I was also PI on an investigator initiated study of a biologic for prosthetic hip loosing and the first CT imaging algorithms to quantify peri-prosthetic osteolysis. (rochester.edu)
Targeted Therapy for Peri-prosthetic Osteolysis Using Macrophage Membrane-encapsulated Human Urine-derived Stem Cell Extracellular Vesicles. (stembook.org)
Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. (cardiff.ac.uk)
The potential, albeit rare, adverse events of using denosumab in arthroplasty patients include osteonecrosis of the jaw and atypical femur fractures, even in the periprosthetic region. (sense-studios.com)
As a result of the osteolysis and wear, patients are at increased risk of several consequences, including periprosthetic fractures from simple falls or minor trauma, aseptic loosening of the prosthesis, or dislocation of the prosthesis. (fixbones.com)
In the context of the heavy macrophage response to wear particles in periprosthetic tissues macrophage-osteoclast differentiation may represent an important cellular mechanism whereby osteolysis is effected in aseptic loosening. (ox.ac.uk)
Arthroplasty4
The article discusses the phenomenon of periprosthetic bone loss following arthroplasty, specifically focusing on vertebral radiographic bone changes around cervical disc replacements. (londonspine.com)
Abstract Background: Periprosthetic bone loss is a common observation following arthroplasty. (londonspine.com)
Periprosthetic bone loss is a common observation following arthroplasty. (londonspine.com)
Understanding the risks associated with the presence of microsporidia in periprosthetic joint infections is essential for proper management of arthroplasty. (cdc.gov)
Polyethylene Wear3
Some of the known modes of failure of TEA are septic loosening, polyethylene wear, osteolysis around the implant and peri prosthetic fracture. (ssri.net.au)
Possible mechanisms for osteolysis are believe to be polyethylene wear secondary to poor implant positioning and edge loading of the polyethylene, flexion impingement, creation of debris and secondary foreign body reaction and component polymethylmethacrylate surface finish (Jeon, Morrey, & Sanchez-Sotelo, 2012). (ssri.net.au)
Therefore, in those patients, alternative bearing surfaces should reduce polyethylene wear and osteolysis that have been present in previous studies using traditional metal-on-polyethylene (MOP). (biomedcentral.com)
Femoral3
The indications for revision were postoperative periprosthetic femoral fracture (n = 6), dislocation (n = 3), and infection (n = 1). (elsevierpure.com)
Radiographic evaluation, performed by an independent observer using a zonal analysis method, included assessment of component migration, Engh's implant-bone femoral fixation score, implant-bone demarcations, and periprosthetic osteolysis. (fondazione.it)
The femoral revision rate was 7 percent 8two hips for asepticloosening, five hips for septic loosening, and twelve hips with osseointegrated stems for severe progressive femoral osteolysis) and the acetabular. (fondazione.it)
Fracture1
However, data on this "selective use" strategy for cemented stems in the population at risk for periprosthetic fracture and implant loosening are limited. (elsevierpure.com)
Implant2
Wear debris generation has been implicated as one of the primary causes of periprosthetic osteolysis and subsequent implant loosening in total joint replacements. (stanford.edu)
The Nexel prosthesis is a recent implant and there are no available studies to show how it is behaving in the long term with osteolysis. (ssri.net.au)
Osteoclasts3
CONCLUSION: This is the first report showing that human macrophages isolated directly from periprosthetic tissues surrounding loosened implants can differentiate into multinucleated cells showing all the functional and cytochemical characteristics of osteoclasts. (ox.ac.uk)
There were 83% fewer osteoclasts at the osteolysis membrane-bone interface in the denosumab group: median 0.05 per mm versus 0.30 mm for placebo. (sense-studios.com)
Although wear remains a problematic issue in THA, its consequences-namely, osteolysis and prosthetic loosening-loom as larger issues. (medscape.com)
Radiographic3
On the second day of ISASS23, Dr. Lanman reviewed the clinical and radiographic findings associated with periprosthetic osteolysis. (kajnews.com)
Radiographic results presented in the study indicate very low wear in vivo with no signs of change over time and no signs of periprosthetic osteolysis in the patient cohort. (massdevice.com)
The Nexel total elbow form #11 - Physician Radiographic Assessment form (published by the prosthesis manufacturer, Zimmer) will be used by the independent observers to qualify and quantify osteolysis on the X-ray. (ssri.net.au)
Particles5
PLGA nanoparticles engineering extracellular vesicles from human umbilical cord mesenchymal stem cells ameliorates polyethylene particles induced periprosthetic osteolysis. (bvsalud.org)
Our in vivo experiments demonstrated that PLGA-Exos effectively suppressed osteolysis induced by polyethylene particles. (bvsalud.org)
Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. (rush.edu)
