OsteolysisArthroplastyFracturesCross-linked polyeInfectionRadiographicImplantHumeralParticlesArthroplastiesOutcomesLinerAcetabular componentsKneeMetallosisVivoOrthopaedicsProsthesisArticulationLinersFemoral headJointDebrisPatientsConventionalUHMWPEAluminaInfectionsReductionLong-term clinicalRadiologicalLaboratoryHighlyResultsEfficacyOutcomeDiagnosisStudies
Osteolysis16
- Much of Harris' research focuses on osteolysis, the deterioration of bone tissue around joint replacement implants, and developing highly cross-linked polyethylene to counter the issue of osteolysis. (wikipedia.org)
- Fifteen years of wide spread use of highly cross-linked polyethylene in patients have shown it to be very effective in preventing osteolysis. (wikipedia.org)
- PLGA nanoparticles engineering extracellular vesicles from human umbilical cord mesenchymal stem cells ameliorates polyethylene particles induced periprosthetic osteolysis. (bvsalud.org)
- While human umbilical cord mesenchymal stem cell-derived exosomes (HucMSCs-Exos, Exos) have been found to effectively promote osteogenesis and angiogenesis, their role in periprosthetic osteolysis remains unexplored. (bvsalud.org)
- Our in vivo experiments demonstrated that PLGA-Exos effectively suppressed osteolysis induced by polyethylene particles. (bvsalud.org)
- These findings suggest that PLGA-Exos hold potential as a therapeutic approach for the prevention and treatment of periprosthetic osteolysis . (bvsalud.org)
- Furthermore, they provide novel insights for the clinical management of osteolysis . (bvsalud.org)
- Radiographic results presented in the study indicate very low wear in vivo with no signs of change over time and no signs of periprosthetic osteolysis in the patient cohort. (massdevice.com)
- The long-term durability of polyethylene lining total hip arthroplasty (THA) mainly depends on periprosthetic osteolysis due to wear particles, especially in young active patients. (openorthopaedicsjournal.com)
- Since the late-1990s, there were two major technological innovations in PE emerged from necessity to overcome the wear-induced periprosthetic osteolysis, i.e., the development of highly crosslinked PEs (HXLPEs). (mishuesosyarticulaciones.com.mx)
- Radiographic evaluation, performed by an independent observer using a zonal analysis method, included assessment of component migration, Engh's implant-bone femoral fixation score, implant-bone demarcations, and periprosthetic osteolysis. (fondazione.it)
- Therefore, in those patients, alternative bearing surfaces should reduce polyethylene wear and osteolysis that have been present in previous studies using traditional metal-on-polyethylene (MOP). (biomedcentral.com)
- Wear debris generation has been implicated as one of the primary causes of periprosthetic osteolysis and subsequent implant loosening in total joint replacements. (stanford.edu)
- As a result of the osteolysis and wear, patients are at increased risk of several consequences, including periprosthetic fractures from simple falls or minor trauma, aseptic loosening of the prosthesis, or dislocation of the prosthesis. (fixbones.com)
- The constrained prosthesis has increased stress at the elbow joint with high rates of osteolysis, loosening, and periprosthetic fractures. (medapparatus.com)
- He noted by email that osteolysis is caused by wear particles, and is "a frequent complication of conventional polyethylene bearing surfaces. (sense-studios.com)
Arthroplasty17
- Arthroplasty, polyethylene, alumina. (openorthopaedicsjournal.com)
- Reinfection after two-stage revision for periprosthetic infection of total knee arthroplasty. (nature.com)
- We hypothesized, that periprosthetic joint infection (PJI) accounts for the major proportion of first (primary) and repeated (secondary) Total Knee Arthroplasty revisions at our university referral arthroplasty center. (biomedcentral.com)
- Polyethylene wear in hip arthroplasty is an early indicator of potential implant failure, with the wear rate directly associated with the probability of requiring a revision surgery highlighting the vital need for precise patient follow-up method. (jmedicalcasereports.org)
- Polyethylene wear is an early indicator of the potential for implant failure in hip arthroplasty, with its rate of wear directly linked to the risk of requiring a revision procedure (Sochart, 1999). (jmedicalcasereports.org)
