections - phages are very specific. (hemopet.org)

Selected phages will be evaluated on a wide range of infections in which PHAXIAM already benefits from considerable expertise, such as lung, blood and urinary tract infections. (krqe.com)

Strathdee advocated and connected with phage researchers around the United States and secured the help of friend and fellow UC San Diego professor, Robert "Chip" Schooley, who was head of the Division of Infectious Disease at the UC San Diego School of Medicine at the time. (wikipedia.org)
Phage researchers can now access PhageBox, an open-source digital microfluidic extension that integrates temperature and electromagnetic modules, which can be used for phage research, as recently demonstrated by Dreycey Albin (University of Colorado) and colleagues. (phagedirectory.com)
Vivek Mutalik at Lawrence Berkeley National Lab is looking for postdoc researchers to study diverse aspects of phage-host interactions. (phagedirectory.com)
With the advent of antibiotic resistance, researchers have started exploring phage therapy once again. (hemopet.org)
Now, with time running out, Steffanie appealed to phage researchers all over the world for help. (concordbookshop.com)

Phynteny, a synteny-based annotation tool for phage genes , has been developed by @susiegriggo_ to assign hypothetical phage proteins to a PHROG category based on gene order conservation. (phagedirectory.com)
Comparison of the DNA profiles of the eluted phage using pre-immunotherapy and post-immunotherapy patient sera will reveal emergence of new antibodies (post-immunotherapy gain of antibodies) against proteins of potential interest for melanoma targeting. (mayo.edu)
The phage-encoded lysis proteins endolysin and holin cause the breakdown of the bacterial layer, bringing about cell passing and arrival of phage particles [ 3 ]. (alliedacademies.org)
Liu and his team have developed multiple technologies including DNA-templated synthesis, phage-assisted continuous evolution (PACE), and a variety of genome editing methods, to apply the principles that drive biological evolution to the discovery of bioactive synthetic small molecules, synthetic polymers, and proteins. (harvard.edu)

This intensive laboratory/lecture course will focus on the construction of combinatorial antibody libraries expressed on the surface of filamentous phage and the subsequent selection of desired antibodies from the library. (cshl.edu)
Our proprietary phage display antibody libraries deliver species-specific drugs for a growing market need. (izb-online.de)

The Ohio State University and IPATH were awarded $175k from the Herbert W. Hoover Foundation to address AMR through phage therapy, with students in OSU's Science Education Alliance-LAB undergraduate program isolating and characterizing phages, and adding them to IPATH's and SEA-LAB's phage libraries for clinical or research purposes. (phagedirectory.com)

Now, with the rise of antibiotic resistance, phage therapy is experiencing a well-deserved rebirth. (asm.org)
We cover the key points of the antibiotic resistance crisis and then explain the biological and evolutionary principles that support the use of phages, their interaction with the immune system, and a comparison with antibiotic therapy. (asm.org)
We are now seeing alarmingly high levels of antibiotic resistance to drugs we've relied on, spurring renewed interest in phage, engineered using synthetic biology approaches pioneered at JCVI. (jcvi.org)

He currently serves on the Board (prior President) of the United States Pharmacopeia (USP), as an independent non-executive director for GlaxoSmithKline plc (chairing its board Science Committee), and is on the Board of Intellia Therapeutics, which is developing CRISPR based treatments for human disease. (sweetrude.net)

IPATH aims to initiate phase I/II phage therapy clinical trials, focusing on patients with cystic fibrosis and infections related to implantable hardware, such as pacemakers and prosthetic joints. (wikipedia.org)
Schooley and Strathdee bring with them numerous years of research experience and experience in designing clinical trials, which they are utilizing to initiate the first phage therapy clinical trials at UC San Diego School of Medicine. (wikipedia.org)
The first NIH-funded phage therapy clinical trial has successfully enrolled the first six patients in Stage 1 for safety and microbiological activity, with no serious adverse events reported, and is now moving into Stage 2a, aiming to enroll 32 subjects across four study arms. (phagedirectory.com)

GangaGen has demonstrated in production animal trials that we can isolate and use phages with full regard for safety, and that are benign to animals, humans and the environment. (news-medical.net)

