• Ovarian diseases refer to diseases or disorders of the ovary. (wikipedia.org)
  • Some of the ovarian diseases or disorders include: endometriosis, ovarian cysts, ovarian epithelial cancer, ovarian germ cell tumors, ovarian low malignant potential tumors, and polycystic ovary syndrome (PCOS). (wikipedia.org)
  • It can be either at ovary, fallopian tubes, or peritoneal spaces. (wikipedia.org)
  • During ovulation, which typically happens monthly, an egg is usually released from 1 ovary and travels through a fallopian tube to the uterus. (cancer.net)
  • The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
  • Ovarian epithelial cancer, fallopian tube cancer, and primary peritoneal cancer are diseases in which malignant (cancer) cells form in the tissue covering the ovary or lining the fallopian tube or peritoneum. (adventhealthcancerinstitute.com)
  • The egg cell goes through the fallopian tube, which attaches the ovary to the uterus , where the egg cell can meet a sperm cell that fertilizes the egg cell. (asu.edu)
  • An ultrasound of the reproductive organs is also an important examination, because the cancer may develop after surgery from cells of the peritoneal epithelium, primary cells from the ovary, fallopian tube and peritoneum, as well as ovarian endometriosis "splinter" after their removal. (health-alphabet.com)
  • However, investigators have demonstrated precursor cancerous lesions in the fallopian tube (tubal in-situ carcinoma [TIC]) and have provided evolutionary evidence that many advanced serous ovarian cancers originate in the fallopian tubes. (medscape.com)
  • [ 1 , 2 ] Currently, both early-stage and advanced-stage fallopian tube cancers are treated in much the same way as ovarian cancers-that is, with surgery followed by chemotherapy. (medscape.com)
  • Surgery is the initial therapy for stage I-IV fallopian tube cancers. (medscape.com)
  • Only a small percentage of women with epithelial fallopian tube cancers are treated with surgery alone. (medscape.com)
  • no randomized trials have specifically addressed fallopian tube cancers. (medscape.com)
  • Accordingly, the chemotherapy used to treat primary fallopian tube cancers is based on the standard management of ovarian cancers. (medscape.com)
  • In this guide, this group of cancers is referred to as "ovarian/fallopian tube cancer" because peritoneal cancer is relatively rare. (cancer.net)
  • When the term "ovarian cancer" is used, it includes both fallopian tube and peritoneal cancers because it may be unclear where the cancer started. (cancer.net)
  • Based on this updated knowledge, when discussing contraception to avoid future pregnancy, some doctors recommend removal of the fallopian tubes, rather than tying or banding the tubes, in order to lower the risk of ovarian/fallopian tube cancers. (cancer.net)
  • Just as with ovarian cancer, some peritoneal cancers may begin in the fallopian tubes and spread from the end of the fallopian tube into the peritoneal cavity. (cancer.net)
  • Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
  • The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (msdmanuals.com)
  • Mercy Medical Center is the first institution in the United States to study the role of CRS/HIPEC for newly diagnosed with ovarian, fallopian tube, or primary peritoneal cancers. (newswise.com)
  • Newly diagnosed patients with advanced-stage ovarian, fallopian tube, or primary peritoneal cancers should always be evaluated by a gynecologic oncologist if possible. (jnccn.org)
  • Some ovarian, fallopian tube, and primary peritoneal cancers are caused by inherited gene mutations (changes). (adventhealthcancerinstitute.com)
  • Oncologists dealing with particularly complex cancers should realize the value that molecular profiling with Caris Molecular Intelligence can play in helping their patients battle this disease as demonstrated by these data," said Caris Life Sciences Chief Medical Officer, Sandeep K. Reddy, M.D. (carislifesciences.com)
  • Alymsys (bevacizumab-maly) is a biosimilar to Avastin (bevacizumab) that is used to treat a variety of cancers, including metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, metastatic renal cell carcinoma, cervical cancer, and epithelial ovarian, fallopian tube, or primary peritoneal cancer. (mdtodate.com)
  • According to recent studies, high-grade serous cancers account for most ovarian/fallopian tube cancers. (zenonco.io)
  • Pancreatic cancer is a rare, life-threatening disease that accounts for about 3% of all cancers in the US. (worldpharmanews.com)
  • Earlier this year an amended ODD status was granted to include both fallopian tube and primary peritoneal cancers following the expanded US approval of Lynparza in August 2017 for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer, who are in a complete or partial response to platinum-based chemotherapy. (worldpharmanews.com)
  • In fact, most patients with stage I disease are treated with adjuvant chemotherapy because of the luminal structure of the organ and the risk of shedding cells out of the tubes and into the abdominal cavity. (medscape.com)