- Morphology and design of ultra-high molecular weight polyethylene (UHMWPE or simply PE) acetabular components used in total hip arthroplasty (THA) have been evolving for more than half a century. (mishuesosyarticulaciones.com.mx)
- They do note: "Revision of anatomical to reverse arthroplasty shows better clinical outcomes and lower complication rates than anatomical revision. (caringmedical.com)
- Methods: The first 300 consecutive primary total hip arthroplasty procedures using a collarless, three-dimensional tapered, straight, titanium alloy stem with a grit-blasted surface (performed in 299 patients) were evaluated with independent clinical and radiographic follow-up examinations up to sixteen years. (fondazione.it)
- Understanding the risks associated with the presence of microsporidia in periprosthetic joint infections is essential for proper management of arthroplasty. (cdc.gov)
- During the life of a total hip arthroplasty, wear primarily affects the polyethylene acetabular liner. (fixbones.com)
- Clinical and radiographic outcomes of a hybrid fixation revision total knee arthroplasty system at short to mid-term follow-up. (orthoinno.com)
- A 41-year-old male has steroid-induced avascular necrosis of the hip and decides to undergo metal on polyethylene total hip arthroplasty. (evoluta.com.br)
- Tsukayama et al based their treatment of infections after total hip arthroplasty (THA) on the clinical presentation-that is, positive intraoperative cultures, early postoperative infection, acute hematogenous infection, or late chronic infection. (medscape.com)
- The unconstrained (unlinked) elbow prosthesis consists of separate humeral and ulnar metal components which articulate through a circular high-density polyethylene component ( figure: unconstrained elbow arthroplasty ). (medapparatus.com)
- The potential, albeit rare, adverse events of using denosumab in arthroplasty patients include osteonecrosis of the jaw and atypical femur fractures, even in the periprosthetic region. (sense-studios.com)
- Recent clinical studies have reported that patients with higher body mass index (BMI) are more likely to experience premature failure of total knee arthroplasty (TKA), lower knee scores, and perhaps more pain in the prosthetic joint. (springer.com)
- We present the case of a patient with total knee arthroplasty presenting with a painful enlarging soft tissue mass at the popliteal fossa and calf associated with metallosis and extensive polyethylene wear mimicking soft tissue sarcoma. (biomedcentral.com)
Fractures2
- Periprosthetic fractures. (caringmedical.com)
- In comparison with other studies, our results are similar in terms of medium-term implant survival (100% after 9 years of follow-up, with the occurrence of nine periprosthetic femur fractures long after the operation). (louvainmedical.be)
Cross-linked polye3
- We reviewed the advantages and disadvantages of ceramicon- polyethylene articulation in THA, hip simulator study and retrieval study for polyethylene wear, in vivo clinical results of THA using alumina ceramic-on-polyethylene bearing surfaces in the literature, and new trial alumina ceramic-onhighly cross linked polyethylene bearing surfaces. (openorthopaedicsjournal.com)
- He said, MicroPort ® Orthopedics' A-Class ® Cross-Linked Polyethylene Liner and Profemur ® TL Stem achieved outstanding result in short-term follow-up. (microport.com)
- This led to the current preference for stems with smooth necks without extraction notches and highly cross-linked polyethylene. (louvainmedical.be)
Infection1
- Patients who had an early postoperative infection are managed with débridement, replacement of the polyethylene (PE) insert of the acetabular/tibial component, retention of the prosthesis, and IV administration of antibiotics for 6 weeks. (medscape.com)
Radiographic3
- The study, by a team from the Massachusetts General Hospital, included radiographic analysis from a 299 patient cohort receiving primary total hip arthroplasties using Zimmer's Durasul or Longevity highly crosslinked polyethylene liners. (massdevice.com)
- PATIENTS AND METHODS: Clinical, radiographic, laboratory, and microbiological data from 30 consecutive patients with failed alumina-on-alumina arthroplasties, 19 with screwed socket and 11 with press-fit socket, were systematically collected and evaluated. (unibo.it)