Ian Connerton, Northern Foods Professor of Food Safety at The University of Nottingham, said: "We are excited to be working with a company like GangaGen that is at the forefront of phage technology development. (news-medical.net)
Built using phage display, a powerful technology that helped propel monoclonal antibodies to become the most successful drug class in human healthcare, these technology platforms provide the means for short development cycles often achieving valuable lead candidates within 1 year after project initiation. (izb-online.de)
This company, originally known as CAT, was founded in 1989 to take advantage of phage display technology for the development of antibody therapeutics. (onenucleus.com)
The unique technology at the core of 48Hour Discovery's innovative phage display platform provides discovery solutions to the pharmaceutical industry, and is further driving innovation in oncology drug development as well as other therapeutics categories. (nbc4i.com)
The research will leverage JCVI's history of synthetic and phage genomics, WRAIR's experience developing phage therapeutics and development of mouse models, and APT's current good manufacturing practice (cGMP) production capabilities and experience with phage clinical trials. (jcvi.org)

The process developed will then become a platform for developing future phage-based therapeutics for other important bacterial pathogens. (jcvi.org)

GangaGen and The University of Nottingham are building a business relationship to commercialise phage technology which has been developed at the University to complement the existing phage expertise of GangaGen. (news-medical.net)
The work on a phage product for the control of Campylobacter will complement GangaGen's food safety product portfolio, which also includes phage products against Salmonella and E. coli O157:H7. (news-medical.net)

The Center for Innovative Phage Applications and Therapeutics (IPATH) is the first phage therapy center in North America, founded in the UC San Diego School of Medicine in June 2018, with seed funding from UC San Diego Chancellor Pradeep Khosla. (wikipedia.org)
Tom Patterson was the first patient to be treated with phage therapy at a UC San Diego hospital in March 2016. (wikipedia.org)
They were involved in the treatment of five other phage therapy patients at UC San Diego School of Medicine and consulted on numerous cases throughout the United States and Europe, before officially establishing IPATH in June 2018. (wikipedia.org)
She also directs the new UC San Diego center for Innovative Phage Application and Therapeutics and is an Adjunct Professor at Johns Hopkins and Simon Fraser Universities. (concordbookshop.com)

As in vitro-based technologies, no animals are harmed during the antibody generation process - another unique capability of phage display. (izb-online.de)
This accomplishment triggered the assignment of the full suite of patents protecting 48Hour Discovery's innovative phage display platform. (nbc4i.com)

Phage therapy was pushed aside when penicillin came along, but it was the only treatment that helped a man overcome a superbug infection. (today.com)
Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. (concordbookshop.com)
In addition to determining in vitro inhibition abilities of a panel of mAbs against BoNT/B1-/B5, this work has determined B12.2 and 2B18.2 to be the best mAbs for sample preparation before Endopep-MS. These mAb characterizations also have the potential to assist with mechanistic studies of BoNT/B protection and treatment, which is important for studying alternative therapeutics for botulism. (cdc.gov)

I don't mean lysogeny, pseudo-lysogeny, or phage fragment storage for "bacterial immunity" but something like horizontal gene transfer from degraded phage DNA to the bacterial genome. (phagedirectory.com)
Morphologically, the phage has a place with the Myoviridae family and includes a huge twofold abandoned DNA genome. (alliedacademies.org)

Evelien Adriaenssens at the Quadram Institute, Norwich, UK is hiring a Research Scientist to analyze the virome of longitudinal gut microbiome studies, as well study as the use of phages to prevent food-borne illness. (phagedirectory.com)
Phage Therapy: Current Research and Applications (Edited by: Jan Borysowski, Ryszard Międzybrodzki and Andrzej Górski). (caister.com)

A few investigations have shown the capability of utilizing phages to treat S. aureus contaminations, and it has been exhibited that phages likewise can disturb bacterial biofilms. (alliedacademies.org)

The term is commonly used in its shortened form, phage. (news-medical.net)

Hello, I'm working on my bachelor's thesis and I need specific information about phage and bacterial genetics. (phagedirectory.com)

Anyone can post a message to the phage community - and it could be anything from collaboration requests, post-doc searches, sequencing help - just ask! (phagedirectory.com)

When phages were discovered 100 years ago, they were used to treat bacterial infections, but then when penicillin came on the scene, it was considered to be a wonder drug. (today.com)
Phages were actually discovered in the early 20th century and were distributed to treat bacterial conditions. (hemopet.org)

Anatomy7

Organisms46

Diseases4

Chemicals and Drugs67

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Phenomena and Processes80

Disciplines and Occupations14

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture10

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20231

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