  • The fallopian tubes are symmetrical paired tubular organs that connect the peritoneal cavity to the endometrium in the uterine cavity. (medscape.com)
  • Following fertilization, the zygote develops into an embryo and continues to travel through the fallopian tube into the uterine cavity, where it implants in the endometrium. (medscape.com)
  • The purpose of these surgeries was to provide an open conduit from the peritoneal cavity into the uterus. (medscape.com)
  • The fallopian tubes have critical functions in the reproductive process, including providing a conduit from the peritoneal cavity to the uterine cavity. (medscape.com)
  • The fallopian tubes are involved in the transport of the ovum and sperm to the site of fertilization and in the movement of the early embryo to the uterine cavity. (medscape.com)
  • Ovarian cancer is an extremely deadly disease characterised by an abnormal growth of ovarian, fallopian tube or primary peritoneal tissue with malignant tumours spreading beyond the site of origin into the peritoneal cavity and affecting the organs within (e.g. the spleen, bowel mesentery and liver). (biomoti.com)
  • Some peritoneal malignancies, like ovarian cancer, can start in the fallopian tubes and progress from the tube's end into the peritoneal cavity. (zenonco.io)
  • Spontaneous bacterial invasion of the peritoneal cavity. (icliniq.com)
  • It may result in granuloma formation in the peritoneal cavity. (medscape.com)
  • Given this new information, several medical professionals advise against tying or banding fallopian tubes for contraception (to prevent future pregnancy) to reduce the risk of ovarian/fallopian tube cancer. (zenonco.io)
  • The epithelial lining of the fallopian tube is of critical importance for human reproduction and has been implicated as a site of origin of high-grade serous ovarian cancer. (nature.com)
  • Staging fallopian tube cancer involves the removal of both fallopian tubes and of the ovaries, uterus, cervix, infracolic omentum, and retroperitoneal lymph nodes, in addition to peritoneal washings and peritoneal biopsies. (medscape.com)
  • Consensus-based guidelines from the National Comprehensive Cancer Network (NCCN) suggest administering three to six cycles of chemotherapy for stage IA-IC disease and six to eight cycles for stage II-IV disease. (medscape.com)
  • As in ovarian cancer, the use of intraperitoneal (IP) chemotherapy must be considered the current standard treatment option in patients with stage II-IV disease. (medscape.com)
  • This is the first page of Cancer.Net's Guide to Ovarian, Fallopian Tube, and Peritoneal Cancer. (cancer.net)
  • see more information below), and in most cases, the cancer actually starts in the tip, or outer end, of the fallopian tubes. (cancer.net)
  • On November 14, the U.S. Food and Drug Administration (FDA) granted accelerated approval to mirvetuximab soravtansine-gynx (Elahere) for adult patients with folate receptor alpha (FRα)-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatment regimens. (ascopost.com)
  • NCT04296890 ), a single-arm trial of 106 patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer. (ascopost.com)
  • This accelerated approval of mirvetuximab soravtansine for [FRα-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer] is incredibly meaningful for patients who have this cancer," Ursula A. Matulonis, MD , Chief of the Division of Gynecologic Oncology and the Brock-Wilson Family Chair at Dana-Farber Cancer Institute and co-leader of the SORAYA study. (ascopost.com)
  • Participant must have histologically documented, platinum resistant, advanced (metastatic and/or unresectable) high-grade serous/endometrioid ovarian, primary peritoneal, or fallopian tube cancer. (uclahealth.org)
  • Primary peritoneal cancer is cancer that forms in the peritoneum and has not spread there from another part of the body. (adventhealthcancerinstitute.com)
  • Signs and symptoms of ovarian, fallopian tube, or peritoneal cancer include pain or swelling in the abdomen. (adventhealthcancerinstitute.com)
  • Ovarian, fallopian tube, or peritoneal cancer may not cause early signs or symptoms. (adventhealthcancerinstitute.com)
  • These signs and symptoms also may be caused by other conditions and not by ovarian, fallopian tube, or peritoneal cancer. (adventhealthcancerinstitute.com)
  • This randomized phase II/III trial studies how well pegylated liposomal doxorubicin hydrochloride with atezolizumab and/or bevacizumab work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back. (clinicaltrialsgps.com)
  • It is not yet known which combination will work better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer. (clinicaltrialsgps.com)
  • Learn about the symptoms of breast cancer and what to look for to protect yourself against this disease. (keckmedicine.org)
  • This includes work in immunocompetent models of advanced ovarian cancer disease. (biomoti.com)
  • please see NCCN Guidelines - Ovarian Cancer, Including Fallopian Tube Cancer and Primary Peritoneal Cancer . (hemonc.org)
