• Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class. (wikipedia.org)
  • Compared with morphine, pethidine was thought to be safer, carry a lower risk of addiction, and to be superior in treating the pain associated with biliary spasm or renal colic due to its putative anticholinergic effects. (wikipedia.org)
  • Like morphine, pethidine exerts its analgesic effects by acting as an agonist at the μ-opioid receptor. (wikipedia.org)
  • Rapid and potent analgesia is crucial in the care of patients presenting with sickle cell crisis, and opioid analgesics, such as pethidine and morphine, have been the mainstay of treatment for decades. (ijmdc.com)
  • At the A&E, parenteral morphine and pethidine were most commonly used. (uwi.edu)
  • Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines (piminodine, anileridine and others), the prodines (alphaprodine, MPPP, etc.), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues. (wikipedia.org)
  • Paracetamol and Pethidine are two prevailing analgesics prescribed for postoperative orthopedic patients, each having different side effects and impacts on fracture healing. (ac.ir)
  • Fatalities have occurred following either oral or intravenous pethidine overdose. (wikipedia.org)
  • Conscious sedation was achieved by giving intravenous pethidine hydrochloride and flunitrazepam. (sages.org)
  • Considering the similar analgesic effects of methadone and pethidine, satisfaction of patients and nursing system with methadone use and the cost benefit of methadone, it can be recommended to use methadone for post operative pain relieving. (ac.ir)
  • The norpethidine metabolite was found to have serotonergic effects, so pethidine could, unlike most opioids, contribute to serotonin syndrome. (wikipedia.org)
  • Pethidine is the most widely used opioid in labour and delivery but has fallen out of favour in some countries, such as the United States, in favour of other opioids, due to its potential drug interactions (especially with serotonergics) and its neurotoxic metabolite, norpethidine. (wikipedia.org)
  • The adverse effects of pethidine administration are primarily those of the opioids as a class: nausea, vomiting, dizziness, diaphoresis, urinary retention, and constipation. (wikipedia.org)
  • The aim of current study was to compare the analgesic efficacy of oral methadone and intra muscular (IM) pethidine which the latter was routinely used in our center in post cesarean pain treatment. (ac.ir)
  • One group of patients received 0.7 mg/kg pethidine every 6 hour IM, and another group received 0.07 mg/kg oral methadone every 6 hour. (ac.ir)
  • Convulsive seizures sometimes observed in patients receiving parenteral pethidine on a chronic basis have been attributed to accumulation in plasma of the metabolite norpethidine (normeperidine). (wikipedia.org)
  • Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as a hydrochloride salt in tablets, as a syrup, or by intramuscular, subcutaneous, or intravenous injection. (wikipedia.org)
  • The mean total dose of pethidine hydrochloride and flunitrazepam were 54 ± 18 and 0.6 ± 0.4, respectively. (sages.org)
  • It is probable that pethidine can also interact with a number of other medications, including muscle relaxants, benzodiazepines, and ethanol. (wikipedia.org)
  • Several previous studies have evaluated the efficacy of intra-articular (IA) pethidine as a compound, which has local anesthetic and opioid agonist properties, on postoperative pain relief in arthroscopic knee surgery (AKS). (ac.ir)
  • This study compared the postoperative analgesic effect of pre- and post-surgical IA pethidine administration in AKS. (ac.ir)
  • The present study shows that preemptive intra-articular pethidine 50 mg injection is more effective than preventive injection for postoperative pain relief at rest and joint movement in arthroscopic knee surgery. (ac.ir)
  • The present study was conducted to compare the impacts of Paracetamol and Pethidine on postoperative pain relief of children with bone fractures. (ac.ir)
  • Given the effectiveness of Paracetamol and Pethidine on postoperative pain, both medications can be used for children with bone fractures. (ac.ir)
  • Seizures may develop when tramadol is given intravenously following, or with, pethidine. (wikipedia.org)
  • However, there are reports in the literature of seizures associated with pethidine use, particularly if used for more than a few days or in patients with kidney disease. (ijmdc.com)
  • A systematic review of the literature was conducted to identify any case reports or studies of the use of pethidine in children presenting with painful sickle cell crisis with a specific focus on the prevalence of seizures in this patient group. (ijmdc.com)
  • Söderlund A, Boreus LO, Westman L, Engström B, Valentin A, Ekblom A. A comparison of 50, 100 and 200 mg of intra-articular pethidine during knee joint surgery, a controlled study with evidence for local demethylation to norpethidine. (ac.ir)
  • The pharmacology and pharmacokinetics of pethidine and its active metabolite norpethidine are briefly explored, along with alternative analgesic approaches, both pharmacological and nonpharmacological. (ijmdc.com)
  • Patients were randomized in three equal groups to receive either 50 mg IA pethidine before surgical incision incision and saline after skin closure (PS), saline before surgical incision and pethedine after skin closure (SP), and only saline at two different times (SS). (ac.ir)
  • All patients routinely received a single IM pethidine dose (50 mg) after CS in the recovery room. (ac.ir)
  • A narcotic antagonist such as naloxone is indicated to reverse respiratory depression and other effects of pethidine. (wikipedia.org)
  • Oldroyd GJ, Tham EJ, Power I. An investigation of the local anaesthetic effects of pethidine in volunteers. (ac.ir)
  • amantadine, pethidine and disopyramide may potentiate the cholinolytic effects of Scopolan. (herbapol.pl)
  • Plant, the Production of, Internation- cocaine and the derivatives of these sub- al and Wholesale Trade in, and Use of the substances of concern while en- stances. (who.int)
  • Pethidine is often employed in the treatment of postanesthetic shivering. (wikipedia.org)
