• Cardiovascular (CV) diseases are the leading cause of morbidity and mortality in diabetic patients. (hindawi.com)
  • Although these medicines are effective in treating … 172 - 174 In a retrospective study of >700 000 Veterans Affairs patients, using International Classification of Diseases-9 codes to identify diabetes mellitus, the risk of pulmonary embolism was 27% higher in the diabetic … It is characterized by high levels of sugar in the blood. (workout-transalp.fr)
  • Neurodegeneration and neurodegenerative diseases (including the shared mechanisms of nerve cell death that contribute to many diseases), Vascular Cognitive Impairment and Dementia (VCID), NINDS tissue/cell resources, basic invertebrate neuromuscular junction (NMJ). (nih.gov)
  • Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. (suaway.com)
  • With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. (nshealth.ca)
  • Thus, tissues which are very sensitive to oxygen levels, such as the retina, develop microangiopathy and may cause blindness (so-called proliferative diabetic retinopathy). (wikipedia.org)
  • After nine years of follow up the group assigned to tight blood pressure control also had a 34% reduction in risk in the proportion of patients with deterioration of retinopathy by two steps (99% confidence interval 11% to 50%) (P=0.0004) and a 47% reduced risk (7% to 70%) (P=0.004) of deterioration in visual acuity by three lines of the early treatment of diabetic retinopathy study (ETDRS) chart. (ox.ac.uk)
  • CONCLUSION: Tight blood pressure control in patients with hypertension and type 2 diabetes achieves a clinically important reduction in the risk of deaths related to diabetes, complications related to diabetes, progression of diabetic retinopathy, and deterioration in visual acuity. (ox.ac.uk)
  • Diabetes mellitus (DM) is associated with macrovascular and microvascular complications (coronary artery disease, ischemic stroke, peripheral arterial disease, nephropathy, and retinopathy) [ 1 , 2 ]. (hindawi.com)
  • A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
  • Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
  • Based on the prominent role of TNF-α in the development of diabetic retinopathy, these observations further validate the significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion, thereby enhancing the therapeutic potential of specific enzyme inhibitors. (diabetesjournals.org)
  • Diabetic retinopathy is a progressive vision-threatening complication of diabetes, characterized by capillary occlusion, formation of microvascular lesions, and retinal neovascularization adjacent to ischemic areas of the retina ( 1 - 2 ). (diabetesjournals.org)
  • It turned out that peptide bioregulators are most effective in case of age-related macular degeneration, retinitis pigmentosa, complicated myopia, diabetic retinopathy. (suaway.com)
  • One of the most severe complications of the diabetes mellitus is a diabetic retinopathy, that is a progressive lesion of the retina, requiring laser and surgical intervention. (suaway.com)
  • Macroangiopathy may cause other complications, such as ischemic heart disease, stroke and peripheral vascular disease which contributes to the diabetic foot ulcers and the risk of amputation. (wikipedia.org)
  • One of the most problematic diabetic complications that is responsible for amputations is a diabetic foot ulcer and hypnosis has shown positive results in increasing peripheral blood circulation. (drdorothy.net)
  • Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • E08.59 Diabetes mellitus due to underlying condition with other circulatory complications E08.6 Diabetes mellitus due to underlying condition with other specified complications E08.61Diabetes mellitus due to underlying condition with diabetic arthropathy E08.610 Diabetes mellitus due to underlying condition with diabetic neuropathicarthropathy Diabetes mellitus due to underlying … The code E13.59 is valid during the fiscal year 2021 from October 01, 2020 through September 30, 2021 for the submission of HIPAA-covered transactions. (workout-transalp.fr)
  • complications 7 Circulatory None 8 Other specified complications Unspecified complications 9 Unspecified complications We investigated the trend of diabetic vascular complication-related deaths between 2000 and 2016 in the global diabetes … Find out here how to recognize the common symptoms of diabetes. (workout-transalp.fr)
  • Diabetic nephropathy (DN) is one of the most serious complications of DM. (biomedcentral.com)
  • Diabetic ulcers are a chronic complication of DM caused by angiopathy, neuropathy and the presence of infection, also of the most detrimental and serious complications of diabetes mellitus, 10% to 25% of diabetic patients develop foot ulcers diabetes. (gunabangsa.ac.id)
  • By FIR irradiation, we can prove the protective effect of PLZF on vascular endothelium in diabetic vascular complications, and identify the detailed mechanism in this project. (tmu.edu.tw)
  • The finding in this project will provide a potential non-invasion therapy for diabetic vascular complications. (tmu.edu.tw)
  • The occurrence of diabetic foot is closely related to micro-angiopathy, micro-thrombosis in the lower limb, which may predate the presentation of diabetic foot. (biomedcentral.com)