  • Nemvaleukin alfa is under clinical development by Alkermes and currently in Phase III for Fallopian Tube Cancer. (pharmaceutical-technology.com)
  • According to GlobalData, Phase III drugs for Fallopian Tube Cancer have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. (pharmaceutical-technology.com)
  • Alkermes is a biopharmaceutical company that focuses on the research, development, and commercialization of drugs for the treatment of cancer, neurodegenerative and central nervous system (CNS) diseases. (pharmaceutical-technology.com)
  • Alymsys, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer who received no more than 2 prior chemotherapy regimens. (mdtodate.com)
  • Efficacy data demonstrated no significant differences between treatment groups for any efficacy parameters, including clinical benefit rate, CRs and PRs, as well as stable disease, time to response [TTR], and duration of response [DOR]," Thomas Herzog, MD, a professor of obstetrics and gynecology and deputy director at University of Cincinnati Cancer Institute, said during a presentation on the findings. (onclive.com)
  • Farletuzumab, a humanized monoclonal antibody, binds to folate receptor alpha, which is known to be highly expressed in epithelial ovarian cancer and is associated with the malignant potential of the disease. (onclive.com)
  • Changes in serum CA-125 can predict optimal cytoreduction to no gross residual disease in patients with advanced stage ovarian cancer treated with neoadjuvant chemotherapy. (ijrcog.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • 1) Due to the late onset of symptoms, patients are often diagnosed after the cancer has progressed to locally advanced or metastatic stages of the disease. (worldpharmanews.com)
  • The use of Lynparza in pancreatic cancer is being assessed in the ongoing Phase III POLO trial, which is testing Lynparza as maintenance monotherapy vs placebo in patients with germline BRCA-mutated metastatic pancreatic cancer whose disease has not progressed following 1st-line platinum-based chemotherapy. (worldpharmanews.com)
  • POLO is a Phase III, randomised, double-blinded, placebo-controlled trial to evaluate the efficacy and safety of Lynparza tablets (300 mg twice daily) as maintenance monotherapy compared with placebo, in patients with germline BRCA-mutated metastatic pancreatic cancer whose disease has not progressed following 1st-line platinum-based chemotherapy. (worldpharmanews.com)
  • PARP inhibitors have been used to treat numerous diseases, but these agents have been approved the longest for use in ovarian cancer. (jnccn.org)
  • Although PARP inhibitors have been developed for multiple diseases, they have been approved the longest for treatment of ovarian cancer, and thus offer the most useful data in that indication, according to Deborah K. Armstrong, MD, Director, Breast and Ovarian Surveillance Service, and Professor of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. (jnccn.org)
  • During the NCCN 2021 Virtual Annual Conference, Dr. Armstrong described data from PARP inhibitor trials in patients with newly diagnosed advanced ovarian cancer, reviewed factors that may affect the extent of clinical benefit from PARP inhibitor therapy, and discussed considerations for selecting recurrence therapy in patients whose disease has progressed on or after PARP inhibitor maintenance. (jnccn.org)
  • The PAOLA-1 study enrolled patients with newly diagnosed, stage III-IV, high-grade serous/endometrioid ovarian, fallopian tube, or primary peritoneal cancer. (jnccn.org)
  • The PRIMA study looked at the PARP inhibitor niraparib in patients with stage III-IV high-grade serous or endometrioid cancer with visible residual disease postsurgery. (jnccn.org)
  • Previous research has established a link between genetic mutations in the BRCA1 and BRCA2 genes to an increased risk of developing ovarian, fallopian tube or peritoneal cancer in women. (medicalxpress.com)
  • Disparities between Uptake of Germline BRCA1/2 Gene Tests and Implementation of Post-test Management Strategies in Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients. (cdc.gov)
  • This guideline covers detecting, diagnosing and treating women (18 years and older) who have, or are suspected of having, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer or borderline ovarian cancer. (bvsalud.org)
  • This guideline covers using colonoscopy to check for signs of bowel cancer in people aged 18 and over with ulcerative colitis or Crohn's disease (types of inflammatory bowel disease) or adenomas (also known as polyps). (bvsalud.org)
  • Fallopian tube carcinomas were once believed to be rare. (medscape.com)
  • Based on a 450 patient cohort, this data reported that treatments consistent with the predictions of molecular profiling significantly improved overall survival in patients with ovarian, primary peritoneal and fallopian tube carcinomas. (carislifesciences.com)
  • Prat J. Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features. (ijrcog.org)
  • A clinical syndrome resulting from the ascending spread of microorganisms from the vagina and endocervix to the endometrium, fallopian tubes, and/or contiguous structures. (cdc.gov)