  • Pethidine has been reported as potentially beneficial for treatment of COVID-19. (c19early.org)
  • A random number table was utilized to classify children into two groups of Paracetamol or pethidine treatment. (ac.ir)
  • Pethidine is the preferred drug for the management of shivering during therapeutic hypothermia, as it provides the greatest reduction in the shivering threshold. (wikipedia.org)
  • this includes pethidine, a Schedule 2 Controlled Drug. (parliament.uk)
  • Independent t-test results revealed a significant difference between the pain intensity of paracetamol (44.24 ± 6.44), and Pethidine (52.68 ± 10.47) groups 6 hours after the surgery (p=0.03). (ac.ir)
  • Six hours after the surgery, the first group received Pethidine (1mg/kg of body weight), and the second group received Paracetamol (1gr). (ac.ir)
  • It will be for local providers to ensure there are arrangements in place for midwives attending home births to obtain pethidine within existing regulations. (parliament.uk)
  • Pethidine is the most widely used opioid in labour and delivery but has fallen out of favour in some countries, such as the United States, in favour of other opioids, due to its potential drug interactions (especially with serotonergics) and its neurotoxic metabolite, norpethidine. (wikipedia.org)
  • Pethidine is an opioid that has been used for many years to help women cope with pain during childbirth. (painmanagementinsurance.com)
  • The mean postoperative total opioid requirement per patient was 32 mg of pethidine. (hkmj.org)
  • There is no information about the distribution of pethidine into breast milk and/or exposure of the breastfed infant during pethidine patient-controlled epidural analgesia after caesarean delivery. (nih.gov)
  • Comparasion of pethidine,buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat. (bvsalud.org)
  • Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as a hydrochloride salt in tablets, as a syrup, or by intramuscular, subcutaneous, or intravenous injection. (wikipedia.org)
  • When pethidine and phenazocine were compared with pentazocine, the mean increases were lower following pentazocine but not to a statistically significant extent. (nih.gov)
  • if pethidine or diamorphine are given too close to the time of delivery, they may affect the baby's breathing - if this happens, another medicine to reverse the effect will be given. (fdotstokes.com)
  • Pethidine is the preferred painkiller for diverticulitis, because it decreases intestinal intraluminal pressure. (wikipedia.org)
  • Pethidine is a strong painkiller. (fdotstokes.com)
  • Convulsive seizures sometimes observed in patients receiving parenteral pethidine on a chronic basis have been attributed to accumulation in plasma of the metabolite norpethidine (normeperidine). (wikipedia.org)
  • Pethidine and metabolite) and for Tampering. (kingdict.com)
  • Pethidine can have an adverse effect on a newborn's sucking ability and breastfeeding. (nct.org.uk)
  • Fatalities have occurred following either oral or intravenous pethidine overdose. (wikipedia.org)
  • Combining Pethidine with such depressants (such as benzos or alcohol) can lead to cumulative overdose and death. (solaceasia.org)
  • A narcotic antagonist such as naloxone is indicated to reverse respiratory depression and other effects of pethidine. (wikipedia.org)
  • Pethidine should never be mixed with other drugs, especially those drugs that depress the central nervous system. (solaceasia.org)
  • Pethidine and paracetamol were the drugs most commonly prescribed (to 66.9% and 42.5% of patients respectively), most often on a regular schedule rather than on-demand. (who.int)
  • It is suggested that the differences found in sucking behaviour may be a central effect of pethidine. (nih.gov)
  • Attempts to synthesise pethidine have resulted in the accidental production of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a compound which is metabolised in the brain by the monoamine oxidase system to a toxic intermediate (MPP+) which selectively destroys the sustantia nigra, resulting in the rapid onset of severe Parkinsonian symptoms. (erowid.org)
  • Sometimes, pethidine is still used to help relieve labour pain during childbirth. (fdotstokes.com)
  • However, this is not to say that pethidine is unsuitable for all patients. (painmanagementinsurance.com)
  • Sur 275 patients, 72,0 % ont ressenti une douleur postopératoire d'intensité modérée à sévère au repos et 89,3 % en action. (who.int)
  • Pethidine is no longer commonly prescribed and its use is discouraged due to the high risk of dependence. (fdotstokes.com)
  • Pethidine is an analgesic that is commonly used for pain relief during labour and delivery. (painmanagementinsurance.com)
  • It is probable that pethidine can also interact with a number of other medications, including muscle relaxants, benzodiazepines, and ethanol. (wikipedia.org)
  • Pethidine is given as an injection (standard dose is 100mg), together with an anti-emetic (anti-sickness) agent, into your upper thigh area by your midwife. (fdotstokes.com)
  • Definitely didn't fancy pethidine because I had heard it can affect baby. (mumsnet.com)
  • Rooting movements which are expected to be vigorous at 30 min after birth were affected both by administration of pethidine and a longer second stage of labour. (nih.gov)
  • Depression of rooting movements in the pethidine group may be caused by exhaustion due to a longer second stage of labour and administration of pethidine. (nih.gov)
  • In addition, a smaller proportion of infants exposed to pethidine started to suckle the breast. (nih.gov)
  • It is recommended that pethidine-exposed mother-infant couples stay together after birth long enough to enable the infant to make the choice to attach or not to attach to the nipple without the forceful helping hand of the health staff. (nih.gov)
  • Pethidine is usually available at hospitals, but you should check with your doctor to determine whether the hospital you choose will stock it and discuss it with your midwife before giving birth. (painmanagementinsurance.com)
  • Although Pethidine is safe for use in a hospital setting, the risks are significant and it should be used with caution. (painmanagementinsurance.com)