  • However, very little data are available on IS of circulating cells of MetS patients although clinical data show that inhibited mTOR, with specific inhibitors such as Serolimus or Everolimus after kidney transplantation, significantly increase the presence of de novo thrombotic micro-angiopathy with artery lesion characterized by intimal cell proliferation, necrosis and narrowed lumen. (biomedcentral.com)
  • Peripheral arterial disease (PAD) is an under-recognized complication of diabetes. (nih.gov)
  • Antiplatelet agents are effective in primary and secondary prevention of arterial thrombosis (cardiovascular events, ischaemic stroke, and peripheral arterial occlusive disease). (hindawi.com)
  • The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
  • Diabetic foot (DF) is a serious diabetic complication that refers to the destruction of the skin and deep tissues (including muscle and bone) distal to the ankle joint, often combined with arterial occlusion and infection of the lower extremity [ 1 ]. (biomedcentral.com)
  • A course method of AP (10 sessions) using body- AP points of general and segmental action and some Ear-points was used for therapy of the functional stage of lower limb diabetic angiopathy in 55 patients with insulin-dependent diabetes mellitus. (med-vetacupuncture.org)
  • A direct noticeable clinical effect was obtained in 78% of cases, determined perhaps by improved elastotonic properties of arteries of average calibre, enhanced blood outflow and regulation of lower limb vascular peripheral resistance. (med-vetacupuncture.org)
  • Lower-limb infections, gangrene, and diabetic foot ulcers were the most common precipitating medical events leading to the need for an amputation. (janssencarepath.com)
  • Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). (wikipedia.org)
  • The best known and most prevalent angiopathy is diabetic angiopathy, a common complication of chronic diabetes. (wikipedia.org)
  • Hypnosis is powerful tool to induce relaxation, decrease psychological morbidity, often associated with diabetes, and accelerate wound healing, in case of diabetic foot ulcers. (drdorothy.net)
  • Abstract: We reviewed 25 diabetic (mean age 68 years) and 25 non-diabetic patients (mean age 71 years) who had undergone decompression for lumbar spinal stenosis at a mean of 3.4 years after operation to determine whether diabetes affected the outcome of surgery. (uniroma1.it)
  • Peripheral vascular deficiency was diagnosed in 20% of patients with diabetes and in 4% of non-diabetics. (uniroma1.it)
  • Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene: E08.52 Assessment: 66 year old male with diabetic peripheral angiopathy. (workout-transalp.fr)
  • Kurdi, Fahruddin dan Ratna Puji Priyanti (2019), Manajemen Ulkus Kaki Diabetikum : Efektifitas Foot Exercise Terhadap Risiko DFU (Diabetic Foot Ulcers) Pasien Diabetes Mellitus Di Al Hijrah Wound Care Center. (gunabangsa.ac.id)
  • METHODS: We investigated associations of biomarkers of tubular injury and inflammation with kidney structural features in 244 adults with type 1 diabetes from the Renin-Angiotensin System Study, a randomized, placebo-controlled trial testing effects of enalapril or losartan on changes in glomerular, tubulointerstitial, and vascular parameters from baseline to 5-year kidney biopsies. (bvsalud.org)
  • See Clinical Findings in Diabetes Mellitus, a Critical Images slideshow, to help identify various cutaneous, ophthalmologic, vascular, and neurologic manifestations of DM. (medscape.com)
  • It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
  • In patients with type 1 diabetes mellitus, INVOKANA ® significantly increases the risk of diabetic ketoacidosis, a life-threatening event, beyond the background rate. (janssencarepath.com)
  • A condition with multiple tumor-like lesions caused either by congenital or developmental malformations of BLOOD VESSELS, or reactive vascular proliferations, such as in bacillary angiomatosis. (uchicago.edu)
  • Damage to nerve cells may cause peripheral neuropathy, and to kidney cells, diabetic kidney disease (Kimmelstiel-Wilson syndrome). (wikipedia.org)
  • Mistaken preoperative diagnosis was the cause of failure in three diabetic patients, two with diabetic neuropathy and one with diabetic angiopathy. (uniroma1.it)
  • The conclusion of this activity is an increase in ability to practice DM foot exercise as an effort to avoid the risk of blood vascular disorders, neuropathy and infection of the feet. (gunabangsa.ac.id)
  • 2014) 'Plantar pressure in diabetic peripheral neuropathy patients with active foot ulceration, previous ulceration and no history of ulceration: A meta-analysis of observational studies', PLoS ONE, 9(6). (gunabangsa.ac.id)
  • The risk of amputation was highest in patients with a baseline history of prior amputation, peripheral vascular disease, and neuropathy. (janssencarepath.com)
  • A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)
  • Gangrene of the diabetic patient, numbness and paraesthesia in the limbs, cramps with the sensation of coldness or absence of any sensation. (reckeweg-india.com)
  • In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
  • The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)