  • Women also experience localized peritonitis from an infected fallopian tube or a ruptured ovarian cyst. (medscape.com)
  • Peritoneal infections are classified as primary (ie, from hematogenous dissemination, usually in the setting of an immunocompromised state), secondary (ie, related to a pathologic process in a visceral organ, such as perforation or trauma, including iatrogenic trauma), or tertiary (ie, persistent or recurrent infection after adequate initial therapy). (medscape.com)
  • Primary peritonitis is most often spontaneous bacterial peritonitis (SBP) seen mostly inpatients with chronic liver disease. (medscape.com)
  • Platinum sensitive disease, defined as disease which progress after 6 or more months after the completion of platinum-based therapy and primary platinum refractory disease, defined as progression while on the upfront platinum-based therapy, is not eligible. (uclahealth.org)
  • The type and extent of surgery depends on the underlying disease process and the severity of intra-abdominal infection. (medscape.com)
  • Peritoneal infections secondary to intra-abdominal lesions, like perforation, nonbacterial peritonitis, and bowel necrosis. (icliniq.com)
  • Laparoscopy also allows checking for further peritoneal or intra-abdominal pathology. (medscape.com)
  • Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)
  • Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
  • Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
  • Therefore, this new organoid model closely mimics the normal physiology and anatomy of the human fallopian tube epithelium and provides a starting point for future investigations into the regulatory mechanisms involved in its cellular renewal and pathology. (nature.com)
  • Fallopian tube reconstruction for tubal disease was first documented in 1896. (medscape.com)
  • They are mainly offered to patients at low risk for tubal disease. (medscape.com)
  • Some doctors also recommend fallopian tube removal when a person is undergoing surgery for a benign disease and does not want to get pregnant in the future. (cancer.net)
  • When a patient has surgery for a benign ailment and does not wish to become pregnant, some doctors also advise fallopian tube removal. (zenonco.io)
  • The FDA grants ODD status to medicines intended for the treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the US. (worldpharmanews.com)
  • Peritonitis is most often caused by introduction of an infection into the otherwise sterile peritoneal environment through organ perforation, but it may also result from other irritants, such as foreign bodies, bile from a perforated gall bladder or a lacerated liver, or gastric acid from a perforated ulcer. (medscape.com)
  • It acts as a precursor of pelvic inflammatory diseases, salphingo-oophoritis (infection of fallopian tube and ovaries) which mostly result in pelvic adhesions like peritoneal adhesions and fallopian tube adhesions which obstruct tubes and may cause infertility. (positivehomeopathy.com)
  • The infection occurs during peritoneal dialysis due to unclean surroundings, poor hygiene, or contaminated equipment. (icliniq.com)
  • Among the most important are platinum sensitivity, the status of BRCA and homologous recombination deficiency (HRD), and the changing indications for PARP inhibitors in recurrent disease and maintenance. (jnccn.org)
  • Patients received mirvetuximab soravtansine at 6 mg/kg (based on adjusted ideal body weight) as an intravenous infusion every 3 weeks until disease progression or unacceptable toxicity. (ascopost.com)
  • The recommended mirvetuximab soravtansine dose is 6 mg/kg adjusted ideal body weight administered once every 3 weeks (21-day cycle) as an intravenous infusion until disease progression or unacceptable toxicity. (ascopost.com)
  • Participant must have radiographic evidence of disease progression based on RECIST criteria following the most recent line of treatment. (uclahealth.org)
  • Biochemical recurrence (eg, CA-125 in ovarian carcinoma) only is not considered as disease progression. (uclahealth.org)
  • Platinum-resistant disease, defined as progression or relapse within 6 months after the completion of platinum-based therapy, is eligible. (uclahealth.org)
  • In all arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. (clinicaltrialsgps.com)
  • Participants in both arms will be treated until disease progression, unacceptable toxicity or any criterion for stopping the study drug or withdrawal from the trial occurs. (ucsd.edu)
  • Study participants were randomized to receive either the PARP inhibitor olaparib or placebo, and were continued on treatment for 2 years if there was no evidence of disease progression. (jnccn.org)
  • A radiomics method based on MR FS-T2WI sequence for diagnosing of autosomal dominant polycystic kidney disease progression. (cdc.gov)
  • in addition, paracentesis should be performed in all patients who do not have an indwelling peritoneal catheter and are suspected of having SBP, because results of aerobic and anaerobic bacterial cultures, used in conjunction with the cell count, are useful in guiding therapy. (medscape.com)
