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  • nuclei
  • The epithelioid cells showed large, round nuclei, and prominent nucleoli with mild pleomorphism ( Fig. 2B , C ). The vascular component is composed of thin-walled vessels. (e-cmh.org)
  • rare
  • The same group coined the term "perivascular epithelioid cell" (PEC) for these cells in 1992 and proposed the presence of this distinctive cell, distinguished in part by strong HMB-45 positivity, as a common link between a number of rare disorders in disparate locations, including AML, CCST, and lymphangiomyomatosis (LAM) of the lung [ 3 ]. (hindawi.com)
  • melanoma
  • Tumor cells were diffusely immunoreactive for human melanoma black 45 (HMB45) and Melan A, focally immunoreactive for smooth muscle actin, but not for hepatocyte specific antigen (HSA). (e-cmh.org)
  • antigen
  • These cells were positive for HMB45, MelanA, and smooth muscle actin and negative for epithelial membrane antigen. (e-cmh.org)
  • known
  • At present this neoplasm does not have a known normal cellular counterpart and the natural history is often unpredictable. (beds.ac.uk)