  • The accumulation of advanced glycation end products (AGE) in diabetic patients can trigger apoptotic changes of vascular endothelial cells and involves in the development and progression of micro- and macroangiopathy. (tmu.edu.tw)
  • NO bioavailability is crucial for maintaining vascular endothelial health and function. (tmu.edu.tw)
  • However, although the currently available treatments have proven to be useful in reducing ischemic events, diabetic patients continue to have a higher risk of adverse events compared with those in non-diabetic patients. (hindawi.com)
  • Hypertension and cerebral amyloid angiopathy (CAA) are the most common causes of primary ICH, but the mechanism of hemorrhage in both conditions is unclear. (nature.com)
  • In primary ICH, hypertension is thought to be the underlying cause in 65% of cases, followed by cerebral amyloid angiopathy (CAA). (nature.com)
  • Therefore, finding indicators that predict the risk of occurrence and progression of diabetic foot and early intervention can help improve the quality of life. (biomedcentral.com)
  • It was held on August 18 2022, at Jabung, Sragen, attended by 20 elderly Posyandu cadres and 20 family with diabetic. (gunabangsa.ac.id)
  • middle ear disorders of vascular genesis, accompanied by hearing loss. (solopharm.com)
  • Diabetic patients must monitor their levels as body's inability to properly utilize and / or produce insulin can pose a serious threat to their health. (healthiack.com)
  • Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
  • This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
  • The role of novel and more potent antiplatelet strategies, currently under clinical development, seems attractive in diabetic patients. (hindawi.com)
  • A large clinical study found that peripheral vascular disease (PAD) in patients with T2DM is a serious complication. (biomedcentral.com)
  • The preoperative symptoms were similar in the two groups except that an abrupt onset of symptoms, the presence of night pain and the absence of any posture-related pain relief were recorded only by diabetic patients. (uniroma1.it)
  • Nerve-conduction velocity was slowed in 80% of the diabetic and in 25% of the nondiabetic patients. (uniroma1.it)
  • The aim of this study was to develop a method to evaluate IS in peripheral lymphocytes to identify altered intracellular molecules in patients with MetS to use as risk biomarkers of vascular thrombosis. (biomedcentral.com)
  • Diabetic vascular complication accounts for disabilities and high mortality rates in diabetic patients. (tmu.edu.tw)
  • Participants of family caregiver showed increased knowledge and ability to provide basic diabetic ulcer care. (gunabangsa.ac.id)
  • Moreover, the concomitant presence of multiple "classical" cardiovascular risk factors in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • Precipitating conditions for diabetic ketoacidosis or other ketoacidosis include acute febrile illness, reduced caloric intake, ketogenic diet, surgery, insulin dose reduction, volume depletion, and alcohol abuse. (janssencarepath.com)
  • Blood glucose levels at presentation may be below those typically expected for diabetic ketoacidosis (eg, less than 250 mg/dL). (janssencarepath.com)
  • There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)
  • It has been shown that MPV is significantly higher in diabetic populations [ 5 ]. (hindawi.com)
  • AP has been said to significantly improve, or even normalize, vibration-induced peripheral ischemia of the upper limb as effectively as, or even more effectively than, balneotherapy (mineral salt bath, underwater whirlpool massage). (med-vetacupuncture.org)
  • Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
  • 5. Evaluate protective effect of PLZF nuclear translocation on vascular endothelium in diabetic mice. (tmu.edu.tw)
  • The pathogenesis of DF is complex and is usually associated with micro-vascular and macro-vascular alterations. (biomedcentral.com)
  • Although there is consensus about the different vascular factors that contribute to BME and AVN, the pathogenesis and cause of pain remain unclear. (biomedcentral.com)
  • In this activity, counseling/education is carried out, demonstrations of foot callus care as well as basic diabetic wound care and care giver assistance in providing diabetic foot care to diabetic. (gunabangsa.ac.id)
  • This activity is to improve the health status of the community with diabetic who can understand the prevention and know about the basic ways of treating diabetic ulcers. (gunabangsa.ac.id)
  • Of the 17 diabetics, on the day 2 visit after the training, 10 were still fully dependent on providing foot care, on the day 5 visit after the training, it increased to 9 who were independent, 6 were still assisted and only 2 were fully dependent. (gunabangsa.ac.id)
  • In vitro, YKL-40 is secreted by various cells, including vascular smooth muscle cells (VSMCs), activated macrophages and macrophages during late stages of differentiation [ 12 ]. (biomedcentral.com)
  • Total mononuclear cells were isolated from peripheral blood using density gradient centrifugation. (biomedcentral.com)
  • Therefore, we hypothesize that PLZF nuclear translocation protects vascular endothelium cells from AGE-induced injury in vivo and in vitro. (tmu.edu.tw)
  • All treatment groups were forest workers of similar age and with similar vascular lesions. (med-vetacupuncture.org)