- We performed a retrospective study of clinical and radiographic results of 1000 primary total hip arthroplasties (THA) performed using the Exeter stem on 881 patients who were followed-up for at least 2 years after surgery. (researchgate.net)
Implant4
- What size implant, whether all poly or a metal backed. (slideshare.net)
- We argue that the antibiotic-eluting UHMWPE joint implant is a promising candidate for clinical trials. (nature.com)
- The acetabular liner is a polyethylene implant that is generally impacted into the acetabular cup. (fixbones.com)
- Currently, despite a wear and survival rate comparable to that of fixed polyethylene, the risk of intra-prosthetic dislocation (2%) specific to this type of implant should make their use cautious, especially in young and active patients (1). (louvainmedical.be)
Humeral2
- Five required open reduction with placement of either a larger humeral tray or polyethylene spacer. (caringmedical.com)
- Index complications in order of frequency included rotator cuff tearing, postoperative glenohumeral instability, and periprosthetic humeral fracture. (sogacot.org)
Particles3
- Polyethylene particles disperse into the joint fluid surrounding a THA. (medscape.com)
- The number of foreign body inflammatory cells (macrophages and giant cells) present correlates with the number of polyethylene wear particles. (medscape.com)
- The wearing process in polyethylene liners produces small particles of polyethylene debris. (fixbones.com)
Arthroplasties2
- Two randomized clinical studies followed patients for five years after total hip arthroplasties with XPE or CP.12 Both studies concluded that, compared with CP, XPE had significantly fewer penetrations of the liner by the femoral head. (fixbones.com)
- Between 1990 and 2000, 431 total shoulder arthroplasties were performed with a cemented all-polyethylene glenoid component. (sogacot.org)
Outcomes5
- This retrospective study reported the clinical outcomes of TKA after UKA failure at our institution and compared the pros and cons of primary prostheses, primary prostheses with tibial stems, and revision prostheses. (biomedcentral.com)
- Clinical (Knee Society Rating System (KSS), Hospital for Special Surgery (HSS) scores, range of motion) and radiodiological outcomes were assessed at last follow-up with a minimal follow-up of 5 years. (sicot-j.org)
- The aim of the present study was to evaluate the influence of the type of fracture treatment and modern ceramic bearing on the clinical outcomes of delayed THA. (biomedcentral.com)
- Intraoperative measures and preoperative and follow-up clinical, radiological, and functional outcomes were compared between the ORIF and non-ORIF groups. (biomedcentral.com)
- Clinical outcomes were recorded at all time points except within 1 week postoperatively. (imperial.ac.uk)
Liner1
- Fig. 1 Illustration of pink ceramic femoral head, white polyethylene liner, and metal acetabular cup. (fixbones.com)
Acetabular components1
- Eight different types of acetabular components, including a cementless alol-polyethylene socket in 80 percent of the cases, were used. (fondazione.it)
Knee2
- Aperion Biologics Inc. announced the enrollment and implantation of the first patients in the Company's clinical trial of its Z-Lig Anterior Cruciate Ligament reconstruction device for the treatment of ligament injuries of the knee. (massdevice.com)
- Clinical examination showed painful restriction of the range of motion of the right knee, and a palpable mass at the posterior-medial aspect of the knee (Figure 1 ). (biomedcentral.com)
Metallosis1
- Intraoperative findings revealed massive metallosis related to extensive polyethylene wear, delamination and deformation. (biomedcentral.com)
Vivo3
- To enhance their in vivo application, we engineered HucMSCs-Exos-encapsulated poly lactic-co-glycolic acid (PLGA) nanoparticles (PLGA-Exos). (bvsalud.org)
- BACKGROUND AND PURPOSE: Ceramic-on-ceramic articulation is an attractive alternative to metal-on-polyethylene (PE) bearings, but little is known about the in vivo effects induced by dissemination of alumina wear debris in the periprosthetic tissues. (unibo.it)
