Peroxisomal marker enzyme. Medical search. Frequent questions

In the cells, four major populations of compartments were identified, containing: (1) a glyoxylate cycle enzyme marker and a protein containing peroxisomal targeting signal 1 (PTS1) tripeptide but lacking the fatty acid marker, (2) the fatty acid marker alone, (3) the glyoxylate cycle enzyme marker alone, and (4) the PTS1 marker alone. (edu.sa)

Also, it has been found to be a subunit of the peroxisomal trifunctional enzyme (pTFE) and contributes only to minor cleavages of the fatty acid chain. (wikipedia.org)
Less than 5% of the compartments contained both fatty acid and peroxisomal markers. (edu.sa)
On the other hand, the ratio of the compartment containing both fatty acid and peroxisomal markers did not change significantly regardless of the culture conditions. (edu.sa)
Additionally, hepatic expression of typical mRNA markers of peroxisome proliferation including those encoding peroxisomal fatty acid metabolizing enzymes and cell cycle control proteins were all significantly elevated in HGF transgenic mice fed WY-14,643 compared with controls. (psu.edu)
Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)

The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)

Here, we assemble a list of potential Chlamydomonas peroxins (PEXs) required for peroxisomal biogenesis to suggest that C. reinhardtii has a complete set of peroxisome biogenesis factors. (edu.sa)
Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import. (ruhr-uni-bochum.de)
Zellweger spectrum disorder (ZSD) is a group of autosomal recessive disorders caused by biallelic pathogenic variants in any one of the 13 PEX genes essential for peroxisomal biogenesis. (stanford.edu)

Lysosomal enzymes then degrade the cargo contained within the autolysosome. (hindawi.com)
The turnover of these molecules depends on their subsequent internalization by endocytosis, their delivery to the lysosomes, and their digestion by lysosomal enzymes. (medscape.com)

Enoyl-CoA isomerases can be categorized into three classes: monofunctional mitochondrial monofunctional peroxisomal multifunctional The monofunctional mitochondrial and peroxisomal enzymes are found in the mitochondria and peroxisomes of eukaryotes, respectively. (wikipedia.org)
There was one enzyme which did not have binding specificity to this antibody: mitochondrial long-chain isomerase. (wikipedia.org)
For example, only 40 out of 302 amino acid sequences (13%) are the same between monofunctional peroxisomal and mitochondrial enzymes in humans. (wikipedia.org)
In fact, in mammals, the peroxisomal enzyme has an extra N-terminal domain that is not present in the mitochondrial counterpart. (wikipedia.org)
In that sense, for many higher organisms, the mitochondrial enzyme is essential for deriving maximum energy from lipids and fueling muscles. (wikipedia.org)
The FHA cycle is active inside the cell, detoxifying superoxide anion radicals (O2·-), which are mainly generated as a result of so-called 'electron leakage' to triplet oxygen (O2) in photosynthetic, mitochondrial, peroxisomal, and probably other electron transport chains (Ozyigit et al. (deepdyve.com)
Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
Although decreased citrulline is used as a newborn screening (NBS) marker to identify proximal urea cycle disorders (UCDs), it is also a feature of some mitochondrial diseases, including MT-ATP6 mitochondrial disease. (stanford.edu)
b Identification of putative peroxisomal enzymes and enyzmes of mitochondrial beta-oxidation. (biomedcentral.com)

As the glyoxylate cycle is an important pathway in the utilization of alternative carbon sources, we also highlight the key metabolic enzymes in the glyoxylate cycle and its necessity for the pathogenesis of C. glabrata . (biomedcentral.com)

We found that the tricarboxylic acid cycle-associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG-dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. (bvsalud.org)
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. (nih.gov)
This gene normally encodes for a peroxisomal membrane protein called ALD-P. (ajnr.org)
Due to an information update of GenBank in December of 2008, the gene LOC728635 , located downstream of DHRS4 and DHRS4L2 and similar to the peroxisomal short-chain alcohol dehydrogenase, was renamed DHRS4L1 . (biomedcentral.com)

In contrast, alcohol oxidase, a peroxisomal methanol utilization pathway enzyme, was virtually absent from per mutant cells. (elsevierpure.com)
The peroxisomal receptor dislocation pathway: to the exportomer and beyond. (ruhr-uni-bochum.de)

Subcellular fractionation experiments indicated that the peroxisomal marker enzyme catalase was mislocalized to the cytosol in both methanol- and oleate-induced cultures of the mutants. (elsevierpure.com)
Therefore, we are interested in two central transport processes: (1) the biogenetic transport of newly synthesised peroxisomal enzymes from the cytosol over the peroxisomal membrane into the matrix as well as (2) the transport of the entire organelle to the vacuolar lumen in the context of selective autophagic degradation. (ruhr-uni-bochum.de)