Green JM, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C. Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. (rush.edu)
He noted by email that osteolysis is caused by wear particles, and is "a frequent complication of conventional polyethylene bearing surfaces. (sense-studios.com)
Acetabular1
CT scan coronal (A) and axial (B) images showing significant osteolysis behind the previously implanted acetabular cup. (fixbones.com)
Revision surgery4
On the other hand, osteolysis is less common, presenting more than a year post-operative and often accompanied by additional complications, leading to revision surgery. (londonspine.com)
Using the latest Next Generation Sequencing technologies, we are investigating miRNA expression profiles in human trabecular bone, synovial fluid and plasma sourced from TJR revision surgery where wear particle associated osteolysis was evident. (edu.au)
To verify which, if any, patient related factors (BMI, hand dominance, underlying pathology, sex or age at the time of surgery) and surgical related factors (radial head replacement or resection, revision surgery, visible impingement) are related to osteolysis around the implants. (ssri.net.au)
As reported in The Lancet Rheumatology, Dr. Wilkinson and colleagues conducted a phase-2 randomized, placebo-controlled, proof-of-concept study of patients scheduled for revision surgery for symptomatic osteolysis. (sense-studios.com)
Implants2
Much of Harris' research focuses on osteolysis, the deterioration of bone tissue around joint replacement implants, and developing highly cross-linked polyethylene to counter the issue of osteolysis. (wikipedia.org)
The loss of bone causes micromotion of the hip implants, and further potentiates osteolysis. (fixbones.com)
Bone loss3
The review highlights the need for clear terminology to distinguish between bone loss and inflammatory osteolysis, as their clinical outcomes and treatment plans differ greatly. (londonspine.com)
Stress shielding may result in periprosthetic bone loss from a reduction in the load transmitted to bone. (medscape.com)
Periprosthetic bone loss may also occur as a result of an inflammatory reaction due to particulate wear debris as generated in the various wear modes (see Presentation , Modes of Wear). (medscape.com)
Furthermore, they provide novel insights for the clinical management of osteolysis . (bvsalud.org)
Prosthesis2
We hypothesize that the osteolysis rate around the prosthesis will be overall the same when care is taken during the procedure to avoid impingement. (ssri.net.au)
To determine osteolysis that has occurred around the Nexel prosthesis up to a 5 year mark. (ssri.net.au)
Impingement1
There is although a potential for impingement in the extreme of range of motion of the elbow in extension and flexion which can produce macroparticles and secondary, increased rate of osteolysis. (ssri.net.au)
Patients2
Fourteen studies reported periprosthetic osteolysis in a total of 46 patients with onset ranging from 15-96 months after the index procedure. (londonspine.com)
Fifteen years of wide spread use of highly cross-linked polyethylene in patients have shown it to be very effective in preventing osteolysis. (wikipedia.org)
Findings1
These findings suggest that PLGA-Exos hold potential as a therapeutic approach for the prevention and treatment of periprosthetic osteolysis . (bvsalud.org)
Failure1
Osteolysis is one of the causes that lead to the failure of total joint replacement (TJR). (edu.au)
Mechanism1
The molecular approach of denosumab treatment--inhibition of osteoclast differentiation and activity via blockade of RANK ligand--hits the core pathological mechanism of wear-induced osteolysis," he said. (sense-studios.com)
Outcomes1
Recently, modern ceramic-on-ceramic (COC) THA has demonstrated decreased risk of wear-induced osteolysis over MOP and then improved the long-term outcomes of THA [ 17 , 18 ]. (biomedcentral.com)
Replacement2
Reuters Health - 20/01/2021 - Denosumab showed biological efficacy against osteolysis after total hip replacement in a proof-of-concept trial. (sense-studios.com)
Here we tested the drug in the setting of osteolysis after hip replacement, a condition that currently has no effective non-surgical treatment. (sense-studios.com)
Results3
Paper of the week: Culturing periprosthetic tissue in blood culture bottles results in isolation of additional microorganisms. (icmphilly.com)
Title: Culturing periprosthetic tissue in blood culture bottles results in isolation of additional microorganisms. (icmphilly.com)
RESULTS: After 24 hours incubation, most cells isolated from the above periprosthetic tissues strongly expressed macrophage (CD11b, CD14) but not osteoclast markers. (ox.ac.uk)
Role1
While human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exos, Exos) have been found to effectively promote osteogenesis and angiogenesis, their role in periprosthetic osteolysis remains unexplored. (bvsalud.org)
Effective1
The effective joint space includes all periprosthetic regions accessible to joint fluid and thereby accessible to particulate wear debris. (medscape.com)