- XPE was introduced into clinical practice in 1999 with the expectation that lower wear rates in-vitro would translate to lower wear rates in vivo. (fixbones.com)
Orthopaedics1
- Clinical Orthopaedics and Related Research. (wikipedia.org)
Prosthesis4
- During the salon activity, Professor Beaule gave a lecture on the clinical follow-up outcome of MicroPort ® Orthopedics hip prosthesis. (microport.com)
- Afterwards, Professor Beaule released the latest clinical follow-up results of MicroPort ® Orthopedics hip prosthesis and had in-depth discussions with the attendees regarding modular neck fracture. (microport.com)
- Professor Beaule also had hot discussions with the R&D, manufacturing, marketing staff of MicroPort ® Orthopedics regarding the design and production of hip prosthesis and instruments, and offered previous R&D suggestions based on his clinical experience. (microport.com)
- Long-term follow-up is critical for patients with total joint replacement for early detection of occult polyethylene wear and prosthesis loosening. (biomedcentral.com)
Articulation3
- In hip simulator study, reports revealed significant wear reduction of the alumina ceramic-on-polyethylene articulation of THA compared with metal-on-polyethylene bearing surfaces. (openorthopaedicsjournal.com)
- However, medium to long-term clinical studies of THA using the alumina ceramic-on-polyethylene are few and the reported wear rate of this articulation is variable. (openorthopaedicsjournal.com)
- Joint articulation was either conventional metal-on-polyethylene (MOP) or ceramic-on-ceramic (COC). (biomedcentral.com)
Liners2
- Although the selection rate of first-generation liners still account for more than half of all the PE THAs (∼58% in 2015), the use of vitamin E-stabilized liners has been steadily growing each year since their clinical introduction in 2010. (mishuesosyarticulaciones.com.mx)
- In these contexts, it is of great importance to evaluate and understand the real clinical benefits of using the new second-generation liners as compared to the first generation. (mishuesosyarticulaciones.com.mx)
Femoral head1
- 2005). This assessment is based on the premise that the displacement of the femoral head within the acetabulum is a consequence of the loss of polyethylene material. (jmedicalcasereports.org)
Joint5
- The effective joint space includes all periprosthetic regions accessible to joint fluid and thereby accessible to particulate wear debris. (medscape.com)
- They had hot discussions on the clinical efficacy of SuperPath™ technique and DAA technique in minimally invasive joint replacement, and shared their clinical experience respectively. (microport.com)
- The optimized UHMWPE eluted antibiotic at a higher concentration for longer than the clinical gold standard antibiotic-eluting bone cement, while retaining the mechanical and wear properties of clinically used UHMWPE joint prostheses. (nature.com)
- In contrast to aseptical revisions, management of periprosthetic joint infections (PJI) necessitates an interdisciplinary setting and special care [ 7 ]. (biomedcentral.com)
- Particulate debris consisting of metals, polyethylene, ceramics, and bone cement have each been shown to provoke a biological response in joint tissues. (stanford.edu)
Debris1
- Periprosthetic bone loss may also occur as a result of an inflammatory reaction due to particulate wear debris as generated in the various wear modes (see Presentation , Modes of Wear). (medscape.com)
Patients3
- MDT ) issued a statement on results from an independent study published online in the journal Circulation , which confirmed both early and sustained clinical benefits for patients receiving the Medtronic CoreValve System for the treatment of aortic valve disease. (massdevice.com)
- The article, "Incidence and Predictors of Early and Late Mortality After Transcatheter Aortic Valve Implantation in 663 Patients With Severe Aortic Stenosis," discusses the largest CoreValve clinical study to date, with 663 consecutive aortic stenosis patients (mean age of 81 years) treated at 14 Italian centers beginning immediately after device commercialization in 2007. (massdevice.com)
- Patients with SA of the native hip resulting from contiguous spreading, hematogenous seeding or direct inoculation differ significantly and should be considered distinct clinical entities. (copernicus.org)