Three different enzymes reside on this entity (multifunctional protein) allowing this enzyme to perform isomerization, hydration, and dehydration. (wikipedia.org)
Isomerase activity on the multifunctional enzyme occurs at the amino-terminal catalytic half of the protein along with the hydratase activity. (wikipedia.org)
In 1997, we identified the NRDR proteins from rabbit liver tissues, and found that this protein had strong retinol oxidation and retinal reduction activities and was a crucial enzyme in the metabolism and synthesis of retinoic acid [ 1 ], an important intracellular signaling molecule involved in the regulation of cell growth, differentiation of embryonic cells, and the regulation of immune functions. (biomedcentral.com)

Elosulfase alfa (Vimizim) was approved in February 2014 as an enzyme replacement for N -acetylgalactosamine-6 sulfatase (GALNS) deficiency in MPS IVA (Morquio A syndrome). (medscape.com)
Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases, each of which is produced by an inherited deficiency of an enzyme involved in the degradation of acid mucopolysaccharides, now called glycosaminoglycans (GAGs). (medscape.com)
16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)

N- acetylgalactosamine-4-sulfatase is a recombinant human enzyme used to treat mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome). (medscape.com)
Alpha-L-iduronidase is a recombinant human enzyme used to treat mucopolysaccharidosis type I that received US patent approval in November 2001 and was approved in April 2003 as a proprietary product. (medscape.com)
Oxidative stress and inflammation in mucopolysaccharidosis type IVA patients treated with enzyme replacement therapy. (medscape.com)

Distribution of peroxins (A), and possible peroxisomal enzymes (B) in metazoan genomes. (biomedcentral.com)

We propose that the specificity of XXT3, XXT4, and XXT5 is directed toward the prior synthesis of the acceptor substrate by the other two enzymes, XXT1 and XXT2. (bvsalud.org)

Combination of ISFET and enzyme carnitine acetyltransferase allowed obtaining a sensor for measurement of L-carnitine. (databasefootball.com)
The enzyme, according to its nature, provides high selectivity and sensitivity towards L-carnitine that enables to detect the reaction directly without additional reagents. (databasefootball.com)

Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering eLife, 9, pp. e54639. (unipv.it)

This enables us to track individual transport events by the use of selective markers and inhibitors by applying fluorescence microscopy as well as biochemical subcellular fractionation. (ruhr-uni-bochum.de)

Using a newly developed enzyme-coupled continuous activity assay, we compare differing NAS proteins identified through multiple sequence alignments and phylogenetic analyses. (bvsalud.org)
12q14 (Sanfilippo syndrome): The diagnosis requires a specific lysosomal enzyme assay for glucosamine ( N -acetyl)-6-sulfatase (GNS) activity. (medscape.com)

To determine involvements of the peroxisomes in the metabolism of exogenously added fatty acids, we examined transgenic C. reinhardtii expressing fluorescent proteins fused to N- or C-terminal peptide of peroxisomal proteins, concomitantly with fluorescently labeled palmitic acid under different trophic conditions. (edu.sa)
Conclusion: Our data suggest that UBE2Q1 as an E2 enzyme of ubiquitination system can interact with B4GALT1 and P53, and may contribute to the accumulation of misfolded important proteins and colorectal tumor development. (eurekaselect.com)

Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase. (harvard.edu)
in this study, the nitrate reductase (niad) and orotidine-5'-monophosphate decarboxylase (pyrg) genes from penicillium camemberti were characterized, and their suitability as metabolic molecular markers for transformation was evaluated. (liverpool.ac.uk)

This removes the need for a substrate transferring enzyme. (wikipedia.org)

2016). AA also takes part in the regeneration of α-tocopherol (vitamin E) in photosynthetic membranes and participates in chloroplast metabolism as a cofactor for violaxanthin de-epoxidase, an enzyme involved in xanthophyll cycle-mediated photoprotection (Smirnoff and Wheeler, 2000). (deepdyve.com)

The cycling peroxisomal targeting signal type 1 - receptor Pex5p: reaching the circle`s end with ubiquitin. (ruhr-uni-bochum.de)

elimination of marker genes from transformed filamentous fungi by unselected transient transfection with a cre-expressing plasmid. (liverpool.ac.uk)
molecular characterization of the niad and pyrg genes from penicillium camemberti, and their use as transformation markers. (liverpool.ac.uk)

The result indicates that β-oxidation may be only a minor occurrence in the peroxisomal population in C. reinhardtii, which supports the idea that lipid biosynthesis and not β-oxidation is the primary metabolic preference of fatty acids in the alga. (edu.sa)

