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  • GLpf
  • Glycerol facilitator, GlpF. (tcdb.org)
  • Three experimental groups reported that p f in AQPZ, the orthodox water channel of Escherichia coli , exceeds p f of the glycerol facilitator from E. coli , GlpF ( 6 - 8 ), whereas three other theoretical groups observed the exact opposite (table S1) ( 9 - 11 ). (sciencemag.org)
  • physiological
  • Although the physiological role of glycerol in the normal function of erythrocytes is not clear, plasma glycerol is an important substrate for lipid biosynthesis of intraerythrocytic malarial parasites. (jhu.edu)
  • [3] This process is vital for any living organism to sustain proper physiological conditions and aquaporins are necessary to sustain this process (i.e. osmosis alone could not provide a sufficient flow of water). (proteopedia.org)
  • Direct physiological evidence from a renal tubular perfusion experiment by Sands and Knepper (1987) demonstrated the existence of urea permeability in the terminal inner medullar collecting duct that was higher than the level accounted for with simple diffusion. (frontiersin.org)
  • protein
  • The image on the left shows the protein, 6 molecules of glycerol and one of beta-octylglucoside. (proteopedia.org)
  • Ramirez-Lorca R, Vizuete ML, Venero JL, Revuelta M, Cano J, Ilundain AA, Echevarria M (1999) Localization of aquaporin-3 mRNA and protein along the gastrointestinal tract of Wistar rats. (springer.com)
  • Protein Kinase C (PKC) has been documented as a common signal transducer among the aquaporins. (proteopedia.org)
  • Benga G. The first discovered water channel protein, later called aquaporin 1: molecular characteristics, functions and medical implications. (proteopedia.org)
  • lipid
  • Bollag WB, Xie D, Zheng X, Zhong X (2007) A potential role for the phospholipase D2-aquaporin-3 signaling module in early keratinocyte differentiation: production of a phosphatidylglycerol signaling lipid. (springer.com)
  • Results: Twenty nanosecond molecular dynamics (MD) simulation of a fully hydrated tetramer of AqpM embedded in a lipid bilayer permitted predictions to be made of key biophysical parameters including: single channel osmotic permeability constant (pf), single channel diffusive permeability constant (pd), channel radius, potential water occupancy of the channel and water orientation inside the pore. (ebscohost.com)
  • yeast
  • Upon high osmolarity conditions, yeast accumulate glycerol by increased production of the osmolyte and by restricting glycerol efflux through Fps1. (tcdb.org)
  • mice
  • Glycerol replacement corrects defective skin hydratation, elasticity, and barrier function in aquaporin-3-deficient mice. (prolekare.cz)
  • 3 Studies of brain edema in AQP4-null mice implied an important role for AQP4 in fluid balance, 20 supporting the possibility that AQP4 may participate in the maintenance of retinal water balance during synaptic transmission and retinal edema. (arvojournals.org)
  • At 3 wk of age (postnatal day 21 ), lenses from null mice ( Aqp0 −/− ) contained polymorphic opacities, whereas lenses from heterozygous mice ( Aqp0 +/− ) were transparent and did not develop frank opacities until ∼24 wk of age. (physiology.org)
  • In addition, a number of aquaporin deletion mice have been generated by targeted gene disruption through homologous recombination. (physiology.org)
  • secretion
  • They are involved in (1) nephrogenic diabetes insipidus, (2) brain water balance and hearing and (3) salivary secretion ( Li and Verkman, 2001 ). (tcdb.org)
  • putative
  • Here, I will summarize our current knowledge of the involvement of aquaporin-formed pores and tight junctions in epidermal water homeostasis - as well as in other functions - and their putative roles in skin dryness. (springer.com)
  • Putative aquaporin, GlpF6. (tcdb.org)
  • AQP0
  • Osmotic water permeability values for Aqp0 +/− and Aqp0 −/− lenses were reduced to ∼46% and ∼20% of wild-type values, respectively, and the focusing power of Aqp0 +/− lenses was significantly lower than that of wild type. (physiology.org)
  • AQP9
  • We conclude that AQP9 is the major glycerol channel in mouse erythrocytes and suggest that this transport pathway may contribute to the virulence of intraerythrocytic stages of malarial infection. (jhu.edu)
  • Studies also suggest that AQP9 may be responsible for the high vascular permeability and interstitial fluid pressure in tumors of the brain, colon, breast and pancreas. (acris-antibodies.com)
  • molecules
  • Glycerol molecules move in a single file through an equally narrow amphipathic channel in which the NPA motifs also play a critical role. (plantphysiol.org)
  • Function
  • Future research on renal water transport will focus on the search for other aquaporins, structure-function relationship of aquaporins, the development of aquaporin inhibitors and their possible use as diuretics, and further elucidation of the renal vasopressin pathway. (springer.com)
  • The function of the skin as a barrier against the environment, and the amount of transepidermal water loss (TEWL), depends on the integrity of the outer layer of the epidermis, the stratum corneum [ 3 , 4 ]. (hindawi.com)
  • These data could lead to a better understanding of aquaporin function not only at the cellular level but also in the whole plant. (plantcell.org)
  • endothelial
  • More specifically, the endothelial cells also possess transporters which show permeability characteristics and allow transport of oxygen and CO 2 across the BBB, bu these selectively prevent other substances from crossing [ 1 ]. (hindawi.com)
  • channel
  • Aquaporin-0 functions as water channel in lens fibers. (proteopedia.org)
  • Aquaporin-Z is a major water channel in bacteria. (proteopedia.org)
  • Rai T, Sasaki S, Uchida S (2006) Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal. (springer.com)
  • Ion channel activity has been shown for Aquaporins 0, 1, and 6, Drosophila Big Brain and plant Nodulin-26 ( Yool and Campbell, 2012 ). (tcdb.org)
  • The extended cytosolic termini of Fps1 contain short domains that are important for regulating glycerol flux through the channel. (tcdb.org)
  • Phosphorylation of serine 256 is reqaired for camp-dependent regulatory exocytosis of the aquaporin-2water channel. (nii.ac.jp)
  • In addition, MD simulation results suggest that AqpM combines characteristics of strict aquaporins, such as the narrow SF and channel radius, with those of aquaglyceroporins, such as a more hydrophobic and less polar SF. (ebscohost.com)
  • As low channel densities (0.1 to 10%) are required for sufficient water permeability, the amphiphilic bilayer matrix will play a critical role in separation performance. (sciencemag.org)
  • human
  • A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 3(278-292aa EENVKLAHVKHKEQI), different from the related rat and mouse sequences by one amino acid. (bosterbio.com)
  • One year later, a Chesebrough-Ponds patent 6 disclosing cosmetic compositions containing phytovitamin D 3 contained a discussion of keratinocytes, which constitute 75-80% of the total number of cells in the human epidermis. (cosmeticsandtoiletries.com)
  • endoplasmic
  • The aquaporin 11 and 12 are localized intracellularly and have positively charged amino acid clusters at the C-terminal end identical to di-lysine (KKXX) motif for an endoplasmic retention signal. (acris-antibodies.com)