Conventional1
- The polyethylene component has gone through two generations, termed "conventional polyethylene," (CP) and "highly crossed-linked polyethylene" (XPE). (fixbones.com)
UHMWPE2
- Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultra-high molecular weight polyethylene (UHMWPE) results in maximized drug elution and the retention of mechanical strength. (nature.com)
- La morfología y el diseño de componentes acetabulares de polietileno de peso molecular ultra alto (UHMWPE o simplemente PE) utilizados en la artroplastia total de cadera (THA) han estado evolucionando durante más de medio siglo. (mishuesosyarticulaciones.com.mx)
Alumina3
- Alumina ceramic was introduced as a bearing surface in the 1971 as an alternative to the metal on-polyethylene couplings. (openorthopaedicsjournal.com)
- These characteristics seem to make less polyethylene wear when alumina ceramic head articulates with polyethylene than metal head. (openorthopaedicsjournal.com)
- In vitro hip simulator studies of alumina ceramic-on-polyethylene articulations, the wear rate of polyethylene with the alumina ceramic head was lower than that of polyethylene with metal head. (openorthopaedicsjournal.com)
Infections1
- Microsporidia are often overlooked in clinical samples because of problematic diagnoses, increasing the likelihood of hidden infections that can cause extensive tissue damage and various nonspecific pathologies and that often go without effective treatment ( 11 ). (cdc.gov)
Reduction2
- Zimmer's Longevity highly crosslinked polyethylene is formulated specifically to resist wear under the conditions found in hips and represents a significant scientific advancement in wear reduction. (massdevice.com)
- Stress shielding may result in periprosthetic bone loss from a reduction in the load transmitted to bone. (medscape.com)
Long-term clinical1
- ZMH ) announced that results of an independent study presented at the 2011 American Academy of Orthopaedic Surgeons (AAOS) annual meeting demonstrated long-term clinical success for Longevity highly crosslinked polyethylene. (massdevice.com)
Radiological1
- It can have several presentations, the clinical and radiological severity of which will guide the treatment. (louvainmedical.be)
Laboratory2
- Dr. Helfet has performed extensive clinical and laboratory research with well over 250 published articles in the speciality of Orthopaedic Trauma, which is presented in scientific conferences both nationally and internationally and widely published in leading medical journals. (nyfracture.com)
- Linear wear is assessed in clinical studies, and volumetric wear in laboratory studies. (fixbones.com)
Highly2
- Our work is highly interdisciplinary, and is driven by unmet clinical needs or key gaps in biology. (stanford.edu)
- It is the largest series and longest follow-up period to date for highly crosslinked polyethylene material. (massdevice.com)
Results4
- Zimmer also announced that results from two clinical studies reinforce the clinical advantages of the company's proprietary Trabecular Metal Technology. (massdevice.com)
- The study results will be used to support regulatory approvals and clinical acceptance of the Z-Lig ACLR device in select markets outside of the United States. (massdevice.com)
- This study analyzed the clinical results of different types of prostheses used in treating failed UKA. (biomedcentral.com)
- Since then, owing to excellent clinical results, the number of stems used has increased year by year and more than 2000 stems were implanted in 2009. (researchgate.net)
Efficacy1
- Our next step would be to confirm that this biological efficacy translates into a clinically measurable benefit by reducing symptoms and re-operation rates in a phase 3 clinical trial, subject to attracting the necessary clinical trial funding. (sense-studios.com)
Outcome1
- For a successful total hip replacement, accurate positioning of the implants is crucial to accomplish a good clinical outcome. (hamiltonhipandknee.com)
Diagnosis1
- Enables clinicians to track diagnosis, courses of treatment, long-term follow-up, and clinical responses to the diseases. (stanford.edu)
Studies1
- 2018). The lack of high-powered studies and well-accepted guidelines further hampers clinical decision-making. (copernicus.org)