The enzyme is taken up into the lysosomes and increases catabolism of GAGs KS and C6S. (medscape.com)
The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma. (harvard.edu)
Therefore, to identify underlying molecular alterations of cancer and to characterize prognostic molecular markers have important implications for personalized cancer treatment. (biomedcentral.com)

Random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) dominant markers were used to assess genetic variability in the aphid Sitobion avenae (Fabricius) in relation to hydroxamic acid levels in their host-plants. (cambridge.org)
Laronidase is a polymorphic variant of the human enzyme alpha-L-iduronidase produced by recombinant DNA technology. (medscape.com)

The multifunctional enzymes are found in bacteria and in the peroxisomes of some eukaryotes, but they serve two functions: the N-terminal domain works the same as the other classes of enoyl-CoA isomerases and the C-terminal domain works as a dehydrogenase, specifically, to 3-hydroxyactyl-CoA. (wikipedia.org)
To begin with, the peroxisomes of rat liver are a multifunctional enzyme including enoyl-CoA isomerase, enoyl-CoA hydratase, and L-(−)-3-hydroxyacyl-CoA dehydrogenase. (wikipedia.org)
Statistical analysis on optically sectioned images found that C. reinhardtii simultaneously carries diverse populations of the peroxisomes in the cell and modulates peroxisomal contents based on light conditions. (edu.sa)

Rape, M. Building ubiquitin chains: E2 enzymes at work. (eurekaselect.com)

It is indicated for MPS type II (Hunter syndrome) because it replaces insufficient levels of the lysosomal enzyme I2S. (medscape.com)
Elosulfase alfa replaces deficient enzyme N-acetylgalactosamine-6 sulfatase (GALNS) to minimize progressive multisystemic manifestations of Morquio A syndrome. (medscape.com)

Callis, J. Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis. (eurekaselect.com)
CD16 and CD56 are markers for NK Cells *Rx for Mycoplasma pneumonia (cold agglutinins) mentioned in stem  Erythromycin, Tetracycline *Guy had occult blood in stool and fibrosis in kidney  Polyarteritis Nodosa *What type of HSN reaction is the PPD test for TB  Type IV HSN Rx *ADH hormone 2nd messenger  adenylyl cyclase / cAMP *Pt. (pdfcoffee.com)

Nevertheless, plasma assays have been found to be unreliable markers for disease progression, irrespective of subtype. (ajnr.org)
Furthermore, clinical markers (neurologic and cognitive scores) are relatively insensitive to early nervous system involvement and minor disease progression (9) . (ajnr.org)

Although all three classes of enzymes have the same function, there is little overlap among their amino acid sequences. (wikipedia.org)
Enzyme replacement therapy may provide clinically important benefits (ie, improved pulmonary function and walking ability, reduced excess carbohydrates stored in organs). (medscape.com)
Their enzyme content and therefore biochemical function can be modulated according to the cellular demands. (ruhr-uni-bochum.de)

However, two of these isomerases had antibody attachment: the short chain isomerase and the peroxisomal multifunctional enzyme. (wikipedia.org)

Contrast-enhanced T1-weighted spin-echo MR imaging may serve as a marker for the presence and the severity of this inflammatory process (12) . (ajnr.org)

As briefly illustrated in Tables one and two, there are many combina tions of cell surface markers that can be employed to pick MSCs from mixtures of cells, that are often performed by cell sorting using FACS or immunomagnetic procedures, although several scientific studies use plastic adher ent stromal cells that are subsequently classified using immunofluorescent phenotyping or movement cytometry. (plasignaling.com)

A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. (harvard.edu)
This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds. (harvard.edu)

we report a method for marker removal that requires no genetic selection. (liverpool.ac.uk)

Idursulfase is a purified form of human I2S, a lysosomal enzyme. (medscape.com)

The complete microsystem consisted of a packaged chip, an immobilized enzyme and a microfluidic channel made of epoxy resin for reagent delivery. (databasefootball.com)

Anatomy24

Organisms6

Diseases9

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes13

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Containing peroxisomal target1

Fatty acid5

Bifunctional enzyme1

Biogenesis3

Lysosomal enzymes2

Mitochondrial9

Glyoxylate cycle1

Gene4

Pathway2

Cytosol2

Protein3

Deficiency3

Mucopolysaccharidosis type3

Peroxins1

Synthesis1

Carnitine2

Alcohol1

Subcellular1

Assay2

Proteins2

Reductase2

Substrate1

Metabolism1

Receptor1

Genes2

Metabolic1

Lysosomes2

Prognostic2

Polymorphic2

Peroxisomes3

Chains1

Syndrome2

Type2

Progression2

Function3

Short chain1

Inflammatory1

Cell1

Includes2

Report1

Human1

Made1