  • To obtain insight into the renewal activity of the human fallopian tube mucosa, we carried out immunofluorescence analysis of healthy samples from gynaecological tissue specimens. (nature.com)
  • In newly diagnosed patients with advanced disease, neoadjuvant chemotherapy can be considered if upfront surgery is felt not to be advisable. (jnccn.org)
  • Patients may present with an acute or insidious onset of symptoms, limited and mild disease, or systemic and severe disease with septic shock. (medscape.com)
  • What are the symptoms of heart disease? (uclahealth.org)
  • The symptoms of heart disease may resemble other conditions or medical problems. (uclahealth.org)
  • NFOSI)-18 disease-related symptoms (DRS). (Phase III study) VI. (clinicaltrialsgps.com)
  • Fallopian tube reconstruction has been the traditional method of restoring reproductive function to women with tubal infertility. (medscape.com)
  • Today, in vitro fertilization (IVF) and embryo transfer (ET) bypass the fallopian tubes in the reproductive process and are additional options in the treatment of these patients. (medscape.com)
  • In individuals without a BRCA mutation, PARP inhibition also prolongs PFS after chemotherapy for platinum-sensitive, PARP-naïve disease. (jnccn.org)
  • In the efficacy-evaluable population of patients who had platinum-resistant, measurable disease and received at least one dose of therapy (n = 104), the confirmed overall response rate was 31.7% (95% confidence interval [CI] = 22.9%-41.6%) and median duration of response was 6.9 months (95% CI = 5.6-9.7 months). (ascopost.com)
  • A new antibody-drug conjugate, mirvetuximab soravtansine, has been approved for use in a subset of patients with platinum-resistant disease. (jnccn.org)
  • Among 36 patients with platinum-resistant disease, 6 patients had partial response (PR) and 12 had stable disease. (targetedonc.com)
  • Finally, PARP inhibitors are active as monotherapy in PARP-naïve, BRCA -mutated relapsed disease, with increased activity observed in platinum-sensitive versus platinum-resistant disease. (jnccn.org)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
  • Wilson Disease Prevalence: Discrepancy Between Clinical Records, Registries and Mutation Carrier Frequency. (cdc.gov)
  • Over time, a better understanding of fallopian tube physiology, advances in perioperative care, and improvements in surgical techniques have resulted in better outcomes. (medscape.com)
  • A 35-year-old man with a history of Crohn disease presented with pain and swelling in the right abdomen. (medscape.com)
  • Exome sequencing and targeted gene panels: a simulated comparison of diagnostic yield using data from 158 patients with rare diseases. (cdc.gov)
  • A liquid called peritoneal fluid covers the tissue's surface. (cancer.net)
  • And fungal, parasitic, bacterial and sexually transmitted diseases are also the prime causative factors. (positivehomeopathy.com)
  • However, historically, the best outcomes have been reported when upfront surgery that leaves no residual disease can be achieved, 3 - 5 and upfront surgery should be considered for patients in whom optimal cytoreduction can be safely achieved. (jnccn.org)
  • Fertilization of the egg by the sperm occurs in the fallopian tube. (medscape.com)
  • Patients were stratified based on the chemotherapeutic agents administered during the course of their disease. (carislifesciences.com)
  • Thirteen patients had stable disease lasting at least 4 months. (targetedonc.com)
  • Out of 50, there were 43 patients (86%) with stage III disease and 7 (14%) with stage IV disease. (ijrcog.org)
  • This is especially true for patients with metastatic disease where the benefits of current treatment options are very limited. (worldpharmanews.com)
  • The SOLO-1 study enrolled patients with a germline or somatic BRCA mutation and stage III-IV disease who had completed initial therapy. (jnccn.org)
  • It is just as important to counsel patients who are found to have patent tubes to try spontaneously for 3-6 months after the intervention, as a good proportion of them will become pregnant without further help. (medscape.com)
  • The management approach to peritonitis and peritoneal abscesses targets correction of the underlying process, administration of systemic antibiotics, and supportive therapy to prevent or limit secondary complications due to organ system failure. (medscape.com)
  • Liver Disease. (policylab.us)
  • The purpose of the study is to evaluate how safe and effective an investigational study drug is compared to a placebo (both groups will receive injections, but the placebo contains no active medication) in the treatment of liver disease. (policylab.us)
  • If you or any of your family members have a confirmed or suspected diagnosis of Alpha-1 Liver Disease, you may be eligible. (policylab.us)
  • It aims to reduce harms (such as liver disease, heart problems, depression and anxiety) from alcohol by improving assessment and setting. (bvsalud.org)